Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children's Cancer Study Group Study L99-15.

abstract：:A t(5;12)(q33;p13) translocation has been detected in two patients with myeloid disorder and eosinophilia. Six other patients with haematological disease with eosinophilia with similar translocation have been published previously. The existence of a new entity, a myeloproliferative disorder with eosinophilia and t(5;1...

journal_title：British journal of haematology

authors： Baranger L,Szapiro N,Gardais J,Hillion J,Derre J,Francois S,Blanchet O,Boasson M,Berger R

更新日期：1994-10-01 00:00:00

abstract：:The Scott syndrome is a rare inherited haemorrhagic disorder characterized by the inability of blood cells to expose aminophospholipids and to shed microparticles. We have had the opportunity to study a recently reported French patient with this syndrome and have confirmed by means of a fluorescence assay for transbil...

journal_title：British journal of haematology

authors： Dachary-Prigent J,Pasquet JM,Fressinaud E,Toti F,Freyssinet JM,Nurden AT

更新日期：1997-12-01 00:00:00

abstract：:Plasma cells isolated from bone marrow (BM) aspirates of 15 patients with active multiple myeloma (MM) were cultured and analysed for in vitro proliferative response and Ig-synthesis upon stimulation with interleukin-3 (IL-3), interleukin-4 (IL-4) and interleukin-6 (IL-6). The proliferative response, determined as Ki-...

journal_title：British journal of haematology

authors： Sonneveld P,Schoester M,de Leeuw K

更新日期：1991-12-01 00:00:00

abstract：:The use of 111Indium oxine as a platelet label for the performance of platelet life-span studies has been examined. Platelet life-span in normal subjects varied between 8 X 10 and 10 X 36 d. Patients with primary thrombocythaemia had clearly reduced platelet life-span whether or not they presented with vascular occlus...

journal_title：British journal of haematology

authors： Bautista AP,Buckler PW,Towler HM,Dawson AA,Bennett B

更新日期：1984-12-01 00:00:00

abstract：:Lack of consensus for first-line marginal zone lymphoma (MZL) treatment and toxicities associated with currently available systemic therapies have inspired evaluation of immunotherapeutic agents yielding robust outcomes with improved tolerability. We previously reported durable efficacy with first-line lenalidomide an...

journal_title：British journal of haematology

authors： Becnel MR,Nastoupil LJ,Samaniego F,Davis RE,You MJ,Green M,Hagemeister FB,Fanale MA,Fayad LE,Westin JR,Wang M,Oki Y,Forbes SG,Feng L,Neelapu SS,Fowler NH

更新日期：2019-06-01 00:00:00

abstract：:The interaction of rare Hb variants with beta(0)-thalassaemia results in a quasihomozygous state where the erythrocytes contain the variant as the only major adult Hb component. Such a situation is a unique model that enables functional studies even in the case of a neutral variant that could not be isolated from Hb A...

journal_title：British journal of haematology

authors： Vassilopoulos G,Papassotiriou I,Voskaridou E,Stamoulakatou A,Premetis E,Kister J,Marden M,Griffon N,Poyart C,Wajcman H

更新日期：1995-11-01 00:00:00

abstract：:Neutralizing anti-IFN alpha antibodies (nIFN alpha Abs) occur in a significant proportion of patients with hairy cell leukaemia, hepatitis or solid tumours treated with recombinant IFN alpha (IFN alpha 2a or IFN alpha 2b), but information on their incidence in chronic myeloid leukaemia (CML) is scanty and their clinic...

journal_title：British journal of haematology

authors： Russo D,Candoni A,Zuffa E,Minisini R,Silvestri F,Fanin R,Zaja F,Martinelli G,Tura S,Botta G,Baccarani M

更新日期：1996-08-01 00:00:00

abstract：:In this population-based survey covering two geographically distinct UK regions, we evaluated the number of myeloma patients aged < or =65 years who have not undergone transplantation. The combined data from both of these regions showed that 57% of age-eligible patients were not transplanted. While early death and com...

journal_title：British journal of haematology

authors： Morris TC,Velangi M,Jackson G,Marks DI,Ranaghan L,Northern Ireland Regional Haematology Group.,Northern Regional Haematologists Group.,Clinical Trials Committee of The British Scoiety for Blood and Marrow Transplantation.

更新日期：2005-02-01 00:00:00

abstract：:Relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) in those unfit or ineligible for autologous stem cell transplantation is associated with a poor outcome and new treatment approaches are needed. Pixantrone is a novel aza-anthracenedione which is structurally similar to anthracyclines and is licenced i...

journal_title：British journal of haematology

authors： Eyre TA,Linton KM,Rohman P,Kothari J,Cwynarski K,Ardeshna K,Bailey C,Osborne WL,Rowntree C,Eden D,Shankara P,Eyre DW,Jasani P,Chaidos A,Collins GP,Hatton CS

更新日期：2016-06-01 00:00:00

abstract：:Interferon(rIFN)-alpha, a successful therapeutic agent in the control of thrombocytosis, has been shown to suppress human megakaryopoiesis. We investigated bone marrow biopsies from 12 patients with thrombocytosis due to chronic myeloproliferative disorders. Prior to treatment as well as during rIFN-alpha-2c therapy, ...

journal_title：British journal of haematology

authors： Chott A,Gisslinger H,Thiele J,Fritz E,Linkesch W,Radaszkiewicz T,Ludwig H

更新日期：1990-01-01 00:00:00

abstract：:During definitive erythropoiesis, erythroid precursors undergo differentiation through multiple nucleated states to an enucleated reticulocyte, which loses its residual RNA/organelles to become a mature erythrocyte. Over the course of these transformations, continuous changes in membrane proteins occur, including shif...

journal_title：British journal of haematology

authors： Kodippili GC,Spector J,Kang GE,Liu H,Wickrema A,Ritchie K,Low PS

更新日期：2010-09-01 00:00:00

abstract：:A stroma free platelet lysate supernatant (PLS) was prepared by repeatedly freezing and thawing a human platelet suspension separated from platelet rich plasma by gel filtration. The material was potently thrombogenic in a stasis model in rabbits, but only when combined with a purified preparation of factor Xa. The do...

journal_title：British journal of haematology

authors： Giles AR,Nesheim ME,Hoogendoorn H,Tracy PB,Mann KG

更新日期：1982-07-01 00:00:00

abstract：:Follow-up studies of natural killer (NK) cells, NK activity and antibody dependent cellular cytotoxicity (ADCC) in the course of hairy cell leukaemia (HCL) were carried out in a series of patients affected by the disease. NK activity against K562 targets was found to be high in all the patients with non-symptomatic st...

journal_title：British journal of haematology

authors： Demeter J,Pálóczi K,Lehoczky D,Benczúr M

更新日期：1989-02-01 00:00:00

abstract：:Sickle cell anaemia is a severe inherited blood disorder for which there is presently no curative therapy other than allogeneic haematopoietic stem cell (HSC) transplantation. This therapeutic option, however, is not available to most patients because of the lack of a matched related donor. Different genetic strategie...

journal_title：British journal of haematology

authors： Mansilla-Soto J,Rivière I,Sadelain M

更新日期：2011-09-01 00:00:00

abstract：:The prognostic role of CD20 expression and Epstein-Barr virus (EBV) positivity in post-transplant lymphoproliferative disease (PTLD) after solid organ transplantation (SOT) in paediatric patients is poorly understood. We retrospectively examined the relationship of CD20 and EBV with the time interval from SOT to PTLD ...

journal_title：British journal of haematology

authors： Orjuela MA,Alobeid B,Liu X,Siebert AL,Kott ER,Addonizio LJ,Morris E,Garvin JH,Lobritto SJ,Cairo MS

更新日期：2011-03-01 00:00:00

abstract：:Recently, leukaemia-associated antigens (LAA) recognized by T lymphocytes, such as Wilm's tumour-1 (WT-1) or pathogenesis-related protein-1 (PR-1), have been identified. For immunotherapies that employ antigen peptides, either alone or pulsed on dendritic cells (DC), the expression of human leucocyte antigen (HLA) mol...

journal_title：British journal of haematology

authors： Vollmer M,Li L,Schmitt A,Greiner J,Reinhardt P,Ringhoffer M,Wiesneth M,Döhner H,Schmitt M

更新日期：2003-03-01 00:00:00

abstract：:Aspergillus fumigatus is an opportunistic filamentous fungus that is currently the most frequent cause of invasive fungal disease in immunosuppressed individuals. Recent advances in our understanding of the pathogenesis of invasive aspergillosis have highlighted the multifactorial nature of A. fumigatus virulence and ...

journal_title：British journal of haematology

authors： Ben-Ami R,Lewis RE,Kontoyiannis DP

更新日期：2010-08-01 00:00:00

abstract：:The prognostic significance of cytogenetic abnormalities was determined in 106 patients with well-characterized idiopathic myelofibrosis who were successfully karyotyped at diagnosis. 35% of the cases exhibited a clonal abnormality (37/106), whereas 65% (69/106) had a normal karyotype. Three characteristic defects, na...

journal_title：British journal of haematology

authors： Reilly JT,Snowden JA,Spearing RL,Fitzgerald PM,Jones N,Watmore A,Potter A

更新日期：1997-07-01 00:00:00

abstract：:We report a series of 20 patients with the myelodysplastic syndrome (MDS) each with a coexistent lymphoid or plasmacytic neoplasm. In none of the patients did chemotherapy play a part in the pathogenesis. The possible reasons for the coincidence of these conditions are discussed. The frequency and variety of associate...

journal_title：British journal of haematology

authors： Copplestone JA,Mufti GJ,Hamblin TJ,Oscier DG

更新日期：1986-05-01 00:00:00

abstract：:Over the past four decades, remarkable progress has been made in the treatment and prognosis of multiple myeloma (MM), although it remains an incurable disease. Chemotherapy resistance is a major hurdle for treatment efficacy. Drug resistance can be innate and so driven by genes involved in the drug metabolism pathway...

journal_title：British journal of haematology

authors： Macauda A,Castelli E,Buda G,Pelosini M,Butrym A,Watek M,Kruszewski M,Vangsted AJ,Rymko M,Jamroziak K,Abildgaard N,Haastrup EK,Mazur G,Ríos R,Jurczyszyn A,Zawirska D,Dudziński M,Raźny M,Dutka M,Tomczak W,Suska A,

更新日期：2018-11-01 00:00:00

abstract：:Neutrophil hypersegmentation (NH) is an important haematological feature of cobalamin or folate deficiency. As iron deficiency and folate deficiency often occur in the same target groups it is important to establish whether iron deficiency alone is a cause of NH. We report a case-control study which addresses this iss...

journal_title：British journal of haematology

authors： Westerman DA,Evans D,Metz J

更新日期：1999-12-01 00:00:00

abstract：:Adult T-cell leukaemia (ATL) is caused by human T-cell leukaemia virus type I (HTLV-I). It has been suggested that cytokines play a role in the development and in the neoplastic cell growth of ATL. However, the precise mechanism involved in this process still remains unclear. Interleukin-21 (IL-21) and its receptor (I...

journal_title：British journal of haematology

authors： Ueda M,Imada K,Imura A,Koga H,Hishizawa M,Uchiyama T

更新日期：2005-01-01 00:00:00

abstract：:Karyotypic analysis was performed in a total of 69 patients with well-characterized idiopathic myelofibrosis. Karyotypic abnormalities were detected in 46% of cases examined during the chronic phase (29/63); with three abnormalities, del(13q), del(20q) and partial trisomy 1q, accounting for 75% of all abnormalities at...

journal_title：British journal of haematology

authors： Reilly JT,Wilson G,Barnett D,Watmore A,Potter A

更新日期：1994-11-01 00:00:00

abstract：:Mastocytosis is an uncommon disease characterized by a proliferation of tissue mast cells involving various organs, particularly the bone marrow. Though rare, the association of mastocytosis and haematological malignancies is well established. However, the frequency of mastocytosis reported in patients with essential ...

journal_title：British journal of haematology

authors： Le Tourneau A,Gaulard P,D'Agay MF,Vainchencker W,Cadiou M,Devidas A,Haioun C,Clauvel JP,Audouin J,Diebold J

更新日期：1991-09-01 00:00:00

abstract：:Constitutive phosphatidylinositide 3-kinase (PI3K) signalling has been implicated in multiple myeloma (MM) pathophysiology and is regarded as an actionable target for pharmacological intervention. Isoform-specific PI3K inhibition may offer the most focused treatment approach and could result in greater clinical effica...

journal_title：British journal of haematology

authors： Hofmann C,Stühmer T,Schmiedl N,Wetzker R,Mottok A,Rosenwald A,Langer C,Zovko J,Chatterjee M,Einsele H,Bargou RC,Steinbrunn T

更新日期：2014-08-01 00:00:00

abstract：:The specific sodium pump antagonist ouabain was used to study the effect of sodium pump inhibition on granulopoietic colony formation by normal human bone marrow cells cultured in soft agar for 7 d. Suppression of colony formation was dose-dependent and occurred at a low and reproducible concentration. The use of an e...

journal_title：British journal of haematology

authors： Steed AJ,Boardman KM,Delamore IW

更新日期：1982-07-01 00:00:00

abstract：:The myelodysplastic syndromes (MDS) have a significant frequency of evolution into acute myeloid leukaemia (AML). Approximately 30% of MDS patients show activating mutations of the N-RAS proto-oncogene, and these patients are at increased risk of leukaemic evolution. Long-term survivors of aplastic anaemia (AA) and pa...

journal_title：British journal of haematology

authors： White JR,Josten KM,Chopra R,Tooze J,Saso R,Gordon-Smith EC,Rutherford TR

更新日期：1995-12-01 00:00:00

abstract：:Restriction fragment length polymorphisms (RFLP) of the X-chromosome genes phosphoglycerate kinase (PGK) and hypoxanthine phorphoribosyltransferase (HPRT) were used to determine the clonal nature of myelodysplastic syndromes (MDS) in 22 patients. These included eight with refractory anaemia (RA), four with RA with rin...

journal_title：British journal of haematology

authors： Tsukamoto N,Morita K,Maehara T,Okamoto K,Karasawa M,Omine M,Naruse T

更新日期：1993-04-01 00:00:00

abstract：:In 2019 the UK Myeloma Research Alliance introduced the Myeloma Risk Profile (MRP) for prediction of outcome in patients with newly diagnosed multiple myeloma (MM), ineligible for autologous stem cell transplantation. To validate the MRP in a population-based setting we performed a study of the entire cohort of transp...

journal_title：British journal of haematology

authors： Redder L,Klausen TW,Vangsted AJ,Gregersen H,Andersen NF,Pedersen RS,Szabo AG,Frederiksen M,Frølund UC,Helleberg C,Nielsen LK,Pedersen PT,Salomo M,Gimsing P,Frederiksen H,Abildgaard N

更新日期：2020-06-09 00:00:00

abstract：:Diamond-Blackfan anaemia (DBA) is a rare bone marrow failure syndrome characterised by anaemia, congenital anomalies and cancer predisposition. Although infections are the second leading cause of mortality in non-transplanted patients, immune function is largely unexplored. We identified quantitative deficits in serum...

journal_title：British journal of haematology

authors： Iskander D,Roberts I,Rees C,Szydlo R,Alikian M,Neale M,Harrington Y,Kelleher P,Karadimitris A,de la Fuente J

更新日期：2019-07-01 00:00:00