Molecular mechanisms of pathology and treatment in Diamond Blackfan Anaemia.

abstract：:Pegfilgrastim is a pegylated form of the granulocyte-colony stimulating factor, filgrastim. Herein, we report the results of a multicentre, randomized, double-blind phase III trial comparing the efficacy and safety of pegfilgrastim with filgrastim in patients with malignant lymphoma. Patients were randomized to receiv...

journal_title：British journal of haematology

authors： Kubo K,Miyazaki Y,Murayama T,Shimazaki R,Usui N,Urabe A,Hotta T,Tamura K

更新日期：2016-08-01 00:00:00

abstract：:We tested whether parvovirus B19 (PVB19) is involved in benign lymph node swelling as a causative agent. The serum specimens from 13 patients with lymph node swelling of unidentified cause were tested for IgM and IgG antibody against PVB19 by Western blot analysis. Five patients had IgM antibody, and PVB19 DNA was det...

journal_title：British journal of haematology

authors： Tsuda H,Maeda Y,Nakagawa K

更新日期：1993-11-01 00:00:00

abstract：:We hypothesized that Wilms tumour 1 gene (WT1) expression levels in acute myeloid leukaemia (AML) patients might have predictive value and reveal molecular relapse kinetics. WT1 level was determined at diagnosis, during therapy and post-therapy follow-up in 89 patients who reached first complete remission (CR1) (952 s...

journal_title：British journal of haematology

authors： Ommen HB,Nyvold CG,Braendstrup K,Andersen BL,Ommen IB,Hasle H,Hokland P,Ostergaard M

更新日期：2008-06-01 00:00:00

abstract：:We performed a retrospective analysis of outcome in 45 patients with multiple myeloma receiving unrelated donor stem cell transplants (UD-SCT) in the UK between 1993 and 2002; 17 received myeloablative conditioning regimens and 28 received reduced intensity conditioning (RIC) protocols. Forty patients received pretran...

journal_title：British journal of haematology

authors： Shaw BE,Peggs K,Bird JM,Cavenagh J,Hunter A,Alejandro Madrigal J,Russell NH,Sirohi B,Towlson K,Williams CD,Marks DI,Clinical Trials Committee of the British Society of Blood and Marrow Transplantation.

更新日期：2003-12-01 00:00:00

abstract：:Multiple myeloma (MM) tumour cells evade host immunity through a variety of mechanisms, which may potentially include the programmed cell death ligand-1 (PD-L1):programmed cell death protein-1 (PD-1) axis. This interaction contributes to the immunosuppressive bone marrow (BM) microenvironment, ultimately leading to re...

journal_title：British journal of haematology

authors： Chen H,Li M,Ng N,Yu E,Bujarski S,Yin Z,Wen M,Hekmati T,Field D,Wang J,Nassir I,Yu J,Huang J,Daniely D,Wang CS,Xu N,Spektor TM,Berenson JR

更新日期：2020-12-20 00:00:00

abstract：:Interferon(rIFN)-alpha, a successful therapeutic agent in the control of thrombocytosis, has been shown to suppress human megakaryopoiesis. We investigated bone marrow biopsies from 12 patients with thrombocytosis due to chronic myeloproliferative disorders. Prior to treatment as well as during rIFN-alpha-2c therapy, ...

journal_title：British journal of haematology

authors： Chott A,Gisslinger H,Thiele J,Fritz E,Linkesch W,Radaszkiewicz T,Ludwig H

更新日期：1990-01-01 00:00:00

abstract：:We examined the in vivo effects and safety of the third generation bisphosphonate, zoledronate (ZOL) alone and combined with imatinib mesylate against primary Philadelphia chromosome positive (Ph+) leukaemic cells. ZOL inhibited the prenylation of Rap1A in leukaemic cells in vitro and synergised with imatinib to enhan...

journal_title：British journal of haematology

authors： Segawa H,Kimura S,Kuroda J,Sato K,Yokota A,Kawata E,Kamitsuji Y,Ashihara E,Yuasa T,Fujiyama Y,Ottmann OG,Maekawa T

更新日期：2005-08-01 00:00:00

abstract：:Routine testing on plasma from a patient due to undergo a coronary artery bypass graft operation revealed a prolonged thrombin clotting time associated with a normal plasma fibrinogen level when this was determined by a method not dependent upon the rate of fibrin formation. Fibrinogen purified from the patient's plas...

journal_title：British journal of haematology

authors： Lane DA,Cuddigan B,VanRoss M,Kakkar VV

更新日期：1980-03-01 00:00:00

abstract：:Unfractionated heparin (UFH) and low-molecular weight heparin (LMWH) are well defined anticoagulant agents. Recent data suggest that both LMWH and UFH may also have potent anti-inflammatory properties; however, their mechanism of action responsible for the anti-inflammatory effect is not yet fully elucidated. This stu...

journal_title：British journal of haematology

authors： Hochart H,Jenkins PV,Smith OP,White B

更新日期：2006-04-01 00:00:00

abstract：:A 69-year-old woman presented with splenic marginal zone lymphoma associated with acquired von Willebrand's disease (AVWD). Laboratory abnormalities included markedly decreased plasma levels of factor VIII coagulant (C) activity (VIII:C 28%), von Willebrand's factor (VWF) antigen (Ag) (vWF:Ag < 6%), and VWF ristocetin...

journal_title：British journal of haematology

authors： Tefferi A,Hanson CA,Kurtin PJ,Katzmann JA,Dalton RJ,Nichols WL

更新日期：1997-03-01 00:00:00

abstract：:The BRAF V600E mutation has recently been described in all cases of hairy cell leukaemia (HCL). We have developed and validated a rapid and sensitive high-resolution melting analysis (HRMA) assay that detects BRAF exon 15 mutations when hairy cells are as low as 5-10% in a sample. All 48 HCL patients were positive for...

journal_title：British journal of haematology

authors： Boyd EM,Bench AJ,van 't Veer MB,Wright P,Bloxham DM,Follows GA,Scott MA

更新日期：2011-12-01 00:00:00

abstract：:Cytometry has become important in the detection and determination of risk of monoclonal B-cell lymphocytosis; methodology has changed, and will continue to change, as cytometric technology changes. ...

journal_title：British journal of haematology

authors： Shapiro HM

更新日期：2007-12-01 00:00:00

abstract：:35 patients with oral anticoagulant (OAC) related intracranial or intraspinal haemorrhage were studied to determine treatment received, outcome and rate of recurrent bleeding and thromboembolism after restarting OAC. All patients underwent active anticoagulant reversal and in 14 patients with prosthetic heart valves (...

journal_title：British journal of haematology

authors： Butler AC,Tait RC

更新日期：1998-12-01 00:00:00

abstract：:Purpura fulminans (PF) is a cutaneous manifestation of a dramatic and deadly syndrome of systemic disseminated intravascular coagulation (DIC). It is characterized by microvascular thrombosis in the dermis followed by perivascular haemorrhage. Since two other related syndromes involve the protein C (PC) system, we und...

journal_title：British journal of haematology

authors： Madden RM,Gill JC,Marlar RA

更新日期：1990-05-01 00:00:00

abstract：:The myelodysplastic syndromes (MDS) display both haematological and biological heterogeneity with variable leukaemia potential. MicroRNAs play an important role in tumour suppression and the regulation of self-renewal and differentiation of haematopoietic progenitors. Using a microarray platform, we evaluated microRNA...

journal_title：British journal of haematology

authors： Sokol L,Caceres G,Volinia S,Alder H,Nuovo GJ,Liu CG,McGraw K,Clark JA,Sigua CA,Chen DT,Moscinski L,Croce CM,List AF

更新日期：2011-04-01 00:00:00

abstract：:Highly purified and cloned preparations of interleukin-1 (IL-1) were found to antagonize the capacity of erythropoietin (Epo) to stimulate the proliferation of mouse spleen and bone marrow erythroid precursor cells (EPC) in culture. Cloned murine IL-1 and purified and cloned human IL-1 alpha and IL-1 beta were approxi...

journal_title：British journal of haematology

authors： Schooley JC,Kullgren B,Allison AC

更新日期：1987-09-01 00:00:00

abstract：:The efficiency of stored platelet transfusion was evaluated in terms of clinical status in 141 thrombocytopenic patients. In a paired prospective study in which fresh platelets were used as controls, clinical efficiency was assessed on the basis of the ability to increase platelet count (recovery) and the time to the ...

journal_title：British journal of haematology

authors： Norol F,Kuentz M,Cordonnier C,Beaujean F,Haioun C,Vernant JP,Duédari N

更新日期：1994-01-01 00:00:00

abstract：:We describe and compare five assay systems for Protein C (PC) in human plasma; a functional assay for PC activity, Laurell electroimmunoassay with EDTA or calcium (EDTA-Laurell or Ca-Laurell), radioimmunoassay (RIA) and immunoradiometric assay (IRMA). The lower limit of sensitivity of PC in normal reference plasma was...

journal_title：British journal of haematology

authors： Mikami S,Tuddenham EG

更新日期：1986-01-01 00:00:00

abstract：:Heparin binding on polymorphonuclear leucocytes (PMNL) was characterized. Heparin binding was specific, rapid, saturable and reversible. One single class of heparin binding sites was found with a dissociation constant of 1.22 mumol/l and 7.7 x 10(6) sites per PMNL. The binding was independent of the anticoagulant acti...

journal_title：British journal of haematology

authors： Leculier C,Benzerara O,Couprie N,Francina A,Lasne Y,Archimbaud E,Fiere D

更新日期：1992-05-01 00:00:00

abstract：:A serial study of coagulation activation and whole-blood viscosity was performed on 37 patients with local or systemic bacterial infection, malaria, or a viral infection. Thrombocytopenia, without consumption of coagulation factors, was the main feature of benign tertian malaria and viral infection, whereas in septica...

journal_title：British journal of haematology

authors： Richardson SG,Matthews KB,Cruickshank JK,Geddes AM,Stuart J

更新日期：1979-07-01 00:00:00

abstract：:The potential role of the infused B cell subset after Hematopoietic Stem Cell Transplantation has not been yet studied. The present study analyzed the impact of B cells on transplant outcome in 254 patients who received a bone marrow graft from a human leucocyte antigen-identical sibling donor. The influence of B line...

journal_title：British journal of haematology

authors： Michonneau D,Peffault de Latour R,Porcher R,Robin M,Benbunan M,Rocha V,Ribaud P,Ferry C,Devergie A,Vanneaux V,Gluckman E,Marolleau JP,Socié G,Larghero J

更新日期：2009-04-01 00:00:00

abstract：:We conducted a study to demonstrate vincristine-induced apoptosis in vivo in peripheral blood mononuclear cells of children with newly diagnosed acute lymphoblastic leukaemia (ALL). In five children, apoptosis was detected by terminal deoxynucleotide transferase-mediated dUTP-digoxigenin nick-end labelling (TUNEL) ass...

journal_title：British journal of haematology

authors： Groninger E,de Graaf SS,Meeuwsen-de Boer GJ,Sluiter WJ,Poppema S

更新日期：2000-12-01 00:00:00

abstract：:Globin-gene mapping of DNA from 13 families with normal Hb A2 beta-thalassaemia (both type 1 and type 2) failed to detect any difference from normal in their globin-gene arrangement. We conclude that deletions such as those responsible for gamma beta-thalassaemia or a 'silent' Hb Lepore are not responsible for this ty...

journal_title：British journal of haematology

authors： Kanavakis E,Metaxotou-Mavromati A,Kattamis C,Aksoy M,Weatherall DJ,Wood WG

更新日期：1982-05-01 00:00:00

abstract：:We studied the incidence and potential prognostic value of thyroid abnormalities after allogeneic bone marrow transplantation (BMT) without total body irradiation (TBI) conditioning. 77 consecutive patients who received a chemotherapy-alone-based conditioning regimen pretransplant were included. Free serum thyroxine (...

journal_title：British journal of haematology

authors： Toubert ME,Socié G,Gluckman E,Aractingi S,Espérou H,Devergie A,Ribaud P,Parquet N,Schlageter MH,Beressi JP,Rain JD,Vexiau P

更新日期：1997-08-01 00:00:00

abstract：:Patients with intermittent claudication have been reported to have disturbances in blood rheology and haemostasis. Whether these disturbances are a result of, or largely independent of, smoking history and arterial narrowing has not yet been established. The levels of whole blood and plasma viscosity, haematocrit, von...

journal_title：British journal of haematology

authors： Lee AJ,Fowkes FG,Rattray A,Rumley A,Lowe GD

更新日期：1996-01-01 00:00:00

abstract：:Although 5-fluorouracil (FUra) has been the drug of choice for the treatment of patients with advanced colorectal carcinoma, the response rates are in the range of 15% and the median survival times do not exceed 9 months. Interferon alpha (IFN alpha) has limited antitumour activity in this disease. Recent clinical tri...

journal_title：British journal of haematology

authors： Rustum YM

更新日期：1991-10-01 00:00:00

abstract：:The International Extranodal Lymphoma Study Group (IELSG) promoted this study to determine the inter-observer agreement in the application of the Groupe d' Etude des Lymphomes de l' Adulte (GELA) histological scoring system for evaluating residual disease in post-treatment gastric biopsies of patients with gastric Muc...

journal_title：British journal of haematology

authors： Copie-Bergman C,Wotherspoon AC,Capella C,Motta T,Pedrinis E,Pileri SA,Bertoni F,Conconi A,Zucca E,Ponzoni M,Ferreri AJ

更新日期：2013-01-01 00:00:00

abstract：:Follicular lymphoma (FL) constitutes a significant proportion of lymphomas and shows frequent relapses. Beyond conventional chemotherapy, new therapeutic approaches have emerged, focussing on the interplay between lymphoma cells and the microenvironment. Here we report the immunophenotypic investigation of the microen...

journal_title：British journal of haematology

authors： Menter T,Tzankov A,Zucca E,Kimby E,Hultdin M,Sundström C,Beiske K,Cogliatti S,Banz Y,Cathomas G,Karjalainen-Lindsberg ML,Grobholz R,Mazzucchelli L,Sander B,Hawle H,Hayoz S,Dirnhofer S

更新日期：2020-05-01 00:00:00

abstract：:The haematological changes in early years following neonatal diagnosis have been observed in representative groups of children with sickle cell-haemoglobin C (SC) disease, sickle cell-beta(+) thalassaemia, and in sickle cell-beta(0) thalassaemia. Most haematological indices in SC disease were intermediate between prev...

journal_title：British journal of haematology

authors： Stevens MC,Maude GH,Beckford M,Grandison Y,Mason K,Serjeant BE,Taylor B,Topley JM,Serjeant GR

更新日期：1985-06-01 00:00:00

abstract：:This retrospective analysis was conducted in 64 patients diagnosed with type I cryoglobulinaemia (CG) followed at two French centres. Median follow-up was 6·75 years. CG was IgG in 60% and IgM in 40% of all cases and was asymptomatic in 16 patients (25%). Cold-triggered ischaemic skin manifestations were observed in 3...

journal_title：British journal of haematology

authors： Harel S,Mohr M,Jahn I,Aucouturier F,Galicier L,Asli B,Malphettes M,Szalat R,Brouet JC,Lipsker D,Fermand JP

更新日期：2015-03-01 00:00:00