Identification of a risk dependent microRNA expression signature in myelodysplastic syndromes.


:The myelodysplastic syndromes (MDS) display both haematological and biological heterogeneity with variable leukaemia potential. MicroRNAs play an important role in tumour suppression and the regulation of self-renewal and differentiation of haematopoietic progenitors. Using a microarray platform, we evaluated microRNA expression from 44 patients with MDS and 17 normal controls. We identified a thirteen microRNA signature with statistically significant differential expression between normal and MDS specimens (P < 0·01), including down-regulation of members of the leukaemia-associated MIRLET7 family. A unique signature consisting of 10 microRNAs was closely associated with International Prognostic Scoring System (IPSS) risk category permitting discrimination between lower (Low/Intermediate-1) and higher risk (Intermediate-2/High) disease (P < 0·01). Selective overexpression of MIR181 family members was detected in higher risk MDS, indicating pathogenetic overlap with acute myeloid leukaemia. Survival analysis of an independent cohort of 22 IPSS lower risk MDS patients revealed a median survival of 3·5 years in patients with high expression of MIR181 family compared to 9·3 years in patients with low MIR181 expression (P = 0·002). Our pilot study suggested that analysis of microRNA expression profile offers diagnostic utility, and provide pathogenetic and prognostic discrimination in MDS.


Br J Haematol


Sokol L,Caceres G,Volinia S,Alder H,Nuovo GJ,Liu CG,McGraw K,Clark JA,Sigua CA,Chen DT,Moscinski L,Croce CM,List AF




Has Abstract


2011-04-01 00:00:00












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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Gross M,Ben-Califa N,McMullin MF,Percy MJ,Bento C,Cario H,Minkov M,Neumann D

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  • Nicotinamide (vitamin B3) increases the polyploidisation and proplatelet formation of cultured primary human megakaryocytes.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Giammona LM,Fuhrken PG,Papoutsakis ET,Miller WM

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  • Monitoring of multiple myeloma and bone marrow fibrosis with aminoterminal propeptide of type III collagen (PIIINP).

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Taube T,Franssila K,Risteli L,Risteli J,Elomaa I

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    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Mahendra A,Padiolleau-Lefevre S,Kaveri SV,Lacroix-Desmazes S

    更新日期:2012-01-01 00:00:00

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    pub_type: 杂志文章,多中心研究


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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Fagan DG,Walker A

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    journal_title:British journal of haematology

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    authors: Politou M,Terpos E,Anagnostopoulos A,Szydlo R,Laffan M,Layton M,Apperley JF,Dimopoulos MA,Rahemtulla A

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    journal_title:British journal of haematology

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    authors: Zambello R,Trentin L,Cassatella MA,Raimondi R,Cerutti A,Enthammer C,Facco M,Agostini C,Semenzato G

    更新日期:1996-02-01 00:00:00

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    journal_title:British journal of haematology

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    authors: Zotz RB,Giers G,Maruhn-Debowski B,Scharf RE

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    authors: Russo D,Candoni A,Zuffa E,Minisini R,Silvestri F,Fanin R,Zaja F,Martinelli G,Tura S,Botta G,Baccarani M

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    authors: Tomiyama J,Ninomiya H,Abe T

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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    journal_title:British journal of haematology

    pub_type: 杂志文章


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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Grossi A,Vannucchi AM,Rafanelli D,Rossi Ferrini P

    更新日期:1989-04-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


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    更新日期:1993-08-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Cavani S,Perfumo C,Argusti A,Pierluigi M,Perroni L,Schmiegelow K,Petersen MB,Cotter FE,Strigini P,Dagna-Bricarelli F,Nizetić D

    更新日期:1998-10-01 00:00:00