Interferon-alpha-induced morphological changes of megakaryocytes: a histomorphometrical study on bone marrow biopsies in chronic myeloproliferative disorders with excessive thrombocytosis.

abstract：:Immune-mediated pathways have been recognized to be of importance in the pathogenesis of chronic lymphocytic leukaemia (CLL). We assessed a broad variety of immune-related and inflammatory conditions and subsequent CLL development among 4 million adult male veterans admitted to VA hospitals. We identified 3,680 CLL ca...

journal_title：British journal of haematology

authors： Landgren O,Gridley G,Check D,Caporaso NE,Morris Brown L

更新日期：2007-12-01 00:00:00

abstract：:We report on the generation and functional characterization of a humanized immunoenzyme comprising a stable humanized single chain Fv (scFv) with grafted specificity of the anti-CD22 murine monoclonal antibody RFB4 and the human ribonuclease angiogenin (ANG). The fusion protein produced from transiently transfected ma...

journal_title：British journal of haematology

authors： Krauss J,Arndt MA,Vu BK,Newton DL,Rybak SM

更新日期：2005-03-01 00:00:00

abstract：:A simple technique to separate erythrocytes from bone marrow by sedimentation under gravity after addition of hydroxyethyl starch is described. This method of removing red blood cells from the donor marrow was evaluated in 23 consecutive allogeneic bone marrow transplants between ABH-incompatible individuals. Infusion...

journal_title：British journal of haematology

authors： Ho WG,Champlin RE,Feig SA,Gale RP

更新日期：1984-05-01 00:00:00

abstract：:Two chemoattractants, the peptide N-formyl-met-leu-phe (FMLP), and the ether phospholipid, platelet activating factor (PAF), each stimulate a variety of in vitro responses in polymorphonuclear leucocytes (PMN). Because often more than one inflammatory mediator is active during inflammation, we determined the effect on...

journal_title：British journal of haematology

authors： Ingraham LM,Lafuze JE,Boxer LA,Baehner RL

更新日期：1987-06-01 00:00:00

abstract：:Minimal residual disease (MRD) assessment is a powerful prognostic factor for determining the risk of relapse in childhood acute lymphoblastic leukaemia (ALL). In this Swedish multi-centre study of childhood ALL diagnosed between 2002 and 2006, the MRD levels were analysed in 726 follow-up samples in 228 children usin...

journal_title：British journal of haematology

authors： Thörn I,Forestier E,Botling J,Thuresson B,Wasslavik C,Björklund E,Li A,Lindström-Eriksson E,Malec M,Grönlund E,Torikka K,Heldrup J,Abrahamsson J,Behrendtz M,Söderhäll S,Jacobsson S,Olofsson T,Porwit A,Lönnerholm G,R

更新日期：2011-03-01 00:00:00

abstract：:In a prospective phase II trial, pentostatin combined with cyclophosphamide and rituximab (PCR) induced strong responses and was well-tolerated in previously untreated patients with advanced-stage, indolent non-Hodgkin lymphoma (iNHL). After a median patient follow-up of more than 108 months, we performed an intent-to...

journal_title：British journal of haematology

authors： Khashab T,Hagemeister F,Romaguera JE,Fanale MA,Pro B,McLaughlin P,Rodriguez MA,Neelapu SS,Fayad L,Younes A,Feng L,Vega F,Kwak LW,Samaniego F

更新日期：2019-05-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) were recently demonstrated to exist in human cord blood. Phytohaemagglutinin (PHA), a potent mitogen for mononuclear cells was used to induce EPCs from unsorted cord blood mononuclear cells (CBMCs). Adherent cells in clusters appeared approximately 24 h after CBMCs were cultured in ...

journal_title：British journal of haematology

authors： Kang HJ,Kim SC,Kim YJ,Kim CW,Kim JG,Ahn HS,Park SI,Jung MH,Choi BC,Kimm K

更新日期：2001-06-01 00:00:00

abstract：:Using two-colour phenotypic analysis with anti-CD38 antibody, human myeloma cells can be classified into VLA-5- immature and VLA-5+ mature cells. We examined the relationship between variations of these subpopulations and clinical responses during treatment in multiple myeloma (MM). 39 patients with MM were treated wi...

journal_title：British journal of haematology

authors： Kawano MM,Mahmoud MS,Huang N,Lisukov IA,Mihara K,Tsujimoto T,Kuramoto A

更新日期：1995-12-01 00:00:00

abstract：:We present an immunocompetent patient with transfusion-associated graft-versus-host disease (GVHD), in which chimaerism of peripheral blood lymphocytes was demonstrated by analysis of a highly polymorphic genome. The patient was treated successfully with anti-CD3 monoclonal antibody, OKT3 and cyclosporin A. Although i...

journal_title：British journal of haematology

authors： Yasukawa M,Shinozaki F,Hato T,Takada K,Ishii Y,Tamai T,Takamatsu H,Shiobara S,Yoshizaki K,Fujita S

更新日期：1994-04-01 00:00:00

abstract：:Mastocytosis is a rare disease with varied presentation, myriad symptomatology and variable prognosis. Most patients present with cutaneous disease and mediator-related symptomatology with a small subset having systemic disease (systemic mastocytosis, SM). A subset of the latter develops synchronous or metachronous ha...

journal_title：British journal of haematology

authors： Radia DH,Green A,Oni C,Moonim M

更新日期：2020-03-01 00:00:00

abstract：:High-dose chemotherapy (HDT) with autologous stem cell transplantation is the standard of care for relapsed/refractory (RR) Hodgkin lymphoma (HL). Given that HDT may cure a sizeable proportion of patients refractory to first salvage, development of newer conditioning regimens remains a priority. We present the results...

journal_title：British journal of haematology

authors： Musso M,Messina G,Di Renzo N,Di Carlo P,Vitolo U,Scalone R,Marcacci G,Scalzulli PR,Moscato T,Matera R,Crescimanno A,Santarone S,Orciuolo E,Merenda A,Pavone V,Pastore D,Donnarumma D,Carella AM,Ciochetto C,Cascavilla

更新日期：2016-01-01 00:00:00

abstract：:When monocytic leukaemia line U937 cells were incubated in the presence of HgCl2 there was a rapid increase in tissue factor (TF)-dependent procoagulant activity, reaching a maximum (equivalent to the total TF activity observed when cells had been subjected to a freeze/thaw cycle) after 15 min at 50 microM HgCl2 and a...

journal_title：British journal of haematology

authors： Kaneko H,Kakkar VV,Scully MF

更新日期：1994-05-01 00:00:00

abstract：:Three novel point mutations were detected in the glucocerebrosidase gene of three unrelated Gaucher's disease patients by direct sequencing of PCR products. The first is a C to G change at position 4263 in the genomic sequence (exon 7) which results in a proline to arginine change at position 266 in the mature enzyme ...

journal_title：British journal of haematology

authors： Walley AJ,Ellis I,Harris A

更新日期：1995-10-01 00:00:00

abstract：:In a randomized study that compared human leucocyte antigen-identical allogeneic granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cell (PBSC) versus bone marrow (BM) transplantation, the expression of activation markers, CD23, CD25 and CD45RO by B cells, was compared in blood before and af...

journal_title：British journal of haematology

authors： Tayebi H,Lapierre V,Saas P,Lienard A,Sutton L,Milpied N,Attal M,Cahn JY,Kuentz M,Blaise D,Hervé P,Tiberghien P,Robinet E,Société Française de Greffe de Moelle et de Therapie Cellulaire.

更新日期：2001-09-01 00:00:00

abstract：:Based on the morphological appearances of the bone marrow and peripheral blood, 43 patients with dysmyelopoietic syndromes were categorized into four types: refractory anaemia with excess of blasts, chronic myelomonocytic leukaemia, primary acquired sideroblastic anaemia and refractory anaemia with cellular marrow, wi...

journal_title：British journal of haematology

authors： Cazzola M,Barosi G,Berzuini C,Dacco M,Orlandi E,Stefanelli M,Ascari E

更新日期：1982-01-01 00:00:00

abstract：:A patient presented with haemolytic anaemia and a negative direct antiglobulin test (DAT), and was found to have an IgG antibody with anti-Jka specificity in his serum. His red cells were typed as Jk(a-b+). Later he developed idiopathic thrombocytopenic purpura (ITP), and had a positive DAT due to anti-Jka bound to hi...

journal_title：British journal of haematology

authors： Ganly PS,Laffan MA,Owen I,Hows JM

更新日期：1988-08-01 00:00:00

abstract：:The very poor outcome of invasive fungal infections (IFI) in patients with haematological malignancies or recipients of haematopoietic stem cell transplantation is largely attributed to their compromised host defence mechanisms. The restoration or augmentation of immune responses in these patients is now considered as...

journal_title：British journal of haematology

authors： Antachopoulos C,Roilides E

更新日期：2005-06-01 00:00:00

abstract：:The prognostic role of CD20 expression and Epstein-Barr virus (EBV) positivity in post-transplant lymphoproliferative disease (PTLD) after solid organ transplantation (SOT) in paediatric patients is poorly understood. We retrospectively examined the relationship of CD20 and EBV with the time interval from SOT to PTLD ...

journal_title：British journal of haematology

authors： Orjuela MA,Alobeid B,Liu X,Siebert AL,Kott ER,Addonizio LJ,Morris E,Garvin JH,Lobritto SJ,Cairo MS

更新日期：2011-03-01 00:00:00

abstract：:This study investigated the response of acute lymphoblastic leukaemia (ALL) cells to Wnt proteins. Accumulation of beta-catenin was measured by Western blotting and immunofluorescence microscopy. Reverse transcription polymerase chain reaction (RT-PCR) analysis of B-cell progenitor acute lymphoblastic leukaemia (ALL) ...

journal_title：British journal of haematology

authors： Khan NI,Bradstock KF,Bendall LJ

更新日期：2007-08-01 00:00:00

abstract：:Sideroblastic anaemia includes a heterogeneous group of rare conditions, characterized by decreased haem synthesis and mitochondrial iron overload, which are diagnosed by the presence of ringed sideroblasts in the bone marrow aspirate. The most frequent form is X-linked sideroblastic anaemia, caused by mutations of de...

journal_title：British journal of haematology

authors： Camaschella C

更新日期：2008-10-01 00:00:00

abstract：:Inherited factor VII (FVII) deficiency is a rare autosomal recessive disorder associated with a bleeding tendency. We describe three patients with congenital FVII deficiency who have been treated with activated recombinant factor VII (rVIIa). Two patients had novel mutations and were treated prophylactically with 1.2 ...

journal_title：British journal of haematology

authors： Mathijssen NC,Masereeuw R,Verbeek K,Lavergne JM,Costa JM,van Heerde WL,Nováková IR

更新日期：2004-05-01 00:00:00

abstract：:No consensus has been obtained about the question whether autoantibodies, in particular antiphospholipid antibodies (aPL), may cause thrombosis by inhibiting thrombomodulin (TM) mediated protein C activation. In order to clarify the mechanism by which autoantibodies inhibit TM-mediated protein C activation, we have sc...

journal_title：British journal of haematology

authors： Oosting JD,Preissner KT,Derksen RH,de Groot PG

更新日期：1993-12-01 00:00:00

abstract：:Cytogenetic deletions of the short arm of chromosome 12 are common recurring alterations found in a wide range of haematological neoplasias, including childhood acute lymphoblastic leukaemia (ALL), the most frequent paediatric malignancy. Such a loss of genetic material suggests the presence of a tumour suppressor gen...

journal_title：British journal of haematology

authors： Baccichet A,Sinnett D

更新日期：1997-10-01 00:00:00

abstract：:Much of the variability in the sensitivity to warfarin in anticoagulated patients is associated with the c.-1639G > A polymorphism of the vitamin K-epoxide reductase (VKORC1) gene. However, its association with the acenocoumarol dose in patients under anticoagulant therapy has not been studied. The c.-1639G > A genoty...

journal_title：British journal of haematology

authors： Montes R,Ruiz de Gaona E,Martínez-González MA,Alberca I,Hermida J

更新日期：2006-04-01 00:00:00

abstract：:Budd-Chiari syndrome and portal vein thrombosis (BCS/PVT) are frequently associated with polycythaemia vera (PV). In an attempt to elucidate the mechanisms of BCS/PVT secondary to PV (T-PV), CD11b neutrophil expression, neutrophil oxidative burst and platelet-neutrophil complexes (PNC) were assessed in 17 such patient...

journal_title：British journal of haematology

authors： Alvarez-Larrán A,García-Pagán JC,Abraldes JG,Arellano E,Reverter JC,Bosch J,Cervantes F

更新日期：2004-02-01 00:00:00

abstract：:The Brown Norwegian rat transplanted with promyelocytic leukaemic cells (BNML) has been used as a model for human acute myeloid leukaemia. We have previously shown that both the blood supply to the bone marrow and the metabolic rate decrease in relation to the leukaemic development in these rats. Here we have investig...

journal_title：British journal of haematology

authors： Mortensen BT,Jensen PO,Helledie N,Iversen PO,Ralfkiaer E,Larsen JK,Madsen MT

更新日期：1998-07-01 00:00:00

abstract：:T cells modified with anti-CD19 chimeric antigen receptor (CAR) containing either CD28 or 4-1BB (also termed TNFRSF9, CD137) costimulatory signalling have shown great potential in the treatment of acute lymphoblastic leukaemia (ALL). However, the difference between CD28 and 4-1BB costimulatory signalling in CAR-T trea...

journal_title：British journal of haematology

authors： Li S,Zhang J,Wang M,Fu G,Li Y,Pei L,Xiong Z,Qin D,Zhang R,Tian X,Wei Z,Chen R,Chen X,Wan J,Chen J,Wei X,Xu Y,Zhang P,Wang P,Peng X,Yang S,Shen J,Yang Z,Chen J,Qian C

更新日期：2018-05-01 00:00:00

abstract：:Erythrocyte sedimentation, viscosity, electrophroetic mobility, and osmotic fragility were measured in a study of the rheological behaviour of the erythrocyte in vitro. In comparison with physiological saline solution, a suspending medium containing a gamma2lambda2 monoclonal IgG from a patient with multiple myeloma c...

journal_title：British journal of haematology

authors： Rovel A,Vigneron C,Streiff F

更新日期：1979-04-01 00:00:00

abstract：:Serum antiplatelet IgG and platelet-associated IgG (PAIgG) were studied in 68 AIDS-free human immunodeficiency virus (HIV)-infected patients with severe immunologic thrombocytopenic purpura (ITP), for the presence of platelet autoantibodies. Serum IgG with antiplatelet activity was found in 72% of the sera. However, t...

journal_title：British journal of haematology

authors： Bettaieb A,Oksenhendler E,Fromont P,Duedari N,Bierling P

更新日期：1989-10-01 00:00:00

abstract：:Non-endemic Burkitt lymphoma (BL) is a rare germinal centre B-cell-derived malignancy with the genetic hallmark of MYC gene translocation and with rapid tumour growth as a distinct clinical feature. To investigate treatment outcomes, loss of lifetime and relapse risk in adult BL patients treated with intensive immunoc...

journal_title：British journal of haematology

authors： Jakobsen LH,Ellin F,Smeland KB,Wästerlid T,Christensen JH,Jørgensen JM,Josefsson PL,Øvlisen AK,Holte H,Blaker YN,Grauslund JH,Bjørn J,Molin D,Lagerlöf I,Smedby KE,Colvin K,Thanarajasingam G,Maurer MJ,Habermann TM,So

更新日期：2020-05-01 00:00:00