Enhanced activation of B cells in a granulocyte colony-stimulating factor-mobilized peripheral blood stem cell graft.

abstract：:Previously thought to be best described as a plasma cell disorder, Waldenström macroglobulinaemia (WM) is now understood to be a distinct clinicobiological entity. WM shares B-cell origin and certain other features with both chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM). WM and CLL arise from B-cells a...

journal_title：British journal of haematology

authors： McMaster ML,Caporaso N

更新日期：2007-12-01 00:00:00

abstract：:Smoking causes atherosclerosis, and smokers have increased thromboxane (TXA2) formation. As aspirin inhibits TXA2 production we speculated that smokers would preferentially profit from inhibition of the TXA2 pathway by aspirin. Increased expression of P-selectin, a constituent of the alpha-granules of platelets, and i...

journal_title：British journal of haematology

authors： Pernerstorfer T,Stohlawetz P,Stummvoll G,Kapiotis S,Szekeres T,Eichler HG,Jilma B

更新日期：1998-09-01 00:00:00

abstract：:Cytogenetic deletions of the short arm of chromosome 12 are common recurring alterations found in a wide range of haematological neoplasias, including childhood acute lymphoblastic leukaemia (ALL), the most frequent paediatric malignancy. Such a loss of genetic material suggests the presence of a tumour suppressor gen...

journal_title：British journal of haematology

authors： Baccichet A,Sinnett D

更新日期：1997-10-01 00:00:00

abstract：:Persistent lymphocytosis is usually associated with a malignant lymphoproliferative disease (MLPD). We report six female patients presenting a chronic, moderate lymphocytosis of 2-16 years duration with atypical binucleated lymphocytes on peripheral blood smears. Further investigation showed a polyclonal increase in s...

journal_title：British journal of haematology

authors： Troussard X,Valensi F,Debert C,Maynadie M,Schillinger F,Bonnet P,Macintyre EA,Flandrin G

更新日期：1994-10-01 00:00:00

abstract：:Prospective studies in children with B-precursor acute lymphoblastic leukaemia (ALL) have shown that polymerase chain reaction (PCR)-based detection of minimal residual disease (MRD) using immunoglobin (Ig) and T-cell receptor (TCR) gene rearrangements as targets can be used to identify patients with a high relapse ri...

journal_title：British journal of haematology

authors： de Haas V,Breunis WB,Dee R,Verhagen OJ,Kroes W,van Wering ER,van Dongen JJ,van den Berg H,van der Schoot CE

更新日期：2002-01-01 00:00:00

abstract：:Hydroxyurea increases fetal haemoglobin in many patients with sickle cell anaemia, but its effectiveness in thalassaemia appears to be less consistent. We describe the response to hydroxyurea in an adult male with homozygous beta thalassaemia, symptomatic paraspinal extramedullary haemopoiesis, bone pain, and progress...

journal_title：British journal of haematology

authors： Saxon BR,Rees D,Olivieri NF

更新日期：1998-06-01 00:00:00

abstract：:Patients with polycythaemia vera and secondary polycythaemia studied with 125I-labelled fibrinogen, had a significantly increased plasma fibrinogen turnover. The abnormalities were greater in polycythaemia vera and correlated with platelet count but not with packed cell volume. In six patients with polycythaemia vera,...

journal_title：British journal of haematology

authors： Boughton BJ,Dallinger KJ

更新日期：1983-01-01 00:00:00

abstract：:The aim of our study was to investigate whether haemophilia A patients with inversion of intron 22 are at high risk for non-inhibitory anti-FVIII antibodies development detected by ELISA. It is known that patients with severe forms of haemophilia A are more likely to develop anti-FVIII antibodies. The incidence of inh...

journal_title：British journal of haematology

authors： Vianello F,Radossi P,Tison T,Dazzi F,Tagariello G,Davoli PG,Girolami A

更新日期：1997-06-01 00:00:00

abstract：:Childhood acute myeloid leukaemia (AML) is uncommon. Children with Fanconi anaemia (FA), however, have a very high risk of developing AML. FA is a rare inherited disease caused by mutations in at least 12 genes, of which Fanconi anaemia group G gene (FANCG) is one of the commonest. To address to what extent FANCG vari...

journal_title：British journal of haematology

authors： Meyer S,Barber LM,White DJ,Will AM,Birch JM,Kohler JA,Ersfeld K,Blom E,Joenje H,Eden TO,Malcolm Taylor G

更新日期：2006-05-01 00:00:00

abstract：:Human amniotic fluid has been shown to contain blood group i as well as I antigens. Crude extracts of amniotic fluids at 16-23 weeks of gestation were in general more active than those obtained at term. A pool of amniotic fluids which had A, B, H as well as I and i activity was fractionated with an insolubilized anti-...

journal_title：British journal of haematology

authors： Feizi T,Cederqvist LL,Childs R

更新日期：1975-08-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF)-induced alteration of phosphoprotein during differentiation of HL-60 cells was studied. From the two-dimensional gel electrophoresis analysis of phosphoproteins, a 45 kD phosphoprotein in the cytosolic fraction of DMSO-pretreated HL-60 cells was rapidly dephosphorylated by...

journal_title：British journal of haematology

authors： Yamaguchi T,Oshizawa T,Yamaguchi T,Suzuki K,Yamamoto Y,Hayakawa T

更新日期：1998-08-01 00:00:00

abstract：:Hereditary angioedema (HAE) is a rare autosomal dominant genetic disorder clinically characterized by recurrent attacks of subcutaneous and mucosal swelling that can result in significant morbidity and even mortality. Several novel therapies introduced since 2008 have dramatically transformed the approach to managemen...

journal_title：British journal of haematology

authors： Zuraw BL,Christiansen SC

更新日期：2016-06-01 00:00:00

abstract：:We evaluated the performance of eight d-assays for the exclusion of deep vein thrombosis (DVT); Biopool AutoDimer, Biopool MiniQuant, bioMèrieux MDA D-Dimer, VIDAS, Dade Behring D-Dimer Plus, Trinity Biotech AMAX, NycoCard D-dimer and IL Test D-Dimer. The assays were evaluated both as stand-alone tests, and in combina...

journal_title：British journal of haematology

authors： Gardiner C,Pennaneac'h C,Walford C,Machin SJ,Mackie IJ

更新日期：2005-03-01 00:00:00

abstract：:The combination of bendamustine, bortezomib and dexamethasone (BBD) was evaluated as a first-line therapy for multiple myeloma. The original treatment regimen of bendamustine 80 mg/m2 , days 1, 4; bortezomib 1·3 mg/m2 , days 1, 4, 8, 11; dexamethasone 40 mg, days 1, 2, 3, 4 on a 28-day cycle (up to 8 cycles) was effic...

journal_title：British journal of haematology

authors： Berdeja JG,Bauer T,Arrowsmith E,Essell J,Murphy P,Reeves JA Jr,Boccia RV,Donnellan W,Flinn I

更新日期：2017-04-01 00:00:00

abstract：:Mature (non-anaplastic) T-cell and natural killer (NK)-lymphomas rarely occur in children or adolescents. Due to the low incidence and heterogeneity, information regarding the aetiology, physiopathology and genetics of paediatric mature (non-anaplastic) T/NK-cell lymphoma is lacking. In addition, standard treatments h...

journal_title：British journal of haematology

authors： Flower A,Xavier AC,Cairo MS

更新日期：2019-05-01 00:00:00

abstract：:High-dose dexamethasone (HD-Dex) has been reported to benefit AL amyloidosis patients with varying response rates. Our preliminary experience with the usual HD-Dex schedule indicated that the induction phase was rather toxic in AL patients. We therefore adopted a milder schedule consisting of dexamethasone 40 mg on d ...

journal_title：British journal of haematology

authors： Palladini G,Anesi E,Perfetti V,Obici L,Invernizzi R,Balduini C,Ascari E,Merlini G

更新日期：2001-06-01 00:00:00

abstract：:Thrombocytopenia can be a complication of hepatitis C viral (HCV) infection. However, there is little published data regarding the clinical and laboratory manifestations of HCV-related thrombocytopenia (HCV-TP) compared with adult chronic immune thrombocytopenic purpura (CITP). We reviewed the medical records for all ...

journal_title：British journal of haematology

authors： Rajan SK,Espina BM,Liebman HA

更新日期：2005-06-01 00:00:00

abstract：:We studied the trends of the Epstein-Barr virus (EBV) positivity rate in Hodgkin's disease (HD) between 1955 and 1999. The overall positivity rate gradually decreased over time [12 out of 23 (52%) in 1955-69; 18 out of 39 (46%) in 1970-84; 13 out of 44 (35%) in 1985-99; P = 0.135]. Interestingly, a marked decrease in ...

journal_title：British journal of haematology

authors： Takeuchi K,Morishita Y,Fukayama M,Mori S

更新日期：2001-05-01 00:00:00

abstract：:This study was designed to investigate the ability of long-term primary cultures of adult human hepatocytes to secrete the main haemostasis proteins. Factors II, V, VII, VIII, PIVKA-II (protein induced by vitamin K 1 absence or antagonist II), fibrinogen and antithrombin were quantified in culture medium by immunologi...

journal_title：British journal of haematology

authors： Biron-Andréani C,Bezat-Bouchahda C,Raulet E,Pichard-Garcia L,Fabre JM,Saric J,Baulieux J,Schved JF,Maurel P

更新日期：2004-06-01 00:00:00

abstract：:Paediatric B-cell non-Hodgkin lymphoma (B-NHL) compromises a heterogeneous group of histological entities of which Burkitt lymphoma is the most common. In resource-rich countries, the expected cure rate is in excess of 85% with application of risk-adapted short intensive chemotherapy. In recent years, large paediatric...

journal_title：British journal of haematology

authors： Giulino-Roth L,Goldman S

更新日期：2016-05-01 00:00:00

abstract：:Hepatitis B virus (HBV) reactivation of various degrees of severity, including fulminant hepatitis, may develop in 20-50% of hepatitis B virus surface antigen (HbsAg)-positive patients undergoing immunosuppressive or cytostatic treatment. Lamivudine is a nucleoside analogue that can directly suppress HBV replication. ...

journal_title：British journal of haematology

authors： Rossi G,Pelizzari A,Motta M,Puoti M

更新日期：2001-10-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) are implicated in cytotoxic drug resistance in leukaemia. In a previous study, expression of mu class GST (GSTM) was associated with poor prognosis in childhood acute lymphoblastic leukaemia (ALL), however, that study did not differentiate between individual GSTM isoforms. This study,...

journal_title：British journal of haematology

authors： Kearns PR,Chrzanowska-Lightowlers ZM,Pieters R,Veerman A,Hall AG

更新日期：2003-01-01 00:00:00

abstract：:The polymerase chain reaction (PCR) assay was used to detect human parvovirus B19 DNA in 38 blood products and start plasma pools from five different manufacturers. The products examined were albumin, factor VIII, intravenous (i.v.) and intramuscular (i.m) immunoglobulin batches. The majority of pools from all the man...

journal_title：British journal of haematology

authors： Saldanha J,Minor P

更新日期：1996-06-01 00:00:00

abstract：:Although many cases of multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) are cytogenetically normal, interphase fluorescence in situ hybridization (FISH) analyses reveal aberrations in the majority of the cases. Most likely, non-neoplastic cells are more prone to divide in culture tha...

journal_title：British journal of haematology

authors： Nilsson T,Lenhoff S,Rylander L,Höglund M,Turesson I,Mitelman F,Westin J,Johansson B

更新日期：2004-08-01 00:00:00

abstract：:Primary systemic amyloidosis (AL) is a plasma cell disorder characterized by deposition of monoclonal light chains in different organ systems. Although multiple and complex numerical chromosomal abnormalities have been described in patients with multiple myeloma, it is currently unknown whether such changes occur in s...

journal_title：British journal of haematology

authors： Fonseca R,Ahmann GJ,Jalal SM,Dewald GW,Larson DR,Therneau TM,Gertz MA,Kyle RA,Greipp PR

更新日期：1998-12-01 00:00:00

abstract：:Thrombopoietin (TPO) is the key growth factor for platelet production and is elevated in states of platelet depletion. As thrombocytopenia is a common finding in malaria, we analysed TPO regulation before, during and after antimalarial treatment. Before treatment, TPO serum levels were significantly higher in patients...

journal_title：British journal of haematology

authors： Kreil A,Wenisch C,Brittenham G,Looareesuwan S,Peck-Radosavljevic M

更新日期：2000-06-01 00:00:00

abstract：:The frequency and prognostic relevance of translocations t(11;14) and t(4;14), the most common translocations involving the immunoglobulin heavy chain (IgH) gene in multiple myeloma (MM), were investigated in 128 patients treated with intensive chemotherapy and autologous stem cell transplant. Myeloma cells were ident...

journal_title：British journal of haematology

authors： Chang H,Sloan S,Li D,Zhuang L,Yi QL,Chen CI,Reece D,Chun K,Keith Stewart A

更新日期：2004-04-01 00:00:00

abstract：:High-dose chemotherapy with melphalan followed by autologous haematopoietic cell transplantation (AHCT) is a standard of care in young patients (<65 years) with multiple myeloma. Most myeloma patients, however, are older than 65 years at the time of diagnosis, and the findings of numerous single-centre and registry st...

journal_title：British journal of haematology

authors： Auner HW,Garderet L,Kröger N

更新日期：2015-11-01 00:00:00

abstract：:Alpha haemoglobin stabilising protein (AHSP) binds free alpha-globin chains and plays an important role in the protection of red cells, particularly during beta-thalassaemia. Murine ASHP was discovered as a GATA-1 target gene and human AHSP is directly regulated by GATA-1. More recently, AHSP was rediscovered as a hig...

journal_title：British journal of haematology

authors： Keys JR,Tallack MR,Hodge DJ,Cridland SO,David R,Perkins AC

更新日期：2007-01-01 00:00:00

abstract：:This study systematically reviewed and meta-analysed the prognostic value of complete remission status at end-of-treatment (18) F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) in diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine and pred...

journal_title：British journal of haematology

authors： Adams HJ,Nievelstein RA,Kwee TC

更新日期：2015-07-01 00:00:00