Recent molecular and therapeutic advances in B-cell non-Hodgkin lymphoma in children.

abstract：UNLABELLED:The action of clopidogrel on platelet receptors was analysed using platelets obtained from 11 healthy volunteers given 75 mg of clopidogrel daily for 8 d. Samples of blood were taken before treatment and after 8 d of medication. Determination of 2-methylthioadenosine diphosphate trisodium (2MesADP)-induced p...

journal_title：British journal of haematology

authors： Contreres JO,Dupuy E,Job B,Habib A,Bryckaert M,Rosa JP,Simoneau G,Herbert JM,Savi P,Levy-Toledano S

更新日期：2003-02-01 00:00:00

abstract：:Over the past four decades, remarkable progress has been made in the treatment and prognosis of multiple myeloma (MM), although it remains an incurable disease. Chemotherapy resistance is a major hurdle for treatment efficacy. Drug resistance can be innate and so driven by genes involved in the drug metabolism pathway...

journal_title：British journal of haematology

authors： Macauda A,Castelli E,Buda G,Pelosini M,Butrym A,Watek M,Kruszewski M,Vangsted AJ,Rymko M,Jamroziak K,Abildgaard N,Haastrup EK,Mazur G,Ríos R,Jurczyszyn A,Zawirska D,Dudziński M,Raźny M,Dutka M,Tomczak W,Suska A,

更新日期：2018-11-01 00:00:00

abstract：:Nine patients with Fanconi anaemia (FA) were conditioned for HLA-identical sibling bone marrow transplant (BMT) with reduced dose of cyclophosphamide (Cy) without radiation or antithymocyte globulin (ATG). The total dose of Cy was 140 mg/kg (n = 2) or 120 mg/kg (n = 7). The median patient age was 8 years (range 4-19)....

journal_title：British journal of haematology

authors： Flowers ME,Zanis J,Pasquini R,Deeg HJ,Ribeiro R,Longton G,Medeiros CR,Doney K,Sanders J,Bryant J

更新日期：1996-03-01 00:00:00

abstract：:Ex vivo expansion of primitive human haematopoietic stem cells (HSC) is clinically relevant for stem cell transplantation and gene therapy. Here, we demonstrate the selective expansion of CD34+CD38- cells from purified CD34+ cells upon stimulation with Flt3-ligand, stem cell factor and thrombopoietin. Over a 100-fold ...

journal_title：British journal of haematology

authors： Ng YY,Bloem AC,van Kessel B,Lokhorst H,Logtenberg T,Staal FJ

更新日期：2002-04-01 00:00:00

abstract：:The prevalence of Helicobacter pylori infection and the effect of its eradication on platelet count in 48 Japanese patients with autoimmune thrombocytopenic purpura (AITP), including 40 chronic idiopathic thrombocytopenic purpura (ITP) and eight secondary AITP, were investigated. H. pylori infection was found in 25 IT...

journal_title：British journal of haematology

authors： Kohda K,Kuga T,Kogawa K,Kanisawa Y,Koike K,Kuroiwa G,Hirayama Y,Sato Y,Niitsu Y

更新日期：2002-08-01 00:00:00

abstract：:The frequency and prognostic relevance of translocations t(11;14) and t(4;14), the most common translocations involving the immunoglobulin heavy chain (IgH) gene in multiple myeloma (MM), were investigated in 128 patients treated with intensive chemotherapy and autologous stem cell transplant. Myeloma cells were ident...

journal_title：British journal of haematology

authors： Chang H,Sloan S,Li D,Zhuang L,Yi QL,Chen CI,Reece D,Chun K,Keith Stewart A

更新日期：2004-04-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma, where survival has been remarkably improved by use of protocols including high dose cytarabine, rituximab and autologous stem cell transplantation, such as the Nordic MCL2/3 protocols. In 2008, a MCL international prognostic index (MIPI) was created to enabl...

journal_title：British journal of haematology

authors： Nordström L,Sernbo S,Eden P,Grønbaek K,Kolstad A,Räty R,Karjalainen ML,Geisler C,Ralfkiaer E,Sundström C,Laurell A,Delabie J,Ehinger M,Jerkeman M,Ek S

更新日期：2014-07-01 00:00:00

abstract：:Interferon(rIFN)-alpha, a successful therapeutic agent in the control of thrombocytosis, has been shown to suppress human megakaryopoiesis. We investigated bone marrow biopsies from 12 patients with thrombocytosis due to chronic myeloproliferative disorders. Prior to treatment as well as during rIFN-alpha-2c therapy, ...

journal_title：British journal of haematology

authors： Chott A,Gisslinger H,Thiele J,Fritz E,Linkesch W,Radaszkiewicz T,Ludwig H

更新日期：1990-01-01 00:00:00

abstract：:Any influence of G-CSF on eosinophils is mostly negative, although reports which have studied this relationship are few with varied results. The aim of this study was to investigate the influence of G-CSF administration to healthy subjects on eosinophils in peripheral blood. Blood eosinophil counts, serum levels of eo...

journal_title：British journal of haematology

authors： Karawajczyk M,Höglund M,Ericsson J,Venge P

更新日期：1997-02-01 00:00:00

abstract：:The safety and efficacy of the combination clofarabine/cyclophosphamide/etoposide were evaluated in children with advanced acute lymphoblastic leukaemia (ALL). The study enrolled 25 paediatric patients (median age 12.5 years) with either refractory (n = 17; 68%) or multiple relapsed (n = 8; 32%) ALL to receive clofara...

journal_title：British journal of haematology

authors： Locatelli F,Testi AM,Bernardo ME,Rizzari C,Bertaina A,Merli P,Pession A,Giraldi E,Parasole R,Barberi W,Zecca M

更新日期：2009-11-01 00:00:00

abstract：:137 patients with severe aplastic anaemia (SAA) were treated in Basel from 1976 to 1986. 34 underwent bone marrow transplantation (BMT) and 103 received antilymphocyte globulin (ALG) therapy. We have analysed the incidence of late haematological complications in both groups of patients. 20 patients treated with ALG de...

journal_title：British journal of haematology

authors： Tichelli A,Gratwohl A,Würsch A,Nissen C,Speck B

更新日期：1988-07-01 00:00:00

abstract：:Over the past decades, a wealth of information has been reported about the pathogenic features of immune thrombocytopenia (ITP). To this day, however, it is unclear whether the immune abnormalities associated with ITP play causative roles in the disease or are secondary epiphenomena brought on by the inflammatory proc...

journal_title：British journal of haematology

authors： McKenzie CG,Guo L,Freedman J,Semple JW

更新日期：2013-10-01 00:00:00

abstract：:Positive selected haematopoietic stem cells are increasingly used for allogeneic transplantation with the CD34 antigen employed in most separation techniques. However, the recently described pentaspan molecule CD133 appears to be a marker of more primitive haematopoietic progenitors. Here we report our experience with...

journal_title：British journal of haematology

authors： Lang P,Bader P,Schumm M,Feuchtinger T,Einsele H,Führer M,Weinstock C,Handgretinger R,Kuci S,Martin D,Niethammer D,Greil J

更新日期：2004-01-01 00:00:00

abstract：:To identify and treat patients at high risk of cytomegalovirus (CMV) pneumonia after bone marrow transplantation (BMT), we tested for CMV viraemia weekly, and performed broncho-alveolar lavage (BAL) on day 35 post-transplant in 63 recipients. 36 allogeneic BMT recipients were at a high risk of CMV pneumonia (25 CMV-se...

journal_title：British journal of haematology

authors： Ibrahim A,Gautier E,Roittmann S,Bourhis JH,Fajac A,Charnoz I,Terrier P,Salord JM,Tancrède C,Hayat M,Bernaudin JF,Pico JL

更新日期：1997-07-01 00:00:00

abstract：:The iron chelator deferasirox (DFX) prevents complications related to transfusional iron overload in several haematological disorders characterized by marrow failure. It is also able to induce haematological responses in a percentage of treated patients, particularly in those affected by myelodysplastic syndromes. The...

journal_title：British journal of haematology

authors： Tataranni T,Agriesti F,Mazzoccoli C,Ruggieri V,Scrima R,Laurenzana I,D'Auria F,Falzetti F,Di Ianni M,Musto P,Capitanio N,Piccoli C

更新日期：2015-07-01 00:00:00

abstract：:The PFA-100(R) (PFA) diagnostic system for the detection of platelet dysfunction was evaluated to determine reference ranges in a normal population. The PFA determines the primary haemostasis capacity (PHC) of anticoagulated whole blood, expressed by the system's closure time (CT). In this study the CT reference range...

journal_title：British journal of haematology

authors： Böck M,De Haan J,Beck KH,Gutensohn K,Hertfelder HJ,Karger R,Heim MU,Beeser H,Weber D,Kretschmer V

更新日期：1999-09-01 00:00:00

abstract：:A novel BCR-ABL transcript was detected by multiplex RT-PCR in a patient with Philadelphia chromosome (Ph) positive chronic myelogenous leukaemia (CML) in accelerated phase. Sequencing of the aberrant transcript revealed an in-frame e2a2 fusion that included a 9 basepairs insertion. Cytogenetic analysis showed t(9;22)...

journal_title：British journal of haematology

authors： Leibundgut EO,Jotterand M,Rigamonti V,Parlier V,Mühlematter D,Tobler A,Solenthaler M

更新日期：1999-09-01 00:00:00

abstract：:A pilot trial was initiated for chronic myeloid leukaemia patients, which employed imatinib for remission induction, followed by reduced-intensity conditioning and an in vivo T-cell depleted graft. Out of nine patients, six experienced a molecular relapse and one patient had a haematological relapse at a median interv...

journal_title：British journal of haematology

authors： Ringhoffer M,Harsdorf Sv,Schmitt M,Wiesneth M,Zenz T,Stilgenbauer S,Greiner J,Döhner K,Marx M,Döhner H,Bunjes D

更新日期：2007-01-01 00:00:00

abstract：:T(3;14)(q27;q32) is frequently detected in B-cell non-Hodgkin's lymphomas, especially the diffuse large cell type and the follicular type. The BCL6 gene encoding a putative transcriptional factor which resides on 3q27 rearranges to the immunoglobulin heavy chain (IgH) gene on 14q32 in this chromosomal translocation. T...

journal_title：British journal of haematology

authors： Kawamata N,Nakamura Y,Miki T,Sato E,Isobe Y,Furusawa S,Hirosawa S,Oshimi K

更新日期：1998-03-01 00:00:00

abstract：:The translocation t(1;19)(q23;p13)/der(19)t(1;19) is a risk stratifying aberration in childhood B-cell precursor acute lymphoblastic leukaemia (BCP ALL) in the Nordic countries. We have identified 47 children/adolescents with t(1;19)/der(19)t(1;19)-positive BCP ALL treated on two successive Nordic Society of Paediatri...

journal_title：British journal of haematology

authors： Andersen MK,Autio K,Barbany G,Borgström G,Cavelier L,Golovleva I,Heim S,Heinonen K,Hovland R,Johannsson JH,Johansson B,Kjeldsen E,Nordgren A,Palmqvist L,Forestier E

更新日期：2011-10-01 00:00:00

abstract：:Up-regulation of Fas/APO-1 (CD95) on haematopoietic progenitors and Fas-mediated apoptosis have been suggested to occur in a possible pathological mechanism in some bone marrow failure syndromes. We examined the expression of Fas antigen and susceptibility to Fas-mediated suppression of donor-derived haematopoietic ce...

journal_title：British journal of haematology

authors： Saheki K,Fujimori Y,Takemoto Y,Kakishita E

更新日期：2000-05-01 00:00:00

abstract：:Molecular genetic studies of lymphoma have led to refinements in disease classification in the most recent World Health Organization update. Nevertheless, a 'one-size-fits-most' treatment strategy based on morphology remains widely used for lymphoma despite significant molecular heterogeneity within histopathologicall...

journal_title：British journal of haematology

authors： El-Galaly TC,Cheah CY,Villa D

更新日期：2019-08-01 00:00:00

abstract：:The Abl kinase inhibitor STI571 (imatinib mesylate) induces haematological remissions in many patients with chronic myeloid leukaemia (CML) but advanced stage CML usually becomes resistant to STI571. We describe a patient in whom progressive resistance to STI571 correlated with the appearance of a mutation in the Bcr-...

journal_title：British journal of haematology

authors： Barthe C,Gharbi MJ,Lagarde V,Chollet C,Cony-Makhoul P,Reiffers J,Goldman JM,Melo JV,Mahon FX

更新日期：2002-10-01 00:00:00

abstract：:We have assessed the effects of the diphosphonate, dichloromethylene diphosphonate (Cl2MDP), in 19 patients with hypercalcaemia and increased bone resorption due to myeloma. Cl2MDP (800-3200 mg daily by mouth or 300 mg daily by intravenous infusion) decreased plasma calcium and biochemical indices of increased bone re...

journal_title：British journal of haematology

authors： Paterson AD,Kanis JA,Cameron EC,Douglas DL,Beard DJ,Preston FE,Russell RG

更新日期：1983-05-01 00:00:00

abstract：:The presence of small amounts of C3d on freshly obtained normal red blood cells (RBC) was demonstrated by a radio-labelled antiglobulin technique; this increased 1.5-fold after incubation in fresh normal serum. No significant further increase in bound C3d was demonstrated for cDE/cDE, CDe/CDe, -D-/-D- RBC maximally se...

journal_title：British journal of haematology

authors： Freedman J,Massey A,Chaplin H,Monroe MC

更新日期：1980-06-01 00:00:00

abstract：:Much of the variability in the sensitivity to warfarin in anticoagulated patients is associated with the c.-1639G > A polymorphism of the vitamin K-epoxide reductase (VKORC1) gene. However, its association with the acenocoumarol dose in patients under anticoagulant therapy has not been studied. The c.-1639G > A genoty...

journal_title：British journal of haematology

authors： Montes R,Ruiz de Gaona E,Martínez-González MA,Alberca I,Hermida J

更新日期：2006-04-01 00:00:00

abstract：:Data on endogenous thrombopoietin (TPO) levels and their regulation in myelodysplastic syndromes (MDS) are sparse. We examined the plasma TPO level of 85 MDS patients by a sensitive enzyme immunoassay and the platelet expression of TPO receptor (TPO-R) protein, which metabolizes endogenous TPO, in 19 MDS patients with...

journal_title：British journal of haematology

authors： Tamura H,Ogata K,Luo S,Nakamura K,Yokose N,Dan K,Tohyama K,Yoshida Y,Hamaguchi H,Sakamaki H,Kuwaki T,Tahara T,Kato T,Nomura T

更新日期：1998-12-01 00:00:00

abstract：:Plasma cells isolated from bone marrow (BM) aspirates of 15 patients with active multiple myeloma (MM) were cultured and analysed for in vitro proliferative response and Ig-synthesis upon stimulation with interleukin-3 (IL-3), interleukin-4 (IL-4) and interleukin-6 (IL-6). The proliferative response, determined as Ki-...

journal_title：British journal of haematology

authors： Sonneveld P,Schoester M,de Leeuw K

更新日期：1991-12-01 00:00:00

abstract：:Bone sialoprotein (BSP) is a glycoprotein essentially found in mineralizing connective tissues. We have recently demonstrated that BSP is ectopically expressed by carcinomas that metastasize to bone with high frequency. Multiple myeloma (MM) is characterized by the localization of tumour plasma cells in the bone marro...

journal_title：British journal of haematology

authors： Bellahcène A,Van Riet I,de Greef C,Antoine N,Young MF,Van Camp B,Castronovo V

更新日期：2000-12-01 00:00:00

abstract：:Clonal heterogeneity in multisited or recurrent lymphoid neoplasms is a phenomenon that has been increasingly studied in recent years. However, in mucosa-associated lymphoid tissue (MALT) lymphomas it remains largely unexplored. Patients diagnosed at our institution with multisited MALT lymphoma, from January 2009 to ...

journal_title：British journal of haematology

authors： Condom M,Climent F,Fernández D,Colomer D,Lopez-Guerra M,Varela M,Carro I,Maluquer C,Mercadal S,Oliveira AC,Pané M,Matias-Guiu X,González-Barca E,Sureda A,Domingo-Domenech E

更新日期：2020-05-23 00:00:00