Assessment of complement binding by anti-D and anti-M antibodies employing labelled antiglobulin antibodies.

Abstract:

:The presence of small amounts of C3d on freshly obtained normal red blood cells (RBC) was demonstrated by a radio-labelled antiglobulin technique; this increased 1.5-fold after incubation in fresh normal serum. No significant further increase in bound C3d was demonstrated for cDE/cDE, CDe/CDe, -D-/-D- RBC maximally sensitized with any of three potent anti-D antibodies. When anti-c, anti-D and anti-E antibodies were used in combination to sensitize cDE/cDE RBC, bound C3d increased by approximately 22%; however, a similar increase occurred with cde/cde RBC and was therefore considered non-Rh specific. Umbilical cord RBC from four infants severely affected by anti-D haemolytic disease of the newborn did not exhibit more bound C3d than cord RBC from normal controls. One serum containing IgM anti-M bound a small amount of complement in vitro; two IgG anti-M sera did not.

journal_name

Br J Haematol

authors

Freedman J,Massey A,Chaplin H,Monroe MC

doi

10.1111/j.1365-2141.1980.tb07150.x

subject

Has Abstract

pub_date

1980-06-01 00:00:00

pages

309-18

issue

2

eissn

0007-1048

issn

1365-2141

journal_volume

45

pub_type

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