Low-dose aspirin does not lower in vivo platelet activation in healthy smokers.

Abstract:

:Smoking causes atherosclerosis, and smokers have increased thromboxane (TXA2) formation. As aspirin inhibits TXA2 production we speculated that smokers would preferentially profit from inhibition of the TXA2 pathway by aspirin. Increased expression of P-selectin, a constituent of the alpha-granules of platelets, and increased levels of circulating (c)P-selectin in plasma are markers for platelet activation. The aim of this study was to compare P-selectin expression on platelets between smokers and nonsmokers, and to compare with placebo the effect of 2 weeks administration of 100 mg/d aspirin on platelet activation in smokers. Smokers exhibited higher P-selectin expression on platelets than non-smokers (2.7+/-1.8% v 1.6+/-0.6%, P=0.018), thus confirming increased platelet activation. Aspirin did not reduce platelet activation as demonstrated by unchanged P-selectin expression on platelets and cP-selectin plasma levels.

journal_name

Br J Haematol

authors

Pernerstorfer T,Stohlawetz P,Stummvoll G,Kapiotis S,Szekeres T,Eichler HG,Jilma B

doi

10.1046/j.1365-2141.1998.00883.x

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

1229-31

issue

5

eissn

0007-1048

issn

1365-2141

journal_volume

102

pub_type

临床试验,杂志文章,随机对照试验
  • Two different quadruplicated alpha globin gene arrangements.

    abstract::The discovery of two different types of alpha globin gene quadruplication is reported. One with the alpha alpha alpha alpha (anti 3.7)/haplotype was present in four members of a Black family from Georgia, while a second with the alpha alpha alpha alpha (anti 4.2)/haplotype was observed in two members of an Indonesian ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1987.tb01306.x

    authors: Gu YC,Landman H,Huisman TH

    更新日期:1987-06-01 00:00:00

  • A novel CSF-1 binding factor in a patient in complete remission following cytotoxic therapy for lymphoma.

    abstract::A novel colony stimulating factor-1 (CSF-1) binding factor present in the serum from a patient in remission from lymphoma is described. Radioimmunoassay (RIA) repeatedly failed to detect circulating levels of CSF-1 in the peripheral blood system of this patient. Molecular analysis showed a normal CSF-1 gene structure ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1995.tb08937.x

    authors: Baker AH,Cachia PG,Tennant GB,Whittaker JA,White D,Stanley ER,Burnett AK,Padua RA

    更新日期:1995-01-01 00:00:00

  • Primary plasma cell leukaemia.

    abstract::Among 750 previously untreated patients with multiple myeloma, 27 (4%) presented with plasma cell leukaemia. All but one patient had high tumour mass and, when compared with comparable patients without leukaemia, more frequent extraosseous involvement, thrombocytopenia, high serum lactate dehydrogenase and hypodiploid...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2141.1994.tb05114.x

    authors: Dimopoulos MA,Palumbo A,Delasalle KB,Alexanian R

    更新日期:1994-12-01 00:00:00

  • Polycythaemia vera. IV. Specific binding of stem cell factor to normal and polycythaemia vera highly purified erythroid progenitor cells.

    abstract::Polycythaemia vera (PV) patients' blood burst-forming units-erythroid (BFU-E) have an enhanced sensitivity to stem cell factor (SCF) compared to normal BFU-E. To characterize SCF receptors on erythroid progenitors from normal individuals and PV patients, we performed binding experiments using radioiodinated recombinan...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1994.tb05065.x

    authors: Dai CH,Krantz SB,Koury ST,Kollar K

    更新日期:1994-11-01 00:00:00

  • Circulating megakaryocyte progenitors in myeloproliferative disorders are hypersensitive to interleukin-3.

    abstract::Previous studies have reported that megakaryocyte progenitors in myeloproliferative disorders (MPD) formed spontaneous megakaryocyte colonies without the addition of megakaryocyte colony-stimulating factor (Meg-CSF). To determine whether this spontaneous colony formation is due to autocrine proliferation of MPD megaka...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1993.tb04688.x

    authors: Kobayashi S,Teramura M,Hoshino S,Motoji T,Oshimi K,Mizoguchi H

    更新日期:1993-04-01 00:00:00

  • Expression profile of wild-type ETV6 in childhood acute leukaemia.

    abstract::Comparative expression analysis of wild-typeETV6 in the disease state showed an absence of expression in ETV6-CBFA2 acute lymphoblastic leukaemia (ALL) when compared with non-ETV6-CBFA2 ALL and acute myeloid leukaemia. Fluorescent in-situ hybridization and loss of heterozygosity studies showed that 73% of the ETV6-CBF...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2003.04399.x

    authors: Patel N,Goff LK,Clark T,Ford AM,Foot N,Lillington D,Hing S,Pritchard-Jones K,Jones LK,Saha V

    更新日期:2003-07-01 00:00:00

  • Mimicking the haematopoietic niche microenvironment provides a novel strategy for expansion of haematopoietic and megakaryocyte-progenitor cells from cord blood.

    abstract::Severe neutropenia and protracted thrombocytopenia remain serious clinical problems following cord blood transplantation (CBT) due to the paucity of stem and progenitor cells in the grafts. Administration of ex-vivo expanded megakaryocyte progenitor cells may facilitate platelet production. We propose a novel strategy...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2009.08041.x

    authors: Deutsch V,Hubel E,Kay S,Ohayon T,Katz BZ,Many A,Zander A,Naparstek E,Grisaru D

    更新日期:2010-04-01 00:00:00

  • A 15q24 microdeletion in transient myeloproliferative disease (TMD) and acute megakaryoblastic leukaemia (AMKL) implicates PML and SUMO3 in the leukaemogenesis of TMD/AMKL.

    abstract::Transient myeloproliferative disorder (TMD) of the newborn and acute megakaryoblastic leukaemia (AMKL) in children with Down syndrome (DS) represent paradigmatic models of leukaemogenesis. Chromosome 21 gene dosage effects and truncating mutations of the X-chromosomal transcription factor GATA1 synergize to trigger TM...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2012.09028.x

    authors: Haemmerling S,Behnisch W,Doerks T,Korbel JO,Bork P,Moog U,Hentze S,Grasshoff U,Bonin M,Rieß O,Janssen JW,Jauch A,Bartram CR,Reinhardt D,Koch KA,Bandapalli OR,Kulozik AE

    更新日期:2012-04-01 00:00:00

  • Overexpression of manganese superoxide dismutase promotes survival in cell lines after doxorubicin treatment.

    abstract::Overexpression of manganese superoxide dismutase (MnSOD) has been postulated as one possible mechanism of protection from oxidative damage and free radicals. Doxorubicin treatment induces oxygen free radicals, leading to cytotoxicity and myelosuppression. The present study was performed to determine whether over-expre...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2003.04074.x

    authors: Suresh A,Guedez L,Moreb J,Zucali J

    更新日期:2003-02-01 00:00:00

  • A multi-centre study of therapeutic efficacy and safety of platelet components treated with amotosalen and ultraviolet A pathogen inactivation stored for 6 or 7 d prior to transfusion.

    abstract::Bacteria in platelet components (PC) may result in transfusion-related sepsis (TRS). Pathogen inactivation of PC with amotosalen (A-PC) can abrogate the risk of TRS and hence facilitate storage to 7 d. A randomized, controlled, double-blinded trial to evaluate the efficacy and safety of A-PC stored for 6-7 d was condu...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1365-2141.2011.08635.x

    authors: Lozano M,Knutson F,Tardivel R,Cid J,Maymó RM,Löf H,Roddie H,Pelly J,Docherty A,Sherman C,Lin L,Propst M,Corash L,Prowse C

    更新日期:2011-05-01 00:00:00

  • Analysis of heat-shock protein expression in myeloid leukaemia cells by flow cytometry.

    abstract::Expression of heat-shock proteins (hsp) was analysed in the leukaemic cells of 12 patients with acute myeloid leukaemia (AML) and nine patients with chronic myeloid leukaemia (CML). Using monoclonal antibodies to hsp70, hsp90 and hsp60 (ML30, a mycobacterial antigen with homology to human hsp60), we measured hsp level...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1995.tb03395.x

    authors: Chant ID,Rose PE,Morris AG

    更新日期:1995-05-01 00:00:00

  • Factor VIII antibody in a patient with mild haemophilia.

    abstract::We present the rare occurrence of an inhibitor of factor VIII procoagulant arising in a patient with mild haemophilia A and rheumatoid arthritis. The inhibitor was transient and behaved like a low titre, type II factor VIII procoagulant inhibitor similar to previously reported cases (Biggs et al, 1972b). In vitro stud...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1985.tb02832.x

    authors: Bovill EG,Burns SL,Golden EA

    更新日期:1985-10-01 00:00:00

  • Production of immunoreactive calcitonin by myeloid leukaemia cells.

    abstract::Raised plasma levels of immunoreactive human calcitonin (i-HCT) have been found in patients with chronic granulocytic leukaemia (CGL) in chronic phase and myeloblastic transformation and in patients with acute myeloid leukaemia at presentation and in relapse. In CGL levels were significantly higher in myeloblastic tra...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1982.tb01911.x

    authors: Foa R,Oscier DG,Hillyard CJ,Incarbone E,McIntyre I,Goldman JM

    更新日期:1982-02-01 00:00:00

  • Mobilization of Ph chromosome-negative peripheral blood stem cells in chronic myeloid leukaemia patients with imatinib mesylate-induced complete cytogenetic remission.

    abstract::Imatinib mesylate (IM, STI 571, Glivec) can induce a high rate of complete cytogenetic response (CCR) in chronic myeloid leukaemia (CML) patients, although to date the majority of patients continue to have detectable disease by sensitive reverse transcription polymerase chain reaction (RT-PCR). It is therefore possibl...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2003.04599.x

    authors: Drummond MW,Marin D,Clark RE,Byrne JL,Holyoake TL,Lennard A,United Kingdom Chronic Myeloid Leukaemia (UK CML) Working Party.

    更新日期:2003-11-01 00:00:00

  • Location, movement and survival: the role of chemokines in haematopoiesis and malignancy.

    abstract::Chemokines are a family of over 40 small (8 kDa) related proteins with the function of moving cells along a chemotactic gradient, either to organise cells within an organ or to facilitate the movement of leucocytes around the body. Mouse models have implicated the importance of the chemokine CXCL12 in haematopoiesis a...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2141.2005.05841.x

    authors: Laurence AD

    更新日期:2006-02-01 00:00:00

  • Long-term overall- and progression-free survival after pentostatin, cyclophosphamide and rituximab therapy for indolent non-Hodgkin lymphoma.

    abstract::In a prospective phase II trial, pentostatin combined with cyclophosphamide and rituximab (PCR) induced strong responses and was well-tolerated in previously untreated patients with advanced-stage, indolent non-Hodgkin lymphoma (iNHL). After a median patient follow-up of more than 108 months, we performed an intent-to...

    journal_title:British journal of haematology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/bjh.15814

    authors: Khashab T,Hagemeister F,Romaguera JE,Fanale MA,Pro B,McLaughlin P,Rodriguez MA,Neelapu SS,Fayad L,Younes A,Feng L,Vega F,Kwak LW,Samaniego F

    更新日期:2019-05-01 00:00:00

  • Reversal of ineffective erythropoiesis in pernicious anaemia following vitamin B12 therapy.

    abstract::Ineffective erythropoiesis was quantitated in a series of patients with pernicious anaemia at different times in relation to vitamin B12 therapy by measuring the incorporation of [15N]delta aminolaevulinic acid and [15N]glycine into early labelled bilirubin. Prior to therapy ineffective erythropoiesis was grossly incr...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1977.tb00578.x

    authors: Samson D,Halliday D,Chanarin I

    更新日期:1977-02-01 00:00:00

  • The mixed epidermal cell lymphocyte-reaction is the most predictive factor of acute graft-versus-host disease in bone marrow graft recipients.

    abstract::Risk factors for acute graft-versus-host disease (GvHD) remain controversial. We performed uni- and multivariate statistical analyses on a series of 37 patients receiving a non-depleted allogeneic bone marrow transplant from an HLA-identical sibling donor for a haematological malignancy, in order to identify risk fact...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1988.tb02508.x

    authors: Bagot M,Mary JY,Heslan M,Kuentz M,Cordonnier C,Vernant JP,Dubertret L,Levy JP

    更新日期:1988-12-01 00:00:00

  • Osteoblast stimulation in multiple myeloma lacking lytic bone lesions.

    abstract::The reasons why some patients with multiple myeloma (MM) do not develop severe bone loss, or even develop sclerotic bone lesions, remain unclear. In order to answer this question at the cellular and tissue level, we evaluated the histological bone condition of 10 patients with MM who never developed lytic bone lesions...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1990.tb07904.x

    authors: Bataille R,Chappard D,Marcelli C,Rossi JF,Dessauw P,Baldet P,Sany J,Alexandre C

    更新日期:1990-12-01 00:00:00

  • A severe transfusion-dependent congenital dyserythropoietic anaemia presenting as hydrops fetalis.

    abstract::We describe a case of congenital dyserythropoietic anaemia (CDA) presenting at week 20 of pregnancy with hydrops fetalis and very severe anaemia. Fetal blood examination showed marked erythroblastosis with morphologic alterations while the basic haematological and biochemical tests were in the normal range. The fetus ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1997.d01-2062.x

    authors: Cantù-Rajnoldi A,Zanella A,Conter U,Faccini P,Soligo D,Gornati G,Vegni C,Nicolini U

    更新日期:1997-03-01 00:00:00

  • Citrullinated histone H3, a biomarker for neutrophil extracellular trap formation, predicts the risk of mortality in patients with cancer.

    abstract::Prior studies indicate that neutrophil extracellular traps (NETs) are associated with arterial thromboembolism (ATE) and mortality. We investigated the association between NET formation biomarkers (citrullinated histone H3 [H3Cit], cell-free DNA [cfDNA], and nucleosomes) and the risk of ATE and all-cause mortality in ...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章

    doi:10.1111/bjh.15906

    authors: Grilz E,Mauracher LM,Posch F,Königsbrügge O,Zöchbauer-Müller S,Marosi C,Lang I,Pabinger I,Ay C

    更新日期:2019-07-01 00:00:00

  • Targeting malignant B-cell lymphoma with a humanized anti-CD22 scFv-angiogenin immunoenzyme.

    abstract::We report on the generation and functional characterization of a humanized immunoenzyme comprising a stable humanized single chain Fv (scFv) with grafted specificity of the anti-CD22 murine monoclonal antibody RFB4 and the human ribonuclease angiogenin (ANG). The fusion protein produced from transiently transfected ma...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2005.05356.x

    authors: Krauss J,Arndt MA,Vu BK,Newton DL,Rybak SM

    更新日期:2005-03-01 00:00:00

  • Influence of the -675 4G/5G dimorphism of the plasminogen activator inhibitor 1 promoter on thrombotic risk in patients with factor V Leiden.

    abstract::Elevated plasminogen activator inhibitor 1 (PAI-1) levels are associated with venous thromboembolism, although their significance is unclear. PAI-1 levels are influenced by a PAI-1 promoter dimorphism (4G/5G), the 4G allele being associated with increased PAI-1 activity. We investigated whether the 4G allele influence...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2000.02152.x

    authors: Visanji JM,Seargent J,Tahri D,Croft SA,Makris M,Preston FE,Peake IR,Daly ME

    更新日期:2000-07-01 00:00:00

  • Bi-directional activation between mesenchymal stem cells and CLL B-cells: implication for CLL disease progression.

    abstract::It was hypothesized that contact between chronic lymphocytic leukaemia (CLL) B-cells and marrow stromal cells impact both cell types. To test this hypothesis, we utilized a long-term primary culture system from bone biopsies that reliably generates a mesenchymal stem cell (MSC). Co-culture of MSC with CLL B-cells prot...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2009.07868.x

    authors: Ding W,Nowakowski GS,Knox TR,Boysen JC,Maas ML,Schwager SM,Wu W,Wellik LE,Dietz AB,Ghosh AK,Secreto CR,Medina KL,Shanafelt TD,Zent CS,Call TG,Kay NE

    更新日期:2009-11-01 00:00:00

  • In non-follicular lymphoproliferative disorders, IGH/BCL2-fusion is not restricted to chronic lymphocytic leukaemia.

    abstract::The translocation t(14;18) and its t(2;18) and t(18,22) variants, which involve the BCL2 genetic hallmark for follicular lymphoma (FL), have been reported in several cases of chronic B-cell lymphoproliferative disease (CLPD) and frequently in chronic lymphocytic leukaemia (CLL). We describe here the clinical, morpholo...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2012.09178.x

    authors: Baseggio L,Geay MO,Gazzo S,Berger F,Traverse-Glehen A,Ffrench M,Hayette S,Callet-Bauchu E,Verney A,Morel D,Jallades L,Magaud JP,Salles G,Felman P

    更新日期:2012-08-01 00:00:00

  • A phase 2 study of bortezomib in combination with ifosfamide/vinorelbine in paediatric patients and young adults with refractory/recurrent Hodgkin lymphoma: a Children's Oncology Group study.

    abstract::A Children's Oncology Group clinical trial aimed to determine if bortezomib (B) increased the efficacy of ifosfamide and vinorelbine (IV) in paediatric Hodgkin lymphoma (HL). This study enrolled 26 relapsed HL patients (<30 years) treated with two to four cycles of IVB. The primary endpoint was anatomic complete respo...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bjh.13388

    authors: Horton TM,Drachtman RA,Chen L,Cole PD,McCarten K,Voss S,Guillerman RP,Buxton A,Howard SC,Hogan SM,Sheehan AM,López-Terrada D,Mrazek MD,Agrawal N,Wu MF,Liu H,De Alarcon PA,Trippet TM,Schwartz CL

    更新日期:2015-07-01 00:00:00

  • Relapse of aplastic anaemia after immunosuppressive treatment: a report from the European Bone Marrow Transplantation Group SAA Working Party.

    abstract::This study was designed to determine the incidence of relapse and factors predictive for relapse in 719 patients with severe aplastic anaemia (SAA) after immunosuppressive treatment (IS). Patients developing myelodysplasia or acute leukaemia after IS, and patients receiving a transplant, were excluded from this analys...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1993.tb03181.x

    authors: Schrezenmeier H,Marin P,Raghavachar A,McCann S,Hows J,Gluckman E,Nissen C,van't Veer-Korthof ET,Ljungman P,Hinterberger W

    更新日期:1993-10-01 00:00:00

  • Iron metabolism in murine erythroleukaemic cells.

    abstract::In an attempt to develop a model system for analysing iron metabolism in a relatively homogeneous population of early red cell precursors, the intracellular distribution of 59Fe was examined in Friend murine erythroleukaemic cells after induction of haemoglobin synthesis with dimethylsulphoxide. After incubation of th...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1983.tb02142.x

    authors: Peto TE,Rutherford TR,Thompson JL,Weatherall DJ

    更新日期:1983-08-01 00:00:00

  • Expression and functional role of c-kit ligand (SCF) in human multiple myeloma cells.

    abstract::In this study we investigated the proliferation of three well-documented MM lines and 10 bone marrow samples from myeloma patients in response to rh-SCF alone and combined with Interleukin-6 (IL-6), IL-3 and IL-3/GM-CSF fusion protein PIXY 321. Neoplastic plasma cells were highly purified (> 90%) by immunomagnetic dep...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1994.tb05115.x

    authors: Lemoli RM,Fortuna A,Grande A,Gamberi B,Bonsi L,Fogli M,Amabile M,Cavo M,Ferrari S,Tura S

    更新日期:1994-12-01 00:00:00

  • G6PD Napoli and Ferrara II: two new glucose-6-phosphate dehydrogenase variants having similar characteristics but different intracellular lability and specific activity.

    abstract::Two new glucose-6-phosphate dehydrogenase (G6PD, D-glucose 6-phosphate: NADP oxido reductase, E.C. 1.1.1.49) variants, designated G6PD Napoli and G6PD Ferrara II, are described in propositi from two unrelated families. Characterization side by side of the two variants according to W.H.O. recommendations reveals minor ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1981.tb02733.x

    authors: De Flora A,Morelli A,Benatti U,Giuntini P,Ferraris AM,Galiano S,Ravazzolo R,Gaetani GF

    更新日期:1981-07-01 00:00:00