Influence of clinical status on the efficiency of stored platelet transfusion.


:The efficiency of stored platelet transfusion was evaluated in terms of clinical status in 141 thrombocytopenic patients. In a paired prospective study in which fresh platelets were used as controls, clinical efficiency was assessed on the basis of the ability to increase platelet count (recovery) and the time to the next transfusion (D). In 48 clinically stable patients, recovery of fresh and stored platelets was similar (47% and 41%, respectively) and the interval to the next transfusion was D4 and D3. In contrast, 27 patients who had bacterial infections showed significantly different recoveries (24%/5%) and the interval to the next transfusion was D3/D1 for fresh and stored platelets respectively. Similarly, in 16 patients who were treated concurrently with amphotericin B, 18 other patients with graft-versus-host disease, nine with splenomegaly and four with veno-occlusive disease (VOD), fresh platelets performed better than stored platelets, showing recoveries of 27%/18%, 29%/15%, 16%/3% and 15%/2%. Furthermore, the need for retransfusion within 24 h was significantly increased with stored platelets. In 19 patients with anti-HLA alloimmunization who were transfused with HLA-matched fresh and stored apheresis platelet concentrate (APC), efficiency was similar (38%/36% and D4/D3). This study indicates that the storage induces an impressive decrease in the in-vivo platelet recovery and survival in patients with certain clinical conditions.


Br J Haematol


Norol F,Kuentz M,Cordonnier C,Beaujean F,Haioun C,Vernant JP,Duédari N




Has Abstract


1994-01-01 00:00:00












  • Short-term phytohaemagglutinin-activated mononuclear cells induce endothelial progenitor cells from cord blood CD34+ cells.

    abstract::Endothelial progenitor cells (EPCs) were recently demonstrated to exist in human cord blood. Phytohaemagglutinin (PHA), a potent mitogen for mononuclear cells was used to induce EPCs from unsorted cord blood mononuclear cells (CBMCs). Adherent cells in clusters appeared approximately 24 h after CBMCs were cultured in ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Kang HJ,Kim SC,Kim YJ,Kim CW,Kim JG,Ahn HS,Park SI,Jung MH,Choi BC,Kimm K

    更新日期:2001-06-01 00:00:00

  • Prolonged inhibition of von Willebrand factor-cleaving protease after splenectomy in a 22-year-old patient with acute and plasma refractory thrombotic thrombocytopenic purpura.

    abstract::We report a 22-year-old woman with acute, plasma refractory thrombotic thrombocytopenic purpura (TTP) in whom splenectomy led to consistent stabilization of platelet counts, but who showed complete inhibition of vonWillebrand factor-cleaving protease (VWF-cp) after 6 months of follow up. Persistent protease deficiency...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Langer F,Bergmann F,Budde U,Hegewisch-Becker S,Hossfeld DK

    更新日期:2002-07-01 00:00:00

  • Haemolytic anaemia in analpha-lipoproteinaemia (Tangier disease): morphological, biochemical, and biophysical properties of the red blood cell.

    abstract::A patient with familial analpha-lipoproteinaemia (Tangier disease) was found to have stomatocytosis and haemolytic anaemia. The analysis of the red cell membrane constituents revealed a low cholesterol content (90 nmol/ml red cells, control 130 nmol/ml red cells), a decreased cholesterol/phospholipid ratio (0.54, cont...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Reinhart WH,Gössi U,Bütikofer P,Ott P,Sigrist H,Schatzmann HJ,Lutz HU,Straub PW

    更新日期:1989-06-01 00:00:00

  • Interleukin-27 enhances the production of tumour necrosis factor-α and interferon-γ by bone marrow T lymphocytes in aplastic anaemia.

    abstract::Aplastic anaemia (AA) is considered as an immune-mediated bone marrow failure syndrome. The mechanism is involved with a variety of immune molecules including interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α) and interleukins (ILs). IL-27 is a novel member of the IL-12 family, which mediates T cell response and e...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Li J,Zhao Q,Xing W,Feng J,Wu H,Li H,Ge M,Tian K,Li X,Zhou J,Liu B,Zhang L,Zheng Y,Han ZC

    更新日期:2011-06-01 00:00:00

  • The fundamental contribution of William Bate Hardy to shape the concept of mast cell heterogeneity.

    abstract::This review article acknowledges the pioneering contribution of William Bate Hardy in shaping the concept of mast cell heterogeneity. In two outstanding papers, published in 1894 and 1895, he focussed on the 'wandering cells' (the modern leucocytes) in different mammalian species and distinguished two types of granula...

    journal_title:British journal of haematology

    pub_type: 传,历史文章,杂志文章


    authors: Crivellato E,Ribatti D

    更新日期:2010-07-01 00:00:00

  • Induction of B-cell chronic lymphocytic leukaemia and hairy cell leukaemia like phenotypes by phorbol ester treatment of normal peripheral blood B-cells.

    abstract::To investigate the relationship between normal B-cells, B-cell chronic lymphocytic leukaemia (B-CLL) cells and hairy cell leukaemia (HCL) cells the three cell types were incubated with phorbol myristic acetate (PMA). The parameters studied were morphology, immunophenotype and tartrate resistant acid phosphatase (TRAP)...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Visser L,Poppema S

    更新日期:1990-07-01 00:00:00

  • Essential role for T cells in human B-cell lymphoproliferative disease development in severe combined immunodeficient mice.

    abstract::Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disease (BLPD)-like lesions develop in severe combined immunodeficient (SCID) mice inoculated with peripheral blood mononuclear cells (PBMCs) from EBV-seropositive donors. We used this model to investigate the pathogenesis of EBV-associated BLPD. Tumour inci...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Johannessen I,Asghar M,Crawford DH

    更新日期:2000-06-01 00:00:00

  • Suppressive effect of ferritin on in vitro lymphocyte function.

    abstract::This study describes the effect of ferritin on lymphocyte function in vitro. Peripheral blood lymphocytes isolated from normal donors were incubated with purified human splenic ferritin, and the mitogenic effect of phytohaemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM) and mixed lymphocyte reaction ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Matzner Y,Hershko C,Polliack A,Konijn AM,Izak G

    更新日期:1979-07-01 00:00:00

  • Specific polymorphisms of cytokine genes are associated with different risks to develop single-system or multi-system childhood Langerhans cell histiocytosis.

    abstract::Cytokines and chemokines determine mobilisation of Langerhans cells and their dysregulation is implicated in the pathogenesis of Langerhans cell histiocytosis (LCH). Twenty point mutations of 12 different cytokine genes were studied in 41 Italian children, 15 with single-system (SS) and 26 with multi-system disease. T...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: De Filippi P,Badulli C,Cuccia M,De Silvestri A,Dametto E,Pasi A,Garaventa A,del Prever AB,Todesco A,Trizzino A,Danesino C,Martinetti M,Aricò M

    更新日期:2006-03-01 00:00:00

  • Osmotic properties of human erythrocytes treated by phospholipase A2 from bee venom.

    abstract::During treatment of human red cells with phospholipase A2 from bee venom, a linear increase of the MCV and of the osmotic fragility occurs in parallel with the cleavage of the accessible phospholipids. However, even after maximal hydrolysis, i.e. degradation of up to 65% of the phosphatidylcholines and up to 6% of the...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Vaysse J,Pilardeau P,Gattegno L,Garnier M

    更新日期:1987-03-01 00:00:00

  • Neuro-meningeal relapse in anaplastic large-cell lymphoma: incidence, risk factors and prognosis - a report from the European intergroup for childhood non-Hodgkin lymphoma.

    abstract::Relapses involving the central nervous system (CNS) are rare in children and adolescents with ALK+ anaplastic large cell lymphoma (ALCL) treated with regimens including CNS prophylaxis. Early identification of patients at high-risk for CNS relapse would enable stratification and better adaptation of initial treatment ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Del Baldo G,Abbas R,Woessmann W,Horibe K,Pillon M,Burke A,Beishuizen A,Rigaud C,Le Deley MC,Lamant L,Brugières L

    更新日期:2020-07-09 00:00:00

  • Lymph node enlargement and risk of haematological and solid cancer.

    abstract::Enlarged lymph nodes may be a marker of occult cancer, but accurate data on cancer risk are limited. We used population-based Danish medical registries to assess cancer risk in a cohort of patients with a first-time inpatient or outpatient hospital contact for enlarged lymph nodes during 1994-2008. Observed cancer inc...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Frederiksen H,Svaerke C,Thomsen RW,Farkas DK,Pedersen L,Weiss NS,Sørensen HT

    更新日期:2013-03-01 00:00:00

  • Cellular levels of mRNA from c-myc, c-myb and c-fes onc-genes in normal myeloid and erythroid precursors of human bone marrow: an in situ hybridization study.

    abstract::The expression of three onc-genes, c-myc, c-myb and c-fes, has been evaluated at the cellular level in myeloid and erythroid precursors of normal human bone marrow, by "in situ" hybridization with tritium-labelled probes. A relatively large amount of m-RNA from the three onc-genes was detected in myeloblasts and promy...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Emilia G,Donelli A,Ferrari S,Torelli U,Selleri L,Zucchini P,Moretti L,Venturelli D,Ceccherelli G,Torelli G

    更新日期:1986-02-01 00:00:00

  • Magnetic counter-gravity flow separation of electrically prepolarised lymphoid cells.

    abstract::A novel principle is proposed for a differential separation of live cells (such as leucocytes) from a main flow. A microfluidic device with planar insulated electrodes as the side walls of the channel was manufactured and tested. An array of insulated vertical conductor wires was inserted along the axis of the channel...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Popa C,Su B,Vadgama P,Cotter F

    更新日期:2007-02-01 00:00:00

  • Purine analogues kill resting lymphocytes by p53-dependent and -independent mechanisms.

    abstract::To resolve the controversy concerning the role of p53 in the killing of resting lymphocytes by purine nucleoside analogues, we examined the cytotoxic effects of chlorodeoxyadenosine, fludarabine and deoxycoformycin (plus deoxyadenosine) on unstimulated spleen cells from p53-knockout versus wild-type mice. p53-knockout...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Pettitt AR,Clarke AR,Cawley JC,Griffiths SD

    更新日期:1999-06-01 00:00:00

  • Antibodies to factor XII and recurrent fetal loss in patients with the anti-phospholipid syndrome.

    abstract::Forty female patients with either primary anti-phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti-phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2-glycoprotein I and factor XII. Twenty-one pa...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Jones DW,MacKie IJ,Gallimore MJ,Winter M

    更新日期:2001-05-01 00:00:00

  • The oxygen affinity of haemoglobin Hammersmith.

    abstract::Oxygen dissociation studies were carried out on red cells and lysates from a patient heterozygous for Hb Hammersmith. The oxygen affinity of the cells at pH 7.1 was decreased, partly by an increased cellular concentration of 2,3-DPG and more importantly by an intrinsic low affinity of Hb Hammersmity. Haem-haem interac...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: May A,Huehns ER

    更新日期:1975-06-01 00:00:00

  • Characterization of a new alpha zero thalassaemia defect in the South African population.

    abstract::A new alpha thalassemia defect has been detected in the South African population. Restriction mapping of the alpha globin gene cluster in affected individuals has established that the defect is associated with the removal of 22.8-23.7 kb of DNA, including the psi zeta 1, psi alpha 1, psi alpha 2, alpha 2 and alpha 1 g...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Vandenplas S,Higgs DR,Nicholls RD,Bester AJ,Mathew CG

    更新日期:1987-08-01 00:00:00

  • Interferon production in leukaemia.

    abstract::Leucocyte interferon production in vitro and circulating interferon levels were studied in healthy subjects and in 80 patients with acute or chronic leukaemia. Circulating interferon was not found in either group. Interferon synthesis in response to a virus was normal in patients with acute leukaemia and appeared to b...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Chisholm M,Cartwright T

    更新日期:1978-09-01 00:00:00

  • Differential expression of CD 180 and IgM by B-cell chronic lymphocytic leukaemia cells using mutated and unmutated immunoglobulin VH genes.

    abstract::We have studied the surface expression of the Toll-like receptor family member CD 180 on cells from 78 patients with B-chronic lymphocytic leukaemia (B-CLL). B-CLL cells had variable levels of CD 180 expression, but this was always less than that expressed by normal blood B cells and was stable for 24 months. Signific...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究


    authors: Porakishvili N,Kulikova N,Jewell AP,Youinou PY,Yong K,Nathwani A,Heelan B,Duke V,Hamblin TJ,Wallace P,Ely P,Clark EA,Lydyard PM

    更新日期:2005-11-01 00:00:00

  • Does sticky blood predict a sticky end? Associations of blood viscosity, haematocrit and fibrinogen with mortality in the West of Scotland.

    abstract::There is increasing evidence that blood viscosity and its major determinants (haematocrit, plasma viscosity and fibrinogen) are associated with an increased risk of incident cardiovascular events; however, their associations with mortality are not established. We therefore studied the associations of these variables w...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Woodward M,Rumley A,Tunstall-Pedoe H,Lowe GD

    更新日期:2003-08-01 00:00:00

  • Challenges and opportunities in the assessment of measurable residual disease in multiple myeloma.

    abstract::Treatment response assessment in multiple myeloma (MM) relies on the detection of paraprotein in serum and/or urine, bone marrow morphology and immunohistochemistry. With remarkable advances in therapy, particularly in the newly diagnosed setting, achievement of complete remission became frequent, creating the need to...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Bal S,Weaver A,Cornell RF,Costa LJ

    更新日期:2019-09-01 00:00:00

  • Novel alleles at the JK blood group locus explain the absence of the erythrocyte urea transporter in European families.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Irshaid NM,Eicher NI,Hustinx H,Poole J,Olsson ML

    更新日期:2002-02-01 00:00:00

  • Analysis of very elderly (≥80 years) non-hodgkin lymphoma: impact of functional status and co-morbidities on outcome.

    abstract::Data on outcome, prognostic factors, and treatment for very elderly non-Hodgkin lymphomas (NHL) is sparse. We conducted a multicentre retrospective analysis of NHL patients ≥80 years (at diagnosis) treated between 1999 and 2009. Detailed characteristics were obtained including geriatric syndromes, activities of daily ...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究


    authors: Nabhan C,Smith SM,Helenowski I,Ramsdale E,Parsons B,Karmali R,Feliciano J,Hanson B,Smith S,McKoy J,Larsen A,Hantel A,Gregory S,Evens AM

    更新日期:2012-01-01 00:00:00

  • Outcomes of treatment for relapsed acute lymphoblastic leukaemia in children with Down syndrome.

    abstract::Children with Down syndrome (DS) have a greater risk for developing both acute lymphoblastic leukaemia (ALL) and significant adverse effects of chemotherapy. We investigated their outcome with, and tolerance of, treatment protocols for relapsed ALL optimized in the paediatric population without DS. Probability of surv...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Meyr F,Escherich G,Mann G,Klingebiel T,Kulozik A,Rossig C,Schrappe M,Henze G,von Stackelberg A,Hitzler J

    更新日期:2013-07-01 00:00:00

  • Effect of different resuspension media on the post-thaw characteristics of frozen blood.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Amer KA,Pepper DS,Prowse CV

    更新日期:1980-04-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Dores GM,Matsuno RK,Weisenburger DD,Rosenberg PS,Anderson WF

    更新日期:2008-07-01 00:00:00

  • A single intra-articular injection with IL-4 plus IL-10 ameliorates blood-induced cartilage degeneration in haemophilic mice.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: van Meegeren ME,Roosendaal G,Coeleveld K,Nieuwenhuizen L,Mastbergen SC,Lafeber FP

    更新日期:2013-02-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Xu F,Gardner A,Tu Y,Michl P,Prager D,Lichtenstein A

    更新日期:1997-05-01 00:00:00

  • Grey platelet syndrome: studies on platelet alpha-granules, lysosomes and defective response to thrombin.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Srivastava PC,Powling MJ,Nokes TJ,Patrick AD,Dawes J,Hardisty RM

    更新日期:1987-04-01 00:00:00