Abstract：
:The in vitro efficacies of three new drugs--clofarabine (CLOF), nelarabine (NEL) and flavopiridol (FP) - were assessed in a panel of acute lymphoblastic leukaemia (ALL) cell lines. The 50% inhibitory concentration (IC50) for CLOF across all lines was 188-fold lower than that of NEL. B-lineage, but not T-lineage lines, were >7-fold more sensitive to CLOF than cytosine arabinoside (ARAC). NEL IC50 was 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T-ALL cells were eightfold more sensitive to NEL than B-lineage but there was considerable overlap. FP was more potent in vitro than glucocorticoids and thiopurines and at doses that recent phase I experience predicts will translate into clinical efficacy. Potential cross-resistance of CLOF, NEL and FP was observed with many front-line ALL therapeutics but not methotrexate or thiopurines. Methotrexate sensitivity was inversely related to that of NEL and FP. Whilst NEL was particularly effective in T-ALL, a subset of patients with B-lineage ALL might also be sensitive. CLOF appeared to be marginally more effective in B-lineage than T-ALL and has a distinct resistance profile that may prove useful in combination with other compounds. FP should be widely effective in ALL if sufficient plasma levels can be achieved clinically.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Beesley AH,Palmer ML,Ford J,Weller RE,Cummings AJ,Freitas JR,Firth MJ,Perera KU,de Klerk NH,Kees URdoi
10.1111/j.1365-2141.2007.06527.xsubject
Has Abstractpub_date
2007-04-01 00:00:00pages
109-16issue
2eissn
0007-1048issn
1365-2141pii
BJH6527journal_volume
137pub_type
杂志文章abstract：:A serial study of coagulation activation and whole-blood viscosity was performed on 37 patients with local or systemic bacterial infection, malaria, or a viral infection. Thrombocytopenia, without consumption of coagulation factors, was the main feature of benign tertian malaria and viral infection, whereas in septica...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1979.tb01155.x
更新日期：1979-07-01 00:00:00
abstract：:Blood donor screening for antibody to hepatitis B core antigen (anti-HBc) implemented in some countries as a surrogate marker for non-A, non-B hepatitis has been superseded by anti-HCV screening. To assess the value of anti-HBc screening for the detection of hepatitis B surface antigen-negative blood donations that mi...
journal_title：British journal of haematology
pub_type： 杂志文章
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abstract：:Intrinsic factor (IF) and cobalamin-R-binding protein (R-binder) linked to polyacrylamide beads were used to absorb cobalamins from solutions and serum extracts. Both binding agents were equally effective in removing [57Co]B12 from aqueous solution. IF was more effective than R-binder in removing [57Co]B12 added to a ...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1983.tb02141.x
更新日期：1983-08-01 00:00:00
abstract：:Plasma from patients with both acute and chronic liver disease has been examined for evidence of acquired dysfibrinogenaemia, using electrophoretic methods and coagulation tests. An examination of isolated fibrins upon SDS polyacryamide gel electrophoresis failed to demonstrate any molecular or structural defect assoc...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1977.tb00586.x
更新日期：1977-02-01 00:00:00
abstract：:Serum antiplatelet IgG and platelet-associated IgG (PAIgG) were studied in 68 AIDS-free human immunodeficiency virus (HIV)-infected patients with severe immunologic thrombocytopenic purpura (ITP), for the presence of platelet autoantibodies. Serum IgG with antiplatelet activity was found in 72% of the sera. However, t...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1989.tb00259.x
更新日期：1989-10-01 00:00:00
abstract：:Givinostat, a histone-deacetylase inhibitor (HDACi), inhibits proliferation of cells bearing the JAK2 V617F mutation and has shown significant activity with good tolerability in patients with chronic myeloproliferative neoplasms (MPN). In this multicentre, open-label, phase II study, 44 patients with polycythaemia ver...
journal_title：British journal of haematology
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1983.tb02075.x
更新日期：1983-05-01 00:00:00
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journal_title：British journal of haematology
pub_type： 杂志文章
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journal_title：British journal of haematology
pub_type： 杂志文章
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更新日期：1984-05-01 00:00:00
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journal_title：British journal of haematology
pub_type： 临床试验,杂志文章
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journal_title：British journal of haematology
pub_type： 杂志文章
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journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1984.tb06115.x
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journal_title：British journal of haematology
pub_type： 杂志文章,评审
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journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1046/j.1365-2141.2003.04376.x
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journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.2007.06667.x
更新日期：2007-08-01 00:00:00
abstract：:Fetal haemoglobin levels have been measured prospectively in 135 autopsy cases of sudden, unexpected infant deaths (31 pre-term, 104 full term) using standard laboratory methods. These results have been compared with Hb F values from a normal control group of 570 living infants (145 pre-term, 425 full-term) with a pos...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1992.tb06440.x
更新日期：1992-10-01 00:00:00
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journal_title：British journal of haematology
pub_type： 杂志文章
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journal_title：British journal of haematology
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journal_title：British journal of haematology
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journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1979.tb03791.x
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journal_title：British journal of haematology
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更新日期：2001-03-01 00:00:00
abstract：:Thrombocytopenia is a common finding in pregnancy, occurring in approximately 7-10% of pregnancies. It may be a diagnostic and management problem, and has many causes, some of which are specific to pregnancy. Although most cases of thrombocytopenia in pregnancy are mild, and have no adverse outcome for either mother o...
journal_title：British journal of haematology
pub_type： 杂志文章,评审
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更新日期：2012-07-01 00:00:00
abstract：:Fanconi anaemia (FA) is an autosomal recessive disease strongly predisposing to bone marrow failure and acute myeloid leukaemia (AML). Four FA genes, corresponding to complementation groups A, C, F and G, have been cloned, but the molecular functions of the corresponding proteins are unknown. The high risk of AML in F...
journal_title：British journal of haematology
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journal_title：British journal of haematology
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journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1992.tb06472.x
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abstract：:Globin-gene mapping of DNA from 13 families with normal Hb A2 beta-thalassaemia (both type 1 and type 2) failed to detect any difference from normal in their globin-gene arrangement. We conclude that deletions such as those responsible for gamma beta-thalassaemia or a 'silent' Hb Lepore are not responsible for this ty...
journal_title：British journal of haematology
pub_type： 杂志文章
doi：10.1111/j.1365-2141.1982.tb07289.x
更新日期：1982-05-01 00:00:00
abstract：:Although 5-fluorouracil (FUra) has been the drug of choice for the treatment of patients with advanced colorectal carcinoma, the response rates are in the range of 15% and the median survival times do not exceed 9 months. Interferon alpha (IFN alpha) has limited antitumour activity in this disease. Recent clinical tri...
journal_title：British journal of haematology
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doi：10.1111/j.1365-2141.1991.tb08120.x
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