Abstract:
:We report three cases of platelet dysfunction characterized by defective Ca2+ ionophore-induced platelet aggregation without impaired production of thromboxane A2 (TXA2). The patients had mild to moderate bleeding tendencies, and their platelet aggregation and secretion induced by ADP, collagen, arachidonic acid, stable TXA2 (STA2) and Ca2+ ionophore A23187 was defective or much reduced. However, ristocetin- or thrombin-induced platelet aggregation was normal. The analysis of second messenger formation showed that inositol 1,4,5-triphosphate formation or Ca2+ mobilization induced by thrombin, STA2 or A23187 was normal. Furthermore, the phosphorylation of 47 kDa protein (pleckstrin) and 20 kDa protein (myosin light chain, MLC) in response to those agonists was normal. These findings suggest that the defective site in the patients' platelets lies in the process distal to or independent of protein kinase C activation, Ca2+ mobilization and MLC phosphorylation.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Fuse I,Higuchi W,Uesugi Y,Aizawa Ydoi
10.1046/j.1365-2141.2001.02637.xsubject
Has Abstractpub_date
2001-03-01 00:00:00pages
603-8issue
3eissn
0007-1048issn
1365-2141pii
bjh2637journal_volume
112pub_type
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journal_title:British journal of haematology
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