Abstract:
:Hodgkin-Reed Sternberg (H-RS) cells harbour clonal immunoglobulin gene (Ig) rearrangements in almost all cases of classical Hodgkin's disease but lack Ig gene expression. In the H-RS cell line L1236, a somatic mutation of the Ig heavy-chain gene promoter octamer motif has been described as a putative reason for absence of Ig gene expression. We addressed transcriptional activity of this mutated promoter by performing reporter gene studies and gel retardation assays. The results showed that the mutation outside the coding region of the rearranged Ig gene in L1236 cells leads to downregulation of Ig gene expression in H-RS cells.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Re D,Staratschek-Jox A,Holtick U,Diehl V,Wolf Jdoi
10.1046/j.1365-2141.2001.03086.xsubject
Has Abstractpub_date
2001-11-01 00:00:00pages
326-8issue
2eissn
0007-1048issn
1365-2141pii
3086journal_volume
115pub_type
杂志文章abstract::Apoptosis is involved in many biological processes, especially during chemotherapy in cancer patients. Chemotherapy is also associated with an increased risk of thrombosis. The relationship between thrombogenicity and apoptosis was studied in various human tumour cell lines and non-tumour cell lines. Apoptosis was ind...
journal_title:British journal of haematology
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journal_title:British journal of haematology
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journal_title:British journal of haematology
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