Beneficial effect of exogenous platelet factor 4 for detecting pathogenic heparin-induced thrombocytopenia antibodies.

abstract：:In an ongoing effort to identify point mutations causing beta-thalassaemia, we have found two previously unreported mutations which are located in the Poly A site of the beta-globin gene. The screening programme used amplified DNA and dot-blot hybridization with several 32P-labelled oligonucleotide probes. DNA samples...

journal_title：British journal of haematology

authors： Jankovic L,Efremov GD,Petkov G,Kattamis C,George E,Yang KG,Stoming TA,Huisman TH

更新日期：1990-05-01 00:00:00

abstract：:Smouldering multiple myeloma (SMM) presents without MM defining symptoms. We aimed to identify patients with SMM with an 80% risk of progression within 2 years using only serum parameters. In total, 527 patients with SMM were included and divided into a training group (287 patients from the Czech Myeloma Group [CMG]) ...

journal_title：British journal of haematology

authors： Hájek R,Sandecka V,Špička I,Raab M,Goldschmidt H,Beck S,Minařík J,Pavlíček P,Radocha J,Heindorfer A,Jelínek T,Stejskal L,Brožová L,Ševčíková S,Straub J,Pika T,Pour L,Maisnar V,Seckinger A,Hose D

更新日期：2020-07-01 00:00:00

abstract：:Leukaemic stem cells (LSC) have been experimentally defined as the leukaemia-propagating population and are thought to be the cellular reservoir of relapse in acute myeloid leukaemia (AML). Therefore, LSC measurements are warranted to facilitate accurate risk stratification. Previously, we published the composition of...

journal_title：British journal of haematology

authors： Hanekamp D,Snel AN,Kelder A,Scholten WJ,Khan N,Metzner M,Irno-Consalvo M,Sugita M,de Jong A,Oude Alink S,Eidhof H,Wilhelm M,Feuring-Buske M,Slomp J,van der Velden VHJ,Sonneveld E,Guzman M,Roboz GJ,Buccisano F,Vyas P

更新日期：2020-09-01 00:00:00

abstract：:Haem biosynthesis is the most important destination for absorbed iron, hence it can be hypothesized that iron absorption regulation should be integrated with haem metabolism. As an initial step to test this hypothesis, the effect on iron absorption of Tin-mesoporphyrin (SnMP), inhibitor of haem oxygenase, altering hae...

journal_title：British journal of haematology

authors： Laftah AH,Raja K,Simpson RJ,Peters TJ

更新日期：2003-07-01 00:00:00

abstract：:Screening of the skeleton by plain radiography was compared to magnetic resonance imaging (MRI) of the lumbar spine in 41 patients with multiple myeloma. In the lumbar spine, myeloma lesions were detected in 15 patients with radiography and in 28 patients with MRI. Radiography of the lumbar spine was not positive in a...

journal_title：British journal of haematology

authors： Tertti R,Alanen A,Remes K

更新日期：1995-11-01 00:00:00

abstract：:Increasing demand for population screening for the haemoglobinopathies gives rise to a requirement for high throughput systems, which allow for cost effective, rapid, sensitive and specific screening of clinically significant haemoglobins. We have developed a practical and efficient approach using tryptic digestion an...

journal_title：British journal of haematology

authors： Daniel YA,Turner C,Haynes RM,Hunt BJ,Dalton RN

更新日期：2005-08-01 00:00:00

abstract：:Splenic lymphoma with villous lymphocytes (SLVL) is a low-grade B-cell lymphoproliferative disorder characterized by splenomegaly and circulating villous lymphocytes. The relationship between SLVL and splenic marginal zone lymphoma (SMZL), a disorder with identical splenic histology to SLVL, is not clear. Previous stu...

journal_title：British journal of haematology

authors： Gruszka-Westwood AM,Matutes E,Coignet LJ,Wotherspoon A,Catovsky D

更新日期：1999-03-01 00:00:00

abstract：:Forty female patients with either primary anti-phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti-phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2-glycoprotein I and factor XII. Twenty-one pa...

journal_title：British journal of haematology

authors： Jones DW,MacKie IJ,Gallimore MJ,Winter M

更新日期：2001-05-01 00:00:00

abstract：:In the Medical Research Council (MRC) Myeloma IX trial (ISRCTN684564111) patients were randomised to sodium clodronate or zoledronic acid and induction treatment: cyclophosphamide, vincristine, doxorubicin and dexamethasone (CVAD) or cyclophosphamide, thalidomide and dexamethasone (CTD) followed by autologous stem cel...

journal_title：British journal of haematology

authors： Royle KL,Gregory WM,Cairns DA,Bell SE,Cook G,Owen RG,Drayson MT,Davies FE,Jackson GH,Morgan GJ,Child JA

更新日期：2018-09-01 00:00:00

abstract：:T(3;14)(q27;q32) is frequently detected in B-cell non-Hodgkin's lymphomas, especially the diffuse large cell type and the follicular type. The BCL6 gene encoding a putative transcriptional factor which resides on 3q27 rearranges to the immunoglobulin heavy chain (IgH) gene on 14q32 in this chromosomal translocation. T...

journal_title：British journal of haematology

authors： Kawamata N,Nakamura Y,Miki T,Sato E,Isobe Y,Furusawa S,Hirosawa S,Oshimi K

更新日期：1998-03-01 00:00:00

abstract：:Employing an immunoblotting procedure, we have identified and characterized an autoantigen carried on glycoprotein (GP) IIb in a patient with chronic idiopathic thrombocytopenic purpura (ITP), and have compared the location of the autoantigen with that of the platelet-specific alloantigen Baka. Immunoblots, using the ...

journal_title：British journal of haematology

authors： Tomiyama Y,Kurata Y,Shibata Y,Honda S,Furubayashi T,Mizutani H,Tsubakio T,Yonezawa T,Tarui S

更新日期：1989-01-01 00:00:00

abstract：:We describe genetic, haematological and biochemical properties of a new mouse pigment mutant, cocoa (coa). Cocoa is a recessive mutation located on the centromeric end of chromosome 3 near the Car-2 locus. The mutation causes increased bleeding time accompanied by symptoms of platelet storage pool deficiency (SPD), in...

journal_title：British journal of haematology

authors： Novak EK,Sweet HO,Prochazka M,Parentis M,Soble R,Reddington M,Cairo A,Swank RT

更新日期：1988-07-01 00:00:00

abstract：:Transient myeloproliferative disorder (TMD) of the newborn and acute megakaryoblastic leukaemia (AMKL) in children with Down syndrome (DS) represent paradigmatic models of leukaemogenesis. Chromosome 21 gene dosage effects and truncating mutations of the X-chromosomal transcription factor GATA1 synergize to trigger TM...

journal_title：British journal of haematology

authors： Haemmerling S,Behnisch W,Doerks T,Korbel JO,Bork P,Moog U,Hentze S,Grasshoff U,Bonin M,Rieß O,Janssen JW,Jauch A,Bartram CR,Reinhardt D,Koch KA,Bandapalli OR,Kulozik AE

更新日期：2012-04-01 00:00:00

abstract：:Two new variants of erythrocytic glucose-6-phosphate dehydrogenase have been found in one German patient and in another patient of Turkish origin. The enzymes were partially purified 165-fold and 111-fold respectively. Both revealed reduced activity, increased thermolability and a pH-optimum in the alkaline region (8....

journal_title：British journal of haematology

authors： Gahr M,Bornhalm D,Schröter W

更新日期：1976-07-01 00:00:00

abstract：:The World Health Organization (WHO) lymphoma classification recognises anaplastic large cell lymphoma (ALCL), angioimmunoblastic lymphoma (AIL) and peripheral T-cell lymphoma, unspecified (PTCU) as nodal mature T-cell lymphomas. Little is known about long-term outcome and prognostic factors of these diseases. A retros...

journal_title：British journal of haematology

authors： Sonnen R,Schmidt WP,Müller-Hermelink HK,Schmitz N

更新日期：2005-05-01 00:00:00

abstract：:Patients with intermittent claudication have been reported to have disturbances in blood rheology and haemostasis. Whether these disturbances are a result of, or largely independent of, smoking history and arterial narrowing has not yet been established. The levels of whole blood and plasma viscosity, haematocrit, von...

journal_title：British journal of haematology

authors： Lee AJ,Fowkes FG,Rattray A,Rumley A,Lowe GD

更新日期：1996-01-01 00:00:00

abstract：:Hereditary haemochromatosis (HH) is an autosomal recessive disorder characterized by excessive intestinal iron absorption resulting in increased pathological body iron stores. It is typically associated with homozygosity for the c.845G>A (p.C282Y) mutation in the HFE gene. However, other HFE alterations have been repo...

journal_title：British journal of haematology

authors： Silva B,Martins R,Proença D,Fleming R,Faustino P

更新日期：2012-08-01 00:00:00

abstract：:Membrane protein synthesis in human immature erythroid cells was studied by incubating the cells with 35S-methionine in vitro. The radioactive precursor amino acid was incorporated into membrane protein in a linear fashion for approximately 60 min, after which there was only a slight increase in incorporation. Intrace...

journal_title：British journal of haematology

authors： Krasnow SH,Pielichowski HJ,Caro J,Burka ER,Ballas SK

更新日期：1981-02-01 00:00:00

abstract：:The F5 G1691A (Factor V Leiden) and F2 G20210A (prothrombin) mutations are linked to an increase in the incidence rate of venous thromboembolism (VTE), but their effects are highly variable. We investigated whether the effects of smoking and obesity might explain this variability. In a case-cohort study including the ...

journal_title：British journal of haematology

authors： Severinsen MT,Overvad K,Johnsen SP,Dethlefsen C,Madsen PH,Tjønneland A,Kristensen SR

更新日期：2010-04-01 00:00:00

abstract：:In patients with sickle cell anaemia (SCA), concomitant glucose-6-phosphate dehydrogenase (G6PD) deficiency is usually described as having no effect and only occasionally as increasing severity. We analysed sequential clinical and biological data for the first 42 months of life in SCA patients diagnosed by neonatal sc...

journal_title：British journal of haematology

authors： Benkerrou M,Alberti C,Couque N,Haouari Z,Ba A,Missud F,Boizeau P,Holvoet L,Ithier G,Elion J,Baruchel A,Ducrocq R

更新日期：2013-12-01 00:00:00

abstract：:A multiparameter flow-cytometrical method for the quantitation of CD34(+)-cells present in adult human peripheral blood cells (PBMC) has been developed. PBMC from 13 healthy adult subjects were analysed for CD34(+)-cells by flow-cytometry, with only the lymphoid population of cells negative for anti-CD3-moAb included ...

journal_title：British journal of haematology

authors： Serke S,Säuberlich S,Huhn D

更新日期：1991-04-01 00:00:00

abstract：:Givinostat, a histone-deacetylase inhibitor (HDACi), inhibits proliferation of cells bearing the JAK2 V617F mutation and has shown significant activity with good tolerability in patients with chronic myeloproliferative neoplasms (MPN). In this multicentre, open-label, phase II study, 44 patients with polycythaemia ver...

journal_title：British journal of haematology

authors： Finazzi G,Vannucchi AM,Martinelli V,Ruggeri M,Nobile F,Specchia G,Pogliani EM,Olimpieri OM,Fioritoni G,Musolino C,Cilloni D,Sivera P,Barosi G,Finazzi MC,Di Tollo S,Demuth T,Barbui T,Rambaldi A

更新日期：2013-06-01 00:00:00

abstract：:We report on the generation and functional characterization of a humanized immunoenzyme comprising a stable humanized single chain Fv (scFv) with grafted specificity of the anti-CD22 murine monoclonal antibody RFB4 and the human ribonuclease angiogenin (ANG). The fusion protein produced from transiently transfected ma...

journal_title：British journal of haematology

authors： Krauss J,Arndt MA,Vu BK,Newton DL,Rybak SM

更新日期：2005-03-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF)-induced alteration of phosphoprotein during differentiation of HL-60 cells was studied. From the two-dimensional gel electrophoresis analysis of phosphoproteins, a 45 kD phosphoprotein in the cytosolic fraction of DMSO-pretreated HL-60 cells was rapidly dephosphorylated by...

journal_title：British journal of haematology

authors： Yamaguchi T,Oshizawa T,Yamaguchi T,Suzuki K,Yamamoto Y,Hayakawa T

更新日期：1998-08-01 00:00:00

abstract：:Haematological characteristics have been compared in 29 subjects with heterozygous beta0 thalassaemia and in 33 subjects with heterozygous beta+ thalassaemia, identified by the type of sickle cell-beta thalassaemia among close relatives, in a Jamaican Negro population. Total haemoglobin, MCV and MCH were significantly...

journal_title：British journal of haematology

authors： Millard DP,Mason K,Serjeant BE,Serjeant GR

更新日期：1977-06-01 00:00:00

abstract：:T-cells from patients with B-cell chronic lymphocytic leukaemia (B-CLL) have abnormal T4/T8 ratios and functions. Previously, we demonstrated that peripheral blood (PB) mononuclear cells from B-CLL patients secrete significant amounts of interleukin 2 (IL2) with an apparent dysregulation of accessory cells controlling...

journal_title：British journal of haematology

authors： Rossi JF,Klein B,Commes T,Jourdan M,Janbon C

更新日期：1988-02-01 00:00:00

abstract：:We report a child with acute promyelocytic leukaemia (APL) who was treated with etoposide (VP16) for Langerhans cell histiocytosis (LCH). A 3-year-old Japanese girl was diagnosed as having LCH. She was treated with combination chemotherapy using VP16 and prednisolone. 56 months after beginning the chemotherapy she dev...

journal_title：British journal of haematology

authors： Matsuzaki A,Inamitsu T,Watanabe T,Ohga S,Ishii E,Nagotoshi Y,Tasaka H,Suda M,Ueda K

更新日期：1994-04-01 00:00:00

abstract：:A reduction of donor effects during centrifugal plateletpheresis with the Haemonetics Blood Processor was achieved by reducing the concentration of the citrate anticoagulant. Serum citrate and ionized calcium levels, immediately and 1 h post-pheresis, were affected to a lesser extent by using 5.0 g total ionized citra...

journal_title：British journal of haematology

authors： Mishler JM,Janes AW,Lowes B,Farfan C,Emerson PM

更新日期：1976-11-01 00:00:00

abstract：:Two single-nucleotide substitutions in PKLR constituted the molecular basis underlying pyruvate kinase (PK) deficiency in a patient with severe haemolytic anaemia. One novel mutation, IVS5+1G>A, abolished the intron 5 donor splice site. The other mutation, c.1436G>A, altered the intron 10 donor splice site consensus s...

journal_title：British journal of haematology

authors： Wijk R,van Wesel AC,Thomas AA,Rijksen G,van Solinge WW

更新日期：2004-04-01 00:00:00

abstract：:Haemophilia B Leyden is characterized by severe factor IX deficiency during childhood with partial resolution at puberty or following the administration of anabolic steroids. The disorder has recently been associated with point mutations in the putative factor IX promoter region, which contains an imperfect direct rep...

journal_title：British journal of haematology

authors： Royle G,Van de Water NS,Berry E,Ockelford PA,Browett PJ

更新日期：1991-02-01 00:00:00