Abstract:
:Interleukin-10 (IL-10) is one of the cytokines implicated in the pathogenesis of diffuse large B-cell lymphoma (DLBCL) in which it acts as auto/paracrine growth factor for lymphoma growth. T-cell non-Hodgkin lymphoma (NHL) is a heterogeneous disease, the biological basis of which is not fully understood. Some evidence suggests that IL-10 might be associated with the progression of T-cell NHLs and that IL-10 may be involved in a rescue effect, protecting T cells from apoptotic cell death associated with upregulated bcl-2 expression. The current study evaluated the impact of IL-10 gene (IL10) polymorphism on the response to chemotherapy and survival in T-cell NHL. IL10 polymorphisms were determined in 108 patients with T-cell NHL. The response to chemotherapy was not dependent on IL10 polymorphism, while survival differed significantly according to IL10 polymorphism. The group with ATA haplotype showed superior overall survival (61.2 +/- 5.9% vs. 21.2 +/- 11.7%, P = 0.001) and failure-free survival (35.0 +/- 5.7% vs. 13.2 +/- 8.7%, P = 0.001) compared to those without ATA haplotype. The ATA haplotype was identified as a favourable prognostic factor compared to non-ATA haplotype (P = 0.037, hazard ratio 2.1), together with international prognostic index (IPI) in a multivariate model for overall survival. In conclusion, IL10 polymorphism may affect the survival of T-cell NHL patients.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Lee JJ,Kim DH,Lee NY,Sohn SK,Kim JG,Kim HJ,Do YR,Park YHdoi
10.1111/j.1365-2141.2007.06570.xsubject
Has Abstractpub_date
2007-05-01 00:00:00pages
329-36issue
4eissn
0007-1048issn
1365-2141pii
BJH6570journal_volume
137pub_type
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