Glycoprotein IIb/IIIa autoantigenic repertoire in chronic idiopathic thrombocytopenic purpura.

abstract：:Heparin binding on polymorphonuclear leucocytes (PMNL) was characterized. Heparin binding was specific, rapid, saturable and reversible. One single class of heparin binding sites was found with a dissociation constant of 1.22 mumol/l and 7.7 x 10(6) sites per PMNL. The binding was independent of the anticoagulant acti...

journal_title：British journal of haematology

authors： Leculier C,Benzerara O,Couprie N,Francina A,Lasne Y,Archimbaud E,Fiere D

更新日期：1992-05-01 00:00:00

abstract：:To identify a commonly deleted region of 13q14 in idiopathic myelofibrosis (IMF), we used fluorescence in situ hybridization analysis to test for deletion of the RB1 and BRCA2 genes, and the microsatellite loci D13S319 and D13S25, in a series of 25 patients. A further two patients with myelofibrosis secondary to polyc...

journal_title：British journal of haematology

authors： Sinclair EJ,Forrest EC,Reilly JT,Watmore AE,Potter AM

更新日期：2001-05-01 00:00:00

abstract：:The Australian Leukaemia Study Group has performed a randomized trial of interferon alpha-2A (Roferon-A) as a co-induction agent together with intensive combination chemotherapy and as maintenance following completion of 12 cycles of induction treatment. When used as a co-induction agent, interferon-alpha did not impr...

journal_title：British journal of haematology

authors： Joshua DE,Penny R,Matthews JP,Laidlaw CR,Gibson J,Bradstock K,Wolf M,Goldstein D

更新日期：1997-04-01 00:00:00

abstract：:The EGFP-tk retroviral vector, encoding enhanced green fluorescent protein (EGFP) and the herpes simplex virus thymidine kinase (HSV-tk) packaged in a Phoenix amphotropic cell line, was used to transduce healthy donor T lymphocytes. Infection yielded a mean of 41.8 +/- 9.3% SD (range 31.1-48.4%) EGFP-positive cells an...

journal_title：British journal of haematology

authors： Di Florio S,Sebastiani C,Fagioli M,Di Ianni M,Alfonsi D,Venditti G,Pelicci PG,Tabilio A

更新日期：2000-09-01 00:00:00

abstract：:We describe genetic, haematological and biochemical properties of a new mouse pigment mutant, cocoa (coa). Cocoa is a recessive mutation located on the centromeric end of chromosome 3 near the Car-2 locus. The mutation causes increased bleeding time accompanied by symptoms of platelet storage pool deficiency (SPD), in...

journal_title：British journal of haematology

authors： Novak EK,Sweet HO,Prochazka M,Parentis M,Soble R,Reddington M,Cairo A,Swank RT

更新日期：1988-07-01 00:00:00

abstract：:SAn ageing population and the continuing expansion of clinical indications for coumadin therapy have increased pressure on hospital anticoagulant clinics. One solution is patient self-testing (PST) of the international normalized ratio (INR) using capillary blood samples on point-of-care coagulation monitors at home. ...

journal_title：British journal of haematology

authors： Gardiner C,Williams K,Mackie IJ,Machin SJ,Cohen H

更新日期：2005-01-01 00:00:00

abstract：:Serum erythropoietin (Epo) was measured in 23 patients before, during and after intensive cytostatic treatment courses for acute leukaemia or before bone marrow transplantation. A marked increase was seen in all patients, starting 1 or 2 d after initiation of treatment. A peak was reached after about 7 d, at levels as...

journal_title：British journal of haematology

authors： Birgegård G,Wide L,Simonsson B

更新日期：1989-07-01 00:00:00

abstract：:Transient myeloproliferative disorder (TMD) of the newborn and acute megakaryoblastic leukaemia (AMKL) in children with Down syndrome (DS) represent paradigmatic models of leukaemogenesis. Chromosome 21 gene dosage effects and truncating mutations of the X-chromosomal transcription factor GATA1 synergize to trigger TM...

journal_title：British journal of haematology

authors： Haemmerling S,Behnisch W,Doerks T,Korbel JO,Bork P,Moog U,Hentze S,Grasshoff U,Bonin M,Rieß O,Janssen JW,Jauch A,Bartram CR,Reinhardt D,Koch KA,Bandapalli OR,Kulozik AE

更新日期：2012-04-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a rare disease, affecting subjects of any age, with extremely variable clinical manifestations. Although most patients with LCH have localized disease, requiring local or even no therapy, those patients with disseminated, 'multi-system' disease require specific therapy because th...

journal_title：British journal of haematology

authors： Aricò M

更新日期：2016-06-01 00:00:00

abstract：:Increasing numbers of patients are surviving after allogeneic bone marrow transplantation and are therefore at risk for developing late complications. Among these complications, avascular necrosis of bone has been reported, but only two single-centre studies included sufficient patients to enable analysis of the risk ...

journal_title：British journal of haematology

authors： Socié G,Cahn JY,Carmelo J,Vernant JP,Jouet JP,Ifrah N,Milpied N,Michallet M,Lioure B,Pico JL,Witz F,Molina L,Fischer A,Bardou VJ,Gluckman E,Reiffers J

更新日期：1997-06-01 00:00:00

abstract：:Factors affecting iron efflux from the isolated perfused rat liver were studied following the intravenous administration of transferrin-(59)Fe or transferrin-(55)Fe administered to the rat from 1.5 h to 3.5 d before perfusion of the liver. The liver was perfused with rat red cells suspended either in rat plasma or Eag...

journal_title：British journal of haematology

authors： Baker E,Morton AG,Tavill AS

更新日期：1980-08-01 00:00:00

abstract：:The Dutch beta zero-thalassaemia has few clinical symptoms in homozygotes, elevated fetal haemoglobin (4-11%) in heterozygotes, and has a DNA deletion previously estimated as 10 kb which removes the beta-globin gene (Gilman et al, 1984). A DNA fragment containing the breakpoints of the Dutch beta zero-thalassaemia del...

journal_title：British journal of haematology

authors： Gilman JG

更新日期：1987-11-01 00:00:00

abstract：:Seventy-seven normal donors underwent leukapheresis for peripheral blood progenitor cell collection beginning on day 4 (n = 45) or day 5 (n = 32) of filgrastim mobilization (12 micrograms/kg/d). The two groups were comparable for age, weight, blood volumes processed during leukapheresis and target CD34+ cell dose to b...

journal_title：British journal of haematology

authors： Anderlini P,Przepiorka D,Huh Y,Lauppe J,Miller P,Sundberg J,Seong D,Champlin R,Körbling M

更新日期：1996-06-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma with a poor prognosis following first relapse. We present a subgroup analysis of an open-label phase II trial investigating the efficacy and safety of lenalidomide in patients with relapsed or refractory MCL. Oral lenalidomide 25 mg was self-administered...

journal_title：British journal of haematology

authors： Habermann TM,Lossos IS,Justice G,Vose JM,Wiernik PH,McBride K,Wride K,Ervin-Haynes A,Takeshita K,Pietronigro D,Zeldis JB,Tuscano JM

更新日期：2009-05-01 00:00:00

abstract：:We investigated the use of a new conditioning regimen followed by allogeneic bone marrow transplantation (BMT) for treating children with acute lymphoblastic leukaemia (ALL) after relapse within 6 months of the completion of therapy. One hundred and sixteen children with acute lymphoblastic leukaemia in second or subs...

journal_title：British journal of haematology

authors： Bordigoni P,Esperou H,Souillet G,Pico J,Michel G,Lacour B,Reiffers J,Sadoun A,Rohrlich P,Jouet JP,Milpied N,Lutz P,Plouvier E,Cornu G,Vannier JP,Gandemer V,Rubie H,Gratecos N,Leverger G,Stephan JL,Boutard P,Vern

更新日期：1998-08-01 00:00:00

abstract：:Early T-cell precursor acute lymphoblastic leukaemia (ETP-ALL) is a recently identified subtype of T-ALL with distinctive gene expression and cell marker profiles, poor response to chemotherapy and a very high risk of relapse. We determined the reliability of restricted panel of cell markers to identify EPT-ALL using ...

journal_title：British journal of haematology

authors： Inukai T,Kiyokawa N,Campana D,Coustan-Smith E,Kikuchi A,Kobayashi M,Takahashi H,Koh K,Manabe A,Kumagai M,Ikuta K,Hayashi Y,Tsuchida M,Sugita K,Ohara A

更新日期：2012-02-01 00:00:00

abstract：:The economic impact of using prophylactic clodronate as an adjunct to chemotherapy in the management of multiple myeloma for the first 4 years following diagnosis was established from the perspective of the National Health Service (NHS). A state-transition model of the course of multiple myeloma was constructed using ...

journal_title：British journal of haematology

authors： Bruce NJ,McCloskey EV,Kanis JA,Guest JF

更新日期：1999-02-01 00:00:00

abstract：:Paroxysmal nocturnal haemoglobinuria (PNH) is a serious form of acquired haemolytic anaemia with several features that make it unique, including the fact that it is caused by clonal expansion, in the context of bone marrow failure, of a haematopoietic stem cell that has a somatic mutation in a gene crucial for the syn...

journal_title：British journal of haematology

authors： Luzzatto L,Gianfaldoni G,Notaro R

更新日期：2011-06-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a heterogenic non-Hodgkin lymphoma entity, with a median survival of about 5 years. In 2008 we reported the early - based on the median observation time of 4 years - results of the Nordic Lymphoma Group MCL2 study of frontline intensive induction immunochemotherapy and autologous stem cel...

journal_title：British journal of haematology

authors： Geisler CH,Kolstad A,Laurell A,Jerkeman M,Räty R,Andersen NS,Pedersen LB,Eriksson M,Nordström M,Kimby E,Bentzen H,Kuittinen O,Lauritzsen GF,Nilsson-Ehle H,Ralfkiaer E,Ehinger M,Sundström C,Delabie J,Karjalainen-Lindsb

更新日期：2012-08-01 00:00:00

abstract：:We assessed the clinical utility of next-generation sequencing (NGS)-based monitoring of minimal residual disease (MRD) in a uniformly treated cohort of 79 patients with paediatric B-cell acute lymphoblastic leukaemia. Bone marrow samples were collected at the time of diagnosis, days 33 and 80, pre- (4-5 months) and p...

journal_title：British journal of haematology

authors： Sekiya Y,Xu Y,Muramatsu H,Okuno Y,Narita A,Suzuki K,Wang X,Kawashima N,Sakaguchi H,Yoshida N,Hama A,Takahashi Y,Kato K,Kojima S

更新日期：2017-01-01 00:00:00

abstract：:Recent studies concerning the numbers of circulating clonal B cells in patients with multiple myeloma (MM) have reported conflicting data regarding the exact levels of clonal B cells and the existence of clonal cells in the CD34 compartment. In this report we show that high numbers of clonal cells with a phenotype of ...

journal_title：British journal of haematology

authors： Rasmussen T,Kastrup J,Knudsen LM,Johnsen HE

更新日期：1999-04-01 00:00:00

abstract：:A 69-year-old woman presented with splenic marginal zone lymphoma associated with acquired von Willebrand's disease (AVWD). Laboratory abnormalities included markedly decreased plasma levels of factor VIII coagulant (C) activity (VIII:C 28%), von Willebrand's factor (VWF) antigen (Ag) (vWF:Ag < 6%), and VWF ristocetin...

journal_title：British journal of haematology

authors： Tefferi A,Hanson CA,Kurtin PJ,Katzmann JA,Dalton RJ,Nichols WL

更新日期：1997-03-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) is mediated by a heparin-dependent antibody/platelet factor 4/heparin complex binding to platelets via the Fc gamma receptor (type IIA). A single base polymorphism at position 131 of Fc gamma RIIA changes the native arginine to histidine. In the presence of murine monoclonal IgG1...

journal_title：British journal of haematology

authors： Burgess JK,Lindeman R,Chesterman CN,Chong BH

更新日期：1995-11-01 00:00:00

abstract：:Primary non-engraftment or early rejection after transplantation of haematopoietic stem cells represent life-threatening complications of allogeneic stem cell transplantation. Management of early graft failure has been problematic, as the risk of fatal infectious complications increases with the time of pancytopenia a...

journal_title：British journal of haematology

authors： Schlegel PG,Eyrich M,Bader P,Handgretinger R,Lang P,Niethammer D,Klingebiel T

更新日期：2000-11-01 00:00:00

abstract：:Factor V Leiden (FVL)-carrying relatives of selected patients with venous thromboembolism (VTE) have much higher venous thrombotic risks than FVL-carrying relatives of unselected consecutive patients with VTE. To find an explanation for this, we explored other risk factors of VTE, in particular the presence of high fa...

journal_title：British journal of haematology

authors： Lensen R,Bertina RM,Vandenbroucke JP,Rosendaal FR

更新日期：2001-08-01 00:00:00

abstract：:Multiple myeloma (MM) is currently incurable, and novel therapies are needed. In this study, we examined a novel recombinant humanized monoclonal antibody against CD40 (rhuCD40 mAb) and demonstrate for the first time that rhuCD40 mAb induces antibody-dependent cell-mediated cytotoxicity (ADCC) against CD40-positive MM...

journal_title：British journal of haematology

authors： Hayashi T,Treon SP,Hideshima T,Tai YT,Akiyama M,Richardson P,Chauhan D,Grewal IS,Anderson KC

更新日期：2003-05-01 00:00:00

abstract：:The use of immunochemotherapy has improved the outcome of follicular lymphoma (FL). Recently, complete response at 30 months (CR30) has been suggested as a surrogate for progression-free survival. This study aimed to analyse the life expectancy of FL patients according to their status at 30 months from the start of tr...

journal_title：British journal of haematology

authors： Magnano L,Alonso-Alvarez S,Alcoceba M,Rivas-Delgado A,Muntañola A,Nadeu F,Setoain X,Rodríguez S,Andrade-Campos M,Espinosa-Lara N,Rodríguez G,Sancho JM,Moreno M,Mercadal S,Carro I,Salar A,Garcia-Pallarols F,Arranz R,Ca

更新日期：2019-05-01 00:00:00

abstract：:A new alpha thalassemia defect has been detected in the South African population. Restriction mapping of the alpha globin gene cluster in affected individuals has established that the defect is associated with the removal of 22.8-23.7 kb of DNA, including the psi zeta 1, psi alpha 1, psi alpha 2, alpha 2 and alpha 1 g...

journal_title：British journal of haematology

authors： Vandenplas S,Higgs DR,Nicholls RD,Bester AJ,Mathew CG

更新日期：1987-08-01 00:00:00

abstract：:We describe two British families with similar, dominantly-inherited, temperature-related variants of hereditary stomatocytosis, consistent with the original description of 'cryohydrocytosis'. The cells show a 5-6-fold increase in passive permeability at 37 degrees C with abnormal intracellular Na and K levels at 15-20...

journal_title：British journal of haematology

authors： Coles SE,Chetty MC,Ho MM,Nicolaou A,Kearney JW,Wright SD,Stewart GW

更新日期：1999-06-01 00:00:00

abstract：:Allogeneic sibling bone marrow transplantation (BMT) is the recommended treatment for relapsed childhood acute lymphoblastic leukaemia (ALL), but appropriate donors are only available in 30% of cases. Unfortunately, BMT from unrelated donors (UD) has been associated with high rates of severe graft-versus-host disease ...

journal_title：British journal of haematology

authors： Oakhill A,Pamphilon DH,Potter MN,Steward CG,Goodman S,Green A,Goulden P,Goulden NJ,Hale G,Waldmann H,Cornish JM

更新日期：1996-09-01 00:00:00