Abstract:
:Recent studies concerning the numbers of circulating clonal B cells in patients with multiple myeloma (MM) have reported conflicting data regarding the exact levels of clonal B cells and the existence of clonal cells in the CD34 compartment. In this report we show that high numbers of clonal cells with a phenotype of late-stage B cells or pre-plasma cells were present in the peripheral blood (PB) of a patient with MM. During treatment the initial high level of PB clonal cells was markedly reduced and remained low (<1%) post transplant, even after disease progression. In addition, we found that the MM clone did not include a B-progenitor population defined by CD34.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Rasmussen T,Kastrup J,Knudsen LM,Johnsen HEsubject
Has Abstractpub_date
1999-04-01 00:00:00pages
265-7issue
1eissn
0007-1048issn
1365-2141journal_volume
105pub_type
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journal_title:British journal of haematology
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journal_title:British journal of haematology
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