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Risk of first venous thromboembolism in and around pregnancy: a population-based cohort study.

Abstract：

:Knowledge of the absolute and relative risk of venous thromboembolism (VTE) in and around pregnancy would be crucial in identifying when to commence and cease thromboprophylaxis in women who would benefit from such intervention. We addressed this hypothesis using a large prospective primary care database from the United Kingdom, containing details on 972683 women aged 15-44years between 1987 and 2004. Risks of a first VTE during antepartum, postpartum and outside of pregnancy were compared using Poisson regression. The rate of VTE during the third trimester antepartum was six times higher than time outside pregnancy [Incidence Rate Ratio (IRR)=6·1; 95% confidence interval, 4·7-7·9]. In contrast, both the first (IRR=1·6) and second (IRR=2·1) trimesters conferred little increase in risk. The first 6weeks postpartum was associated with a 22-fold increase in risk, with the peak occurring in the first 3weeks. Increased age was found to be associated with VTE during postpartum and outside of pregnancy, but not during antepartum. Our findings of a notably raised risk of VTE persisting for 3 weeks postpartum and of a raised antepartum risk constrained to the third trimester have implications for modifying the current recommendations for VTE prophylaxis in pregnancy and the puerperium.

journal_name

Br J Haematol

journal_title

British journal of haematology

authors

Sultan AA,West J,Tata LJ,Fleming KM,Nelson-Piercy C,Grainge MJ

doi

10.1111/j.1365-2141.2011.08956.x

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

366-73

issue

3

eissn

0007-1048

issn

1365-2141

journal_volume

156

pub_type

杂志文章

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