Circulating microparticles are elevated in haemophiliacs and non-haemophilic individuals aged

abstract：:This study analysed the outcome of 267 patients with relapse/refractory acute myeloid leukaemia (AML) who received sequential chemotherapy including fludarabine, cytarabine and amsacrine followed by reduced-intensity conditioning (RIC) and allogeneic haematopoietic stem cell transplantation (HSCT). The transplants in ...

journal_title：British journal of haematology

authors： Ringdén O,Labopin M,Schmid C,Sadeghi B,Polge E,Tischer J,Ganser A,Michallet M,Kanz L,Schwerdtfeger R,Nagler A,Mohty M,Acute Leukaemia Working Party of the EBMT.

更新日期：2017-02-01 00:00:00

abstract：:Protein S is expressed in a number of tissue types, one of the most physiologically relevant being the liver. However, transcriptional control of protein S gene expression is poorly understood. We have characterised a 638 bp area in the 5' flanking region of the human protein S gene, spanning all 10 previously reporte...

journal_title：British journal of haematology

authors： Hall AJ,Peake IR,Winship PR

更新日期：2006-11-01 00:00:00

abstract：:Pleiotrophin (PTN), a tightly regulated angiogenic and mitogenic heparin-binding protein, is markedly elevated in a variety of aggressive solid tumours. The role of PTN in haematological malignancies, however, has not been previously evaluated. This study demonstrated that PTN serum levels were elevated in multiple my...

journal_title：British journal of haematology

authors： Yeh HS,Chen H,Manyak SJ,Swift RA,Campbell RA,Wang C,Li M,Lee HJ,Waterman G,Gordon MS,Ma J,Bonavida B,Berenson JR

更新日期：2006-06-01 00:00:00

abstract：:Plasma cells isolated from bone marrow (BM) aspirates of 15 patients with active multiple myeloma (MM) were cultured and analysed for in vitro proliferative response and Ig-synthesis upon stimulation with interleukin-3 (IL-3), interleukin-4 (IL-4) and interleukin-6 (IL-6). The proliferative response, determined as Ki-...

journal_title：British journal of haematology

authors： Sonneveld P,Schoester M,de Leeuw K

更新日期：1991-12-01 00:00:00

abstract：:The laboratory diagnosis of heparin-induced thrombocytopenia (HIT) is based on an enzyme immunoassay combined with a functional test, and serotonin release assay (SRA) is the gold standard for detecting activating HIT antibodies. However, a recent atypical history of HIT prompted us to evaluate whether addition of pla...

journal_title：British journal of haematology

authors： Vayne C,Guery EA,Kizlik-Masson C,Rollin J,Bauters A,Gruel Y,Pouplard C

更新日期：2017-12-01 00:00:00

abstract：:The reasons why some patients with multiple myeloma (MM) do not develop severe bone loss, or even develop sclerotic bone lesions, remain unclear. In order to answer this question at the cellular and tissue level, we evaluated the histological bone condition of 10 patients with MM who never developed lytic bone lesions...

journal_title：British journal of haematology

authors： Bataille R,Chappard D,Marcelli C,Rossi JF,Dessauw P,Baldet P,Sany J,Alexandre C

更新日期：1990-12-01 00:00:00

abstract：:In previously reported cases, congenital deficiency of coagulation factor XIII has been found to result from the absence of the enzymatically active A subunits. In the family reported here two members were found to be heterozygous for an unstable A subunit which, in the homozygous state, or in the heterozygous state w...

journal_title：British journal of haematology

authors： Castle S,Board PG,Anderson RA

更新日期：1981-06-01 00:00:00

abstract：:We report the data of CD34+ cell immunoselection from peripheral blood after G-CSF-alone mobilization (10 micrograms/kg/d s.c.) in nine children with neuroblastoma (median age 4-5 years (2-8), median body weight 16 kg (10-20). Leukaphereses were carried out on a Cobe Spectra separator and two consecutive harvests (4 b...

journal_title：British journal of haematology

authors： Kanold J,Berger M,Rapatel C,de Lumley L,Lutz P,Plantaz D,Vannier JP,Bergeron C,Mechinaud F,Favrot M

更新日期：1995-10-01 00:00:00

abstract：:We retrospectively report data on 28 patients with haematological malignancy and trisomy 13 (25 cases) or tetrasomy 13 (three cases) as the primary acquired cytogenetic change. Peripheral blood and/or bone marrow morphology was reviewed in 25/28 cases and the final diagnosis was as follows: AML M0 (11), AML M1 (6), AM...

journal_title：British journal of haematology

authors： Mehta AB,Bain BJ,Fitchett M,Shah S,Secker-Walker LM

更新日期：1998-06-01 00:00:00

abstract：:The translocation t(14;18) and its t(2;18) and t(18,22) variants, which involve the BCL2 genetic hallmark for follicular lymphoma (FL), have been reported in several cases of chronic B-cell lymphoproliferative disease (CLPD) and frequently in chronic lymphocytic leukaemia (CLL). We describe here the clinical, morpholo...

journal_title：British journal of haematology

authors： Baseggio L,Geay MO,Gazzo S,Berger F,Traverse-Glehen A,Ffrench M,Hayette S,Callet-Bauchu E,Verney A,Morel D,Jallades L,Magaud JP,Salles G,Felman P

更新日期：2012-08-01 00:00:00

abstract：:Hodgkin's lymphoma (HL) can be cured in most of the patients, but in case of refractory disease or relapse after autologous stem cell transplantation (SCT) the prognosis becomes very poor. In these patients a consensus about the standard approach has not been achieved so far and only allogeneic SCT has shown a long-te...

journal_title：British journal of haematology

authors： Corradini P,Sarina B,Farina L

更新日期：2011-02-01 00:00:00

abstract：:Thrombomodulin (TM) is an endothelial cell glycoprotein that acts as an anticoagulant. Mutation in the TM gene is a potential risk factor for thrombosis. The first TM mutation identified was a heterozygous substitution of T for G at nucleotide position 1456, which predicted Asp468 with Tyr in a Ser/Thr-rich domain. To...

journal_title：British journal of haematology

authors： Nakazawa F,Koyama T,Saito T,Shibakura M,Yoshinaga H,Chung DH,Kamiyama R,Hirosawa S

更新日期：1999-08-01 00:00:00

abstract：:The contribution of red cell size (mean cell volume) to the clinical and haematological manifestations of homozygous sickle cell (SS) disease has been investigated by comparing the features of two groups of patients with low (less than or equal to 80 fl) and high (greater than 95 fl) MCV values after matching for age,...

journal_title：British journal of haematology

authors： Serjeant GR,Foster K,Serjeant BE

更新日期：1981-07-01 00:00:00

abstract：:Unlike previously reported cases with total protein 4.2 deficiency due to mutations in the EPB42 gene, we describe a total deficiency in protein 4.2 with normal EPB42 alleles. Hereditary spherocytosis (HS) was observed in a Japanese woman (unsplenectomized) and her daughter (splenectomized). The mother showed a partia...

journal_title：British journal of haematology

authors： Kanzaki A,Hayette S,Morlé L,Inoue F,Matsuyama R,Inoue T,Yawata A,Wada H,Vallier A,Alloisio N,Yawata Y,Delaunay J

更新日期：1997-12-01 00:00:00

abstract：:The glycoprotein localization of the platelet-specific antigens Zwa, Zwb and Baka and their presence on tryptic fragments of glycoproteins was studied by immunoblotting. Human platelets were solubilized and pre-cleared from platelet-associated IgG. The glycoproteins were separated on SDS polyacrylamide gels, transferr...

journal_title：British journal of haematology

authors： van der Schoot CE,Wester M,Von Dem Borne AE,Huisman HG

更新日期：1986-12-01 00:00:00

abstract：:A previous dose-finding study has suggested that romiplostim is effective in patients with refractory aplastic anaemia (AA) and 10 µg/kg once weekly was recommended as a starting dose. In this Phase II/III, multicentre, open-label study, romiplostim was administered subcutaneously at a fixed dose of 10 µg/kg once week...

journal_title：British journal of haematology

authors： Jang JH,Tomiyama Y,Miyazaki K,Nagafuji K,Usuki K,Uoshima N,Fujisaki T,Kosugi H,Matsumura I,Sasaki K,Kizaki M,Sawa M,Hidaka M,Kobayashi N,Ichikawa S,Yonemura Y,Enokitani K,Matsuda A,Ozawa K,Mitani K,Lee JW,Nakao

更新日期：2021-01-01 00:00:00

abstract：:Relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) in those unfit or ineligible for autologous stem cell transplantation is associated with a poor outcome and new treatment approaches are needed. Pixantrone is a novel aza-anthracenedione which is structurally similar to anthracyclines and is licenced i...

journal_title：British journal of haematology

authors： Eyre TA,Linton KM,Rohman P,Kothari J,Cwynarski K,Ardeshna K,Bailey C,Osborne WL,Rowntree C,Eden D,Shankara P,Eyre DW,Jasani P,Chaidos A,Collins GP,Hatton CS

更新日期：2016-06-01 00:00:00

abstract：:Massive genomic analyses have underscored the diversity of chronic lymphocytic leukaemia (CLL) between patients. Genetic heterogeneity of tumour clones within a patient may fuel tumour evolution. Several recurrently deregulated intra-cellular pathways are candidates for targeted therapies that are very promising and a...

journal_title：British journal of haematology

authors： Ghamlouch H,Nguyen-Khac F,Bernard OA

更新日期：2017-09-01 00:00:00

abstract：:Translocations involving the MLL gene on the chromosome 11 (11q23) are frequently observed in acute leukaemia. The detection of this genetic change has a unique significance as a result of its implication of poor prognosis. To reveal the utility of fluorescence in situ hybridization (FISH) in detecting the MLL translo...

journal_title：British journal of haematology

authors： Kim HJ,Cho HI,Kim EC,Ko EK,See CJ,Park SY,Lee DS

更新日期：2002-12-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a major cause of transplant-related mortality (TRM) after allogeneic haematopoietic stem cell transplantation (HSCT) and presents a challenge in haploidentical HSCT. GVHD may be prevented by ex vivo graft T-cell depletion or in vivo depletion of proliferating lymphocytes. However, b...

journal_title：British journal of haematology

authors： Roy DC,Lachance S,Cohen S,Delisle JS,Kiss T,Sauvageau G,Busque L,Ahmad I,Bernard L,Bambace N,Boumédine RS,Guertin MC,Rezvani K,Mielke S,Perreault C,Roy J

更新日期：2019-09-01 00:00:00

abstract：:There is limited information concerning the impact of physical activity and obesity on non-Hodgkin lymphoma (NHL) prognosis. We examined the associations between pre-diagnosis physical activity and body mass index (BMI) with survival in 238 diffuse large B-cell (DLBCL) and 175 follicular lymphoma cases, with follow-up...

journal_title：British journal of haematology

authors： Boyle T,Connors JM,Gascoyne RD,Berry BR,Sehn LH,Bashash M,Spinelli JJ

更新日期：2017-08-01 00:00:00

abstract：:Intrinsic factor (IF) and cobalamin-R-binding protein (R-binder) linked to polyacrylamide beads were used to absorb cobalamins from solutions and serum extracts. Both binding agents were equally effective in removing [57Co]B12 from aqueous solution. IF was more effective than R-binder in removing [57Co]B12 added to a ...

journal_title：British journal of haematology

authors： Muir M,Chanarin I

更新日期：1983-08-01 00:00:00

abstract：:Panobinostat in combination with bortezomib and dexamethasone demonstrated a significant and clinically meaningful progression-free survival benefit compared with placebo, bortezomib and dexamethasone in the phase 3 PANORAMA 1 (Panobinostat Oral in Multiple Myeloma 1) trial. Despite this benefit, patients in the panob...

journal_title：British journal of haematology

authors： San-Miguel JF,Hungria VTM,Yoon SS,Beksac M,Dimopoulos MA,Elghandour A,Jedrzejczak WW,Guenther A,Na Nakorn T,Siritanaratkul N,Schlossman RL,Hou J,Moreau P,Lonial S,Lee JH,Einsele H,Salwender H,Sopala M,Redhu S,Paul S

更新日期：2017-10-01 00:00:00

abstract：:Previous studies have suggested that phorbol ester-activated neutrophils kill both antibody non-coated and antibody-coated K562 target cells. In this report the contribution of the receptors Fc gamma III (CD16) and CR3 (CD11b/CD18) in the lytic process was investigated. In neutrophils CD16 and CR3 are up-regulated by ...

journal_title：British journal of haematology

authors： Gavioli R,Spisani S,Giuliani AL,Cosulich E,Risso A,Traniello S

更新日期：1991-10-01 00:00:00

abstract：:Kidney iron deposition measured by R2* (magnetic resonance imaging) MRI is posited to result from tubular reabsorption of filtered haemoglobin due to intravascular haemolysis. In chronically transfused sickle cell disease (SCD), R2* is elevated and positively correlated with lactate dehydrogenase (LDH). To account for...

journal_title：British journal of haematology

authors： Denton CC,Detterich JA,Coates TD,Wood JC

更新日期：2020-11-20 00:00:00

abstract：:Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by remodelling of the bone marrow, including progressive myelofibrosis and exaggerated angiogenesis. Advanced PMF frequently shows a full-blown fibre meshwork, which avoids aspiration of cells, and the expression profile of genes related to str...

journal_title：British journal of haematology

authors： Bock O,Muth M,Theophile K,Winter M,Hussein K,Büsche G,Kröger N,Kreipe H

更新日期：2009-09-01 00:00:00

abstract：:The specific sodium pump antagonist ouabain was used to study the effect of sodium pump inhibition on granulopoietic colony formation by normal human bone marrow cells cultured in soft agar for 7 d. Suppression of colony formation was dose-dependent and occurred at a low and reproducible concentration. The use of an e...

journal_title：British journal of haematology

authors： Steed AJ,Boardman KM,Delamore IW

更新日期：1982-07-01 00:00:00

abstract：SUMMARY:We report two patients with chronic myeloid leukaemia (CML) developing hypoplasia and karyotype conversion after conventional busulphan therapy. Initially, the percentage of Ph-positive metaphases in marrow for both patients was 100%, which steadily diminished up to a complete disappearance in case 1 and decrea...

journal_title：British journal of haematology

authors： Xue Y,Zhou XJ,Yu F,Gu J,Guo Y,Xie X,Lin B

更新日期：1996-03-01 00:00:00

abstract：:The findings of morphologically dysplastic features in haemopoietic cells in de novo acute myeloid leukaemia (AML) has been named AML with trilineage myelodysplasia (AML/TMDS). We analysed the clinical data, karyotypes, and treatment outcomes of 230 de novo AML patients treated with the Japan Adult Leukaemia Study Gro...

journal_title：British journal of haematology

authors： Kuriyama K,Tomonaga M,Matsuo T,Kobayashi T,Miwa H,Shirakawa S,Tanimoto M,Adachi K,Emi N,Hiraoka A

更新日期：1994-04-01 00:00:00

abstract：:We report the clinical presentation and the morphological, immunophenotypic, cytogenetic and molecular genetic characteristics of a 14 1/2-year-old boy who had French-American-British (FAB) type M1 acute non-lymphocytic (ANLL) leukaemia with a common T-ALL immunological phenotype, with no myeloid associated antigen, e...

journal_title：British journal of haematology

authors： Lelong F,Chretien P,Jouault H,Bayani N,Bernaudin F,Lemerle S

更新日期：1994-01-01 00:00:00