当前位置： SCI文献检索 > BRITISH JOURNAL OF HAEMATOLOGY期刊下所有文献 > Regulation of the human protein S gene promoter by liver enriched transcription factors.

Regulation of the human protein S gene promoter by liver enriched transcription factors.

Abstract：

:Protein S is expressed in a number of tissue types, one of the most physiologically relevant being the liver. However, transcriptional control of protein S gene expression is poorly understood. We have characterised a 638 bp area in the 5' flanking region of the human protein S gene, spanning all 10 previously reported transcription initiation sites, which demonstrates promoter activity in the human liver-derived cell line HepG2. More refined reporter gene analysis of this region enabled the identification of three transcription initiation sites whose absence is associated with significantly reduced promoter activity, together with a number of positively and negatively acting transcriptional regulatory elements. Consistent with these findings, DNaseI footprinting analysis identified eleven sites (I-XI) from within this 638 bp region that show evidence of binding nuclear proteins. We present evidence to show that the liver-specific factors hepatocyte nuclear factor 1 (HNF1) and HNF4 bind regions of the protein S promoter, which lie within the identified protein binding sites V and VIII, respectively, and that HNF4 activates the protein S promoter. Reporter gene analysis suggests that members of the CCAAT/enhancer binding protein (C/EBP) family of transcription factors are potent activators of protein S gene transcription in HepG2 cells.

journal_name

Br J Haematol

journal_title

British journal of haematology

authors

Hall AJ,Peake IR,Winship PR

doi

10.1111/j.1365-2141.2006.06327.x

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

538-46

issue

4

eissn

0007-1048

issn

1365-2141

pii

BJH6327

journal_volume

135

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF HAEMATOLOGY文献大全
  • Nordic MCL2 trial update: six-year follow-up after intensive immunochemotherapy for untreated mantle cell lymphoma followed by BEAM or BEAC + autologous stem-cell support: still very long survival but late relapses do occur.

    abstract：:Mantle cell lymphoma (MCL) is a heterogenic non-Hodgkin lymphoma entity, with a median survival of about 5 years. In 2008 we reported the early - based on the median observation time of 4 years - results of the Nordic Lymphoma Group MCL2 study of frontline intensive induction immunochemotherapy and autologous stem cel...

    journal_title：British journal of haematology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2141.2012.09174.x

    authors： Geisler CH,Kolstad A,Laurell A,Jerkeman M,Räty R,Andersen NS,Pedersen LB,Eriksson M,Nordström M,Kimby E,Bentzen H,Kuittinen O,Lauritzsen GF,Nilsson-Ehle H,Ralfkiaer E,Ehinger M,Sundström C,Delabie J,Karjalainen-Lindsb

    更新日期：2012-08-01 00:00:00

  • Isoferritins in normal leucocytes.

    abstract：:Monocytes, lymphocytes and polymorphs were separated from the peripheral blood of normal human subjects. Ferritin concentrations were determined with antibodies to both human spleen and heart ferritins. The heart type ferritin concentration in monocytes was 38.4 +/- 21.6 fg/cell (mean +/- SD), in lymphocytes 8.6 +/- 6...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1983.tb01225.x

    authors： Jones BM,Worwood M,Jacobs A

    更新日期：1983-09-01 00:00:00

  • A left shift in the oxyhaemoglobin dissociation curve in patients with severe coronavirus disease 2019 (COVID-19).

    abstract：:Critically ill patients with coronavirus disease 2019 (COVID-19) present with hypoxaemia and are mechanically ventilated to support gas exchange. We performed a retrospective, observational study of blood gas analyses (n = 3518) obtained from patients with COVID-19 to investigate changes in haemoglobin oxygen (Hb-O2 )...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.17128

    authors： Vogel DJ,Formenti F,Retter AJ,Vasques F,Camporota L

    更新日期：2020-11-01 00:00:00

  • Lymphotoxin, tumour necrosis factor and interleukin-6 gene transcripts are present in Hodgkin and Reed-Sternberg cells of most Hodgkin's disease cases.

    abstract：:Tissue specimens from 26 cases of Hodgkin's disease (HD) and six HD-derived cell lines were analysed for tumour necrosis factor (TNF), lymphotoxin (LT), and interleukin (IL)-6 RNA transcripts by in situ hybridization, in some cases subsequent to immunohistology for CD30 antigen. LT and TNF transcripts were found in tu...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1993.tb03138.x

    authors： Foss HD,Herbst H,Oelmann E,Samol J,Grebe M,Blankenstein T,Matthes J,Qin ZH,Falini B,Pileri S

    更新日期：1993-08-01 00:00:00

  • Serum levels of macrophage inflammatory protein-1 alpha (MIP-1alpha) correlate with the extent of bone disease and survival in patients with multiple myeloma.

    abstract：:The role of serum macrophage inflammatory protein-1 alpha (MIP-1alpha) in bone disease and survival was evaluated in 85 newly diagnosed multiple myeloma (MM) patients. MIP-1alpha was elevated in MM patients and correlated with the extent of bone disease, bone resorption markers and levels of soluble receptor activator...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2003.04561.x

    authors： Terpos E,Politou M,Szydlo R,Goldman JM,Apperley JF,Rahemtulla A

    更新日期：2003-10-01 00:00:00

  • Histopathology, cell proliferation indices and clinical outcome in 304 patients with mantle cell lymphoma (MCL): a clinicopathological study from the European MCL Network.

    abstract：:Mantle cell lymphoma (MCL) is a distinct lymphoma subtype with a particularly poor clinical outcome. The clinical relevance of the morphological characteristics of these tumours remains uncertain. The European MCL Network reviewed 304 cases of MCL to determine the prognostic significance of histopathological character...

    journal_title：British journal of haematology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1365-2141.2005.05716.x

    authors： Tiemann M,Schrader C,Klapper W,Dreyling MH,Campo E,Norton A,Berger F,Kluin P,Ott G,Pileri S,Pedrinis E,Feller AC,Merz H,Janssen D,Hansmann ML,Krieken H,Möller P,Stein H,Unterhalt M,Hiddemann W,Parwaresch R,Europ

    更新日期：2005-10-01 00:00:00

  • Safety and efficacy of cyclophosphamide, adriamycin, vincristine, prednisone and rituximab in patients with human immunodeficiency virus-associated diffuse large B-cell lymphoma: results of a phase II trial.

    abstract：:Immunochemotherapy with cyclophosphamide, adriamycin, vincristine, prednisone and rituximab (R-CHOP) is the standard treatment in non-immunosuppressed patients with diffuse large B-cell lymphoma (DLBCL), but its adequacy has not been definitively established in patients with human immunodeficiency virus (HIV)-related ...

    journal_title：British journal of haematology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1365-2141.2007.06943.x

    authors： Ribera JM,Oriol A,Morgades M,González-Barca E,Miralles P,López-Guillermo A,Gardella S,López A,Abella E,García M,PETHEMA, GELTAMO, GELCAB and GESIDA Groups.

    更新日期：2008-02-01 00:00:00

  • Results of treatment of children with refractory anaemia with excess blasts (RAEB) and RAEB in transformation (RAEBt) in Great Britain 1990-99.

    abstract：:Between 1990 and 1999, 36 children with refractory anaemia with excess blasts (RAEB) and RAEB in transformation (RAEBt), not associated with Down's syndrome, were diagnosed in Britain. A total of 31 children received intensive chemotherapy, six of whom proceeded to a bone marrow allograft in first remission, whereas t...

    journal_title：British journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2141.2002.03369.x

    authors： Webb DK,Passmore SJ,Hann IM,Harrison G,Wheatley K,Chessells JM

    更新日期：2002-04-01 00:00:00

  • The expression of ABH antigens during in vitro megakaryocyte maturation: origin of heterogeneity of antigen density.

    abstract：:An indirect immunofluorescence technique with single and double labelling has been used to examine cultured human megakaryocytes for ABH antigens. This technique demonstrated the presence of these antigens on megakaryocytes and a population of small mononuclear cells that probably represent the differentiated precurso...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1986.tb02971.x

    authors： Dunstan RA

    更新日期：1986-03-01 00:00:00

  • Expression of GNAZ, encoding the Gαz protein, predicts survival in mantle cell lymphoma.

    abstract：:Mantle cell lymphoma (MCL), a malignancy of B-lymphocytes, has a poor prognosis. It is thus necessary to improve the understanding of the pathobiology of MCL and identify factors contributing to its aggressiveness. Our studies, based on Affymetrix data from 17 MCL biopsies, real-time quantitative polymerase chain reac...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.15810

    authors： Mundt F,Merrien M,Nygren L,Sutton LA,Christensson B,Wahlin BE,Rosenquist R,Sander B,Wasik AM

    更新日期：2019-05-01 00:00:00

  • Suppressed intrinsic fibrinolytic activity by monoclonal anti-beta-2 glycoprotein I autoantibodies: possible mechanism for thrombosis in patients with antiphospholipid syndrome.

    abstract：:beta2-glycoprotein I (beta2GPI) bears the epitope(s) for autoimmune anticardiolipin antibodies (aCL) frequently present in patients with antiphospholipid syndrome (APS). beta2GPI is involved in coagulation and fibrinolytic systems, including inhibition of contact activation. Coagulation factor XII is an initiator of i...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2002.03928.x

    authors： Takeuchi R,Atsumi T,Ieko M,Amasaki Y,Ichikawa K,Koike T

    更新日期：2002-12-01 00:00:00

  • Cytomegalovirus infection and non-neutropenic fever after autologous stem cell transplantation: high rates of reactivation in patients with multiple myeloma and lymphoma.

    abstract：:In a retrospective study, we examined the association between cytomegalovirus (CMV) infection and non-neutropenic fever immediately following autologous peripheral blood stem cell transplantation for a variety of haematological malignancies and solid tumours. Sixty non-neutropenic febrile episodes (41 in CMV-seroposit...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2001.02487.x

    authors： Fassas AB,Bolaños-Meade J,Buddharaju LN,Rapoport A,Cottler-Fox M,Chen T,Lovchik JC,Cross A,Tricot G

    更新日期：2001-01-01 00:00:00

  • Predictive value of early 18F-fluoro-deoxyglucose positron emission tomography in chemosensitive relapsed lymphoma.

    abstract：:18F-fluoro-deoxyglucose (FDG) positron emission tomography (PET) might be a better tool than computerized tomography (CT) in predicting long-term treatment outcome in patients with relapsed chemosensitive lymphoma who are candidates for autologous stem cell transplantation (ASCT). We studied patients with recurrent or...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2003.04593.x

    authors： Schot B,van Imhoff G,Pruim J,Sluiter W,Vaalburg W,Vellenga E

    更新日期：2003-10-01 00:00:00

  • Low-dose aspirin does not lower in vivo platelet activation in healthy smokers.

    abstract：:Smoking causes atherosclerosis, and smokers have increased thromboxane (TXA2) formation. As aspirin inhibits TXA2 production we speculated that smokers would preferentially profit from inhibition of the TXA2 pathway by aspirin. Increased expression of P-selectin, a constituent of the alpha-granules of platelets, and i...

    journal_title：British journal of haematology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2141.1998.00883.x

    authors： Pernerstorfer T,Stohlawetz P,Stummvoll G,Kapiotis S,Szekeres T,Eichler HG,Jilma B

    更新日期：1998-09-01 00:00:00

  • Antibodies to factor XII and recurrent fetal loss in patients with the anti-phospholipid syndrome.

    abstract：:Forty female patients with either primary anti-phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti-phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2-glycoprotein I and factor XII. Twenty-one pa...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2001.02776.x

    authors： Jones DW,MacKie IJ,Gallimore MJ,Winter M

    更新日期：2001-05-01 00:00:00

  • A three-base deletion removing a leucine residue in a leucine-rich repeat of platelet glycoprotein Ib alpha associated with a variant of Bernard-Soulier syndrome (Nancy I).

    abstract：:Leucine-rich repeats are conserved structural motifs present in the four components of the human platelet glycoprotein Ib/IX/V complex receptor for the adhesive protein von Willebrand factor. The absence or abnormality of this complex is responsible for Bernard-Soulier disease, an autosomal recessive bleeding disorder...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1995.tb03316.x

    authors： de la Salle C,Baas MJ,Lanza F,Schwartz A,Hanau D,Chevalier J,Gachet C,Briquel ME,Cazenave JP

    更新日期：1995-02-01 00:00:00

  • Sequential chemotherapy followed by reduced-intensity conditioning and allogeneic haematopoietic stem cell transplantation in adult patients with relapse or refractory acute myeloid leukaemia: a survey from the Acute Leukaemia Working Party of EBMT.

    abstract：:This study analysed the outcome of 267 patients with relapse/refractory acute myeloid leukaemia (AML) who received sequential chemotherapy including fludarabine, cytarabine and amsacrine followed by reduced-intensity conditioning (RIC) and allogeneic haematopoietic stem cell transplantation (HSCT). The transplants in ...

    journal_title：British journal of haematology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/bjh.14428

    authors： Ringdén O,Labopin M,Schmid C,Sadeghi B,Polge E,Tischer J,Ganser A,Michallet M,Kanz L,Schwerdtfeger R,Nagler A,Mohty M,Acute Leukaemia Working Party of the EBMT.

    更新日期：2017-02-01 00:00:00

  • Sickle cell disease in Saudi Arabia: the phenotype in adults with the Arab-Indian haplotype is not benign.

    abstract：:Sickle cell disease (SCD) in Saudi patients from the Eastern Province is associated with the Arab-Indian (AI) HBB (β-globin gene) haplotype. The phenotype of AI SCD in children was described as benign and was attributed to their high fetal haemoglobin (HbF). We conducted a hospital-based study to assess the pattern of...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.12650

    authors： Alsultan A,Alabdulaali MK,Griffin PJ,Alsuliman AM,Ghabbour HA,Sebastiani P,Albuali WH,Al-Ali AK,Chui DH,Steinberg MH

    更新日期：2014-02-01 00:00:00

  • Maternal HLA genotyping is not useful for predicting severity of fetal and neonatal alloimmune thrombocytopenia.

    abstract：:Lack of reliable laboratory parameters is the main challenge in the management of fetal and neonatal alloimmune thrombocytopenia (FNAIT). Despite the long-known association between the HLA-DRB3*01:01 allele and human platelet antigen 1a (HPA-1a) alloimmunisation, maternal human leucocyte antigen (HLA) typing has been ...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.14385

    authors： Sainio S,Javela K,Tuimala J,Haimila K

    更新日期：2017-01-01 00:00:00

  • Platelet antibodies in thrombocytopenic patients.

    abstract：:Platelet antibodies either bound to the surface of platelets or free in the serum were sought in patients who had low platelet counts for a variety of reasons. They were detected by finding excess IgG on the surface of washed platelets either directly or after incubation of the serum with normal platelets. The techniq...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1977.tb00567.x

    authors： Hegde UM,Gordon-Smith EC,Worlledge S

    更新日期：1977-01-01 00:00:00

  • Frequent deletion of chromosome 12p12.3 in children with acute lymphoblastic leukaemia.

    abstract：:Cytogenetic deletions of the short arm of chromosome 12 are common recurring alterations found in a wide range of haematological neoplasias, including childhood acute lymphoblastic leukaemia (ALL), the most frequent paediatric malignancy. Such a loss of genetic material suggests the presence of a tumour suppressor gen...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.1997.3663180.x

    authors： Baccichet A,Sinnett D

    更新日期：1997-10-01 00:00:00

  • A case of peroxidase-positive acute leukaemia expressing only T lineage lymphoid markers.

    abstract：:We report the clinical presentation and the morphological, immunophenotypic, cytogenetic and molecular genetic characteristics of a 14 1/2-year-old boy who had French-American-British (FAB) type M1 acute non-lymphocytic (ANLL) leukaemia with a common T-ALL immunological phenotype, with no myeloid associated antigen, e...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1994.tb03276.x

    authors： Lelong F,Chretien P,Jouault H,Bayani N,Bernaudin F,Lemerle S

    更新日期：1994-01-01 00:00:00

  • Genetic strategies for the treatment of sickle cell anaemia.

    abstract：:Sickle cell anaemia is a severe inherited blood disorder for which there is presently no curative therapy other than allogeneic haematopoietic stem cell (HSC) transplantation. This therapeutic option, however, is not available to most patients because of the lack of a matched related donor. Different genetic strategie...

    journal_title：British journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2141.2011.08773.x

    authors： Mansilla-Soto J,Rivière I,Sadelain M

    更新日期：2011-09-01 00:00:00

  • The myelodysplastic syndromes: an analysis of prognostic factors in 226 cases from a single institution.

    abstract：:Two hundred and twenty-six patients were diagnosed with myelodysplastic syndrome (MDS), according to the French-American-British (FAB) criteria, over a 13-year period, and studied retrospectively in a single institution in order to study indicators which were prognostically significant. Analysis of clinical and labora...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1995.tb05590.x

    authors： Cunningham I,MacCallum SJ,Nicholls MD,Byth K,Hewson JW,Arnold B,Motum PI,Mulligan SP,Crane GG

    更新日期：1995-07-01 00:00:00

  • Alterations in size, shape and osmotic behaviour of red cells after splenectomy: a study of their age dependence.

    abstract：:In whole blood from splenectomized subjects (n = 20), red cells showed a significant increase of mean surface area (MSA), mean cell volume (MCV), MSA/MCV-ratio and osmotic resistance, with the mean cell haemoglobin concentration (MCHC) being decreased. Studies on red cell populations of different cell age revealed tha...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1988.tb07605.x

    authors： de Haan LD,Werre JM,Ruben AM,Huls HA,de Gier J,Staal GE

    更新日期：1988-05-01 00:00:00

  • Allogeneic marrow transplantation for aplastic anaemia associated with dyskeratosis congenita.

    abstract：:Eight patients with aplastic anaemia associated with dyskeratosis congenita received allogeneic marrow grafts from either HLA-identical siblings (six patients) or HLA-matched unrelated donors (two patients). Patients who received marrow from HLA-identical siblings were conditioned with cyclophosphamide (140-200 mg/kg)...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.1996.424984.x

    authors： Langston AA,Sanders JE,Deeg HJ,Crawford SW,Anasetti C,Sullivan KM,Flowers ME,Storb R

    更新日期：1996-03-01 00:00:00

  • Treatment of acute lymphoblastic leukaemia with the second generation of CD19 CAR-T containing either CD28 or 4-1BB.

    abstract：:T cells modified with anti-CD19 chimeric antigen receptor (CAR) containing either CD28 or 4-1BB (also termed TNFRSF9, CD137) costimulatory signalling have shown great potential in the treatment of acute lymphoblastic leukaemia (ALL). However, the difference between CD28 and 4-1BB costimulatory signalling in CAR-T trea...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.15195

    authors： Li S,Zhang J,Wang M,Fu G,Li Y,Pei L,Xiong Z,Qin D,Zhang R,Tian X,Wei Z,Chen R,Chen X,Wan J,Chen J,Wei X,Xu Y,Zhang P,Wang P,Peng X,Yang S,Shen J,Yang Z,Chen J,Qian C

    更新日期：2018-05-01 00:00:00

  • Determinants of haemoglobin level in sickle cell-haemoglobin C disease.

    abstract：:The determinants of steady state haemoglobin levels in sickle cell-haemoglobin C (SC) disease were investigated by measuring routine haematological and biochemical indices, red cell survival, oxygen affinity, pitted erythrocytes, and red cell and plasma volumes in 31 adult patients (15 male; 16 female). Red cell survi...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1979.tb03718.x

    authors： Bannerman RM,Serjeant B,Seakins M,England JM,Serjeant GR

    更新日期：1979-09-01 00:00:00

  • Clinical significance of Aspergillus fungaemia in patients with haematological malignancies and invasive aspergillosis.

    abstract：:The clinical significance of Aspergillus fungaemia in the setting of a deep-seated aspergillosis has not been clearly established. Among 107 microbiologically documented Aspergillus infections in patients with haematological diseases observed over a 17-year period, blood cultures grew Aspergillus species from 10 cases...

    journal_title：British journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2141.2001.02901.x

    authors： Girmenia C,Nucci M,Martino P

    更新日期：2001-07-01 00:00:00

  • Homozygosity for dominant form of hereditary spherocytosis.

    abstract：:A 6-month-old male infant with hereditary spherocytosis (HS) who was the first child of a cousin marriage is presented. The patient had splenomegaly and severe anaemia. Examination of the peripheral blood smear revealed spherocytes and the osmotic fragility of red blood cells was greatly increased. Physical examinatio...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1992.tb06473.x

    authors： Duru F,Gürgey A,Oztürk G,Yörükan S,Altay C

    更新日期：1992-11-01 00:00:00