Abstract:
:The role of serum macrophage inflammatory protein-1 alpha (MIP-1alpha) in bone disease and survival was evaluated in 85 newly diagnosed multiple myeloma (MM) patients. MIP-1alpha was elevated in MM patients and correlated with the extent of bone disease, bone resorption markers and levels of soluble receptor activator of nuclear factor-kappaB (RANK) ligand. MIP-1alpha was also associated with survival; the 3-year probability of survival was 85% and 44% for MIP-1alpha levels below and above 48 pg/ml respectively (P = 0.021). This suggests that MIP-1alpha contributes to the pathogenesis of bone disease in MM and possibly in tumour growth, as reflected by its impact on survival.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Terpos E,Politou M,Szydlo R,Goldman JM,Apperley JF,Rahemtulla Adoi
10.1046/j.1365-2141.2003.04561.xsubject
Has Abstractpub_date
2003-10-01 00:00:00pages
106-9issue
1eissn
0007-1048issn
1365-2141pii
4561journal_volume
123pub_type
杂志文章abstract::We report on two adult patients with CD10+ positive acute lymphoblastic leukaemia (ALL) who presented with similar clinical and laboratory features and with a new chromosomal translocation: t(3;17)(q23;q21). This translocation may be involved in the formation of a new chimaeric transcription factor. Both patients shar...
journal_title:British journal of haematology
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journal_title:British journal of haematology
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journal_title:British journal of haematology
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journal_title:British journal of haematology
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