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Serum pleiotrophin levels are elevated in multiple myeloma patients and correlate with disease status.

Abstract：

:Pleiotrophin (PTN), a tightly regulated angiogenic and mitogenic heparin-binding protein, is markedly elevated in a variety of aggressive solid tumours. The role of PTN in haematological malignancies, however, has not been previously evaluated. This study demonstrated that PTN serum levels were elevated in multiple myeloma (MM) patients when compared with healthy subjects (P < 0.0001). Serum levels of this protein significantly increased during progression of disease, and decreased during response to anti-MM therapy (P < 0.001). These results suggest that serum PTN may be a new biomarker for monitoring the disease status and therapeutic response of MM patients.

journal_name

Br J Haematol

journal_title

British journal of haematology

authors

Yeh HS,Chen H,Manyak SJ,Swift RA,Campbell RA,Wang C,Li M,Lee HJ,Waterman G,Gordon MS,Ma J,Bonavida B,Berenson JR

doi

10.1111/j.1365-2141.2006.06052.x

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

526-9

issue

5

eissn

0007-1048

issn

1365-2141

pii

BJH6052

journal_volume

133

pub_type

杂志文章

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