Aspects of folate metabolism in renal failure.

abstract：:Positron emission tomography using fluorine-18 (FDG-PET) is increasingly used in the staging and follow-up of malignant lymphomas, although its precise role has not yet been determined. This review considers the results reported at the different stages in the disease history and separately considers the major histolog...

journal_title：British journal of haematology

authors： Burton C,Ell P,Linch D

更新日期：2004-09-01 00:00:00

abstract：:Laboratory (LTLS) and clinical (CTLS) tumour lysis syndrome (TLS) are frequent complications in newly diagnosed children with advanced mature B cell non-Hodgkin lymphoma (B-NHL). Rasburicase, compared to allopurinol, results in more rapid reduction of uric acid in paediatric patients at risk for TLS. However, the safe...

journal_title：British journal of haematology

authors： Galardy PJ,Hochberg J,Perkins SL,Harrison L,Goldman S,Cairo MS

更新日期：2013-11-01 00:00:00

abstract：:A murine monoclonal IgM erythrocyte antibody appeared to have anti-P (anti-globoside) specificity. The antibody was a relatively weak cold agglutinin, but a strong haemolysin and its reactivity with red cells was markedly enhanced by enzyme treatment. This antibody was used to study the cell and tissue distribution of...

journal_title：British journal of haematology

authors： von dem Borne AE,Bos MJ,Joustra-Maas N,Tromp JF,van't Veer MB,van Wijngaarden-du Bois R,Tetteroo PA

更新日期：1986-05-01 00:00:00

abstract：:Non-endemic Burkitt lymphoma (BL) is a rare germinal centre B-cell-derived malignancy with the genetic hallmark of MYC gene translocation and with rapid tumour growth as a distinct clinical feature. To investigate treatment outcomes, loss of lifetime and relapse risk in adult BL patients treated with intensive immunoc...

journal_title：British journal of haematology

authors： Jakobsen LH,Ellin F,Smeland KB,Wästerlid T,Christensen JH,Jørgensen JM,Josefsson PL,Øvlisen AK,Holte H,Blaker YN,Grauslund JH,Bjørn J,Molin D,Lagerlöf I,Smedby KE,Colvin K,Thanarajasingam G,Maurer MJ,Habermann TM,So

更新日期：2020-05-01 00:00:00

abstract：:Transient leukaemia (TL) in neonates with Down syndrome (DS) is characterized by the transient appearance of blast cells in the peripheral blood that resolves spontaneously. Some TL patients die at an early age due to organ failure. Seventy DS patients with TL were studied retrospectively to identify clinical and labo...

journal_title：British journal of haematology

authors： Muramatsu H,Kato K,Watanabe N,Matsumoto K,Nakamura T,Horikoshi Y,Mimaya J,Suzuki C,Hayakawa M,Kojima S

更新日期：2008-08-01 00:00:00

abstract：:Three distinct categories of marginal zone lymphomas (MZLs) are currently recognized, principally based on their site of occurrence. They are thought to represent unique entities, but the relationship of one subtype with another is poorly understood. We investigated 17 non-splenic MZLs (seven nodal, 10 extranodal) by ...

journal_title：British journal of haematology

authors： Novak U,Basso K,Pasqualucci L,Dalla-Favera R,Bhagat G

更新日期：2011-11-01 00:00:00

abstract：:Reversible aggregation of red blood cells (RBC) plays an important role in determining blood flow properties, and it is this aggregation which increases blood viscosity at low shear rates. The structure and sites of venous thrombi, as well as the fact that stasis is a major predisposing factor in venous thrombosis, su...

journal_title：British journal of haematology

authors： Chabanel A,Horellou MH,Conard J,Samama MM

更新日期：1994-09-01 00:00:00

abstract：:We investigated the molecular basis of factor VII deficiency in a Japanese patient and identified a novel missense mutation in the signal sequence of the gene. Factor VII activity and antigen level measured in the patient were 10.7% and 11% of normal, respectively. All exons except 1B and the 5'-flanking region contai...

journal_title：British journal of haematology

authors： Ozawa T,Takikawa Y,Niiya K,Ejiri N,Suzuki K,Sato S,Sakuragawa N

更新日期：1998-04-01 00:00:00

abstract：:Platelet and cell stimulation lead to plasma membrane remodelling, resulting in phosphatidylserine (PS) externalisation in the outer leaflet of the membrane, associated with the shedding of PS-rich microparticles (MPs), and contributes to thrombin generation by promoting the assembly of coagulation enzyme complexes. A...

journal_title：British journal of haematology

authors： Proulle V,Hugel B,Guillet B,Grunebaum L,Lambert T,Freyssinet JM,Dreyfus M

更新日期：2005-11-01 00:00:00

abstract：:The induction of anaemia and reticulocytosis by arylhydrazines was influenced by substituents on the benzene ring of phenylhydrazine. Arylhydrazines with ortho substituents, which would hinder the binding by haemoglobin of a ligand derived from the arylhydrazine, resulted in the least anaemia and reticulocytosis. Thes...

journal_title：British journal of haematology

authors： Itano HA,Hosokawa K,Hirota K

更新日期：1976-01-01 00:00:00

abstract：:Haematopoietic cell transplantation (HCT) survivors are at increased risk for developing congestive heart failure (CHF), primarily due to pre-HCT exposure to anthracyclines. We examined the association between the development of CHF after HCT and polymorphisms in 16 candidate genes involved in anthracycline metabolism...

journal_title：British journal of haematology

authors： Armenian SH,Ding Y,Mills G,Sun C,Venkataraman K,Wong FL,Neuhausen SL,Senitzer D,Wang S,Forman SJ,Bhatia S

更新日期：2013-10-01 00:00:00

abstract：:Canine cyclic haematopoiesis (CH) appears to be a multipotential stem cell defect, possibly due to an intrinsic marrow defect. The in vitro adherent marrow cells of the cyclic haematopoietic (CH) dog were cultured as underlayers beneath normal dog nonadherent marrow cells. The marrow granulocyte-committed colony formi...

journal_title：British journal of haematology

authors： Jones JB,Jolly JD

更新日期：1982-04-01 00:00:00

abstract：:t(11;18)(q21;q21) has been recognized as a characteristic chromosomal translocation in mucosa-associated lymphoid tissue (MALT)-type lymphoma, and recent studies have demonstrated that this translocation results in the chimaeric transcript of API2 (apoptosis inhibitor 2)-MALT1 (mucosa-associated lymphoid tissue lympho...

journal_title：British journal of haematology

authors： Yonezumi M,Suzuki R,Suzuki H,Yoshino T,Oshima K,Hosokawa Y,Asaka M,Morishima Y,Nakamura S,Seto M

更新日期：2001-12-01 00:00:00

abstract：:Erythrocytes from elderly donors (> 70 years), but not young donors (18-35 years), are shown to undergo sequestration in an in vitro erythrophagocytosis assay. Comparable levels of sequestration are observed for high density erythrocytes from young individuals and both low density and high density erythrocytes from el...

journal_title：British journal of haematology

authors： Shapiro S,Kohn D,Gershon H

更新日期：1993-04-01 00:00:00

abstract：:Allogeneic haematopoietic stem cell transplantation (HSCT) after a reduced-intensity conditioning (RIC) regimen with fludarabine, melphalan and alemtuzmab is an effective therapy for haematological malignancies. Alemtuzumab, a monoclonal antibody against CD52, a glycosylphosphatidylinositol-anchor-bound surface protei...

journal_title：British journal of haematology

authors： Woelfinger P,Epp K,Schaefer L,Kriege D,Theobald M,Bopp T,Wagner-Drouet EM

更新日期：2020-10-01 00:00:00

abstract：:Serum concentrations of the thrombopoiesis-enhancing cytokines thrombopoietin (TPO), erythropoietin (EPO), interleukin (IL)-6 and IL-11 were determined in 119 healthy whole-blood (WBD) and 101 platelet donors (PD) prior to donation. The 90% TPO reference interval in WBD of 64-867 pg/ml (median 163, 100% range 45-7572)...

journal_title：British journal of haematology

authors： Tacke F,Schöffski P,Trautwein C,Martin MU,Stangel W,Seifried E,Manns MP,Ganser A,Petersen D

更新日期：1999-05-01 00:00:00

abstract：:The following diagnostic criteria are proposed to classify four clinical subtypes of HTLV-1 associated adult T-cell leukaemia-lymphoma (ATL): (1) Smouldering type, 5% or more abnormal lymphocytes of T-cell nature in PB, normal lymphocyte level (less than 4 x 10(9)/l), no hypercalcaemia (corrected calcium level less th...

journal_title：British journal of haematology

authors： Shimoyama M

更新日期：1991-11-01 00:00:00

abstract：:The Kidd (JK) blood group system is of importance in transfusion medicine. The Jk(null) phenotype is associated with absence of the urea transporter in erythrocytes and moderately reduced ability to concentrate urine. We and others recently reported different molecular alterations in the silenced Jkb-like alleles of P...

journal_title：British journal of haematology

authors： Irshaid NM,Eicher NI,Hustinx H,Poole J,Olsson ML

更新日期：2002-02-01 00:00:00

abstract：:MHC-unrestricted cytotoxic lymphocytes, namely natural killer (NK) and lymphokine activated killer (LAK) cells, have been implicated in the regulation of haemopoiesis. To investigate the possible role of these lymphocytes in the pathogenesis of aplastic anaemia (AA), we studied their functions in the peripheral blood ...

journal_title：British journal of haematology

authors： Myint AA,Malkovska V,Morgan S,Luckit J,Wonke B,Gordon-Smith EC

更新日期：1990-08-01 00:00:00

abstract：:A number of disorders cause iron overload: some are of genetic origin, such as hereditary haemochromatosis, while others are acquired, for instance due to repeated transfusions. This article reviews the treatment options for hereditary haemochromatosis, with special attention to the use of erythrocytapheresis. In gene...

journal_title：British journal of haematology

authors： Rombout-Sestrienkova E,van Kraaij MG,Koek GH

更新日期：2016-12-01 00:00:00

abstract：:Three patients with probable congenital erythrocytosis were studied to determine the role of erythropoietin (ESF) in their disease. In addition, haemoglobin function was measured and ESF excretion determined in response to reduction in the haemoglobin concentration. In two cases ESF excretion was clearly elevated abov...

journal_title：British journal of haematology

authors： Whitcomb WH,Peschle C,Moore M,Nitschke R,Adamson JW

更新日期：1980-01-01 00:00:00

abstract：:We hypothesized that Wilms tumour 1 gene (WT1) expression levels in acute myeloid leukaemia (AML) patients might have predictive value and reveal molecular relapse kinetics. WT1 level was determined at diagnosis, during therapy and post-therapy follow-up in 89 patients who reached first complete remission (CR1) (952 s...

journal_title：British journal of haematology

authors： Ommen HB,Nyvold CG,Braendstrup K,Andersen BL,Ommen IB,Hasle H,Hokland P,Ostergaard M

更新日期：2008-06-01 00:00:00

abstract：:A uniform system of classification and nomenclature of the acute leukaemias, at present lacking, should permit more accurate recording of the distribution of cases entered into clinical trials, and could provide a reference standard when newly developed cell-surface markers believed to characterize specific cell types...

journal_title：British journal of haematology

authors： Bennett JM,Catovsky D,Daniel MT,Flandrin G,Galton DA,Gralnick HR,Sultan C

更新日期：1976-08-01 00:00:00

abstract：:Novel agents have provided a new foundation for multiple myeloma therapies. When combined with other anti-myeloma agents, these compounds significantly enhance clinical efficacy. High-dose steroids are frequently used in anti-myeloma combination regimens; however, the doses employed are often poorly tolerated, especia...

journal_title：British journal of haematology

authors： Sher T,Ailawadhi S,Miller KC,Manfredi D,Wood M,Tan W,Wilding G,Czuczman MS,Hernandez-Ilizaliturri FJ,Hong F,Sood R,Soniwala S,Lawrence W,Jamshed S,Masood A,Iancu D,Lee K,Chanan-Khan A

更新日期：2011-07-01 00:00:00

abstract：:The combination of tumour necrosis factor alpha (TNF alpha) and gamma-interferon induced transcription of class I HLA genes in chronic myelogenous leukaemia (CML) cell lines through the formation of a complex between nuclear proteins and the transcriptional enhancers associated with these genes. Although gamma-interfe...

journal_title：British journal of haematology

authors： Seong D,Sims S,Johnson E,Lyding J,Lopez A,Garovoy M,Talpaz M,Kantarjian H,Lopez-Berestein G,Reading C

更新日期：1991-07-01 00:00:00

abstract：:A novel human leukaemia cell line, designated TMD7, was established from blast cells of a patient with de novo acute myeloblastic leukaemia with trilineage myelodysplasia (AML/TLD). As seen in the original blast cells, TMD7 cells expressed CD7, CD13, CD33 and CD34 and showed an abnormal karyotype containing -5, -7, -8...

journal_title：British journal of haematology

authors： Tohda S,Sakano S,Ohsawa M,Murakami N,Nara N

更新日期：2002-05-01 00:00:00

abstract：:Two single-nucleotide substitutions in PKLR constituted the molecular basis underlying pyruvate kinase (PK) deficiency in a patient with severe haemolytic anaemia. One novel mutation, IVS5+1G>A, abolished the intron 5 donor splice site. The other mutation, c.1436G>A, altered the intron 10 donor splice site consensus s...

journal_title：British journal of haematology

authors： Wijk R,van Wesel AC,Thomas AA,Rijksen G,van Solinge WW

更新日期：2004-04-01 00:00:00

abstract：:Thrombocytopenia can be a complication of hepatitis C viral (HCV) infection. However, there is little published data regarding the clinical and laboratory manifestations of HCV-related thrombocytopenia (HCV-TP) compared with adult chronic immune thrombocytopenic purpura (CITP). We reviewed the medical records for all ...

journal_title：British journal of haematology

authors： Rajan SK,Espina BM,Liebman HA

更新日期：2005-06-01 00:00:00

abstract：:Drug-induced agranulocytosis (neutrophil count <0.5 x 10(9)/l) is a rare haematological complication with an incidence of no more than 10 cases per million inhabitants per year in Europe. Over the past few years there has been a steady decline in mortality rate, (currently at <5%), which can be partly explained by ear...

journal_title：British journal of haematology

authors： Andrès E,Maloisel F,Zimmer J

更新日期：2010-07-01 00:00:00

abstract：:It has been proposed that iron accumulation may contribute to atherogenesis by increasing free radical formation and oxidative stress. Epidemiological studies in which the association of iron status with atherosclerosis was assessed raised conflicting results. To test whether genetic haemochromatosis is associated wit...

journal_title：British journal of haematology

authors： Franco RF,Zago MA,Trip MD,ten Cate H,van den Ende A,Prins MH,Kastelein JJ,Reitsma PH

更新日期：1998-09-01 00:00:00