A role for complement as the major opsonin in the sequestration of erythrocytes from elderly and young donors.

abstract：:Our paper describes two Sardinian families with alpha-beta thalassaemia interaction. In the first (family S), the propositus, whose haemoglobin pattern at birth consisted of about 25% Hb Bart's and 75% Hb F, successively developed a clinical and haematological picture typical of Cooleys anaemia. Haematological and glo...

journal_title：British journal of haematology

authors： Furbetta M,Galanello R,Ximenes A,Angius A,Melis MA,Serra P,Cao A

更新日期：1979-02-01 00:00:00

abstract：:The clinical characteristics and prognostic relevance of acute myeloid leukaemia (AML) with myelodysplastic features remains to be clarified in children. We prospectively examined 443 newly diagnosed patients in a multicentre clinical trial for paediatric de novo AML, and found 'AML with myelodysplasia-related changes...

journal_title：British journal of haematology

authors： Kinoshita A,Miyachi H,Matsushita H,Yabe M,Taki T,Watanabe T,Saito AM,Tomizawa D,Taga T,Takahashi H,Matsuo H,Kodama K,Ohki K,Hayashi Y,Tawa A,Horibe K,Adachi S

更新日期：2014-10-01 00:00:00

abstract：:Identification of the molecular basis of the beta-thalassaemias and sickle cell disease (SCD) has made it clear that patients with the same beta-globin genotypes can have very variable patterns of clinical expression. Extensive biochemical and pathophysiological studies over the last 50 years have derived two major mo...

journal_title：British journal of haematology

authors： Thein SL

更新日期：2008-05-01 00:00:00

abstract：:Murine monoclonal antibodies (MoAbs) were produced against the blood group KEL1 glycoprotein (93 kD component) immunopurified from human erythrocytes. One monoclonal antibody, 5A11 (IgGa, kappa), detects by immunoblotting a 93 and 184 kD component from KEL: 1,-2 or KEL: -1,2 red cell membrane preparations, separated b...

journal_title：British journal of haematology

authors： Jaber A,Loirat MJ,Willem C,Bloy C,Cartron JP,Blanchard D

更新日期：1991-10-01 00:00:00

abstract：:β- thalassaemia is a disorder of globin gene synthesis resulting in reduced or absent production of the β-globin chain in red blood cells. In this study, haematopoietic stem cells were isolated from the peripheral blood of six transfusion dependent β-thalassaemia patients and six healthy controls. Following 7 and 14 d...

journal_title：British journal of haematology

authors： Forster L,McCooke J,Bellgard M,Joske D,Finlayson J,Ghassemifar R

更新日期：2015-07-01 00:00:00

abstract：:Follicular lymphoma (FL) is a heterogeneous disease; therefore, reliable prognostic tools are needed to plan treatment strategies. The FL International Prognostic Index (FLIPI) was developed before the rituximab era, while the PRIMA-PI was built on rituximab chemotherapy. Our objective was to evaluate these two progno...

journal_title：British journal of haematology

authors： Kimby E,Lockmer S,Holte H,Hagberg H,Wahlin BE,Brown P,Østenstad B

更新日期：2020-05-14 00:00:00

abstract：:We report a case of indolent B-chronic lymphocytic leukaemia (B-CLL) in a stage A patient, treated for 10 years only by theophylline for bronchial asthma. As suggested by the spontaneous apoptosis in the patient's blood (10%), theophylline at 50 micrograms/ml increased spontaneous apoptosis after 72 h in culture by a ...

journal_title：British journal of haematology

authors： Mentz F,Merle-Beral H,Ouaaz F,Binet JL

更新日期：1995-08-01 00:00:00

abstract：:The profile of thymidine kinase isoenzymes was determined in peripheral blood lymphocytes from 14 patients with chronic lymphocytic leukaemia (CLL) and 31 controls. Twelve patients with indolent disease showed TK2 isoenzyme activity, while two patients in whom the disease evolved and two patients who presented with ag...

journal_title：British journal of haematology

authors： Ellims PH,Gan TE,Van der Weyden MB

更新日期：1981-11-01 00:00:00

abstract：:Bone marrow from 39 patients who received a bone marrow transplant (BMT) from a matched donor of different sex were studied by chromosome analysis for evidence of mixed haemopoietic chimaerism (MC). Recipient metaphases were detected in the bone marrow of 10 patients after BMT. Patients in whom MC was detected within ...

journal_title：British journal of haematology

authors： Walker H,Singer CR,Patterson J,Goldstone AH,Prentice HG

更新日期：1986-02-01 00:00:00

abstract：:This study describes the use of a simple charcoal product (DOAC-RemoveTM ) to allow haemostasis assays on patients taking direct oral anticoagulants (DOAC). In the proposed algorithm, patients taking DOAC are screened using the dilute thrombin time (dTT) and anti-Xa assay. If either are positive then DOAC-Remove is ut...

journal_title：British journal of haematology

authors： Cox-Morton S,MacDonald S,Thomas W

更新日期：2019-11-01 00:00:00

abstract：:Shwachman-Diamond Syndrome (SDS) is a multi-system genetic disorder with bone marrow failure. SBDS, the gene associated with SDS, has been postulated to play a role in ribosome biogenesis and RNA processing, but its functions are still unknown. To study whether these pathways are interrupted when Sbds protein is lost,...

journal_title：British journal of haematology

authors： Rujkijyanont P,Adams SL,Beyene J,Dror Y

更新日期：2009-06-01 00:00:00

abstract：:The PFA-100(R) (PFA) diagnostic system for the detection of platelet dysfunction was evaluated to determine reference ranges in a normal population. The PFA determines the primary haemostasis capacity (PHC) of anticoagulated whole blood, expressed by the system's closure time (CT). In this study the CT reference range...

journal_title：British journal of haematology

authors： Böck M,De Haan J,Beck KH,Gutensohn K,Hertfelder HJ,Karger R,Heim MU,Beeser H,Weber D,Kretschmer V

更新日期：1999-09-01 00:00:00

abstract：:We report the analysis of prognostic factors in a cohort of 660 patients entered in the first Medical Research Council trial in chronic lymphocytic leukaemia (CLL) between 1978 and 1984. The majority (94%) of patients were aged 50 or over and the number of men (M) was almost twice that of women (F) with an M:F ratio o...

journal_title：British journal of haematology

authors： Catovsky D,Fooks J,Richards S

更新日期：1989-06-01 00:00:00

abstract：:Immunoglobulin kappa (Igkappa) gene recombinations can be used - similarly to IgH rearrangements - as clonal markers in B-lineage leukaemias. Based on the extensive junctional diversity, these rearrangements represent valuable targets for the analysis of minimal residual disease (MRD). In order to provide a simple met...

journal_title：British journal of haematology

authors： Stolz F,Panzer S,Panzer-Grümayer ER

更新日期：1999-08-01 00:00:00

abstract：:This work aimed to provide a means of assaying directly the effects of transient expression of introduced genes on the survival, proliferation, lineage commitment and differentiation of haemopoietic progenitor cells. For this purpose, we have developed a system that allows isolation of productively transfected, muliti...

journal_title：British journal of haematology

authors： McIvor ZJ,Heyworth CM,Johnson BA,Pearson S,Fiegler H,Hampson L,Dexter TM,Cross MA

更新日期：2000-09-01 00:00:00

abstract：:The changes in bone marrow (BM) stem cell reserve and function and stromal cell function in patients with active systemic lupus erythematosus (SLE) were investigated. The study was carried out on seven SLE patients and 28 healthy controls using flow cytometry and in vitro cell culture assays. We found that patients ha...

journal_title：British journal of haematology

authors： Papadaki HA,Boumpas DT,Gibson FM,Jayne DR,Axford JS,Gordon-Smith EC,Marsh JC,Eliopoulos GD

更新日期：2001-10-01 00:00:00

abstract：:The platelets of a young man with the grey platelet syndrome were severely depleted of all seven alpha-granule proteins assayed as well as partially deficient in alpha-mannosidase and alpha-fucosidase; four other lysosomal enzymes were present in normal concentrations. Total platelet 5-hydroxytryptamine (5HT) and aden...

journal_title：British journal of haematology

authors： Srivastava PC,Powling MJ,Nokes TJ,Patrick AD,Dawes J,Hardisty RM

更新日期：1987-04-01 00:00:00

abstract：:The myelotoxicities of three antiretroviral agents, 3'-azido-3'-deoxythymidine (AZT), carbovir (CBV) and 2',3'-didehydro-2',3'-dideoxythymidine (d4T), were evaluated in vitro with normal human and murine haematopoietic progenitor cells. These studies demonstrated that continuous AZT exposure was more inhibitory to hum...

journal_title：British journal of haematology

authors： Du DL,Volpe DA,Grieshaber CK,Murphy MJ Jr

更新日期：1992-04-01 00:00:00

abstract：:The odds ratio of homozygosity or heterozygosity for the TNF2 polymorphism in 575 patients with venous thromboembolism compared to controls was found to be 1.0 (95% CI 0.4-2.1) and 1.1 (95% CI 0.8-1.4) respectively. Comparing subgroups of patients and controls with the factor V Leiden mutation the odds ratio for the T...

journal_title：British journal of haematology

authors： Brown K,Luddington R,Baglin T

更新日期：1998-06-01 00:00:00

abstract：:Bone marrow culture in a patient with aplastic anaemia responding to anabolic steroid (methandienone) therapy, showed an unusually high degree of growth in unstimulated cultures. Growth in unstimulated cultures is due to factors with colony stimulating activity (CSA) released by monocyte macrophages in the bone marrow...

journal_title：British journal of haematology

authors： Francis GE,Berney JJ,Bateman SM,Hoffbrand AV

更新日期：1977-08-01 00:00:00

abstract：:The significance of serum lactate dehydrogenase (LDH) in light chain (AL) amyloidosis has not been previously explored. We studied 1019 newly diagnosed patients and correlated the elevation of LDH above the upper limit of normal (ULN) with disease characteristics and outcome. Four hundred and nine patients had an LDH ...

journal_title：British journal of haematology

authors： Muchtar E,Dispenzieri A,Lacy MQ,Buadi FK,Kapoor P,Hayman SR,Gonsalves W,Warsame R,Kourelis TV,Chakraborty R,Russell S,Lust JA,Lin Y,Go RS,Zeldenrust S,Dingli D,Leung N,Rajkumar SV,Kyle RA,Kumar SK,Gertz MA

更新日期：2017-09-01 00:00:00

abstract：:The presence of oestrogen receptors (ER) and type II oestrogen binding sites (type II EBS) have been investigated by a whole cell assay in seven cases of acute lymphoid leukaemia (ALL) and 16 cases of acute myeloid leukaemia (AML). ER were detected in 6/7 ALL patients with values ranging between 133 and 2268 sites/cel...

journal_title：British journal of haematology

authors： Larocca LM,Piantelli M,Leone G,Sica S,Teofili L,Panici PB,Scambia G,Mancuso S,Capelli A,Ranelletti FO

更新日期：1990-08-01 00:00:00

abstract：:A new method of in vivo bioassay for erythropoietin (EPO) is described. This method is based on the measurement of immature reticulocytes in EPO-treated mice using an automatic microcell counter, and is simpler and more precise than the existing methods of polycythaemic mouse assay and starved rat assay. Normal mice w...

journal_title：British journal of haematology

authors： Kawamura A,Imai N,Kawaguchi T,Hayakawa T

更新日期：1991-03-01 00:00:00

abstract：:Mature (non-anaplastic) T-cell and natural killer (NK)-lymphomas rarely occur in children or adolescents. Due to the low incidence and heterogeneity, information regarding the aetiology, physiopathology and genetics of paediatric mature (non-anaplastic) T/NK-cell lymphoma is lacking. In addition, standard treatments h...

journal_title：British journal of haematology

authors： Flower A,Xavier AC,Cairo MS

更新日期：2019-05-01 00:00:00

abstract：:The success of genetically engineered T cells that express chimeric antigen receptors (CARTs) has been a momentous step forward in harnessing the potent cancer fighting abilities of the immune system. The efficacy seen in relapsed/refractory (r/r) acute lymphoblastic leukaemia (ALL), not only by inducing remission, bu...

journal_title：British journal of haematology

authors： Orlowski RJ,Porter DL,Frey NV

更新日期：2017-04-01 00:00:00

abstract：:beta2-glycoprotein I (beta2GPI) bears the epitope(s) for autoimmune anticardiolipin antibodies (aCL) frequently present in patients with antiphospholipid syndrome (APS). beta2GPI is involved in coagulation and fibrinolytic systems, including inhibition of contact activation. Coagulation factor XII is an initiator of i...

journal_title：British journal of haematology

authors： Takeuchi R,Atsumi T,Ieko M,Amasaki Y,Ichikawa K,Koike T

更新日期：2002-12-01 00:00:00

abstract：:A mechanism has been proposed in which nitric oxide (NO) may bind to cysteine beta93 and be transported by haemoglobin from the lungs to the tissues and modify vascular tone. In addition, it has been reported that treatment of sickle cell anaemia blood with 80 p.p.m. NO gas in air shifts the oxygen affinity, as measur...

journal_title：British journal of haematology

authors： Hrinczenko BW,Alayash AI,Wink DA,Gladwin MT,Rodgers GP,Schechter AN

更新日期：2000-08-01 00:00:00

abstract：:Mucormycosis has emerged as an increasingly important cause of morbidity and mortality in immunocompromised patients, but contemporary data in children are lacking. We conducted a nationwide multicentre study to investigate the characteristics of mucormycosis in children with haematological malignancies. The cohort in...

journal_title：British journal of haematology

authors： Elitzur S,Arad-Cohen N,Barg A,Litichever N,Bielorai B,Elhasid R,Fischer S,Fruchtman Y,Gilad G,Kapelushnik J,Kharit M,Konen O,Laor R,Levy I,Raviv D,Shachor-Meyouhas Y,Shvartser-Beryozkin Y,Toren A,Yaniv I,Nirel R,I

更新日期：2020-04-01 00:00:00

abstract：:Clusters and chains of basophilic micro-organisms were found on the red cells of a woman who suffered from malignant melanoma. The infection was clinically silent for at least 7 years. During her last year of life the patient became febrile and anaemic. Her spleen enlarged and the basophilic bodies on her red cells be...

journal_title：British journal of haematology

authors： Clark KG

更新日期：1975-02-01 00:00:00

abstract：:Liposome-entrapped desferrioxamine was administered to iron-over-loaded 59Fe lavelled mice. When given orally or intraperitoneally entrapment did not enhance the effect of the chelator, but given intravenously liposomal desferrioxamine doubled the 59Fe excretion for a given dose of the drug, and excretion after a sing...

journal_title：British journal of haematology

authors： Young SP,Baker E,Huehns ER

更新日期：1979-03-01 00:00:00