A common polymorphism in the tumour necrosis factor-alpha gene associated with high TNF levels is not a risk factor for venous thromboembolism.

abstract：:The existence of functional gap junctions between haematopoietic progenitor cells (HPCs) and stromal cells of the haematopoietic microenvironment in the human system is a controversial issue. Primary CD34+ HPCs isolated from leukapheresis products were co-incubated with the human fibroblastoid bone marrow stromal cell...

journal_title：British journal of haematology

authors： Dürig J,Rosenthal C,Halfmeyer K,Wiemann M,Novotny J,Bingmann D,Dührsen U,Schirrmacher K

更新日期：2000-11-01 00:00:00

abstract：:Using Southern blot, the restriction digests of genomic DNAs in 11 patients with Glanzmann thrombasthenia from 10 unrelated kindreds were probed with a full-length GPIIb cDNA. An additional 2.3 kb Taq I fragment and two 1.65 kb and 0.65 kb fragments with reduced band intensity were found in the genes of two affected s...

journal_title：British journal of haematology

authors： Gu JM,Xu WF,Wang XD,Wu QY,Chi CW,Ruan CG

更新日期：1993-03-01 00:00:00

abstract：:The humanized CD52 monoclonal antibody Campath-1H was used as first-line therapy in nine patients with progressive chronic lymphocytic leukaemia (CLL). Intravenous (n = 5) or subcutaneous (n = 4) injections (up to 30 mg/inj.) were given three times a week for a maximum of 18 weeks. Three patients achieved a complete r...

journal_title：British journal of haematology

authors： Osterborg A,Fassas AS,Anagnostopoulos A,Dyer MJ,Catovsky D,Mellstedt H

更新日期：1996-04-01 00:00:00

abstract：:It was previously shown that the abnormal surface characteristics and defective bactericidal function of polymorphonuclear leucocytes (PMN) in the Chediak-Higashi syndrome (CHS) are correlated with impaired microtubule assembly, and in one patient direct electron microscopic evidence for an anomaly in microtubule asse...

journal_title：British journal of haematology

authors： Boxer LA,Albertini DF,Baehner RL,Oliver JM

更新日期：1979-10-01 00:00:00

abstract：:Peripheral blood and bone marrow mononuclear cells from 10 patients with newly diagnosed Waldenström's macroglobulinaemia were analysed for the presence of leucocyte differentiation antigens using flow cytometry. Most patients had circulating intracytoplasmic-mu cells that were positive for the B-cell specific antigen...

journal_title：British journal of haematology

authors： Kucharska-Pulczynska M,Ellegaard J,Hokland P

更新日期：1987-04-01 00:00:00

abstract：:Although the expression patterns of the members of the tumour necrosis factor receptor and ligand families have extensively been studied by flow-cytometry on stimulated peripheral blood mononuclear cells (PBMNC), little or no flow-cytometric or immunohistological data exist about their expression in lymphoid tissue. A...

journal_title：British journal of haematology

authors： Dürkop H,Anagnostopoulos I,Bulfone-Paus S,Stein H

更新日期：1997-09-01 00:00:00

abstract：:We analysed the results of haematopoietic cell transplantation (HCT) in 30 patients aged 60-78 (median 65) years, with primary myelofibrosis or myelofibrosis evolving from antecedent polycythaemia vera or essential thrombocythaemia. Donors were human leucocyte antigen (HLA)-identical siblings (N = 15) or unrelated ind...

journal_title：British journal of haematology

authors： Samuelson S,Sandmaier BM,Heslop HE,Popat U,Carrum G,Champlin RE,Storb R,Prchal JT,Gooley TA,Deeg HJ

更新日期：2011-04-01 00:00:00

abstract：:Karyotypic analysis was performed in a total of 69 patients with well-characterized idiopathic myelofibrosis. Karyotypic abnormalities were detected in 46% of cases examined during the chronic phase (29/63); with three abnormalities, del(13q), del(20q) and partial trisomy 1q, accounting for 75% of all abnormalities at...

journal_title：British journal of haematology

authors： Reilly JT,Wilson G,Barnett D,Watmore A,Potter A

更新日期：1994-11-01 00:00:00

abstract：:We analysed the incidence of graft failure, graft-versus-host disease (GVHD) and relapse of leukaemia in 208 patients undergoing allogeneic bone marrow transplantation (BMT) for chronic myeloid leukaemia in chronic phase in eight transplant centres in Europe and the United States. 106 patients received unmanipulated d...

journal_title：British journal of haematology

authors： Apperley JF,Mauro FR,Goldman JM,Gregory W,Arthur CK,Hows J,Arcese W,Papa G,Mandelli F,Wardle D

更新日期：1988-06-01 00:00:00

abstract：:The dependence of survival time on a set of prognostic factors was explored by means of Cox's regression model in 137 cases of myelofibrosis with myeloid metaplasia (MMM). The following parameters recorded at diagnosis proved to be important independent indicators of a poor prognosis: a higher value for age, a lower v...

journal_title：British journal of haematology

authors： Barosi G,Berzuini C,Liberato LN,Costa A,Polino G,Ascari E

更新日期：1988-12-01 00:00:00

abstract：:An optimal antitumoral immune response requires the participation of both CD8 and CD4 T lymphocytes, which are activated by peptide antigen presentation via human leucocyte antigen (HLA) class I and class II molecules respectively. Loss of HLA molecules has been observed in different malignancies, and provides a mecha...

journal_title：British journal of haematology

authors： Drénou B,Le Friec G,Bernard M,Pangault C,Grosset JM,Lamy T,Fauchet R,Amiot L

更新日期：2002-11-01 00:00:00

abstract：:Since glycoprotein IV (GPIV) has been shown to play an important role in the interaction of platelets with collagen and thrombospondin, the aggregation and secretion of GPIV-deficient platelets were examined. Using a binding assay with monoclonal 125I-OKM5 antibody against CD36 antigen and crossed immunoelectrophoresi...

journal_title：British journal of haematology

authors： Yamamoto N,Akamatsu N,Yamazaki H,Tanoue K

更新日期：1992-05-01 00:00:00

abstract：:Amiodarone has been implicated as a cause of thrombocytopenia but the responsible mechanism is unknown. We performed studies in three patients to characterize the pathogenesis of this complication. No amiodarone-dependent, platelet-reactive antibodies were identified using conventional serological techniques. However,...

journal_title：British journal of haematology

authors： Sahud MA,Caulfield M,Clarke N,Koch R,Bougie D,Aster R

更新日期：2013-10-01 00:00:00

abstract：:Addition of the inflammatory cytokine interleukin (IL)-6 to the culture medium of human cord blood haematopoietic stem and progenitor cells (HSPCs) has been shown to lead to an altered stromal cell-derived factor-1alpha-dependent migratory phenotype. This study investigated whether this effect was attributed to a diff...

journal_title：British journal of haematology

authors： Kasenda B,Kassmer SH,Niggemann B,Schiermeier S,Hatzmann W,Zänker KS,Dittmar T

更新日期：2008-09-01 00:00:00

abstract：:We performed a retrospective analysis of outcome in 45 patients with multiple myeloma receiving unrelated donor stem cell transplants (UD-SCT) in the UK between 1993 and 2002; 17 received myeloablative conditioning regimens and 28 received reduced intensity conditioning (RIC) protocols. Forty patients received pretran...

journal_title：British journal of haematology

authors： Shaw BE,Peggs K,Bird JM,Cavenagh J,Hunter A,Alejandro Madrigal J,Russell NH,Sirohi B,Towlson K,Williams CD,Marks DI,Clinical Trials Committee of the British Society of Blood and Marrow Transplantation.

更新日期：2003-12-01 00:00:00

abstract：:The 32 kD lipid-raft-associated membrane protein 'stomatin' is deficient from the erythrocyte membrane in the Na+-K+ leaky haemolytic anaemia, overhydrated hereditary stomatocytosis (OHSt). To date, no mutation in the gene coding for this protein has so far been found in OHSt. In this study, we have analysed the distr...

journal_title：British journal of haematology

authors： Fricke B,Parsons SF,Knöpfle G,von Düring M,Stewart GW

更新日期：2005-10-01 00:00:00

abstract：:A double-blind, crossover, placebo-controlled study of the effect of vitamin E on platelet functions was performed on nine splenectomized and 16 non-splenectomized beta-thalassaemia/haemoglobin E (beta-thalassaemia/HbE) patients. The patients were supplemented with a daily dose of vitamin E (525 IU) for 3 months. The ...

journal_title：British journal of haematology

authors： Unchern S,Laoharuangpanya N,Phumala N,Sipankapracha P,Pootrakul P,Fucharoen S,Wanachivanawin W,Chantharaksri U

更新日期：2003-11-01 00:00:00

abstract：:Future progress in the treatment of multiple myeloma (MM) requires both the characterisation of key drivers of the disease and novel, innovative approaches to tackle these vulnerabilities. The present study focussed on the pre-clinical evaluation of a novel drug class, BMI-1 modulators, in MM. We demonstrate potent ac...

journal_title：British journal of haematology

authors： Bolomsky A,Muller J,Stangelberger K,Lejeune M,Duray E,Breid H,Vrancken L,Pfeiffer C,Hübl W,Willheim M,Weetall M,Branstrom A,Zojer N,Caers J,Ludwig H

更新日期：2020-09-01 00:00:00

abstract：:Sialic acid-binding immunoglobulin-like lectin (Siglec)-5 or CD170 is a CD33-related receptor, containing cytoplasmic immune receptor-based tyrosine signalling motifs, that has previously been reported to be myeloid-specific like CD33 and thus may be useful in the characterization of both normal and malignant haemopoi...

journal_title：British journal of haematology

authors： Virgo P,Denning-Kendall PA,Erickson-Miller CL,Singha S,Evely R,Hows JM,Freeman SD

更新日期：2003-11-01 00:00:00

abstract：:Folate analogues were added to human bone marrow cells to determine their effect on deoxyuridine utilization in the deoxyuridine suppression test. Formyltetrahydrofolates fully corrected the impairment of dU utilization in pernicious anaemia marrows but tetrahydrofolate was relatively ineffective. All these analogues ...

journal_title：British journal of haematology

authors： Deacon R,Chanarin I,Perry J,Lumb M

更新日期：1980-12-01 00:00:00

abstract：:Umbilical cord blood is an alternative stem cell source for patients without matched family donors. In this study, we examined several parameters that have not been studied in detail -- radiation dose, cell dose, age of mice, and maternal and neonatal characteristics of the cord blood donor -- that affect engraftment ...

journal_title：British journal of haematology

authors： Ballen KK,Valinski H,Greiner D,Shultz LD,Becker PS,Hsieh CC,Stewart FM,Quesenberry PJ

更新日期：2001-07-01 00:00:00

abstract：:Malignant histiocytosis (MH)-like B-cell lymphoma (BCL) is a neoplastic proliferation of large B cells clinically characterized by fever, hepatosplenomegaly, haemophagocytosis and abnormal laboratory data, without lymphadenopathy or skin lesions. Interestingly, most cases have been reported in Asian patients, and it i...

journal_title：British journal of haematology

authors： Murase T,Nakamura S,Tashiro K,Suchi T,Hiraga J,Hayasaki N,Kimura M,Murakami M,Mizoguchi Y,Suzuki T,Saito H

更新日期：1997-12-01 00:00:00

abstract：:Drug-related neutropenia is a common observation in AIDS patients. Haematological growth factors are therefore increasingly used in combination with myelotoxic agents to reduce the risk of infection and to improve the haematological tolerance of these regimens. We report a case of an AIDS patient with Kaposi's sarcoma...

journal_title：British journal of haematology

authors： Hermans P,Gori A,Lemone M,Franchioly P,Clumeck N

更新日期：1994-06-01 00:00:00

abstract：:Terminal B-cell differentiation is a multi-step process, from short-lived plasmablasts to mature long-lived plasma cells (PC). The anti-apoptotic Bcl-2 family member Bfl-1/A1 plays a critical role in the survival of mature B cells. However, its potential involvement at the later stages of B-cell development remains hi...

journal_title：British journal of haematology

authors： Tarte K,Jourdan M,Veyrune JL,Berberich I,Fiol G,Redal N,Shaughnessy J Jr,Klein B

更新日期：2004-05-01 00:00:00

abstract：:The bone marrow (BM) microenvironment supports leukaemia cell survival and proliferation. The roles played by adhesive receptor interactions in the survival of T-lineage acute lymphoblastic leukaemia (T-ALL) cells on BM stromal cells are not well understood. Recently, we have developed an assay that partially recapitu...

journal_title：British journal of haematology

authors： Winter SS,Sweatman JJ,Lawrence MB,Rhoades TH,Hart AL,Larson RS

更新日期：2001-12-01 00:00:00

abstract：:Sickle cell disease (SCD) in Saudi patients from the Eastern Province is associated with the Arab-Indian (AI) HBB (β-globin gene) haplotype. The phenotype of AI SCD in children was described as benign and was attributed to their high fetal haemoglobin (HbF). We conducted a hospital-based study to assess the pattern of...

journal_title：British journal of haematology

authors： Alsultan A,Alabdulaali MK,Griffin PJ,Alsuliman AM,Ghabbour HA,Sebastiani P,Albuali WH,Al-Ali AK,Chui DH,Steinberg MH

更新日期：2014-02-01 00:00:00

abstract：:Cytotoxic T lymphocyte (CTL) lines specific for allogeneic antigens were generated by in vitro stimulation of donor-derived peripheral blood mononuclear cells obtained from patients who received human leucocyte antigen (HLA)-matched allogeneic haematopoietic stem cell transplantation (HSCT). One of the allogeneic anti...

journal_title：British journal of haematology

authors： Matsushita M,Yamazaki R,Ikeda H,Mori T,Sumimoto H,Fujita T,Okamoto S,Ikeda Y,Kawakami Y

更新日期：2006-01-01 00:00:00

abstract：:Eltrombopag has been added to first-line treatment of immune aplastic anaemia (AA), resulting in higher responses. We analysed marrow samples of AA patients who responded to immunosuppressive therapy (IST) alone or in combination with eltrombopag for the composition of the haematopoietic stem and progenitor cell (HSPC...

journal_title：British journal of haematology

authors： Quintino de Oliveira B,Catto LFB,Santana BAA,Tellechea MF,Scheucher PS,Scheinberg P,Calado RT

更新日期：2020-11-20 00:00:00

abstract：:Increased osteoclastic bone resorption is the major causal factor of bone disease in multiple myeloma. Recently, non-invasive methods have been developed for the estimation of bone resorptive activity. To evaluate the biological sensitivity and clinical usefulness of five biochemical assays for measuring the C-termina...

journal_title：British journal of haematology

authors： Abildgaard N,Brixen K,Kristensen JE,Eriksen EF,Nielsen JL,Heickendorff L

更新日期：2003-01-01 00:00:00

abstract：:A significant number of patients diagnosed with beta-thalassaemia develop clinical and histopathological manifestations similar to those of an inherited disorder called Pseudoxanthoma elasticum (PXE). The inherited PXE is caused by mutations in the ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (ABCC6) gene an...

journal_title：British journal of haematology

authors： Hamlin N,Beck K,Bacchelli B,Cianciulli P,Pasquali-Ronchetti I,Le Saux O

更新日期：2003-09-01 00:00:00