Acute thrombocytopenia in patients treated with amiodarone is caused by antibodies specific for platelet membrane glycoproteins.

abstract：:A collaborative study on factor VIII related antigen (VIII R:Ag) has been carried out, involving 11 laboratories in the U.K. Samples of two different freeze-dried plasmas were assayed against participants' own local standards by the Laurell electroimmunoassay method. There was reasonably good agreement on the relative...

journal_title：British journal of haematology

authors： Kirkwood TB,Barrowcliffe TW

更新日期：1980-11-01 00:00:00

abstract：:To determine the long-term efficacy of FLT3 inhibitors (FLT3i) in the salvage setting for relapsed and refractory (rel/ref) acute myeloid leukemia (AML) with FLT3 internal tandem duplication (AML FLT3-ITD), we conducted a retrospective study of 120 patients with rel/ref AML FLT3-ITD who received salvage therapy with e...

journal_title：British journal of haematology

authors： Takahashi K,Kantarjian H,Pemmaraju N,Andreeff M,Borthakur G,Faderl S,Garcia-Manero G,Pierce S,Luthra R,Cardenas-Turanzas M,Estrov Z,Ravandi F,Cortes J

更新日期：2013-06-01 00:00:00

abstract：:MYD88 mutations are present in 95% of Waldenstrom Macroglobulinaemia (WM) patients, and support diagnostic discrimination from other IgM-secreting B-cell malignancies. Diagnostic discrimination can be difficult among suspected wild-type MYD88 (MYD88WT ) WM cases. We systematically reviewed the clinical, pathological a...

journal_title：British journal of haematology

authors： Treon SP,Gustine J,Xu L,Manning RJ,Tsakmaklis N,Demos M,Meid K,Guerrera ML,Munshi M,Chan G,Chen J,Kofides A,Patterson CJ,Yang G,Liu X,Severns P,Dubeau T,Hunter ZR,Castillo JJ

更新日期：2018-02-01 00:00:00

abstract：:The use of 111Indium oxine as a platelet label for the performance of platelet life-span studies has been examined. Platelet life-span in normal subjects varied between 8 X 10 and 10 X 36 d. Patients with primary thrombocythaemia had clearly reduced platelet life-span whether or not they presented with vascular occlus...

journal_title：British journal of haematology

authors： Bautista AP,Buckler PW,Towler HM,Dawson AA,Bennett B

更新日期：1984-12-01 00:00:00

abstract：:Severe combined immune deficient (SCID) mice were engrafted with human (Hu) peripheral blood lymphocytes (PBL) from a previously alloimmunized donor and transfused with HLA-mismatched platelets. We have previously shown this to be a useful model for platelet transfusion. These engrafted mice (Hu-PBL-SCID mice) produce...

journal_title：British journal of haematology

authors： Crow AR,Freedman J,Hannach B,Blanchette V,Lazarus AH

更新日期：1999-03-01 00:00:00

abstract：:Reversible aggregation of red blood cells (RBC) plays an important role in determining blood flow properties, and it is this aggregation which increases blood viscosity at low shear rates. The structure and sites of venous thrombi, as well as the fact that stasis is a major predisposing factor in venous thrombosis, su...

journal_title：British journal of haematology

authors： Chabanel A,Horellou MH,Conard J,Samama MM

更新日期：1994-09-01 00:00:00

abstract：:The present study analysed whether autologous peripheral blood stem cell transplantation (PSCT) improves engraftment, quality of life and cost-effectiveness when compared with autologous bone marrow transplantation (ABMT). Relapsing progressive lymphoma patients (n = 204; non-Hodgkin's lymphoma n = 166; Hodgkin's dise...

journal_title：British journal of haematology

authors： Vellenga E,van Agthoven M,Croockewit AJ,Verdonck LF,Wijermans PJ,van Oers MH,Volkers CP,van Imhoff GW,Kingma T,Uyl-de Groot CA,Fibbe WE

更新日期：2001-08-01 00:00:00

abstract：:We have studied the surface expression of the Toll-like receptor family member CD 180 on cells from 78 patients with B-chronic lymphocytic leukaemia (B-CLL). B-CLL cells had variable levels of CD 180 expression, but this was always less than that expressed by normal blood B cells and was stable for 24 months. Signific...

journal_title：British journal of haematology

authors： Porakishvili N,Kulikova N,Jewell AP,Youinou PY,Yong K,Nathwani A,Heelan B,Duke V,Hamblin TJ,Wallace P,Ely P,Clark EA,Lydyard PM

更新日期：2005-11-01 00:00:00

abstract：:Erythrocyte sedimentation, viscosity, electrophroetic mobility, and osmotic fragility were measured in a study of the rheological behaviour of the erythrocyte in vitro. In comparison with physiological saline solution, a suspending medium containing a gamma2lambda2 monoclonal IgG from a patient with multiple myeloma c...

journal_title：British journal of haematology

authors： Rovel A,Vigneron C,Streiff F

更新日期：1979-04-01 00:00:00

abstract：:We report a patient who was treated with recombinant (r)-hirudin for heparin-induced thrombocytopenia and developed a flush reaction twice upon re-exposure to 25 mg of subcutaneous r-hirudin. Antihirudin IgG antibodies developed. The patient received 50 mg of PEG-hirudin subcutaneously over 2 days. No side-effects occ...

journal_title：British journal of haematology

authors： Harenberg J,Hoffmann U,Huhle G,Song XH,Wang LC

更新日期：2000-03-01 00:00:00

abstract：:T- and B-cell function after autologous bone marrow transplantation (ABMT) was assessed and compared with that found after allogeneic BMT and after chemotherapy only. In all 16 patients with acute leukaemia in remission treated with high-dose chemotherapy and single or double ABMT, T-helper numbers and function in an ...

journal_title：British journal of haematology

authors： Armitage RJ,Goldstone AH,Richards JD,Cawley JC

更新日期：1986-08-01 00:00:00

abstract：:We examined the in vivo effects and safety of the third generation bisphosphonate, zoledronate (ZOL) alone and combined with imatinib mesylate against primary Philadelphia chromosome positive (Ph+) leukaemic cells. ZOL inhibited the prenylation of Rap1A in leukaemic cells in vitro and synergised with imatinib to enhan...

journal_title：British journal of haematology

authors： Segawa H,Kimura S,Kuroda J,Sato K,Yokota A,Kawata E,Kamitsuji Y,Ashihara E,Yuasa T,Fujiyama Y,Ottmann OG,Maekawa T

更新日期：2005-08-01 00:00:00

abstract：:The effects of donor T cells, or their CD8+ subset, on engraftment and tolerance induction in fetal transplantation were evaluated using an F1-into-parent mouse-model that does not permit a graft-versus-host effect. Gestational day 13 C57BL/6 (H-2Kb) fetuses were transplanted with B6D2F1 (H-2Kb/d) light density bone m...

journal_title：British journal of haematology

authors： Chen JC,Chang ML,Lee H,Muench MO

更新日期：2004-08-01 00:00:00

abstract：:Sideroblastic anaemia includes a heterogeneous group of rare conditions, characterized by decreased haem synthesis and mitochondrial iron overload, which are diagnosed by the presence of ringed sideroblasts in the bone marrow aspirate. The most frequent form is X-linked sideroblastic anaemia, caused by mutations of de...

journal_title：British journal of haematology

authors： Camaschella C

更新日期：2008-10-01 00:00:00

abstract：:Cold agglutinin syndrome (CAS) is usually associated with IgM cold agglutinins with titres exceeding 1000 at 4 degrees C and a thermal amplitude of 30-32 degrees C. Occasionally patients are encountered who although having clinical and laboratory findings compatible with CAS do not have the characteristic serological ...

journal_title：British journal of haematology

authors： Garratty G,Petz LD,Hoops JK

更新日期：1977-04-01 00:00:00

abstract：:Bone marrow blast cells of 174 child and 188 adult patients with AML were examined and characterized in terms of their FAB type, immunological phenotype (102 children, 123 adults) and karyotype (69 children, 95 adults). The incidence of FAB variants of AML proved similar in children and adults. In patients under 15 an...

journal_title：British journal of haematology

authors： Frenkel MA,Tupitsyn NN,Protasova AK,Kadagidze ZG,Konstantinova LN,Fleischman EW

更新日期：1994-08-01 00:00:00

abstract：:Two new glucose-6-phosphate dehydrogenase (G6PD, D-glucose 6-phosphate: NADP oxido reductase, E.C. 1.1.1.49) variants, designated G6PD Napoli and G6PD Ferrara II, are described in propositi from two unrelated families. Characterization side by side of the two variants according to W.H.O. recommendations reveals minor ...

journal_title：British journal of haematology

authors： De Flora A,Morelli A,Benatti U,Giuntini P,Ferraris AM,Galiano S,Ravazzolo R,Gaetani GF

更新日期：1981-07-01 00:00:00

abstract：:The prognostic significance of SOCS3 protein expression was determined in de novo follicular lymphomas (FL) with t(14;18) and bcl-2 overexpression. Presentation lymph nodes from 82 FL patients for whom clinical information was available were immunohistochemically segregated into SOCS3-positive (n = 42) or -negative (n...

journal_title：British journal of haematology

authors： Krishnadasan R,Bifulco C,Kim J,Rodov S,Zieske AW,Vanasse GJ

更新日期：2006-10-01 00:00:00

abstract：:During periods of immunosuppression, such as postallogeneic stem cell transplantation (SCT), patients are at significant risk for severe viral infections. Human adenovirus (HAdV) infection is a serious complication post-SCT, especially in children. Virus-specific T cells are essential for the clearance of HAdV, as ant...

journal_title：British journal of haematology

authors： Feuchtinger T,Matthes-Martin S,Richard C,Lion T,Fuhrer M,Hamprecht K,Handgretinger R,Peters C,Schuster FR,Beck R,Schumm M,Lotfi R,Jahn G,Lang P

更新日期：2006-07-01 00:00:00

abstract：:Highly efficient systems remove toxic and pro-inflammatory haemoglobin (Hb) from the circulation and local sites of tissue damage. Macrophages are major Hb-clearing cells; CD163 was recently recognized as the specific haemoglobin-haptoglobin scavenger receptor (HSR). We show that dexamethasone strongly induced the spe...

journal_title：British journal of haematology

authors： Schaer DJ,Boretti FS,Schoedon G,Schaffner A

更新日期：2002-10-01 00:00:00

abstract：:Investigations into the nature of the molecular interactions mediating the recognition of the haemopoietic progenitor cells by the haemopoietic stroma, indicate that ubiquitin mediates the binding between murine haemopoietic progenitors and the haemopoietic stroma. The adhesion of haemopoietic progenitors to anti-ubiq...

journal_title：British journal of haematology

authors： Parakh KA,Kannan K

更新日期：1993-06-01 00:00:00

abstract：:Human IgG monoclonal antibodies (mabs) against the Rh D antigen have considerable potential for the prophylaxis of haemolytic disease of the newborn. We have carried out in vitro testing for cross-reactions with tissue components by screening two such mabs against animal tissues and a wide panel of human organs from n...

journal_title：British journal of haematology

authors： Thorpe SJ,Bailey SW

更新日期：1993-02-01 00:00:00

abstract：:The records of 637 patients with lymphoproliferative disorders and 346 patients with myeloproliferative disorders were retrospectively analysed for the presence of additional autoimmune derangements. The frequency of autoimmune perturbations in lymphoproliferative diseases (51 cases; 8.0%) was significantly higher tha...

journal_title：British journal of haematology

authors： Dührsen U,Augener W,Zwingers T,Brittinger G

更新日期：1987-10-01 00:00:00

abstract：:Glanzmann's thrombasthenia (GT) results from a qualitative or quantitative defect of GPIIb-IIIa complexes (integrin alphaIIbbeta3). the fibrinogen receptor on platelets. This integrin plays a critical role in platelet aggregation. In this report we describe the molecular abnormalities of a patient with clinical and la...

journal_title：British journal of haematology

authors： Ruan J,Peyruchaud O,Alberio L,Valles G,Clemetson K,Bourre F,Nurden AT

更新日期：1998-09-01 00:00:00

abstract：:Thrombocytopenia is common (40-65%) and potentially serious in myelodysplastic syndromes (MDS). A systematic review was conducted to determine the safety and efficacy of adding a thrombopoietin-receptor (THPO-R) agonist to standard MDS treatment. MEDLINE, EMBASE and CENTRAL databases were searched. We included randomi...

journal_title：British journal of haematology

authors： Prica A,Sholzberg M,Buckstein R

更新日期：2014-12-01 00:00:00

abstract：:Human monocytes contain a series of alpha-naphthyl acetate (alpha NA) esterases which are not present in other blood cells and which can be specifically inhibited by bis(4-nitrophenyl)-phosphate (BNPP). This inhibitor is non-toxic at the concentration used and thus enabled studies on the possible significance of this ...

journal_title：British journal of haematology

authors： Oertel J,Hagner G,Kastner M,Huhn D

更新日期：1985-12-01 00:00:00

abstract：:The prognostic role of CD20 expression and Epstein-Barr virus (EBV) positivity in post-transplant lymphoproliferative disease (PTLD) after solid organ transplantation (SOT) in paediatric patients is poorly understood. We retrospectively examined the relationship of CD20 and EBV with the time interval from SOT to PTLD ...

journal_title：British journal of haematology

authors： Orjuela MA,Alobeid B,Liu X,Siebert AL,Kott ER,Addonizio LJ,Morris E,Garvin JH,Lobritto SJ,Cairo MS

更新日期：2011-03-01 00:00:00

abstract：:Four unrelated patients with a bleeding diathesis (bleeding time longer than 30 min), some spontaneous platelet aggregation, thrombocytopenia and large platelets, had decreased levels of factor VIII-von Willebrand factor (FVIII-VWF) related properties and impaired platelet adherence to human artery subendothelium. The...

journal_title：British journal of haematology

authors： Sakariassen KS,Nieuwenhuis HK,Sixma JJ

更新日期：1985-03-01 00:00:00

abstract：:Ph-negative chronic myeloproliferative disorders (CMPD) are characterized by constitutive Janus kinase-signal transducer and activator of transcription (JAK-STAT) activation. SOCS3, SOCS1 and PTPN6 (SHP1) are negative regulators of the JAK-STAT pathway. We investigated epigenetic and genetic inactivation of SOCS3, SOC...

journal_title：British journal of haematology

authors： Capello D,Deambrogi C,Rossi D,Lischetti T,Piranda D,Cerri M,Spina V,Rasi S,Gaidano G,Lunghi M

更新日期：2008-05-01 00:00:00

abstract：:This case study provides evidence for clonal evolution in pre-B-cell leukaemia. At diagnosis, the lymphoblasts from a 3-year-old boy were morphologically subtyped as L1 (French-American-British classification). Their immunophenotype was CALLA+, CIgM+, SIg-, TdT+, and the karyotype was pseudodiploid with a 1;19 translo...

journal_title：British journal of haematology

authors： Abromowitch M,Williams DL,Melvin SL,Stass S

更新日期：1984-03-01 00:00:00