Abstract:
:This case study provides evidence for clonal evolution in pre-B-cell leukaemia. At diagnosis, the lymphoblasts from a 3-year-old boy were morphologically subtyped as L1 (French-American-British classification). Their immunophenotype was CALLA+, CIgM+, SIg-, TdT+, and the karyotype was pseudodiploid with a 1;19 translocation. Striking shifts were apparent when the child relapsed 16 months later. The morphologic subtype had changed to L3, CALLA and TdT had disappeared, and a consistent karyotype was lacking. The modal chromosome number had increased through clonal evolution to 85, the 1;19 translocation was retained, and a new marker, a 14q+ (partial duplication) appeared and was present in a majority of cells. These cytogenetic findings are characteristic of a transforming state. However, despite the loss of TdT, the appearance of classic L3 morphology and the acquisition of a 14q+ marker, the cells retained a predominantly pre-B phenotype.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Abromowitch M,Williams DL,Melvin SL,Stass Sdoi
10.1111/j.1365-2141.1984.tb03971.xsubject
Has Abstractpub_date
1984-03-01 00:00:00pages
409-16issue
3eissn
0007-1048issn
1365-2141journal_volume
56pub_type
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