Advances in understanding the pathogenesis of graft-versus-host disease.

Abstract:

:Acute graft-versus-host disease (GVHD) remains a major complication after allogeneic haematopoietic stem cell transplantation (allo-HSCT). The emergence of different immuno-prophylaxis strategies, such as post-transplant cyclophosphamide or anti-thymocyteglobulin has reduced the incidence of acute GVHD in recent years. The biology of the acute GVHD we observe in the clinic may change due to the use of novel immuno-stimulatory agents, including immune checkpoint inhibitors or anti-neoplastic immune-modifiers, like lenalidomide, given before or after allo-HSCT. Here we discuss the recent advances in our understanding of acute GVHD with a focus on early events of the disease, including tissue damaging factors, innate immune cells, costimulatory pathways, immune cell signalling, immuno-regulatory cell types, biomarkers of GVHD and regenerative approaches. New insight in the pathogenesis of acute GVHD has revealed the role of pro-inflammatory intracellular signalling, defects in intestinal tissue regeneration and anti-bacterial defence, as well as a reduced diversity of the microbiome, which will be the basis for the development of novel therapies.

journal_name

Br J Haematol

authors

Zeiser R

doi

10.1111/bjh.16190

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

563-572

issue

5

eissn

0007-1048

issn

1365-2141

journal_volume

187

pub_type

杂志文章,评审
  • Circulating clonal cells in multiple myeloma do not express CD34 mRNA, as measured by single-cell and real-time RT-PCR assays.

    abstract::The peripheral blood (PB) mononuclear cells in patients with multiple myeloma (MM) have been reported to include CD34-expressing cells that are clonally related to the myeloma cells. To determine whether there were elevated levels of CD34 mRNA or whether CD34+ cells in the PB include myeloma-related cells, we develope...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1999.01770.x

    authors: Rasmussen T,Jensen L,Honoré L,Andersen H,Johnsen HE

    更新日期:1999-12-01 00:00:00

  • Unrelated donor bone marrow transplantation to treat severe aplastic anaemia in children and young adults.

    abstract::Alternative donor bone marrow transplantation (BMT) to treat severe aplastic anaemia (SAA) in children and young adults has been complicated by high rates of graft rejection and severe graft-versus-host disease (GVHD). We hypothesized that increased immunosuppression combined with T-cell depletion of the marrow graft ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1996.d01-1772.x

    authors: Margolis D,Camitta B,Pietryga D,Keever-Taylor C,Baxter-Lowe LA,Pierce K,Kupst MJ,French J 3rd,Truitt R,Lawton C,Murray K,Garbrecht F,Flomenberg N,Casper J

    更新日期:1996-07-01 00:00:00

  • Determination of factor IX allotypes for carrier identification in haemophilia B.

    abstract::The existence of two genetic variants (allotypes) of normal human factor IX is used for carrier detection in three families with severe and one with mild haemophilia B. By analysis of IX:Ag with two different monoclonal antibodies in 93 members of the families, allelic assignment is shown to be a complement in carrier...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1987.tb06164.x

    authors: Wallmark A,Ljung R,Nilsson IM

    更新日期:1987-12-01 00:00:00

  • Effect of hydrocortisone on the growth of human bone marrow fibroblasts.

    abstract::Fibroblast-like cells may be grown from human bone marrow. Adherent cultures show a logarithmic phase of growth lasting 6 d. Hydrocortisone (1 x 10(-8) M) decreases cell growth in 40-60% when measured as cell number and DNA synthesis. Fibroblasts bind the hormone by a high affinity, saturable process showing a Kd of 2...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1982.tb03893.x

    authors: Minguell JJ,Martínez J,Walter T

    更新日期:1982-10-01 00:00:00

  • Prognostic implications of the microenvironment for follicular lymphoma under immunomodulation therapy.

    abstract::Follicular lymphoma (FL) constitutes a significant proportion of lymphomas and shows frequent relapses. Beyond conventional chemotherapy, new therapeutic approaches have emerged, focussing on the interplay between lymphoma cells and the microenvironment. Here we report the immunophenotypic investigation of the microen...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/bjh.16414

    authors: Menter T,Tzankov A,Zucca E,Kimby E,Hultdin M,Sundström C,Beiske K,Cogliatti S,Banz Y,Cathomas G,Karjalainen-Lindsberg ML,Grobholz R,Mazzucchelli L,Sander B,Hawle H,Hayoz S,Dirnhofer S

    更新日期:2020-05-01 00:00:00

  • Evidence for a critical role of DNA topoisomerase IIalpha in drug sensitivity revealed by inducible antisense RNA in a human leukaemia cell line.

    abstract::To examine the role of human DNA topoisomerase IIalpha (topo IIalpha) in drug resistance, we selectively inhibited topo IIalpha gene expression in U937 human monocytic leukaemia cells stably transfected with a plasmid that allowed for Zn-mediated conditional expression of a human alpha-topo IIalpha antisense sequence....

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1998.00713.x

    authors: Towatari M,Adachi K,Marunouchi T,Saito H

    更新日期:1998-06-01 00:00:00

  • Serum ferritin in haemochromatosis: changes in the isoferritin composition during venesection therapy.

    abstract::The isoferritin composition of serum ferritin in 13 patients with untreated idiopathic haemochromatosis (IHC) has been shown to differ from normal in exhibiting an increase in isoferritins in the pH range 5.54-5.62. A similar change was observed in four patients with gross iron overload secondary to haemolytic anaemia...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1977.tb00663.x

    authors: Halliday JW,McKeering LV,Tweedale R,Powell LW

    更新日期:1977-07-01 00:00:00

  • Delineation of receptor-mediated colony-stimulating factor (CSF-1) utilization and cell production by precursors of mononuclear phagocytic series at various stages of differentiation.

    abstract::Colony-stimulating factor-1 (CSF-1) is a specific haematopoietic growth factor that stimulates the production of macrophages by both bone marrow macrophage precursors (GM-CFC) and certain more mature peripheral tissue macrophages. The relationship of CSF-1 utilization and cell production by macrophage precursors at va...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1987.tb06157.x

    authors: Chen BD,Chou TH,Clark CR

    更新日期:1987-12-01 00:00:00

  • The iron chelator deferasirox affects redox signalling in haematopoietic stem/progenitor cells.

    abstract::The iron chelator deferasirox (DFX) prevents complications related to transfusional iron overload in several haematological disorders characterized by marrow failure. It is also able to induce haematological responses in a percentage of treated patients, particularly in those affected by myelodysplastic syndromes. The...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/bjh.13381

    authors: Tataranni T,Agriesti F,Mazzoccoli C,Ruggieri V,Scrima R,Laurenzana I,D'Auria F,Falzetti F,Di Ianni M,Musto P,Capitanio N,Piccoli C

    更新日期:2015-07-01 00:00:00

  • Homozygosity for dominant form of hereditary spherocytosis.

    abstract::A 6-month-old male infant with hereditary spherocytosis (HS) who was the first child of a cousin marriage is presented. The patient had splenomegaly and severe anaemia. Examination of the peripheral blood smear revealed spherocytes and the osmotic fragility of red blood cells was greatly increased. Physical examinatio...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1992.tb06473.x

    authors: Duru F,Gürgey A,Oztürk G,Yörükan S,Altay C

    更新日期:1992-11-01 00:00:00

  • Co-expression of haemopoietic antigens on vascular endothelial cells: a detailed phenotypic analysis.

    abstract::Over 1000 monoclonal antibodies (MAB), previously characterized in terms of reactivity with various haemopoietic cells and including representatives from each of the currently known Clusters of Differentiation (CD), have now been evaluated by us for reactivity against human endothelial cells. In the current study, scr...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1990.tb06324.x

    authors: Favaloro EJ,Moraitis N,Bradstock K,Koutts J

    更新日期:1990-04-01 00:00:00

  • Plasminogen activator inhibitor-1 is an independent diagnostic marker as well as severity predictor of hepatic veno-occlusive disease after allogeneic bone marrow transplantation in adults conditioned with busulphan and cyclophosphamide.

    abstract::We attempted to identify the diagnostic markers and severity predictors of hepatic veno-occlusive disease (VOD) in 115 adult patients who were uniformly conditioned with busulphan and cyclophosphamide and who underwent allogeneic bone marrow transplantation (BMT). A diagnosis of VOD was made according to clinical crit...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2002.03748.x

    authors: Lee JH,Lee KH,Lee JH,Kim S,Seol M,Park CJ,Chi HS,Kang W,Kim ST,Kim WK,Lee JS

    更新日期:2002-09-01 00:00:00

  • Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests, prevention and treatment.

    abstract::Non-haemolytic transfusion reactions are the most common type of transfusion reaction and include transfusion-related acute lung injury, transfusion-associated circulatory overload, allergic reactions, febrile reactions, post-transfusion purpura and graft-versus- host disease. Although life-threatening anaphylaxis occ...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/bjh.12150

    authors: Hirayama F

    更新日期:2013-02-01 00:00:00

  • Relevance of the criteria commonly used to diagnose myeloproliferative disorder in patients with splanchnic vein thrombosis.

    abstract::Myeloproliferative disorders (MPD) are reported in 25-65% of patients with splanchnic vein thrombosis (SVT). Diagnostic criteria for MPD have not been fully established in this context. Using clusters of abnormal megakaryocytes in bone marrow (BM) biopsy as a reference standard for Philadelphia negative MPD, we assess...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2005.05490.x

    authors: Chait Y,Condat B,Cazals-Hatem D,Rufat P,Atmani S,Chaoui D,Guilmin F,Kiladjian JJ,Plessier A,Denninger MH,Casadevall N,Valla D,Brière JB

    更新日期:2005-05-01 00:00:00

  • Molecular features of primary mediastinal B-cell lymphoma: involvement of p16INK4A, p53 and c-myc.

    abstract::Primary mediastinal B-cell lymphoma (PMBL) shows chromosome 9p anomalies in 50% of cases. Based on reports that p16INK4A gene, located on this chromosomal arm, is frequently altered in aggressive lymphomas, we analysed for alterations of this gene in 27 cases of PMBL, which were part of a series of 32 PMBL cases that ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1999.01678.x

    authors: Scarpa A,Moore PS,Rigaud G,Inghirami G,Montresor M,Menegazzi M,Todeschini G,Menestrina F

    更新日期:1999-10-01 00:00:00

  • A comparison of molecular and enzyme-based assays for the detection of thiopurine methyltransferase mutations.

    abstract::S-Methylation by thiopurine methyltransferase (TPMT) is an important route of metabolism for the thiopurine drugs. About one in 300 individuals are homozygous for a TPMT mutation associated with very low enzyme activity and severe myelosuppression if treated with standard doses of drug. To validate the use of molecula...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2000.02218.x

    authors: Coulthard SA,Rabello C,Robson J,Howell C,Minto L,Middleton PG,Gandhi MK,Jackson G,McLelland J,O'Brien H,Smith S,Reid MM,Pearson AD,Hall AG

    更新日期:2000-09-01 00:00:00

  • Factor IX Cardiff: a variant factor IX protein that shows abnormal activation is caused by an arginine to cysteine substitution at position 145.

    abstract::Crude barium chloride eluates prepared from 12 unrelated patients with cross-reacting material positive (CRM+) haemophilia B were activated with celite eluate, the reaction products resolved after reduction by 13% SDS-PAGE, and factor IX antigenic material detected by probing with radiolabelled immunopurified rabbit a...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1989.tb04323.x

    authors: Liddell MB,Peake IR,Taylor SA,Lillicrap DP,Giddings JC,Bloom AL

    更新日期:1989-08-01 00:00:00

  • Elevation of serum lactate dehydrogenase in AL amyloidosis reflects tissue damage and is an adverse prognostic marker in patients not eligible for stem cell transplantation.

    abstract::The significance of serum lactate dehydrogenase (LDH) in light chain (AL) amyloidosis has not been previously explored. We studied 1019 newly diagnosed patients and correlated the elevation of LDH above the upper limit of normal (ULN) with disease characteristics and outcome. Four hundred and nine patients had an LDH ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/bjh.14830

    authors: Muchtar E,Dispenzieri A,Lacy MQ,Buadi FK,Kapoor P,Hayman SR,Gonsalves W,Warsame R,Kourelis TV,Chakraborty R,Russell S,Lust JA,Lin Y,Go RS,Zeldenrust S,Dingli D,Leung N,Rajkumar SV,Kyle RA,Kumar SK,Gertz MA

    更新日期:2017-09-01 00:00:00

  • Safety and efficacy of thrombopoietin-receptor agonists in myelodysplastic syndromes: a systematic review and meta-analysis of randomized controlled trials.

    abstract::Thrombocytopenia is common (40-65%) and potentially serious in myelodysplastic syndromes (MDS). A systematic review was conducted to determine the safety and efficacy of adding a thrombopoietin-receptor (THPO-R) agonist to standard MDS treatment. MEDLINE, EMBASE and CENTRAL databases were searched. We included randomi...

    journal_title:British journal of haematology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/bjh.13088

    authors: Prica A,Sholzberg M,Buckstein R

    更新日期:2014-12-01 00:00:00

  • The addition of rituximab to anthracycline-based chemotherapy significantly improves outcome in 'Western' patients with intravascular large B-cell lymphoma.

    abstract::Some case reports and a Japanese series suggest benefit from the use of rituximab in patients with intravascular large B-cell lymphoma (IVL). Rituximab efficacy was evaluated in Western patients with IVL, comparing outcome of 10 patients treated with rituximab + chemotherapy (R-CT) and of 20 patients treated with chem...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2141.2008.07338.x

    authors: Ferreri AJ,Dognini GP,Bairey O,Szomor A,Montalbán C,Horvath B,Demeter J,Uziel L,Soffietti R,Seymour JF,Ambrosetti A,Willemze R,Martelli M,Rossi G,Candoni A,De Renzo A,Doglioni C,Zucca E,Cavalli F,Ponzoni M,Interna

    更新日期:2008-10-01 00:00:00

  • Large granular lymphocytic leukaemia after solid organ and haematopoietic stem cell transplantation.

    abstract::T-cell large granular lymphocytic leukaemia (T-LGLL) is a chronic clonal lymphoproliferative disorder of cytotoxic T lymphocytes which commonly occurs in older patients and is often associated with autoimmune diseases. Among 246 patients with T-LGLL seen at our institution over the last 10 years, we encountered 15 cas...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/bjh.16336

    authors: Awada H,Mahfouz RZ,Durrani J,Kishtagari A,Jagadeesh D,Lichtin AE,Hill BT,Hamilton BK,Carraway HE,Nazha A,Majhail NS,Sobecks R,Visconte V,Kalaycio M,Sekeres MA,Maciejewski JP

    更新日期:2020-04-01 00:00:00

  • Outcome disparities in multiple myeloma: a SEER-based comparative analysis of ethnic subgroups.

    abstract::Studies of ethnic disparities in malignancies have revealed variation in clinical outcomes. In multiple myeloma (MM), previous literature has focused only on patients of Caucasian and African-American (AA) descent. We present a Surveillance Epidemiology and End Results (SEER)-based outcome analysis of MM patients from...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2012.09124.x

    authors: Ailawadhi S,Aldoss IT,Yang D,Razavi P,Cozen W,Sher T,Chanan-Khan A

    更新日期:2012-07-01 00:00:00

  • Genetic typing of human platelet antigen 1 (HPA-1) by oligonucleotide ligation assay in a specific and reliable semi-automated system.

    abstract::Genotyping of platelet alloantigens with the possibility of using any type of cellular material as a source of DNA has become a preferred procedure, particularly in thrombocytopenic patients when platelet counts are too low for phenotyping. Recently human platelet antigen 1 (HPA-1) has been identified as an inherited ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1997.d01-1980.x

    authors: Zotz RB,Giers G,Maruhn-Debowski B,Scharf RE

    更新日期:1997-01-01 00:00:00

  • L-DEP regimen salvage therapy for paediatric patients with refractory Epstein-Barr virus-associated haemophagocytic lymphohistiocytosis.

    abstract::Epstein-Barr virus-associated haemophagocytic lymphohistiocytosis (EBV-HLH) is one of the most common subtypes of secondary HLH. However, more than 30% of patients do not respond to traditional treatment. Here, we investigated the efficacy and safety of the L-DEP regimen as a salvage therapy for paediatric refractory ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/bjh.16861

    authors: Zhao Y,Li Z,Zhang L,Lian H,Ma H,Wang D,Zhao X,Zhang Q,Wang T,Zhang R

    更新日期:2020-11-01 00:00:00

  • Transplantation of a combination of CD133+ and CD34+ selected progenitor cells from alternative donors.

    abstract::Positive selected haematopoietic stem cells are increasingly used for allogeneic transplantation with the CD34 antigen employed in most separation techniques. However, the recently described pentaspan molecule CD133 appears to be a marker of more primitive haematopoietic progenitors. Here we report our experience with...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2003.04747.x

    authors: Lang P,Bader P,Schumm M,Feuchtinger T,Einsele H,Führer M,Weinstock C,Handgretinger R,Kuci S,Martin D,Niethammer D,Greil J

    更新日期:2004-01-01 00:00:00

  • Multiplex ligation-dependent probe amplification screening of isolated increased HbF levels revealed three cases of novel rearrangements/deletions in the beta-globin gene cluster.

    abstract::Investigations of naturally occurring mutations, such as the deletional thalassaemias and hereditary persistence of fetal haemoglobins (HPFHs), have brought many insights into human globin switching, but limited data have been reported so far. We selected 15 individuals with elevated fetal haemoglobin (HbF) levels (>5...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2009.07927.x

    authors: Lee ST,Yoo EH,Kim JY,Kim JW,Ki CS

    更新日期:2010-01-01 00:00:00

  • Analysis of very elderly (≥80 years) non-hodgkin lymphoma: impact of functional status and co-morbidities on outcome.

    abstract::Data on outcome, prognostic factors, and treatment for very elderly non-Hodgkin lymphomas (NHL) is sparse. We conducted a multicentre retrospective analysis of NHL patients ≥80 years (at diagnosis) treated between 1999 and 2009. Detailed characteristics were obtained including geriatric syndromes, activities of daily ...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2141.2011.08934.x

    authors: Nabhan C,Smith SM,Helenowski I,Ramsdale E,Parsons B,Karmali R,Feliciano J,Hanson B,Smith S,McKoy J,Larsen A,Hantel A,Gregory S,Evens AM

    更新日期:2012-01-01 00:00:00

  • Phase I/II study exploring ImMucin, a pan-major histocompatibility complex, anti-MUC1 signal peptide vaccine, in multiple myeloma patients.

    abstract::ImMucin, a 21-mer cancer vaccine encoding the signal peptide domain of the MUC1 tumour-associated antigen, possesses a high density of T- and B-cell epitopes but preserves MUC1 specificity. This phase I/II study assessed the safety, immunity and clinical response to 6 or 12 bi-weekly intradermal ImMucin vaccines, co-a...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bjh.13245

    authors: Carmon L,Avivi I,Kovjazin R,Zuckerman T,Dray L,Gatt ME,Or R,Shapira MY

    更新日期:2015-04-01 00:00:00

  • Diagnostic markers for CNS lymphoma in blood and cerebrospinal fluid: a systematic review.

    abstract::Diagnosing central nervous system (CNS) lymphoma remains a challenge. Most patients have to undergo brain biopsy to obtain tissue for diagnosis, with associated risks of serious complications. Diagnostic markers in blood or cerebrospinal fluid (CSF) could facilitate early diagnosis with low complication rates. We perf...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/bjh.15410

    authors: van Westrhenen A,Smidt LCA,Seute T,Nierkens S,Stork ACJ,Minnema MC,Snijders TJ

    更新日期:2018-08-01 00:00:00

  • Cardiac morbidity in advanced chronic myelogenous leukaemia patients treated by successive allogeneic stem cell transplantation with busulphan/cyclophosphamide conditioning after imatinib mesylate administration.

    abstract::Imatinib mesylate is useful for facilitating allogeneic stem cell transplantation (allo-SCT) in advanced-phase chronic myelogenous leukaemia (AP-CML) patients. However, although the side-effects of imatinib are usually minor, cardiac morbidity can develop as a latent adverse effect post SCT when a myeloablative SCT is...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2003.04288.x

    authors: Sohn SK,Kim JG,Kim DH,Lee KB

    更新日期:2003-05-01 00:00:00