Standardization of Factor VIII. II. A British Standard for Factor VIII related antigen.

abstract：:Endogenous production of carbon monoxide (VCO), red cell survival and iron kinetics were studied in 15 subjects with Hodgkin's disease. The subjects were divided into two groups, namely: eight patients with anaemia (group A, haemoglobin (Hb) concentration less than 11.5 g/dl) and seven patients without anaemia (group ...

journal_title：British journal of haematology

authors： Cavallin-Ståhl E,Mercke C,Lundh B

更新日期：1976-02-01 00:00:00

abstract：:Very few studies have investigated the effects of exercise on the biological parameters involved in vaso-occlusive events in sickle cell anaemia (SCA). The aim of this study was to test how a mild-moderate endurance exercise modulates oxidative stress, nitric oxide bioavailability and endothelial activation in SCA pat...

journal_title：British journal of haematology

authors： Faes C,Balayssac-Siransy E,Connes P,Hivert L,Danho C,Bogui P,Martin C,Pialoux V

更新日期：2014-01-01 00:00:00

abstract：:Therapeutic options for treatment of recurrence of leukaemia after allogeneic bone marrow transplantation (BMT) are limited. A beneficial effect of donor lymphocyte infusions (DLI) has not previously been described in acute myeloid leukaemia (AML) relapse. We report a case of AML with t(8;21), relapsing 3 months after...

journal_title：British journal of haematology

authors： Buzyn-Veil A,Belanger C,Audat F,Hermine O,Bodemer C,Ribrag V,Radford I,Poirel H,Chane C,Valensi F,Macintyre E,Varet B

更新日期：1996-02-01 00:00:00

abstract：:The Hodgkin lymphomas are a family of unique lymphoma subtypes, in which the nature of the neoplastic cell was enigmatic for many years. Much of the mystery has been solved, with all forms now considered to be of B-cell origin, in most cases of germinal centre derivation. Today we recognize Hodgkin lymphoma as an epon...

journal_title：British journal of haematology

authors： Wang HW,Balakrishna JP,Pittaluga S,Jaffe ES

更新日期：2019-01-01 00:00:00

abstract：:A new putative hepatitis virus has recently been discovered and termed GB virus C (GBV-C). We investigated the prevalence of this virus among 50 haemophiliacs treated with non-virus-inactivated clotting factor concentrates prior to 1985 and 21 haemophiliacs treated exclusively with virus-inactivated clotting factor co...

journal_title：British journal of haematology

authors： Uhle C,Zimmermann R,Goeser T,Seelig R

更新日期：1997-12-01 00:00:00

abstract：:Over the last few years there has been rapid and radical change in the way clinical research in the UK is funded and supported within the NHS. This has resulted from restructuring and major new investment in research infrastructure, co-ordinated through Clinical Local Research Networks (CLRNs) and equivalent organisat...

journal_title：British journal of haematology

authors： Collins PW,Baglin TP,Dang R,Evans G,Greaves M,Laffan M,Pasi KJ,Rose P,Stanworth S,Toh CH

更新日期：2010-09-01 00:00:00

abstract：:Both atypical haemolytic uraemic syndrome (aHUS) and the HELLP syndrome (haemolytic anaemia, elevated liver enzymes, and low platelets) are thrombotic microangiopathies characterized by microvascular endothelial activation, cell injury and thrombosis. aHUS is a disease of complement dysregulation, specifically a gain ...

journal_title：British journal of haematology

authors： Fang CJ,Richards A,Liszewski MK,Kavanagh D,Atkinson JP

更新日期：2008-11-01 00:00:00

abstract：:Splanchnic vein thrombosis (SVT) is one of the most important complications of myeloproliferative neoplasms (MPN). Although MPN are common causes of SVT, the pathophysiological mechanisms underlying this predisposition, their epidemiology and natural history are not fully understood. Studies have concentrated on the g...

journal_title：British journal of haematology

authors： Sekhar M,McVinnie K,Burroughs AK

更新日期：2013-09-01 00:00:00

abstract：:In whole blood from splenectomized subjects (n = 20), red cells showed a significant increase of mean surface area (MSA), mean cell volume (MCV), MSA/MCV-ratio and osmotic resistance, with the mean cell haemoglobin concentration (MCHC) being decreased. Studies on red cell populations of different cell age revealed tha...

journal_title：British journal of haematology

authors： de Haan LD,Werre JM,Ruben AM,Huls HA,de Gier J,Staal GE

更新日期：1988-05-01 00:00:00

abstract：:Six hundred and nineteen patients with de novo acute myeloid leukaemia, entered into the Medical Research Council's eighth trial of therapy have been studied. All patients were treated with the same remission induction regimen. Pretreatment variables comprising age, clinical status, haematological status and a detaile...

journal_title：British journal of haematology

authors： Swirsky DM,de Bastos M,Parish SE,Rees JK,Hayhoe FG

更新日期：1986-11-01 00:00:00

abstract：:Umbilical cord blood is a valuable source of haemopoietic stem/progenitor cells (HSC) for transplantation. This study explored the effect of maternal plasma/human serum albumin (HSA) in the purification and culture conditions of CD34+ cells derived from human umbilical cord blood. During CD34+ cell enrichment, includi...

journal_title：British journal of haematology

authors： Kwok YK,Tang MH,Law HK,Ngai CS,Lau YL,Lau ET

更新日期：2007-06-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH), the most common histiocytic disorder, is characterized by the accumulation of CD1A(+) /CD207(+) mononuclear phagocytes within granulomatous lesions that can affect nearly all organ systems. Historically, LCH has been presumed to arise from transformed or pathologically activated ep...

journal_title：British journal of haematology

authors： Berres ML,Merad M,Allen CE

更新日期：2015-04-01 00:00:00

abstract：:This trial explored the efficacy of re-induction chemotherapy including bortezomib in paediatric relapsed/refractory acute lymphoblastic leukaemia. Patients were randomized 1:1 to bortezomib (1.3 mg/m2 /dose) administered early or late to a dexamethasone and vincristine backbone. Both groups did not differ regarding p...

journal_title：British journal of haematology

authors： Kaspers GJL,Niewerth D,Wilhelm BAJ,Scholte-van Houtem P,Lopez-Yurda M,Berkhof J,Cloos J,de Haas V,Mathôt RA,Attarbaschi A,Baruchel A,de Bont ES,Fagioli F,Rössig C,Klingebiel T,De Moerloose B,Nelken B,Palumbo G,Reinhar

更新日期：2018-05-01 00:00:00

abstract：:Iron is required for monocyte/macrophage differentiation of HL-60 leukaemia cells. Differentiation requires induction of the cyclin-dependent kinase inhibitor p21 (WAF1/CIP1), and cell cycle arrest at the G1/S checkpoint. With iron depletion, p21 induction and differentiation are blocked. To establish the roles of iro...

journal_title：British journal of haematology

authors： Kramer JL,Baltathakis I,Alcantara OS,Boldt DH

更新日期：2002-06-01 00:00:00

abstract：:Serum erythropoietin (Epo) was measured in 23 patients before, during and after intensive cytostatic treatment courses for acute leukaemia or before bone marrow transplantation. A marked increase was seen in all patients, starting 1 or 2 d after initiation of treatment. A peak was reached after about 7 d, at levels as...

journal_title：British journal of haematology

authors： Birgegård G,Wide L,Simonsson B

更新日期：1989-07-01 00:00:00

abstract：:In this study, quiescent bone marrow-derived CD34+ erythroid burst-forming units (BFU-E) were found to be resistant to the inhibitory effects of tumour necrosis factor (TNF)-alpha and -beta as well as interferon (IFN)-alpha, -beta and -gamma, in contrast to those stimulated by a combination of erytrhropoietin (Epo) pl...

journal_title：British journal of haematology

authors： Ratajczak J,Kucia M,Reca R,Zhang J,Machalinski B,Ratajczak MZ

更新日期：2003-10-01 00:00:00

abstract：:Polycythaemia vera (PV) patients' blood burst-forming units-erythroid (BFU-E) have an enhanced sensitivity to stem cell factor (SCF) compared to normal BFU-E. To characterize SCF receptors on erythroid progenitors from normal individuals and PV patients, we performed binding experiments using radioiodinated recombinan...

journal_title：British journal of haematology

authors： Dai CH,Krantz SB,Koury ST,Kollar K

更新日期：1994-11-01 00:00:00

abstract：:The expression of EBV proteins and immunological properties were studied in the first stable cell line (SM) established from a patient presenting with persistent polyclonal B-cell lymphocytosis (PPBL). SM cells which represent a small population of EBV-positive atypical cells found in the peripheral blood of the patie...

journal_title：British journal of haematology

authors： Larcher C,Fend F,Mitterer M,Prang N,Schwarzmann F,Huemer HP

更新日期：1995-07-01 00:00:00

abstract：:A t(5;12)(q33;p13) translocation has been detected in two patients with myeloid disorder and eosinophilia. Six other patients with haematological disease with eosinophilia with similar translocation have been published previously. The existence of a new entity, a myeloproliferative disorder with eosinophilia and t(5;1...

journal_title：British journal of haematology

authors： Baranger L,Szapiro N,Gardais J,Hillion J,Derre J,Francois S,Blanchet O,Boasson M,Berger R

更新日期：1994-10-01 00:00:00

abstract：:Thrombopoietin (TPO) is the key growth factor for platelet production and is elevated in states of platelet depletion. As thrombocytopenia is a common finding in malaria, we analysed TPO regulation before, during and after antimalarial treatment. Before treatment, TPO serum levels were significantly higher in patients...

journal_title：British journal of haematology

authors： Kreil A,Wenisch C,Brittenham G,Looareesuwan S,Peck-Radosavljevic M

更新日期：2000-06-01 00:00:00

abstract：:Cooley's original description of beta-thalassaemia major included marked bone deformities as a characteristic feature. These were thought to be due to expansion of haemopoiesis attempting to compensate for the congenital anaemia. Regular blood transfusions from infancy prevents these skeletal problems. Nevertheless, s...

journal_title：British journal of haematology

authors： Jensen CE,Tuck SM,Agnew JE,Koneru S,Morris RW,Yardumian A,Prescott E,Hoffbrand AV,Wonke B

更新日期：1998-12-01 00:00:00

abstract：:To examine any role of macrophage colony-stimulating factor (M-CSF), in the immune responses in Kawasaki disease (KD), we serially assayed M-CSF and several related cytokines using ELISA. In 10 paediatric patients with KD the level of M-CSF was significantly higher in the acute phase than in the convalescent phase (14...

journal_title：British journal of haematology

authors： Igarashi H,Hatake K,Tomizuka H,Yamada M,Gunji Y,Momoi MY

更新日期：1999-06-01 00:00:00

abstract：:Reduced-intensity conditioning (RIC) regimens for allogeneic haematopoietic stem cell transplantation (SCT) have been shown to lead to engraftment of donor stem cells without the severe extra-haematological toxicities of traditional myeloablative transplants. Between December 1998 and December 2000, 76 patients underw...

journal_title：British journal of haematology

authors： Martino R,Caballero MD,Canals C,Simón JA,Solano C,Urbano-Ispízua A,Bargay J,Rayón C,Léon A,Sarrá J,Odriozola J,Conde JG,Sierra J,San Miguel J,ALLOPBSCT Subcommittee of the Spanish Group for Haematopoietic Transplantation (GET

更新日期：2001-12-01 00:00:00

abstract：:We evaluated the blood from 150 patients with primary AL-amyloidosis for circulating monoclonal plasma cells using a sensitive slide-based immunofluorescence technique. The percentage of monoclonal blood plasma cells (BPC) that were in S-phase was determined by the bromodeoxyuridine labelling index (BLI). Monoclonal B...

journal_title：British journal of haematology

authors： McElroy EA Jr,Witzig TE,Gertz MA,Greipp PR,Kyle RA

更新日期：1998-02-01 00:00:00

abstract：:A multiparameter flow-cytometrical method for the quantitation of CD34(+)-cells present in adult human peripheral blood cells (PBMC) has been developed. PBMC from 13 healthy adult subjects were analysed for CD34(+)-cells by flow-cytometry, with only the lymphoid population of cells negative for anti-CD3-moAb included ...

journal_title：British journal of haematology

authors： Serke S,Säuberlich S,Huhn D

更新日期：1991-04-01 00:00:00

abstract：:A female patient with delayed haemolytic transfusion reaction due to anti-M antibody is described. Diagnosis was based on laboratory evidence of haemolysis and on characteristic serological findings. Anti-M was detected in the recipient's serum 7 d after the last transfusion episode. This alloantibody had not been pre...

journal_title：British journal of haematology

authors： Sancho JM,Pujol M,Fernández F,Soler M,Manzano P,Feliu E

更新日期：1998-10-01 00:00:00

abstract：:Studies of ethnic disparities in malignancies have revealed variation in clinical outcomes. In multiple myeloma (MM), previous literature has focused only on patients of Caucasian and African-American (AA) descent. We present a Surveillance Epidemiology and End Results (SEER)-based outcome analysis of MM patients from...

journal_title：British journal of haematology

authors： Ailawadhi S,Aldoss IT,Yang D,Razavi P,Cozen W,Sher T,Chanan-Khan A

更新日期：2012-07-01 00:00:00

abstract：:T cells modified with anti-CD19 chimeric antigen receptor (CAR) containing either CD28 or 4-1BB (also termed TNFRSF9, CD137) costimulatory signalling have shown great potential in the treatment of acute lymphoblastic leukaemia (ALL). However, the difference between CD28 and 4-1BB costimulatory signalling in CAR-T trea...

journal_title：British journal of haematology

authors： Li S,Zhang J,Wang M,Fu G,Li Y,Pei L,Xiong Z,Qin D,Zhang R,Tian X,Wei Z,Chen R,Chen X,Wan J,Chen J,Wei X,Xu Y,Zhang P,Wang P,Peng X,Yang S,Shen J,Yang Z,Chen J,Qian C

更新日期：2018-05-01 00:00:00

abstract：:In emicizumab prophylaxis, the concomitant therapy using bypassing agents (BPAs) is required for breakthrough bleeding and invasive procedures with attention to thrombotic complications. To predict coagulant effects of BPAs in emicizumab-treated patients with haemophilia A (PwHA) with inhibitor (PwHAwI), blood samples...

journal_title：British journal of haematology

authors： Furukawa S,Nogami K,Shimonishi N,Nakajima Y,Matsumoto T,Shima M

更新日期：2020-09-01 00:00:00

abstract：:The levels of platelet-associated Igs (PAIgs) and plasma circulating antiplatelet antibodies were evaluated by a flow cytometric immunofluorescence assay (FCIFA), an enzyme-linked immunoassay (ELISA), and a platelet radioactive antiglobulin test (PRAT), in a group of 45 human immunodeficiency virus (HIV)-infected intr...

journal_title：British journal of haematology

authors： Gonzalez-Conejero R,Rivera J,Rosillo MC,Cano A,Rodriguez T,Vicente V

更新日期：1996-05-01 00:00:00