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Moderate endurance exercise in patients with sickle cell anaemia: effects on oxidative stress and endothelial activation.

Abstract：

:Very few studies have investigated the effects of exercise on the biological parameters involved in vaso-occlusive events in sickle cell anaemia (SCA). The aim of this study was to test how a mild-moderate endurance exercise modulates oxidative stress, nitric oxide bioavailability and endothelial activation in SCA patients and healthy individuals. Eleven patients with SCA and 15 healthy subjects completed a 20-min duration submaximal cycling exercise at ≈45 Watts. Plasma markers of oxidative stress, antioxidant activity, endothelial activation and nitric oxide bioavailability were investigated before and after the exercise. Nitric oxide levels, anti-oxidant capacity, soluble (s)E-selectin and sP-selectin did not change in response to this exercise. Except for the malondialdehyde levels, which increased in the two groups, the other markers of oxidative stress remained unchanged in both groups in response to exercise. Soluble vascular cell adhesion molecule 1 levels were increased at the end of exercise in both groups. sL-selectin decreased and soluble intercellular adhesion molecule 1 increased with exercise in SCA patients only. The present data suggest that patients with SCA may undertake mild-moderate physical activities without any acute clinical complications, but care should be taken because oxidative stress and endothelial activation significantly increased in some patients.

journal_name

Br J Haematol

journal_title

British journal of haematology

authors

Faes C,Balayssac-Siransy E,Connes P,Hivert L,Danho C,Bogui P,Martin C,Pialoux V

doi

10.1111/bjh.12594

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

124-30

issue

1

eissn

0007-1048

issn

1365-2141

journal_volume

164

pub_type

杂志文章

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