Management of relapse in acute promyelocytic leukaemia treated with up-front arsenic trioxide-based regimens.

Abstract:

:The standard of care for patients with acute promyelocytic leukaemia (APL) relapsing after front-line treatment with arsenic trioxide (ATO)-based regimens remains to be defined. A total of 67 patients who relapsed after receiving ATO-based up-front therapy and were also salvaged using an ATO-based regimen were evaluated. The median (range) age of patients was 28 (4-54) years. While 63/67 (94%) achieved a second molecular remission (MR) after salvage therapy, three (4·5%) died during salvage therapy. An autologous stem cell transplant (auto-SCT) was offered to all patients who achieved MR, 35/63 (55·6%) opted for auto-SCT the rest were administered an ATO + all-trans retinoic acid maintenance regimen. The mean (SD) 5-year Kaplan-Meier estimate of overall survival and event-free survival of those who received auto-SCT versus those who did not was 90·3 (5·3)% versus 58·6 (10·4)% (P = 0·004), and 87·1 (6·0)% versus 47·7 (10·3)% (P = 0·001) respectively. On multivariate analysis, failure to consolidate MR with an auto-SCT was associated with a significantly increased risk of relapse [hazard ratio (HR) 4·91, 95% confidence interval (CI) 1·56-15·41; P = 0·006]. MR induction with ATO-based regimens followed by an auto-SCT in children and young adults with relapsed APL who were treated with front-line ATO-based regimens was associated with excellent long-term survival.

journal_name

Br J Haematol

authors

Fouzia NA,Sharma V,Ganesan S,Palani HK,Balasundaram N,David S,Kulkarni UP,Korula A,Devasia AJ,Nair SC,Janet NB,Abraham A,Mani T,Lakshmanan J,Balasubramanian P,George B,Mathews V

doi

10.1111/bjh.17221

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

292-299

issue

2

eissn

0007-1048

issn

1365-2141

journal_volume

192

pub_type

杂志文章
  • Genetic strategies for the treatment of sickle cell anaemia.

    abstract::Sickle cell anaemia is a severe inherited blood disorder for which there is presently no curative therapy other than allogeneic haematopoietic stem cell (HSC) transplantation. This therapeutic option, however, is not available to most patients because of the lack of a matched related donor. Different genetic strategie...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2141.2011.08773.x

    authors: Mansilla-Soto J,Rivière I,Sadelain M

    更新日期:2011-09-01 00:00:00

  • alpha-Interferon in myelofibrosis: a case report.

    abstract::A patient with advanced myeloid metaplasia was treated with alpha-interferon (29 months) with a remarkable response. He had anaemia, thrombocytopenia and hepatosplenomegaly with infarction. The initial bone marrow showed replacement with fibrosis with no evident haemopoietic cells. Post-therapy, the patient became asy...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1994.tb04802.x

    authors: Dalla KP,Zeigler ZR,Shadduck RK

    更新日期:1994-03-01 00:00:00

  • Bone involvement in sickle cell disease.

    abstract::Bone involvement is the commonest clinical manifestation of sickle cell disease both in the acute setting such as painful vaso-occlusive crises, and as a source of chronic, progressive disability such as avascular necrosis. Management of these problems is often difficult because of the diagnostic imprecision of most l...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2141.2005.05476.x

    authors: Almeida A,Roberts I

    更新日期:2005-05-01 00:00:00

  • The iron chelator deferasirox affects redox signalling in haematopoietic stem/progenitor cells.

    abstract::The iron chelator deferasirox (DFX) prevents complications related to transfusional iron overload in several haematological disorders characterized by marrow failure. It is also able to induce haematological responses in a percentage of treated patients, particularly in those affected by myelodysplastic syndromes. The...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/bjh.13381

    authors: Tataranni T,Agriesti F,Mazzoccoli C,Ruggieri V,Scrima R,Laurenzana I,D'Auria F,Falzetti F,Di Ianni M,Musto P,Capitanio N,Piccoli C

    更新日期:2015-07-01 00:00:00

  • A non-human primate model for the study of oral iron chelators.

    abstract::Recent studies have demonstrated that parenteral deferroxamine can prolong life in patients with iron overload. We have developed a non-human primate model of iron overload and have accurately determined negative iron balance in parenteral and oral studies of deferroxamine and a new chelator, desferrithiocin. Cebus mo...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1989.tb07732.x

    authors: Wolfe LC,Nicolosi RJ,Renaud MM,Finger J,Hegsted M,Peter H,Nathan DG

    更新日期:1989-07-01 00:00:00

  • The use of direct oral anticoagulants in chronic kidney disease.

    abstract::Increasing use of direct oral anticoagulants (DOACs) has made management of non-valvular atrial fibrillation and venous thromboembolism easier in most patients. But the presence of co-existing renal impairment could render the use of DOACs problematic because all of these drugs have varying degrees of renal excretion....

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/bjh.15564

    authors: Parker K,Thachil J

    更新日期:2018-10-01 00:00:00

  • Rh immunization facilitated by passively-administered anti-Rh?

    abstract::The response to 0.8 ml of D-positive (ccDEE) red cells injected i.v., together with 1 microgram anti-D i.m., was studied in 13 D-negative male volunteers (test subjects); the red cells were labelled with 51Cr and were found to have a mean survival time of 24 d, after correction for Cr elution. Within the following 5 m...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1983.tb01997.x

    authors: Contreras M,Mollison PL

    更新日期:1983-01-01 00:00:00

  • Advances in the understanding of myeloma bone disease and tumour growth.

    abstract::Advances in multiple myeloma support the notion that the associated bone disease, characterized by increased osteoclastogenesis and suppressed osteoblastogenesis, is both a consequence and necessity of tumour progression. Osteoblastogenesis is suppressed by secreted inhibitors and dysregulation of cell-surface 'coupli...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2141.2010.08141.x

    authors: Yaccoby S

    更新日期:2010-05-01 00:00:00

  • Characterization of blast cells in chronic granulocytic leukaemia in transformation, acute myelofibrosis and undifferentiated leukaemia. I. Ultrastructural morphology and cytochemistry.

    abstract::A systematic analysis of the blast cell population was carried out on samples from 50 patients suffering from blast transformation of chronic granulocytic leukaemia (CGL) (31) and of myelofibrosis (4), acute myelofibrosis (AM) (11) and undifferentiated acute leukaemia (4). Transmission electron microscopy (TEM), used ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1985.tb02994.x

    authors: Polli N,O'Brien M,Tavares de Castro J,Matutes E,San Miguel JF,Catovsky D

    更新日期:1985-02-01 00:00:00

  • Immune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies following unrelated donor stem cell transplantation for chronic myeloid leukaemia: perpetuation by granulocyte colony-stimulating factor.

    abstract::A case of immune neutropenia following unrelated stem cell transplantation for chronic myeloid leukaemia is described. The neutropenia developed following herpes zoster viral infection and was associated with antibodies to the human neutrophil antigen (HNA)-2a (formerly known as NB1). The neutropenia was prolonged, pr...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2001.02779.x

    authors: Pocock CF,Lucas GF,Giles C,Vassiliou G,Cwynarski K,Rezvani K,Apperley JF,Goldman JM

    更新日期:2001-05-01 00:00:00

  • Non-anaplastic peripheral T-cell lymphoma in children and adolescents--a retrospective analysis of the NHL-BFM study group.

    abstract::Mature (peripheral) T-cell lymphoma (PTCL) other than anaplastic large cell lymphoma is a heterogeneous group of diseases and exceedingly rare in children and adolescents. Survival rates range between 46% and 85%. This study reports the disease characteristics, treatment and outcome of all patients with the diagnosis ...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bjh.13216

    authors: Kontny U,Oschlies I,Woessmann W,Burkhardt B,Lisfeld J,Salzburg J,Janda A,Attarbaschi A,Niggli F,Zimmermann M,Reiter A,Klapper W

    更新日期:2015-03-01 00:00:00

  • Epigenetic induction of adaptive immune response in multiple myeloma: sequential azacitidine and lenalidomide generate cancer testis antigen-specific cellular immunity.

    abstract::Patients with multiple myeloma (MM) undergoing high dose therapy and autologous stem cell transplantation (SCT) remain at risk for disease progression. Induction of the expression of highly immunogenic cancer testis antigens (CTA) in malignant plasma cells in MM patients may trigger a protective immune response follow...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2012.09225.x

    authors: Toor AA,Payne KK,Chung HM,Sabo RT,Hazlett AF,Kmieciak M,Sanford K,Williams DC,Clark WB,Roberts CH,McCarty JM,Manjili MH

    更新日期:2012-09-01 00:00:00

  • Clonal chromosomal abnormalities as direct evidence for clonality in nasal T/natural killer cell lymphomas.

    abstract::Nasal T/natural killer (NK) cell lymphoma is a distinct clinicopathologic entity which is more prevalent in Asia than in America and Europe. The clonal nature of the infiltrating lymphoid cells is difficult to demonstrate because of the lack of immunologic markers for clonality and the absence of clonal T-cell recepto...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1997.752711.x

    authors: Tien HF,Su IJ,Tang JL,Liu MC,Lee FY,Chen YC,Chuang SM

    更新日期:1997-06-01 00:00:00

  • Kinetic analysis of 52Fe-labelled iron(III) hydroxide-sucrose complex following bolus administration using positron emission tomography.

    abstract::Kinetic analysis of a single intravenous injection of 100 mg iron(III) hydroxide-sucrose complex (Venofer) mixed with 52Fe(III) hydroxide-sucrose as a tracer was followed for 3-6 h in four generally anaesthetized, artificially ventilated minipigs using positron emission tomography (PET). The amount of injected radioac...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1999.01170.x

    authors: Beshara S,Lundqvist H,Sundin J,Lubberink M,Tolmachev V,Valind S,Antoni G,Långström B,Danielson BG

    更新日期:1999-02-01 00:00:00

  • Risk factors for pericardial effusion in adult patients receiving allogeneic haematopoietic stem cell transplantation.

    abstract::Pericardial effusion (PE) is a rare but potentially life-threatening complication for allogeneic haematopoietic stem cell transplantation (HSCT) recipients. The risk factors, aetiology, incidence and therapy are largely unclear. To investigate this issue, we reviewed 391 adult patients undergoing allogeneic HSCT betwe...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/bjh.13357

    authors: Liu YC,Chien SH,Fan NW,Hu MH,Gau JP,Liu CJ,Yu YB,Liu CY,Hsiao LT,Liu JH,Chiou TJ,Tzeng CH

    更新日期:2015-06-01 00:00:00

  • Erythropoiesis and mean red-cell lifespan in normal subjects and in patients with the anaemia of active rheumatoid arthritis.

    abstract::Recently developed ferrokinetic methods offer a tool to measure effective and ineffective erythropoiesis and mean red-cell lifespan (Ricketts et al, 1975). We have used this tool to investigate erythropoiesis in normal subjects and in patients with the anaemia of active rheumatoid arthritis. In normal subjects the res...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1978.tb01114.x

    authors: Dinant HJ,de Maat CE

    更新日期:1978-07-01 00:00:00

  • Differences in the distribution of CD34 epitopes on normal haemopoietic progenitor cells and leukaemic blast cells.

    abstract::The CD34 molecule expressed on haemopoietic progenitor cells contains a large number of epitopes whose expression may be related to the maturation or function of the cells. Monoclonal antibodies specific for different epitopes have been reported to detect different numbers of CD34+ leukaemic blast cells. We wanted to ...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1996.7052322.x

    authors: Steen R,Tjønnfjord GE,Gaudernack G,Brinch L,Egeland T

    更新日期:1996-09-01 00:00:00

  • Activation of class I HLA expression by TNF-alpha and gamma-interferon is mediated through protein kinase C-dependent pathway in CML cell lines.

    abstract::The combination of tumour necrosis factor alpha (TNF alpha) and gamma-interferon induced transcription of class I HLA genes in chronic myelogenous leukaemia (CML) cell lines through the formation of a complex between nuclear proteins and the transcriptional enhancers associated with these genes. Although gamma-interfe...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1991.tb04449.x

    authors: Seong D,Sims S,Johnson E,Lyding J,Lopez A,Garovoy M,Talpaz M,Kantarjian H,Lopez-Berestein G,Reading C

    更新日期:1991-07-01 00:00:00

  • Pulmonary function in thalassaemia major and its correlation with body iron stores.

    abstract::This study compared pulmonary function tests (PFTs) with cardiac, pancreatic and liver iron in 76 thalassemia major (TM) patients. Restrictive lung disease was observed in 16%, hyperinflation in 32% and abnormal diffusing capacity in 3%. While no patients met Global Initiative for Chronic Lung Disease criteria for air...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2011.08808.x

    authors: Sohn EY,Noetzli LJ,Gera A,Kato R,Coates TD,Harmatz P,Keens TG,Wood JC

    更新日期:2011-10-01 00:00:00

  • Identification of the CD33-related Siglec receptor, Siglec-5 (CD170), as a useful marker in both normal myelopoiesis and acute myeloid leukaemias.

    abstract::Sialic acid-binding immunoglobulin-like lectin (Siglec)-5 or CD170 is a CD33-related receptor, containing cytoplasmic immune receptor-based tyrosine signalling motifs, that has previously been reported to be myeloid-specific like CD33 and thus may be useful in the characterization of both normal and malignant haemopoi...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.2003.04625.x

    authors: Virgo P,Denning-Kendall PA,Erickson-Miller CL,Singha S,Evely R,Hows JM,Freeman SD

    更新日期:2003-11-01 00:00:00

  • Advances in understanding of pathogenesis of aHUS and HELLP.

    abstract::Both atypical haemolytic uraemic syndrome (aHUS) and the HELLP syndrome (haemolytic anaemia, elevated liver enzymes, and low platelets) are thrombotic microangiopathies characterized by microvascular endothelial activation, cell injury and thrombosis. aHUS is a disease of complement dysregulation, specifically a gain ...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2141.2008.07324.x

    authors: Fang CJ,Richards A,Liszewski MK,Kavanagh D,Atkinson JP

    更新日期:2008-11-01 00:00:00

  • Clofarabine in combination with pegylated asparaginase in the frontline treatment of childhood acute lymphoblastic leukaemia: a feasibility report from the CoALL 08-09 trial.

    abstract::Clofarabine was the latest new drug to be approved, in 2004, for relapsed or refractory acute lymphoblastic leukaemia (ALL). To investigate its value in the frontline treatment of ALL we applied clofarabine 5 × 40 mg/m(2) in combination with pegylated asparaginase (PEG-ASP) 1 × 2500 iu/m(2) in high risk ALL patients a...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bjh.12520

    authors: Escherich G,Zur Stadt U,Zimmermann M,Horstmann MA,CoALL study group.

    更新日期:2013-10-01 00:00:00

  • Inactivation of the retinoblastoma gene appears to be very uncommon in myelodysplastic syndromes.

    abstract::Rearrangements of the retinoblastoma (RB) gene have been reported in a few cases of myelodysplastic syndromes (MDS). In addition, low or absent expression of the RB protein is found in 20-30% of cases of acute myeloid leukaemias (AML), particularly in AML with a monocytic component (M4 or M5). We performed Southern bl...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.1994.tb04871.x

    authors: Preudhomme C,Vachee A,Lepelley P,Vanrumbeke M,Zandecki M,Quesnel B,Cosson A,Fenaux P

    更新日期:1994-05-01 00:00:00

  • Association between hyperflexibility of the thumb and an unexplained bleeding tendency: is it a rule of thumb?

    abstract::A bleeding tendency manifested by petechiae and ecchymoses is one of the most common causes for referral of patients to haematology clinics. Vessel wall pathology is not usually considered to be a cause for deranged haemostasis, although coexistence of increased capillary fragility and joint hypermobility have been re...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1998.00697.x

    authors: Kaplinsky C,Kenet G,Seligsohn U,Rechavi G

    更新日期:1998-05-01 00:00:00

  • Double heterozygosity of the GPIIb gene in a Swiss patient with Glanzmann's thrombasthenia.

    abstract::Glanzmann's thrombasthenia (GT) results from a qualitative or quantitative defect of GPIIb-IIIa complexes (integrin alphaIIbbeta3). the fibrinogen receptor on platelets. This integrin plays a critical role in platelet aggregation. In this report we describe the molecular abnormalities of a patient with clinical and la...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1998.00852.x

    authors: Ruan J,Peyruchaud O,Alberio L,Valles G,Clemetson K,Bourre F,Nurden AT

    更新日期:1998-09-01 00:00:00

  • Red blood cell phenotypes in the alpha + thalassaemias from early childhood to maturity.

    abstract::The alpha+ thalassaemias are the most common single gene disorders of humans, yet little is known about their haematological characteristics in childhood. Blood samples have been collected randomly from more than 2000 individuals in village communities in Vanuatu in the South West Pacific and analysed for alpha thalas...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1996.d01-1906.x

    authors: Williams TN,Maitland K,Ganczakowski M,Peto TE,Clegg JB,Weatherall DJ,Bowden DK

    更新日期:1996-11-01 00:00:00

  • Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl-2 expression.

    abstract::Mantle cell lymphoma (MCL) is an incurable mature B cell proliferation, combining the unfavourable clinical features of aggressive and indolent lymphomas. The blastic variant of MCL has an even worse prognosis and new treatment options are clearly needed. We analysed the effects of BL22, an immunotoxin composed of the...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2009.07939.x

    authors: Bogner C,Dechow T,Ringshausen I,Wagner M,Oelsner M,Lutzny G,Licht T,Peschel C,Pastan I,Kreitman RJ,Decker T

    更新日期:2010-01-01 00:00:00

  • Thrombotic thrombocytopenic purpura in patients with retroviral infection is highly responsive to plasma infusion therapy.

    abstract::We prospectively studied presentation biological differences and the response to therapy in patients with thrombotic thrombocytopenic purpura (TTP) associated with, or unrelated to human immunodeficiency virus (HIV) infection. TTP patients underwent standard evaluations and were treated with prednisone 1 mg/kg in addi...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2141.2004.05325.x

    authors: Novitzky N,Thomson J,Abrahams L,du Toit C,McDonald A

    更新日期:2005-02-01 00:00:00

  • Activation of endothelium by immunotherapy with interleukin-2 in patients with malignant disorders.

    abstract::Treatment with intravenous recombinant human interleukin-2 (rh IL-2) is frequently accompanied by the capillary leak syndrome and disturbances of the coagulation system. Although the exact mechanisms are still not fully understood, the involvement of the endothelium is proven. This investigation aimed to elucidate mor...

    journal_title:British journal of haematology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2141.1999.01453.x

    authors: Locker GJ,Kapiotis S,Veitl M,Mader RM,Stoiser B,Kofler J,Sieder AE,Rainer H,Steger GG,Mannhalter C,Wagner OF

    更新日期:1999-06-01 00:00:00

  • Tandem transplants with different high-dose regimens improve the complete remission rates in multiple myeloma. Results of a Grupo Español de Síndromes Linfoproliferativos/Trasplante Autólogo de Médula Osea phase II trial.

    abstract::Between 1994 and 1999, 88 multiple myeloma (MM) patients were included in a phase II study to evaluate a tandem autologous stem cell transplantation (ASCT) programme. The first was conditioned with melphalan 200 mg/m2 (MEL200-ASCT1), and the second with cyclophosphamide, etoposide and BCNU (CBV-ASCT2). All patients we...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1046/j.1365-2141.2003.04067.x

    authors: Lahuerta JJ,Grande C,Martínez-Lopez J,De La Serna J,Toscano R,Ortiz MC,Larregla S,Conde E,Insunza A,Gonzalez-San Miguel JD,Bargay J,Cabrera R,García-Ruiz JC,Albó C,García-Alonso L,Solano F,Vivancos P,León A,San Miguel

    更新日期:2003-01-01 00:00:00