Thrombotic thrombocytopenic purpura in patients with retroviral infection is highly responsive to plasma infusion therapy.

abstract：:The aim of our study was to investigate whether haemophilia A patients with inversion of intron 22 are at high risk for non-inhibitory anti-FVIII antibodies development detected by ELISA. It is known that patients with severe forms of haemophilia A are more likely to develop anti-FVIII antibodies. The incidence of inh...

journal_title：British journal of haematology

authors： Vianello F,Radossi P,Tison T,Dazzi F,Tagariello G,Davoli PG,Girolami A

更新日期：1997-06-01 00:00:00

abstract：:The existence of a phenomenon of rebound hypercoagulability after cessation of oral anticoagulant therapy is controversial. The sensitive procoagulant markers for in vivo thrombin and fibrin formation are potential tools for the reassessment of the presence of each a phenomenon. We examined 19 patients anticoagulated ...

journal_title：British journal of haematology

authors： Genewein U,Haeberli A,Straub PW,Beer JH

更新日期：1996-02-01 00:00:00

abstract：:Cytometry has become important in the detection and determination of risk of monoclonal B-cell lymphocytosis; methodology has changed, and will continue to change, as cytometric technology changes. ...

journal_title：British journal of haematology

authors： Shapiro HM

更新日期：2007-12-01 00:00:00

abstract：:Therapeutic plasma exchange (TPE) has been mainly used in the treatment of autoimmune diseases. The main mechanisms of action of TPE include the removal of circulating autoantibodies, immune complexes, complement components, cytokines and adhesion molecules, along with sensitization of antibody-producing cells to immu...

journal_title：British journal of haematology

authors： Zanatta E,Cozzi M,Marson P,Cozzi F

更新日期：2019-07-01 00:00:00

abstract：:The number of novel therapies for the treatment of myeloma is rapidly increasing, as are the clinical trials evaluating them in combination with other novel and established therapies. Proteasome inhibitors, immunomodulatory agents and monoclonal antibodies are the most well known and studied classes of novel agents ta...

journal_title：British journal of haematology

authors： Wallington-Beddoe CT,Sobieraj-Teague M,Kuss BJ,Pitson SM

更新日期：2018-07-01 00:00:00

abstract：:Erythroid colonies derived from the circulating early erythroid precursor (BFU-E) of a patient with congenital dyserythropoietic anaemia type I (CDA I) have been grown in plasma clot and studied by electron microscopy. The number of circulating BFU-E was in the normal range with a roughly normal appearance at the ligh...

journal_title：British journal of haematology

authors： Vainchenker W,Guichard J,Bouguet J,Breton-Gorius J

更新日期：1980-09-01 00:00:00

abstract：:Recent studies concerning the numbers of circulating clonal B cells in patients with multiple myeloma (MM) have reported conflicting data regarding the exact levels of clonal B cells and the existence of clonal cells in the CD34 compartment. In this report we show that high numbers of clonal cells with a phenotype of ...

journal_title：British journal of haematology

authors： Rasmussen T,Kastrup J,Knudsen LM,Johnsen HE

更新日期：1999-04-01 00:00:00

abstract：:Bone marrow blast cells of 174 child and 188 adult patients with AML were examined and characterized in terms of their FAB type, immunological phenotype (102 children, 123 adults) and karyotype (69 children, 95 adults). The incidence of FAB variants of AML proved similar in children and adults. In patients under 15 an...

journal_title：British journal of haematology

authors： Frenkel MA,Tupitsyn NN,Protasova AK,Kadagidze ZG,Konstantinova LN,Fleischman EW

更新日期：1994-08-01 00:00:00

abstract：:We report a series of 20 patients with the myelodysplastic syndrome (MDS) each with a coexistent lymphoid or plasmacytic neoplasm. In none of the patients did chemotherapy play a part in the pathogenesis. The possible reasons for the coincidence of these conditions are discussed. The frequency and variety of associate...

journal_title：British journal of haematology

authors： Copplestone JA,Mufti GJ,Hamblin TJ,Oscier DG

更新日期：1986-05-01 00:00:00

abstract：:The heterogeneity of pyruvate kinase (PK) deficiency associated with hereditary haemolytic anaemia is emphasized by studies of a kindred harbouring two distinct mutant forms of this enzyme, both of which were kinetically defective with markedly decreased affinities for the substrate, phosphoenolypyruvate. The two isoe...

journal_title：British journal of haematology

authors： Pagila DE,Gray GR,Growe GH,Valentine WN

更新日期：1976-09-01 00:00:00

abstract：:Epstein-Barr virus-associated haemophagocytic lymphohistiocytosis (EBV-HLH) is one of the most common subtypes of secondary HLH. However, more than 30% of patients do not respond to traditional treatment. Here, we investigated the efficacy and safety of the L-DEP regimen as a salvage therapy for paediatric refractory ...

journal_title：British journal of haematology

authors： Zhao Y,Li Z,Zhang L,Lian H,Ma H,Wang D,Zhao X,Zhang Q,Wang T,Zhang R

更新日期：2020-11-01 00:00:00

abstract：:The peripheral blood lymphoid cells of five patients with Sézary syndrome (SS) were examined with respect to their surface membrane characteristics and their response to mitogens. These cells showed markedly defective mitogenic responses to a broad dose range of phytohaemagglutinin (PHA), pokeweed mitogen, concanavali...

journal_title：British journal of haematology

authors： Braylan R,Variakojis D,Yachnin S

更新日期：1975-12-01 00:00:00

abstract：:Surgical interventions in patients suffering from haemophilia A require infusions of large doses of factor VIII (F VIII) concentrates. These are expensive and may pose a burden on the immune system, which is already compromised in many haemophiliacs. F VIII is usually given as bolus injections, although there are repo...

journal_title：British journal of haematology

authors： Martinowitz U,Schulman S,Gitel S,Horozowski H,Heim M,Varon D

更新日期：1992-12-01 00:00:00

abstract：:The Hodgkin lymphomas are a family of unique lymphoma subtypes, in which the nature of the neoplastic cell was enigmatic for many years. Much of the mystery has been solved, with all forms now considered to be of B-cell origin, in most cases of germinal centre derivation. Today we recognize Hodgkin lymphoma as an epon...

journal_title：British journal of haematology

authors： Wang HW,Balakrishna JP,Pittaluga S,Jaffe ES

更新日期：2019-01-01 00:00:00

abstract：:We evaluated the feasibility of collecting peripheral blood progenitor cells (PBPC) in patients with acute myeloid leukaemia (AML) following two cycles of induction chemotherapy with idarubicin, cytarabine and etoposide (ICE), and one cycle of consolidation therapy with high-dose cytarabine and mitoxantrone (HAM). Thi...

journal_title：British journal of haematology

authors： Schlenk RF,Döhner H,Pförsich M,Benner A,Fischer K,Hartmann F,Fischer JT,Weber W,Gunzer U,Pralle H,Haas R

更新日期：1997-11-01 00:00:00

abstract：:Mature (peripheral) T-cell lymphoma (PTCL) other than anaplastic large cell lymphoma is a heterogeneous group of diseases and exceedingly rare in children and adolescents. Survival rates range between 46% and 85%. This study reports the disease characteristics, treatment and outcome of all patients with the diagnosis ...

journal_title：British journal of haematology

authors： Kontny U,Oschlies I,Woessmann W,Burkhardt B,Lisfeld J,Salzburg J,Janda A,Attarbaschi A,Niggli F,Zimmermann M,Reiter A,Klapper W

更新日期：2015-03-01 00:00:00

abstract：:A radioimmunoassay has been developed to measure platelet factor 4 (PF4) in biological fluids both in vitro and in vivo. The assay has been shown to be highly specific for PF4 and has a sensitivity of 0.08 ng/assay tube and 1.6 ng/ml of plasma. The preparation of plasma for the measurement of in vivo levels of PF4 req...

journal_title：British journal of haematology

authors： Chesterman CN,McGready JR,Doyle DJ,Morgan FJ

更新日期：1978-11-01 00:00:00

abstract：:Despite its' central role, the precise mechanisms of the phosphoinositide 3-kinase/Akt (PI3K)/Akt pathway activation in acute myeloid leukaemia (AML) have not been elucidated. Recently, a recurrent novel AKT1 pleckstrin homology domain (PHD) mutation leading to membrane translocation, constitutive AKT activation and l...

journal_title：British journal of haematology

authors： Tibes R,Kornblau SM,Qiu Y,Mousses SM,Robbins C,Moses T,Carpten JD

更新日期：2008-02-01 00:00:00

abstract：:Erythrocyte sedimentation, viscosity, electrophroetic mobility, and osmotic fragility were measured in a study of the rheological behaviour of the erythrocyte in vitro. In comparison with physiological saline solution, a suspending medium containing a gamma2lambda2 monoclonal IgG from a patient with multiple myeloma c...

journal_title：British journal of haematology

authors： Rovel A,Vigneron C,Streiff F

更新日期：1979-04-01 00:00:00

abstract：:The haematological changes in early years following neonatal diagnosis have been observed in representative groups of children with sickle cell-haemoglobin C (SC) disease, sickle cell-beta(+) thalassaemia, and in sickle cell-beta(0) thalassaemia. Most haematological indices in SC disease were intermediate between prev...

journal_title：British journal of haematology

authors： Stevens MC,Maude GH,Beckford M,Grandison Y,Mason K,Serjeant BE,Taylor B,Topley JM,Serjeant GR

更新日期：1985-06-01 00:00:00

abstract：:We have studied the surface expression of the Toll-like receptor family member CD 180 on cells from 78 patients with B-chronic lymphocytic leukaemia (B-CLL). B-CLL cells had variable levels of CD 180 expression, but this was always less than that expressed by normal blood B cells and was stable for 24 months. Signific...

journal_title：British journal of haematology

authors： Porakishvili N,Kulikova N,Jewell AP,Youinou PY,Yong K,Nathwani A,Heelan B,Duke V,Hamblin TJ,Wallace P,Ely P,Clark EA,Lydyard PM

更新日期：2005-11-01 00:00:00

abstract：:We tested four negative and two positive selection methods for separation of CD34+ cells from mobilized blood cells, and analysed fold-enrichment, purity and recovery of CD34+ cells after selection procedures. The elimination of mature CD34- cells was achieved by adhesion to nylon-wool fibre (5.9 +/- 1.0 mean fold-enr...

journal_title：British journal of haematology

authors： Di Nicola M,Bregni M,Siena S,Ruffini PA,Milanesi M,Ravagnani F,Gianni AM

更新日期：1996-09-01 00:00:00

abstract：:Mutations of the p53 tumour suppressor gene have frequently been observed in several types of solid tumours and are believed to be implicated in the development of these tumours. To determine the relevance of p53 mutations in haematologic neoplasms, we performed polymerase chain reaction-single strand conformation pol...

journal_title：British journal of haematology

authors： Mori N,Wada M,Yokota J,Terada M,Okada M,Teramura M,Masuda M,Hoshino S,Motoji T,Oshimi K

更新日期：1992-06-01 00:00:00

abstract：:It is widely recognized that thrombosis is the major event in the evolution of stable vascular disease to unstable ischaemic syndromes including myocardial infarction and stroke. The purpose of this case-control study was to establish clinical and laboratory data on the possible relationship between specific component...

journal_title：British journal of haematology

authors： Freeburn JC,Wallace JM,Strain JJ,Sinnamon DG,Craig BM,Johnson D,Gilmore WS

更新日期：1998-07-01 00:00:00

abstract：:Lack of consensus for first-line marginal zone lymphoma (MZL) treatment and toxicities associated with currently available systemic therapies have inspired evaluation of immunotherapeutic agents yielding robust outcomes with improved tolerability. We previously reported durable efficacy with first-line lenalidomide an...

journal_title：British journal of haematology

authors： Becnel MR,Nastoupil LJ,Samaniego F,Davis RE,You MJ,Green M,Hagemeister FB,Fanale MA,Fayad LE,Westin JR,Wang M,Oki Y,Forbes SG,Feng L,Neelapu SS,Fowler NH

更新日期：2019-06-01 00:00:00

abstract：:We studied the activity and stage of chronic liver disease in 45 HCV-seropositive/HIV-seronegative patients with severe haemophilia followed for at least 10 years. HCV-RNA was detected in serum in 36 patients (80%) Viraemic cases were further analysed for HCV genotypes: 10 (28%) were infected by type 1a, 10 (28%) by t...

journal_title：British journal of haematology

authors： Tagariello G,Pontisso P,Davoli PG,Ruvoletto MG,Traldi A,Alberti A

更新日期：1995-11-01 00:00:00

abstract：:Multiple myeloma (MM) is currently incurable, and novel therapies are needed. In this study, we examined a novel recombinant humanized monoclonal antibody against CD40 (rhuCD40 mAb) and demonstrate for the first time that rhuCD40 mAb induces antibody-dependent cell-mediated cytotoxicity (ADCC) against CD40-positive MM...

journal_title：British journal of haematology

authors： Hayashi T,Treon SP,Hideshima T,Tai YT,Akiyama M,Richardson P,Chauhan D,Grewal IS,Anderson KC

更新日期：2003-05-01 00:00:00

abstract：:We report two cases of acute myeloid leukaemia FAB classification M4Eo with high white cell counts at presentation, who developed acute respiratory failure with pulmonary infiltrates on chest radiograph soon after commencing conventional cytotoxic chemotherapy plus all-trans retinoic acid (ATRA). We suggest that in pa...

journal_title：British journal of haematology

authors： Lester WA,Hull DR,Fegan CD,Morris TC

更新日期：2000-06-01 00:00:00

abstract：:Due to the development of neurological toxicity and resistance to methotrexate (MTX), other antifolates have been evaluated for its potential replacement in the treatment of childhood acute lymphoblastic leukaemia (ALL). Aminopterin (AMT) has been suggested to provide clinical advantages over MTX and other antifolates...

journal_title：British journal of haematology

authors： Kang MH,Harutyunyan N,Hall CP,Papa RA,Lock RB

更新日期：2009-05-01 00:00:00

abstract：:A patient with pure red cell aplasia (PRCA) and autoimmune haemolytic anaemia (AIHA), associated with a thymoma which had already been removed, was studied in order to investigate the pathogenesis of PRCA and AIHA. The autoantibody eluted from the surface of the patient's red blood cells (RBC) reacted with the large E...

journal_title：British journal of haematology

authors： Taniguchi S,Shibuya T,Morioka E,Okamura T,Okamura S,Inaba S,Niho Y

更新日期：1988-04-01 00:00:00