The role of plasma exchange in the management of autoimmune disorders.

abstract：:We evaluated the presence of P-glycoprotein (P-gp)-170, multidrug resistance protein (MRP), lung resistance protein (LRP)-56 and Bcl-2 in CD19-positive cells from 100 cases of chronic lymphocytic leukaemia (CLL). P-gp-170 was found in 73% of the CLL cases with no significant difference regarding stage or previous trea...

journal_title：British journal of haematology

authors： Consoli U,Santonocito A,Stagno F,Fiumara P,Privitera A,Parisi G,Giustolisi GM,Pavone B,Palumbo GA,Di Raimondo F,Milone G,Guglielmo P,Giustolisi R

更新日期：2002-03-01 00:00:00

abstract：:We studied the outcome of 24 peripheral blood stem cell (PBSC) graft recipients, who were T-cell depleted (TCD) with either 20 mg (n = 14) or 10 mg (n = 10) Campath-1H in vitro, in comparison with a retrospective cohort of 23 unmanipulated (UM) PBSC recipients. While the neutrophil engraftment was similar, the platele...

journal_title：British journal of haematology

authors： Chakrabarti S,MacDonald D,Hale G,Holder K,Turner V,Czarnecka H,Thompson J,Fegan C,Waldmann H,Milligan DW

更新日期：2003-04-01 00:00:00

abstract：:CD37 is cell surface tetraspanin present on normal and malignant B cells. Otlertuzumab (TRU-016) is a novel humanized anti-CD37 protein therapeutic. Patients with relapsed or refractory follicular non-Hodgkin lymphoma (FL), mantle cell lymphoma (MCL), or Waldenström's macroglobulinaemia (WM) received otlertuzumab at 2...

journal_title：British journal of haematology

authors： Pagel JM,Spurgeon SE,Byrd JC,Awan FT,Flinn IW,Lanasa MC,Eisenfeld AJ,Stromatt SC,Gopal AK

更新日期：2015-01-01 00:00:00

abstract：:The importance of the subclassification of nodular sclerosing Hodgkin's disease (NSHD) according to the British National Lymphoma Investigation Group (BNLI) criteria, which had an independent prognostic value for 90 unselected patients diagnosed in our region in the period 1972-83, is still equivocal. Because survival...

journal_title：British journal of haematology

authors： van Spronsen DJ,Vrints LW,Hofstra G,Crommelin MA,Coebergh JW,Breed WP

更新日期：1997-02-01 00:00:00

abstract：:Human megakaryocytes have been isolated from marrow obtained from ribs removed at thoracotomy. All but one of the patients had normal pre-operative platelet and leucocyte counts. Megakaryocytes averaged 0.37% of all cells in marrow cell suspensions from nine consecutive subjects. A 283-fold purification (to 10.3%) was...

journal_title：British journal of haematology

authors： Levine RF

更新日期：1980-07-01 00:00:00

abstract：:Minimal residual disease (MRD) assessments were performed retrospectively after allogeneic stem cell transplantation (SCT) in 32 patients (23 children and nine adults) with acute lymphoblastic leukaemia (ALL). Using immunoglobulin and T-cell receptor rearrangements as clonal markers, MRD was detected after SCT in nine...

journal_title：British journal of haematology

authors： Uzunel M,Jaksch M,Mattsson J,Ringdén O

更新日期：2003-09-01 00:00:00

abstract：:A double-blind, crossover, placebo-controlled study of the effect of vitamin E on platelet functions was performed on nine splenectomized and 16 non-splenectomized beta-thalassaemia/haemoglobin E (beta-thalassaemia/HbE) patients. The patients were supplemented with a daily dose of vitamin E (525 IU) for 3 months. The ...

journal_title：British journal of haematology

authors： Unchern S,Laoharuangpanya N,Phumala N,Sipankapracha P,Pootrakul P,Fucharoen S,Wanachivanawin W,Chantharaksri U

更新日期：2003-11-01 00:00:00

abstract：:In recent years, the most common cause of infection in neutropenic patients has shifted from Gram-negative to Gram-positive bacteria. To compare the efficacy and toxicity of teicoplanin and vancomycin in neutropenic patients, we conducted a prospective study of 151 adult leukaemic patients hospitalized for intensive c...

journal_title：British journal of haematology

authors： Cony-Makhoul P,Brossard G,Marit G,Pellegrin JL,Texier-Maugein J,Reiffers J

更新日期：1990-12-01 00:00:00

abstract：:The haematological and immunological characteristics of 34 healthy anti-HTLV-I antibody-positive individuals (HTLV-I carriers) in southwestern Japan were examined. No significant difference was noted between carriers and the controls in counts of RBC, WBC and the absolute number of lymphocytes. The serum IgG in the ca...

journal_title：British journal of haematology

authors： Yasuda K,Sei Y,Yokoyama MM,Tanaka K,Hara A

更新日期：1986-09-01 00:00:00

abstract：:Erythrocyte sedimentation, viscosity, electrophroetic mobility, and osmotic fragility were measured in a study of the rheological behaviour of the erythrocyte in vitro. In comparison with physiological saline solution, a suspending medium containing a gamma2lambda2 monoclonal IgG from a patient with multiple myeloma c...

journal_title：British journal of haematology

authors： Rovel A,Vigneron C,Streiff F

更新日期：1979-04-01 00:00:00

abstract：:We analysed the results of haematopoietic cell transplantation (HCT) in 30 patients aged 60-78 (median 65) years, with primary myelofibrosis or myelofibrosis evolving from antecedent polycythaemia vera or essential thrombocythaemia. Donors were human leucocyte antigen (HLA)-identical siblings (N = 15) or unrelated ind...

journal_title：British journal of haematology

authors： Samuelson S,Sandmaier BM,Heslop HE,Popat U,Carrum G,Champlin RE,Storb R,Prchal JT,Gooley TA,Deeg HJ

更新日期：2011-04-01 00:00:00

abstract：:Plasmas having no detectable factor VIII-related antigen but moderate factor VIII coagulant were obtained from two unrelated dogs homozygous for von Willebrand's disease and with the severe clinical expression of the disease. when these plasmas were gel-filtered in a buffer at physiologic ionic strength, the factor VI...

journal_title：British journal of haematology

authors： Benson RE,Johnson GS,Dodds WJ

更新日期：1981-12-01 00:00:00

abstract：:Restriction fragment length polymorphisms (RFLP) of the X-chromosome genes phosphoglycerate kinase (PGK) and hypoxanthine phorphoribosyltransferase (HPRT) were used to determine the clonal nature of myelodysplastic syndromes (MDS) in 22 patients. These included eight with refractory anaemia (RA), four with RA with rin...

journal_title：British journal of haematology

authors： Tsukamoto N,Morita K,Maehara T,Okamoto K,Karasawa M,Omine M,Naruse T

更新日期：1993-04-01 00:00:00

abstract：:The economic impact of using prophylactic clodronate as an adjunct to chemotherapy in the management of multiple myeloma for the first 4 years following diagnosis was established from the perspective of the National Health Service (NHS). A state-transition model of the course of multiple myeloma was constructed using ...

journal_title：British journal of haematology

authors： Bruce NJ,McCloskey EV,Kanis JA,Guest JF

更新日期：1999-02-01 00:00:00

abstract：:In this study we investigated the proliferation of three well-documented MM lines and 10 bone marrow samples from myeloma patients in response to rh-SCF alone and combined with Interleukin-6 (IL-6), IL-3 and IL-3/GM-CSF fusion protein PIXY 321. Neoplastic plasma cells were highly purified (> 90%) by immunomagnetic dep...

journal_title：British journal of haematology

authors： Lemoli RM,Fortuna A,Grande A,Gamberi B,Bonsi L,Fogli M,Amabile M,Cavo M,Ferrari S,Tura S

更新日期：1994-12-01 00:00:00

abstract：:The presence of small amounts of C3d on freshly obtained normal red blood cells (RBC) was demonstrated by a radio-labelled antiglobulin technique; this increased 1.5-fold after incubation in fresh normal serum. No significant further increase in bound C3d was demonstrated for cDE/cDE, CDe/CDe, -D-/-D- RBC maximally se...

journal_title：British journal of haematology

authors： Freedman J,Massey A,Chaplin H,Monroe MC

更新日期：1980-06-01 00:00:00

abstract：:Imatinib mesylate is useful for facilitating allogeneic stem cell transplantation (allo-SCT) in advanced-phase chronic myelogenous leukaemia (AP-CML) patients. However, although the side-effects of imatinib are usually minor, cardiac morbidity can develop as a latent adverse effect post SCT when a myeloablative SCT is...

journal_title：British journal of haematology

authors： Sohn SK,Kim JG,Kim DH,Lee KB

更新日期：2003-05-01 00:00:00

abstract：:In a retrospective study, we examined the association between cytomegalovirus (CMV) infection and non-neutropenic fever immediately following autologous peripheral blood stem cell transplantation for a variety of haematological malignancies and solid tumours. Sixty non-neutropenic febrile episodes (41 in CMV-seroposit...

journal_title：British journal of haematology

authors： Fassas AB,Bolaños-Meade J,Buddharaju LN,Rapoport A,Cottler-Fox M,Chen T,Lovchik JC,Cross A,Tricot G

更新日期：2001-01-01 00:00:00

abstract：:Bone mineral content (BMC) of the radius was measured using single photon absorptiometry (SPA) in nine children with congenital neutropenia. Five had normal values. Two children with severe congenital neutropenia (SCN) had low BMC, and two boys with Schwachman syndrome had biochemistry suggestive of rickets. ...

journal_title：British journal of haematology

authors： Fewtrell MS,Kinsey SE,Williams DM,Bishop NJ

更新日期：1997-06-01 00:00:00

abstract：:Smouldering multiple myeloma (SMM) presents without MM defining symptoms. We aimed to identify patients with SMM with an 80% risk of progression within 2 years using only serum parameters. In total, 527 patients with SMM were included and divided into a training group (287 patients from the Czech Myeloma Group [CMG]) ...

journal_title：British journal of haematology

authors： Hájek R,Sandecka V,Špička I,Raab M,Goldschmidt H,Beck S,Minařík J,Pavlíček P,Radocha J,Heindorfer A,Jelínek T,Stejskal L,Brožová L,Ševčíková S,Straub J,Pika T,Pour L,Maisnar V,Seckinger A,Hose D

更新日期：2020-07-01 00:00:00

abstract：:Clonal T cells that cause pure red cell aplasia were demonstrated in a patient with chronic B-cell lymphocytic leukaemia. The T-cell fraction was enriched by the immunomagnetic method and shown to have T-cell receptor-beta gene rearrangement. Cryopreserved T cells, obtained during the period of anaemia, suppressed aut...

journal_title：British journal of haematology

authors： Yamada O,Yun-Hua W,Motoji T,Mizoguchi H

更新日期：1998-05-01 00:00:00

abstract：:Guidelines for the use of polymerase chain reaction (PCR)-based assays to aid the diagnosis of invasive aspergillosis (IA) in high-risk haematology patients have not been formulated. We prospectively evaluated a nested PCR assay to detect Aspergillus in blood during 95 febrile neutropenic episodes, in patients with ha...

journal_title：British journal of haematology

authors： Halliday C,Hoile R,Sorrell T,James G,Yadav S,Shaw P,Bleakley M,Bradstock K,Chen S

更新日期：2006-02-01 00:00:00

abstract：:The F5 G1691A (Factor V Leiden) and F2 G20210A (prothrombin) mutations are linked to an increase in the incidence rate of venous thromboembolism (VTE), but their effects are highly variable. We investigated whether the effects of smoking and obesity might explain this variability. In a case-cohort study including the ...

journal_title：British journal of haematology

authors： Severinsen MT,Overvad K,Johnsen SP,Dethlefsen C,Madsen PH,Tjønneland A,Kristensen SR

更新日期：2010-04-01 00:00:00

abstract：:Much of the variability in the sensitivity to warfarin in anticoagulated patients is associated with the c.-1639G > A polymorphism of the vitamin K-epoxide reductase (VKORC1) gene. However, its association with the acenocoumarol dose in patients under anticoagulant therapy has not been studied. The c.-1639G > A genoty...

journal_title：British journal of haematology

authors： Montes R,Ruiz de Gaona E,Martínez-González MA,Alberca I,Hermida J

更新日期：2006-04-01 00:00:00

abstract：:Thrombocytopenia absent radii (TAR) syndrome is clearly defined by the combination of radial aplasia and reduced platelet counts. The genetics of TAR syndrome has recently been resolved and comprises a microdeletion on Chromosome 1 including the RBM8A gene and a single nucleotide polymorphism (SNP) either at the 5' un...

journal_title：British journal of haematology

authors： Manukjan G,Bösing H,Schmugge M,Strauß G,Schulze H

更新日期：2017-11-01 00:00:00

abstract：:The replicative potential of human CD56(+) CD3(-) natural killer (NK) cells is unknown. We found that by exposing NK cells to the leukaemic cell line K562 genetically modified to express 4-1BB ligand and interleukin 15 (K562-mb15-41BBL), they expanded for up to 30 population doublings, achieving numbers that ranged fr...

journal_title：British journal of haematology

authors： Fujisaki H,Kakuda H,Imai C,Mullighan CG,Campana D

更新日期：2009-06-01 00:00:00

abstract：:Minimal residual disease (MRD) in acute myeloid leukaemia (AML) poses a major challenge due to drug insensitivity and high risk of relapse. Intensification of chemotherapy and stem cell transplantation are often pivoted on MRD status. Relapse rates are high even with the integration of first-generation FMS-like tyrosi...

journal_title：British journal of haematology

authors： Zabkiewicz J,Lazenby M,Edwards G,Bygrave CA,Omidvar N,Zhuang L,Knapper S,Guy C,Hills RK,Burnett AK,Alvares CL

更新日期：2020-10-01 00:00:00

abstract：:Sickle cell disease (SCD) is increasingly appreciated as an inflammatory condition associated with alterations in immune phenotype and function. In this cross-sectional study we performed a multiparameter analysis of 18 immune markers in 114 paediatric SCD patients divided by treatment group [those receiving hydroxycr...

journal_title：British journal of haematology

authors： Nickel RS,Osunkwo I,Garrett A,Robertson J,Archer DR,Promislow DE,Horan JT,Hendrickson JE,Kean LS

更新日期：2015-05-01 00:00:00

abstract：:Therapeutic options for treatment of recurrence of leukaemia after allogeneic bone marrow transplantation (BMT) are limited. A beneficial effect of donor lymphocyte infusions (DLI) has not previously been described in acute myeloid leukaemia (AML) relapse. We report a case of AML with t(8;21), relapsing 3 months after...

journal_title：British journal of haematology

authors： Buzyn-Veil A,Belanger C,Audat F,Hermine O,Bodemer C,Ribrag V,Radford I,Poirel H,Chane C,Valensi F,Macintyre E,Varet B

更新日期：1996-02-01 00:00:00

abstract：:The contribution of red cell size (mean cell volume) to the clinical and haematological manifestations of homozygous sickle cell (SS) disease has been investigated by comparing the features of two groups of patients with low (less than or equal to 80 fl) and high (greater than 95 fl) MCV values after matching for age,...

journal_title：British journal of haematology

authors： Serjeant GR,Foster K,Serjeant BE

更新日期：1981-07-01 00:00:00