Cardiac morbidity in advanced chronic myelogenous leukaemia patients treated by successive allogeneic stem cell transplantation with busulphan/cyclophosphamide conditioning after imatinib mesylate administration.

Abstract:

:Imatinib mesylate is useful for facilitating allogeneic stem cell transplantation (allo-SCT) in advanced-phase chronic myelogenous leukaemia (AP-CML) patients. However, although the side-effects of imatinib are usually minor, cardiac morbidity can develop as a latent adverse effect post SCT when a myeloablative SCT is given to patients taking imatinib. Two AP-CML patients who were treated with imatinib manifested severe cardiac dysfunction after an allo-SCT, whereas cardiac morbidity was not observed in 45 other patients who had not received imatinib. It would appear that exposure to imatinib may have an adverse impact on the heart in AP-CML patients who receive an allo-SCT conditioned with busulphan/cyclophosphamide.

journal_name

Br J Haematol

authors

Sohn SK,Kim JG,Kim DH,Lee KB

doi

10.1046/j.1365-2141.2003.04288.x

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

469-72

issue

3

eissn

0007-1048

issn

1365-2141

pii

4288

journal_volume

121

pub_type

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