Clonal T-cell proliferation causing pure red cell aplasia in chronic B-cell lymphocytic leukaemia: successful treatment with cyclosporine following in vitro abrogation of erythroid colony-suppressing activity.

abstract：:This study assessed the relevance of 2013 European LeukaemiaNet (ELN) response categories on patients treated with common frontline tyrosine kinase inhibitors (TKI) in chronic myeloid leukaemia in chronic phase (CML-CP). Four hundred and eighty-seven patients treated with imatinib (400 mg; IM 400, n = 70; 800 mg; IM80...

journal_title：British journal of haematology

authors： Jain P,Kantarjian H,Sasaki K,Jabbour E,Dasarathula J,Nogueras Gonzalez G,Verstovsek S,Borthakur G,Wierda W,Kadia T,Dellasala S,Pierce S,Ravandi F,O'Brien S,Cortes J

更新日期：2016-04-01 00:00:00

abstract：:The isoferritin composition of serum ferritin in 13 patients with untreated idiopathic haemochromatosis (IHC) has been shown to differ from normal in exhibiting an increase in isoferritins in the pH range 5.54-5.62. A similar change was observed in four patients with gross iron overload secondary to haemolytic anaemia...

journal_title：British journal of haematology

authors： Halliday JW,McKeering LV,Tweedale R,Powell LW

更新日期：1977-07-01 00:00:00

abstract：:Parental longevity is associated with an increased life expectancy; results with regard to specific diseases are conflicting. There are limited data focusing on host characteristics and their effect on survival among multiple myeloma (MM) patients and individuals with monoclonal gammopathy of undetermined significance...

journal_title：British journal of haematology

authors： Sverrisdóttir IS,Lund SH,Turesson I,Björkholm M,Goldin LR,Landgren O,Kristinsson SY

更新日期：2019-07-01 00:00:00

abstract：:Nijmegen breakage syndrome (NBS) is an autosomal recessive DNA repair disorder with a high predisposition for lymphoid malignancies. The majority of NBS patients carry a homozygous founder mutation (657del5) within the NBS1 gene. The observation of a high incidence of cancer in close relatives of NBS patients suggests...

journal_title：British journal of haematology

authors： Stanulla M,Stümm M,Dieckvoss BO,Seidemann K,Schemmel V,Müller Brechlin A,Schrappe M,Welte K,Reiter A

更新日期：2000-04-01 00:00:00

abstract：:Hereditary angioedema (HAE) is a rare autosomal dominant genetic disorder clinically characterized by recurrent attacks of subcutaneous and mucosal swelling that can result in significant morbidity and even mortality. Several novel therapies introduced since 2008 have dramatically transformed the approach to managemen...

journal_title：British journal of haematology

authors： Zuraw BL,Christiansen SC

更新日期：2016-06-01 00:00:00

abstract：:We used minisatellite probes to analyse by DNA fingerprints the long-term engraftment (median 4.3 years, range 1-2) of 21 bone marrow transplantation recipients for severe aplastic anaemia. Patients received their graft from histocompatible siblings. They were conditioned with cyclophosphamide (150 mg/kg) and a 6GY th...

journal_title：British journal of haematology

authors： Keable H,Bourhis JH,Brison O,Lehn P,Schenmetzler C,Devergie A,Gluckman E

更新日期：1989-04-01 00:00:00

abstract：:Pentose phosphate shunt activity was studied by the release of 14CO2 from 14C-1-glucose and 14C-2-glucose in the red cells of five patients with pyruvate kinase deficiency and found to be significantly decreased after new methylene blue stimulation when compared to high reticulocyte controls. Incubated Heinz body form...

journal_title：British journal of haematology

authors： Tomoda A,Lachant NA,Noble NA,Tanaka KR

更新日期：1983-07-01 00:00:00

abstract：:Hydroxycarbamide (HC) (or hydroxyurea) has been reported to increase fetal haemoglobin levels and improve clinical symptoms in sickle cell anaemia (SCA) patients. However, the complete pathway by which HC acts remains unclear. To study the mechanisms involved in the action of HC, global gene expression profiles were o...

journal_title：British journal of haematology

authors： Costa FC,da Cunha AF,Fattori A,de Sousa Peres T,Costa GG,Machado TF,de Albuquerque DM,Gambero S,Lanaro C,Saad ST,Costa FF

更新日期：2007-01-01 00:00:00

abstract：:The routine methods for estimating erythrocyte size (volume and surface area) are not generally unbiased. Using geometric models introduces a bias determined by the ways in which real red blood corpuscles depart in size and shape from the simplistic ideal. Employing haematocrit and red corpuscle count to estimate mean...

journal_title：British journal of haematology

authors： Mayhew TM,Mwamengele GL,Self TJ,Travers JP

更新日期：1994-02-01 00:00:00

abstract：:Knowledge of the absolute and relative risk of venous thromboembolism (VTE) in and around pregnancy would be crucial in identifying when to commence and cease thromboprophylaxis in women who would benefit from such intervention. We addressed this hypothesis using a large prospective primary care database from the Unit...

journal_title：British journal of haematology

authors： Sultan AA,West J,Tata LJ,Fleming KM,Nelson-Piercy C,Grainge MJ

更新日期：2012-02-01 00:00:00

abstract：:Erythroid colonies derived from the circulating early erythroid precursor (BFU-E) of a patient with congenital dyserythropoietic anaemia type I (CDA I) have been grown in plasma clot and studied by electron microscopy. The number of circulating BFU-E was in the normal range with a roughly normal appearance at the ligh...

journal_title：British journal of haematology

authors： Vainchenker W,Guichard J,Bouguet J,Breton-Gorius J

更新日期：1980-09-01 00:00:00

abstract：:A 6-month-old male infant with hereditary spherocytosis (HS) who was the first child of a cousin marriage is presented. The patient had splenomegaly and severe anaemia. Examination of the peripheral blood smear revealed spherocytes and the osmotic fragility of red blood cells was greatly increased. Physical examinatio...

journal_title：British journal of haematology

authors： Duru F,Gürgey A,Oztürk G,Yörükan S,Altay C

更新日期：1992-11-01 00:00:00

abstract：:MDX-1097 is an antibody specific for a unique B cell antigen called kappa myeloma antigen (KMA) that consists of cell membrane-associated free kappa light chain (κFLC). KMA was detected on kappa human multiple myeloma cell lines (κHMCLs), on plasma cells (PCs) from kappa multiple myeloma (κMM) patients and on κPC dysc...

journal_title：British journal of haematology

authors： Asvadi P,Cuddihy A,Dunn RD,Jiang V,Wong MX,Jones DR,Khong T,Spencer A

更新日期：2015-05-01 00:00:00

abstract：:The spleen acts as a blood filter and lymphopoietic organ. Asplenic and hyposplenic individuals are more susceptible to serious infections caused by encapsulated bacteria but they can be protected by antibiotic prophylaxis and immunizations. Recent progress in vaccinology means prophylaxis is now successful in the vas...

journal_title：British journal of haematology

authors： Kuchar E,Miśkiewicz K,Karlikowska M

更新日期：2015-12-01 00:00:00

abstract：:Plasma iron turnover (PIT) and ferritin synthesis in the liver and spleen were studied in rats within the first 24 h of inflammation produced by turpentine injection. Comparison of the sequential changes in PIT and ferritin synthesis showed that alterations in ferritin synthesis preceded the changes in plasma iron exc...

journal_title：British journal of haematology

authors： Konijn AM,Hershko C

更新日期：1977-09-01 00:00:00

abstract：:Death during the induction phase of chemotherapy remains a common event in patients with aggressive non-Hodgkin's lymphoma (NHL). In a series of patients with aggressive NHL homogeneously treated with intensive induction chemotherapy [ACVB (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) regimen], we ...

journal_title：British journal of haematology

authors： Dumontet C,Mounier N,Munck JN,Bosly A,Morschauser F,Simon D,Marit G,Casasnovas O,Reman O,Molina T,Reyes F,Coiffier B

更新日期：2002-07-01 00:00:00

abstract：:Follow-up studies of natural killer (NK) cells, NK activity and antibody dependent cellular cytotoxicity (ADCC) in the course of hairy cell leukaemia (HCL) were carried out in a series of patients affected by the disease. NK activity against K562 targets was found to be high in all the patients with non-symptomatic st...

journal_title：British journal of haematology

authors： Demeter J,Pálóczi K,Lehoczky D,Benczúr M

更新日期：1989-02-01 00:00:00

abstract：:Five out of nine adults (55%) with lymphoblastic disease developed severe avascular necrosis of bone (AVN) when treated with a Berlin-Frankfurt-Munster (BFM) ALL protocol similar to the current joint MRC-ECOG ALL trial (UKALL XII). The principal purpose of these intensified regimens is to improve long-term disease-fre...

journal_title：British journal of haematology

authors： Chan-Lam D,Prentice AG,Copplestone JA,Weston M,Williams M,Hutton CW

更新日期：1994-01-01 00:00:00

abstract：:Erythroid regeneration is an important and separate element in the engraftment process in allogeneic and autologous bone marrow transplantation (alloBMT, autoBMT). Qualitative visual reticulocyte counting has proved inadequate in the evaluation of erythropoiesis after BMT but automated flow cytometry now allows the re...

journal_title：British journal of haematology

authors： Davies SV,Cavill I,Bentley N,Fegan CD,Poynton CH,Whittaker JA

更新日期：1992-05-01 00:00:00

abstract：:We report a series of 20 patients with the myelodysplastic syndrome (MDS) each with a coexistent lymphoid or plasmacytic neoplasm. In none of the patients did chemotherapy play a part in the pathogenesis. The possible reasons for the coincidence of these conditions are discussed. The frequency and variety of associate...

journal_title：British journal of haematology

authors： Copplestone JA,Mufti GJ,Hamblin TJ,Oscier DG

更新日期：1986-05-01 00:00:00

abstract：:A retrospective study of 37 patients with haematological malignancy (21 acute myeloid leukaemia, 11 acute lymphoid leukaemia, two lymphoma, two hairy cell leukaemia, one Hodgkin's disease) and histologically documented mucormycosis was conducted to evaluate the clinical characteristics and ascertain the factors which ...

journal_title：British journal of haematology

authors： Pagano L,Ricci P,Tonso A,Nosari A,Cudillo L,Montillo M,Cenacchi A,Pacilli L,Fabbiano F,Del Favero A

更新日期：1997-11-01 00:00:00

abstract：:Epistaxis is a common problem amongst anti-coagulated patients. Application of first-aid principles can control the majority of bleeds. In our sample of 60 patients attending the anticoagulant clinic, 40% were unable to think of a single measure that would be helpful in controlling a nose bleed. 6 weeks after being gi...

journal_title：British journal of haematology

authors： Lavy J

更新日期：1996-10-01 00:00:00

abstract：:A comparison has been made between the prothrombin time test using British Comparative Thromboplastin (BCT) and a chromogenic substrate assay for factor VII in the assessment of laboratory control of oral anticoagulants in short-term and long-term patients. Opportunity was also taken to compare the findings with paral...

journal_title：British journal of haematology

authors： Poller L,Thomson JM,Bodzenta A,Easton AC,Latallo ZS,Chmielewska J

更新日期：1981-09-01 00:00:00

abstract：:Simultaneous evaluation of coagulation and fibrinolysis facilitates an overall understanding of normal and pathological haemostasis. We established an assay for assessing clot formation and fibrinolysis simultaneously using clot waveform analysis by the trigger of a mixture of activated partial thromboplastin time rea...

journal_title：British journal of haematology

authors： Nogami K,Matsumoto T,Sasai K,Ogiwara K,Arai N,Shima M

更新日期：2019-11-01 00:00:00

abstract：:Sideroblastic anaemia includes a heterogeneous group of rare conditions, characterized by decreased haem synthesis and mitochondrial iron overload, which are diagnosed by the presence of ringed sideroblasts in the bone marrow aspirate. The most frequent form is X-linked sideroblastic anaemia, caused by mutations of de...

journal_title：British journal of haematology

authors： Camaschella C

更新日期：2008-10-01 00:00:00

abstract：:Chemokines are a family of over 40 small (8 kDa) related proteins with the function of moving cells along a chemotactic gradient, either to organise cells within an organ or to facilitate the movement of leucocytes around the body. Mouse models have implicated the importance of the chemokine CXCL12 in haematopoiesis a...

journal_title：British journal of haematology

authors： Laurence AD

更新日期：2006-02-01 00:00:00

abstract：:An efficient method for the culture of human megakaryocyte precursors in serum-free medium has been developed facilitating study of the effect of regulators of megakaryocyte growth and maturation without interference by serum-derived factors. We have investigated how megakaryocytes and their precursors respond to the ...

journal_title：British journal of haematology

authors： Plantier JL,Berthier R,Rival Y,Schweitzer A,Rabiet MJ

更新日期：1994-08-01 00:00:00

abstract：:CD19 and CD21 (CR2) are co-receptors found on B-cells and various B-cell lymphomas, including non-Hodgkin lymphoma. To evaluate their suitability as targets for therapy of such lymphomas using internalization-dependent antibody-drug conjugates [such as antibody-4-(N-maleimidomethyl)cyclohexane-1-carboxylate, (N2'-deac...

journal_title：British journal of haematology

authors： Ingle GS,Chan P,Elliott JM,Chang WS,Koeppen H,Stephan JP,Scales SJ

更新日期：2008-01-01 00:00:00

abstract：:In the last few years, mutations that cause disease through increased efficiency of mRNA translation have been discovered. Hereditary hyperferritinaemia-cataract syndrome (HHCS) arises from various point mutations or deletions within the iron-responsive element (IRE) in the 5'-UTR of the L-ferritin mRNA. Each unique m...

journal_title：British journal of haematology

authors： Cazzola M,Foglieni B,Bergamaschi G,Levi S,Lazzarino M,Arosio P

更新日期：2002-03-01 00:00:00

abstract：:Screening of the skeleton by plain radiography was compared to magnetic resonance imaging (MRI) of the lumbar spine in 41 patients with multiple myeloma. In the lumbar spine, myeloma lesions were detected in 15 patients with radiography and in 28 patients with MRI. Radiography of the lumbar spine was not positive in a...

journal_title：British journal of haematology

authors： Tertti R,Alanen A,Remes K

更新日期：1995-11-01 00:00:00