Mutations of the p53 tumour suppressor gene in haematologic neoplasms.


:Mutations of the p53 tumour suppressor gene have frequently been observed in several types of solid tumours and are believed to be implicated in the development of these tumours. To determine the relevance of p53 mutations in haematologic neoplasms, we performed polymerase chain reaction-single strand conformation polymorphism analysis on the p53 gene in 45 patients with various types of haematologic neoplasms. In exons 5-8 containing highly conserved regions, mobility shifts indicating sequence alterations were detected in four of the 45 patients, and subsequent sequencing was performed. A point mutation resulting in a novel stop codon was detected at codon 213 in one of 23 cases of chronic myelogenous leukaemia (one of five cases of blast crisis). Point mutations causing amino acid substitutions were detected in one of four cases of myelodysplastic syndrome at codon 195, one of three cases of adult T-cell leukaemia at codon 281, and one of eight cases of acute lymphoblastic leukaemia at codon 281, and these missense mutations were accompanied by loss of the wild type allele. Patients harbouring these nonsense and missense mutations were in advanced disease stages. These findings suggest that mutational inactivation of the p53 gene is infrequent but is involved in the tumorigenesis of several types of haematologic neoplasms at least in some cases.


Br J Haematol


Mori N,Wada M,Yokota J,Terada M,Okada M,Teramura M,Masuda M,Hoshino S,Motoji T,Oshimi K




Has Abstract,Author List Incomplete


1992-06-01 00:00:00












  • Is the beta thalassaemia trait of clinical importance?

    abstract::Although the beta thalassaemia trait affects millions of people worldwide, there have been no controlled studies to determine whether it is associated with any clinical disability or abnormal physical signs. To address this question, 402 individuals were studied: 217 with beta thalassaemia trait, of whom 154 were awar...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Premawardhena A,Arambepola M,Katugaha N,Weatherall DJ

    更新日期:2008-05-01 00:00:00

  • Quantitation of subclasses of mononuclear cells in normal human blood by membrane receptor studies.

    abstract::A technique for quantitating mononuclear cells expressing E, EA(IgG), EAC receptors, immunoglobulin carrying cells and phagocytic cells in normal human venous blood is described; normal values for each of these classes of mononuclear cell are established. The effects of different methods of cell preparation have been ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Habeshaw JA,Young GA

    更新日期:1975-01-01 00:00:00

  • Homozygosity for dominant form of hereditary spherocytosis.

    abstract::A 6-month-old male infant with hereditary spherocytosis (HS) who was the first child of a cousin marriage is presented. The patient had splenomegaly and severe anaemia. Examination of the peripheral blood smear revealed spherocytes and the osmotic fragility of red blood cells was greatly increased. Physical examinatio...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Duru F,Gürgey A,Oztürk G,Yörükan S,Altay C

    更新日期:1992-11-01 00:00:00

  • Effect of hydrocortisone on long-term human marrow cultures.

    abstract::In human long-term marrow cultures a relatively high concentration of hydrocortisone (10(-6) M or more) is necessary for the development and subsequent maintenance of some cellular components in the adherent cell layer. However, such concentrations of hydrocortisone seem to be inhibitory for the production of granuloc...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Suda T,Dexter TM

    更新日期:1981-08-01 00:00:00

  • Stem cell mobilization in normal donors for allogeneic transplantation: analysis of safety and factors affecting efficacy.

    abstract::The use of peripheral blood stem cells instead of bone marrow as the source of haemopoietic cells for allogeneic transplantation is being increasingly explored. We have analysed data from 17 normal donors who underwent stem cell mobilization for allogeneic transplantation with an identical protocol using G-CSF at a do...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Miflin G,Charley C,Stainer C,Anderson S,Hunter A,Russell N

    更新日期:1996-11-01 00:00:00

  • Cyclosporin A in the treatment of severe acute aplastic anaemia.

    abstract::Twelve consecutive adults with severe acute aplastic anaemia, not having a bone marrow transplantation option, were prospectively randomized to receive either cyclosporin A alone or an equivalent amount of this immunosuppressive agent in combination with antilymphocyte serum. The minimum follow-up is 36 months, with h...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jacobs P,Wood L,Martell RW

    更新日期:1985-10-01 00:00:00

  • Recombinant, activated factor VII for surgery in factor VII deficiency: a prospective evaluation - the surgical STER.

    abstract::Excessive bleeding represents a major complication of surgical interventions and its control is especially relevant in patients with Congenital Bleeding Disorders (CBD). In factor VII (FVII) deficiency, scanty data on surgery is available to guide treatment strategies. The STER (Seven Treatment Evaluation Registry) is...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Mariani G,Dolce A,Batorova A,Auerswald G,Schved JF,Siragusa S,Napolitano M,Knudsen JB,Ingerslev J,STER and the International Factor VII Deficiency Study Groups.

    更新日期:2011-02-01 00:00:00

  • Interleukin-6 inhibits the chemotaxis of human malignant plasma cell lines.

    abstract::The chemotaxis of human malignant plasma cells is promoted by two extracellular matrix proteins (ECMs): fibronectin (FN) and laminin (LN). We examined the effect of the supernatant from a bone marrow stroma cell line, KM-101, on the chemotaxis of human malignant plasma cell lines to assess the chemotaxis-regulatory ro...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Shibayama H,Tagawa S,Hattori H,Harigaya K,Taga T,Machii T,Kitani T

    更新日期:1996-06-01 00:00:00

  • Double-negative regulatory T cells induce allotolerance when expanded after allogeneic haematopoietic stem cell transplantation.

    abstract::Double-negative (DN) regulatory T cells (Tregs) are specialized T lymphocytes involved in the down-modulation of immune responses, resulting in allotolerance after allogeneic haematopoietic stem cell transplantation (HSCT). Most of the properties of DN Tregs were identified in murine models, including the unique abili...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: McIver Z,Serio B,Dunbar A,O'Keefe CL,Powers J,Wlodarski M,Jin T,Sobecks R,Bolwell B,Maciejewski JP

    更新日期:2008-04-01 00:00:00

  • Allodepleted T-cell immunotherapy after haploidentical haematopoietic stem cell transplantation without severe acute graft-versus-host disease (GVHD) in the absence of GVHD prophylaxis.

    abstract::Graft-versus-host disease (GVHD) is a major cause of transplant-related mortality (TRM) after allogeneic haematopoietic stem cell transplantation (HSCT) and presents a challenge in haploidentical HSCT. GVHD may be prevented by ex vivo graft T-cell depletion or in vivo depletion of proliferating lymphocytes. However, b...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Roy DC,Lachance S,Cohen S,Delisle JS,Kiss T,Sauvageau G,Busque L,Ahmad I,Bernard L,Bambace N,Boumédine RS,Guertin MC,Rezvani K,Mielke S,Perreault C,Roy J

    更新日期:2019-09-01 00:00:00

  • Clonal T-cell proliferation causing pure red cell aplasia in chronic B-cell lymphocytic leukaemia: successful treatment with cyclosporine following in vitro abrogation of erythroid colony-suppressing activity.

    abstract::Clonal T cells that cause pure red cell aplasia were demonstrated in a patient with chronic B-cell lymphocytic leukaemia. The T-cell fraction was enriched by the immunomagnetic method and shown to have T-cell receptor-beta gene rearrangement. Cryopreserved T cells, obtained during the period of anaemia, suppressed aut...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Yamada O,Yun-Hua W,Motoji T,Mizoguchi H

    更新日期:1998-05-01 00:00:00

  • BIOMED-2 PCR assays for IGK gene rearrangements are essential for B-cell clonality analysis in follicular lymphoma.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Payne K,Wright P,Grant JW,Huang Y,Hamoudi R,Bacon CM,Du MQ,Liu H

    更新日期:2011-10-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Lass-Flörl C,Griff K,Mayr A,Petzer A,Gastl G,Bonatti H,Freund M,Kropshofer G,Dierich MP,Nachbaur D

    更新日期:2005-10-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Giulino-Roth L,Goldman S

    更新日期:2016-05-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Castillo JJ,Abeykoon JP,Gustine JN,Zanwar S,Mein K,Flynn CA,Demos MG,Guerrera ML,Kofides A,Liu X,Munshi M,Tsakmaklis N,King R,Yang G,Hunter ZR,Advani RH,Palomba ML,Ansell SM,Gertz MA,Kapoor P,Treon SP

    更新日期:2020-11-18 00:00:00

  • The use of anti-T-cell receptor-Vbeta antibodies for the estimation of treatment success and phenotypic characterization of clonal T-cell populations in cutaneous T-cell lymphomas.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Schwab C,Willers J,Niederer E,Ludwig E,Kündig T,Grob P,Burg G,Dummer R

    更新日期:2002-09-01 00:00:00

  • Lymphocytes from multi-transfused patients exhibit cytotoxicity against autologous cells.

    abstract::We previously demonstrated that multitransfused patients with severe aplastic anaemia (SAA) exhibit high numbers of alloreactive cytotoxic T lymphocyte precursors directed against their HLA identical siblings. In this study a group of patients who had received multiple blood transfusions for SAA, other haematological ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Kaminski ER,Hows JM,Goldman JM,Batchelor JR

    更新日期:1992-05-01 00:00:00

  • A possible anti-emetic role for sodium valproate in cytotoxic chemotherapy.

    abstract::We report two patients with acute leukaemia who received emetogenic cytotoxic drugs and were on therapeutic doses of sodium valproate for epilepsy. Neither patient reported significant nausea nor vomited at any time during the chemotherapy, at times requiring no anti-emetic treatment whatsoever. We suggest that this a...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Aiken TC,Collin RC

    更新日期:1995-04-01 00:00:00

  • The relationship between serum viscosity, hypervolaemia and clinical manifestations associated with circulating paraprotein.

    abstract::In 44 of 56 patients with malignant paraproteinaemia the relationship of serum viscosity, plasma volume (PV), estimated blood volume (BV) and clinical findings was investigated and in the remaining 12 patients one or more of these parameters was studied. There was a correlation between increased PV and serum viscosity...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Russell JA,Powles RL

    更新日期:1978-06-01 00:00:00

  • Low-dose aspirin does not lower in vivo platelet activation in healthy smokers.

    abstract::Smoking causes atherosclerosis, and smokers have increased thromboxane (TXA2) formation. As aspirin inhibits TXA2 production we speculated that smokers would preferentially profit from inhibition of the TXA2 pathway by aspirin. Increased expression of P-selectin, a constituent of the alpha-granules of platelets, and i...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pernerstorfer T,Stohlawetz P,Stummvoll G,Kapiotis S,Szekeres T,Eichler HG,Jilma B

    更新日期:1998-09-01 00:00:00

  • Results of a UK National Cancer Research Institute Phase II study of brentuximab vedotin using a response-adapted design in the first-line treatment of patients with classical Hodgkin lymphoma unsuitable for chemotherapy due to age, frailty or comorbidity

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Gibb A,Pirrie SJ,Linton K,Warbey V,Paterson K,Davies AJ,Collins GP,Menne T,McKay P,Fields PA,Miall FM,Nagy E,Wheatley K,Reed R,Baricevic-Jones I,Barrington S,Radford J

    更新日期:2020-09-14 00:00:00

  • Prolonged disease-free survival in relapsed/refractory low-grade lymphoma treated with fludarabine: a report of four cases.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Sternberg AJ,Matutes E,Killick S,Wotherspoon AC,Catovsky D

    更新日期:1998-07-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Fouzia NA,Sharma V,Ganesan S,Palani HK,Balasundaram N,David S,Kulkarni UP,Korula A,Devasia AJ,Nair SC,Janet NB,Abraham A,Mani T,Lakshmanan J,Balasubramanian P,George B,Mathews V

    更新日期:2021-01-01 00:00:00

  • Translocation t(3;17)(q23;q21): a new translocation in acute lymphoblastic leukaemia.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Raanani P,Berkowicz M,Rosner E,Rosenthal E,Berman S,Rechavi G,Ben-Bassat I

    更新日期:1996-10-01 00:00:00

  • Bleeding time, blood groups and von Willebrand factor.

    abstract::The bleeding time in healthy volunteers was determined according to both the Ivy and the Simplate II techniques. A significantly longer bleeding time in people with blood group O than in people with non-O blood groups was demonstrated with both techniques. This difference could not be attributed to a difference in sex...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Caekebeke-Peerlinck KM,Koster T,Briët E

    更新日期:1989-10-01 00:00:00

  • Collection of peripheral blood stem cells from normal donors 60 years of age or older.

    abstract::We report 14 normal peripheral blood stem cell (PBSC) donors > or = 60 years of age who had cytokine mobilization followed by PBSC apheresis for allogeneic transplantation. Mobilization was achieved with filgrastim (6 microg/kg twice daily). Their median age was 63.5 years (range 60-77), and 43% had a positive medical...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Anderlini P,Przepiorka D,Lauppe J,Seong D,Giralt S,Champlin R,Körbling M

    更新日期:1997-05-01 00:00:00

  • Progenitor cell subsets and engraftment kinetics in children undergoing autologous peripheral blood stem cell transplantation.

    abstract::The main objective of the present study was to determine the role of CD34+ cell subsets in the haemopoietic recovery of children undergoing peripheral blood stem cell transplantation. For this purpose, 38 leukaphereses from 33 children with malignancies mobilized with G-CSF were analysed. Using dual-colour flow cytome...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Gonzalez-Requejo A,Madero L,Díaz MA,Villa M,García-Escribano C,Balas A,Lillo R,García-Sanchez F,Benito A,Vicario JL

    更新日期:1998-04-01 00:00:00

  • Platelet hyperactivation in multiple myeloma is also evident in patients with premalignant monoclonal gammopathy of undetermined significance.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: O'Sullivan LR,Meade-Murphy G,Gilligan OM,Mykytiv V,Young PW,Cahill MR

    更新日期:2021-01-01 00:00:00

  • Effective lysis of lymphoma cells with a stabilised bispecific single-chain Fv antibody against CD19 and FcgammaRIII (CD16).

    abstract::A recombinant bispecific single-chain fragment variable antibody (bsscFv), directed against the B-cell antigen CD19 and the low affinity Fc-receptor FcgammaRIII (CD16), was designed for use in the treatment of patients with leukaemias and lymphomas. The Fc-portions of whole antibodies were deliberately eliminated in t...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Bruenke J,Barbin K,Kunert S,Lang P,Pfeiffer M,Stieglmaier K,Niethammer D,Stockmeyer B,Peipp M,Repp R,Valerius T,Fey GH

    更新日期:2005-07-01 00:00:00

  • Absence of N-RAS point mutations in peripheral blood cells of patients with aplastic anaemia and paroxysmal nocturnal haemoglobinurea.

    abstract::The myelodysplastic syndromes (MDS) have a significant frequency of evolution into acute myeloid leukaemia (AML). Approximately 30% of MDS patients show activating mutations of the N-RAS proto-oncogene, and these patients are at increased risk of leukaemic evolution. Long-term survivors of aplastic anaemia (AA) and pa...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: White JR,Josten KM,Chopra R,Tooze J,Saso R,Gordon-Smith EC,Rutherford TR

    更新日期:1995-12-01 00:00:00