Interaction of thrombin with human platelets.

abstract：:An 18-month-old child, who had no evidence of liver disease, malabsorption, or chronic ingestion of coumarin compounds, was found to have plasma deficiencies of factors II, VII, IX and X. Assays for factor II and X by immunological techniques (antibody neutralization and immunoelectrophoresis) revealed normal or eleva...

journal_title：British journal of haematology

authors： Johnson CA,Chung KS,McGrath KM,Bean PE,Roberts HR

更新日期：1980-03-01 00:00:00

abstract：:We describe two British families with similar, dominantly-inherited, temperature-related variants of hereditary stomatocytosis, consistent with the original description of 'cryohydrocytosis'. The cells show a 5-6-fold increase in passive permeability at 37 degrees C with abnormal intracellular Na and K levels at 15-20...

journal_title：British journal of haematology

authors： Coles SE,Chetty MC,Ho MM,Nicolaou A,Kearney JW,Wright SD,Stewart GW

更新日期：1999-06-01 00:00:00

abstract：:Human intravenous immunoglobulin (IVIg) and anti-D immunoglobulin preparations are used in the treatment of immune thrombocytopenic purpura (ITP). One mechanism proposed to explain their therapeutic effects in ITP patients is the induction of expression of anti-inflammatory cytokines, such as interleukin (IL)-10 or IL...

journal_title：British journal of haematology

authors： Aubin E,Lemieux R,Bazin R

更新日期：2007-03-01 00:00:00

abstract：:The anti-CD30 immunotoxin (IT) Ber-H2/saporin is effective in patients with refractory Hodgkin's disease. However, responses are short and partial, one of the main reasons being the inability to repeat IT doses because of formation of human antibodies against the murine antibody and/or the toxin. To overcome this prob...

journal_title：British journal of haematology

authors： Terenzi A,Bolognesi A,Pasqualucci L,Flenghi L,Pileri S,Stein H,Kadin M,Bigerna B,Polito L,Tazzari PL,Martelli MF,Stirpe F,Falini B

更新日期：1996-03-01 00:00:00

abstract：:Canine cyclic haematopoiesis (CH) appears to be a multipotential stem cell defect, possibly due to an intrinsic marrow defect. The in vitro adherent marrow cells of the cyclic haematopoietic (CH) dog were cultured as underlayers beneath normal dog nonadherent marrow cells. The marrow granulocyte-committed colony formi...

journal_title：British journal of haematology

authors： Jones JB,Jolly JD

更新日期：1982-04-01 00:00:00

abstract：:Fibroblast-like cells may be grown from human bone marrow. Adherent cultures show a logarithmic phase of growth lasting 6 d. Hydrocortisone (1 x 10(-8) M) decreases cell growth in 40-60% when measured as cell number and DNA synthesis. Fibroblasts bind the hormone by a high affinity, saturable process showing a Kd of 2...

journal_title：British journal of haematology

authors： Minguell JJ,Martínez J,Walter T

更新日期：1982-10-01 00:00:00

abstract：:Forty female patients with either primary anti-phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti-phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2-glycoprotein I and factor XII. Twenty-one pa...

journal_title：British journal of haematology

authors： Jones DW,MacKie IJ,Gallimore MJ,Winter M

更新日期：2001-05-01 00:00:00

abstract：:The existence of functional gap junctions between haematopoietic progenitor cells (HPCs) and stromal cells of the haematopoietic microenvironment in the human system is a controversial issue. Primary CD34+ HPCs isolated from leukapheresis products were co-incubated with the human fibroblastoid bone marrow stromal cell...

journal_title：British journal of haematology

authors： Dürig J,Rosenthal C,Halfmeyer K,Wiemann M,Novotny J,Bingmann D,Dührsen U,Schirrmacher K

更新日期：2000-11-01 00:00:00

abstract：:Paroxysmal nocturnal haemoglobinuria (PNH) is a serious form of acquired haemolytic anaemia with several features that make it unique, including the fact that it is caused by clonal expansion, in the context of bone marrow failure, of a haematopoietic stem cell that has a somatic mutation in a gene crucial for the syn...

journal_title：British journal of haematology

authors： Luzzatto L,Gianfaldoni G,Notaro R

更新日期：2011-06-01 00:00:00

abstract：:Unfractionated heparin (UFH) and low-molecular weight heparin (LMWH) are well defined anticoagulant agents. Recent data suggest that both LMWH and UFH may also have potent anti-inflammatory properties; however, their mechanism of action responsible for the anti-inflammatory effect is not yet fully elucidated. This stu...

journal_title：British journal of haematology

authors： Hochart H,Jenkins PV,Smith OP,White B

更新日期：2006-04-01 00:00:00

abstract：:Microcirculatory disorders are a common finding in sepsis. We have analysed the influence of two factors released in sepsis, endotoxin and tumour necrosis factor (TNF), on rheological properties of blood cells. The deformability of mixed cell suspensions, isolated erythrocytes, mononuclear cells, or polymorphonuclear ...

journal_title：British journal of haematology

authors： Betticher DC,Keller H,Maly FE,Reinhart WH

更新日期：1993-01-01 00:00:00

abstract：:There are considerable differences in haemopoietic activity between young children and adults on the one hand, and between adults and the elderly on the other. A fundamental unanswered question is whether these differences relate to discrete stages or are part of a continuous process. We have sought to define aspects ...

journal_title：British journal of haematology

authors： Marley SB,Lewis JL,Davidson RJ,Roberts IA,Dokal I,Goldman JM,Gordon MY

更新日期：1999-07-01 00:00:00

abstract：:The inv(8)(p11q13) chromosomal abnormality, described in acute myeloid leukaemias (AML), fuses the histone acetyl-transferase (HAT) MYST3 (MOZ) gene with another HAT gene, NCOA2 (TIF2). We generated a transgenic zebrafish in which the MYST3/NCOA2 fusion gene was expressed under control of the spi1 promoter. An AML dev...

journal_title：British journal of haematology

authors： Zhuravleva J,Paggetti J,Martin L,Hammann A,Solary E,Bastie JN,Delva L

更新日期：2008-11-01 00:00:00

abstract：:We report a case of indolent B-chronic lymphocytic leukaemia (B-CLL) in a stage A patient, treated for 10 years only by theophylline for bronchial asthma. As suggested by the spontaneous apoptosis in the patient's blood (10%), theophylline at 50 micrograms/ml increased spontaneous apoptosis after 72 h in culture by a ...

journal_title：British journal of haematology

authors： Mentz F,Merle-Beral H,Ouaaz F,Binet JL

更新日期：1995-08-01 00:00:00

abstract：:Post-transplantation lymphoproliferative disorders (PTLDs) are a well-recognized and potentially life-threatening complication of solid organ transplantation. While the vast majority of PTLDs are B-cell lymphoproliferations, T-cell PTLDs are rarely seen. Among 898 patients receiving cardiac transplants between 1990 an...

journal_title：British journal of haematology

authors： Draoua HY,Tsao L,Mancini DM,Addonizio LJ,Bhagat G,Alobeid B

更新日期：2004-11-01 00:00:00

abstract：:High-dose chemotherapy with autologous stem cell transplantation (SCT) is widely used as a treatment for systemic AL amyloidosis, but its efficacy has not been proved and it has substantial toxicity in this setting. We report here the outcome of 92 patients evaluated at the UK National Amyloidosis Centre who underwent...

journal_title：British journal of haematology

authors： Goodman HJ,Gillmore JD,Lachmann HJ,Wechalekar AD,Bradwell AR,Hawkins PN

更新日期：2006-08-01 00:00:00

abstract：:The effects of donor T cells, or their CD8+ subset, on engraftment and tolerance induction in fetal transplantation were evaluated using an F1-into-parent mouse-model that does not permit a graft-versus-host effect. Gestational day 13 C57BL/6 (H-2Kb) fetuses were transplanted with B6D2F1 (H-2Kb/d) light density bone m...

journal_title：British journal of haematology

authors： Chen JC,Chang ML,Lee H,Muench MO

更新日期：2004-08-01 00:00:00

abstract：:Chemokines are a family of over 40 small (8 kDa) related proteins with the function of moving cells along a chemotactic gradient, either to organise cells within an organ or to facilitate the movement of leucocytes around the body. Mouse models have implicated the importance of the chemokine CXCL12 in haematopoiesis a...

journal_title：British journal of haematology

authors： Laurence AD

更新日期：2006-02-01 00:00:00

abstract：:Platelet function was evaluated in eight patients with chronic granulocytic leukaemia (CGL), seven Ph1 positive and one Ph1 negative. Seven of the eight patients' platelets had an absence of the second wave of adrenaline induced aggregation on at least one occasion, while five had impaired collagen aggregation. The pl...

journal_title：British journal of haematology

authors： Gerrard JM,Stoddard SF,Shapiro RS,Coccia PF,Ramsay NK,Nesbit ME,Rao GH,Krivit W,White JG

更新日期：1978-12-01 00:00:00

abstract：:The endothelial hybridoma (EAhy926) cell line was employed to clarify whether antiphospholipid antibodies (aPA) [lupus anticoagulant (LA), antiprothrombin antibody (aPT) and/or anticardiolipin antibody (aCL)] and anti-endothelial cell antibodies (AECA) are identical, and establish whether beta2-glycoprotein I (beta2-G...

journal_title：British journal of haematology

authors： Matsuda J,Gotoh M,Gohchi K,Kawasugi K,Tsukamoto M,Saitoh N

更新日期：1997-04-01 00:00:00

abstract：:Site-specific deletions of the 5' part of the TAL1 gene (tal(d)) are among the most frequent non-random genetic abnormalities in T-cell acute lymphoblastic leukaemia (T-ALL). They are usually detected by PCR from DNA with several primer pairs or by Southern blot analysis. Since tal(d) lead to expression of a SIL-TAL1 ...

journal_title：British journal of haematology

authors： Delabesse E,Bernard M,Landman-Parker J,Davi F,Leboeuf D,Varet B,Valensi F,Macintyre EA

更新日期：1997-12-01 00:00:00

abstract：:An examination of HLA antigens in 72 unrelated Caucasian subjects with pernicious anaemia (PA) has revealed no significant association of any HLA-A or B genes with the disease. These data do not confirm the previous reports in the literature which had suggested an increased frequency of the B7 and/or A3 antigen among ...

journal_title：British journal of haematology

authors： Wright JP,Callender ST,Grumet FC,Payne RO,Taylor KB

更新日期：1977-05-01 00:00:00

abstract：:The growth of marrow fibroblasts from patients with myeloproliferative disorders (MPD) was investigated using platelet derived growth factor (PDGF) and human serum as mitogens in the presence of human plasma derived serum. The proliferation of fibroblasts in MPD patients was increased compared to normal individuals, e...

journal_title：British journal of haematology

authors： Kimura A,Katoh O,Kuramoto A

更新日期：1988-06-01 00:00:00

abstract：:We hypothesized that Wilms tumour 1 gene (WT1) expression levels in acute myeloid leukaemia (AML) patients might have predictive value and reveal molecular relapse kinetics. WT1 level was determined at diagnosis, during therapy and post-therapy follow-up in 89 patients who reached first complete remission (CR1) (952 s...

journal_title：British journal of haematology

authors： Ommen HB,Nyvold CG,Braendstrup K,Andersen BL,Ommen IB,Hasle H,Hokland P,Ostergaard M

更新日期：2008-06-01 00:00:00

abstract：:Primary systemic amyloidosis (AL) is a plasma cell disorder characterized by deposition of monoclonal light chains in different organ systems. Although multiple and complex numerical chromosomal abnormalities have been described in patients with multiple myeloma, it is currently unknown whether such changes occur in s...

journal_title：British journal of haematology

authors： Fonseca R,Ahmann GJ,Jalal SM,Dewald GW,Larson DR,Therneau TM,Gertz MA,Kyle RA,Greipp PR

更新日期：1998-12-01 00:00:00

abstract：:This trial explored the efficacy of re-induction chemotherapy including bortezomib in paediatric relapsed/refractory acute lymphoblastic leukaemia. Patients were randomized 1:1 to bortezomib (1.3 mg/m2 /dose) administered early or late to a dexamethasone and vincristine backbone. Both groups did not differ regarding p...

journal_title：British journal of haematology

authors： Kaspers GJL,Niewerth D,Wilhelm BAJ,Scholte-van Houtem P,Lopez-Yurda M,Berkhof J,Cloos J,de Haas V,Mathôt RA,Attarbaschi A,Baruchel A,de Bont ES,Fagioli F,Rössig C,Klingebiel T,De Moerloose B,Nelken B,Palumbo G,Reinhar

更新日期：2018-05-01 00:00:00

abstract：:Establishing a precise diagnosis is essential in inborn haematological cytopenias to enable appropriate treatment decisions and avoid secondary organ damage. However, both diversity and phenotypic overlap of distinct disease entities may make the identification of underlying genetic aetiologies by classical Sanger seq...

journal_title：British journal of haematology

authors： Kager L,Jimenez Heredia R,Hirschmugl T,Dmytrus J,Krolo A,Müller H,Bock C,Zeitlhofer P,Dworzak M,Mann G,Holter W,Haas O,Boztug K

更新日期：2018-07-01 00:00:00

abstract：:Type 3 von Willebrand disease, a recessive autosomally inherited bleeding disorder, refers to complete deficiency of von Willebrand factor (VWF). The novel Q1311X mutation was detected in the homozygous state in four Spanish patients from two apparently unrelated families of gypsy origin. The lack of specific amplific...

journal_title：British journal of haematology

authors： Casaña P,Martínez F,Haya S,Lorenzo JI,Espinós C,Aznar JA

更新日期：2000-11-01 00:00:00

abstract：:The prevalence, clinical associations and pathogenic role of newly identified autoantibodies to the erythropoietin receptor (EPOR) in patients with anaemia were investigated. Sera from 203 patients with immune-related or chronic kidney diseases were screened for anti-EPOR antibodies by enzyme-linked immunosorbent assa...

journal_title：British journal of haematology

authors： Hara A,Furuichi K,Higuchi M,Iwata Y,Sakai N,Kaneko S,Wada T

更新日期：2013-01-01 00:00:00

abstract：:We have investigated the molecular basis of alpha thalassaemia in the so-called 'Cape Coloured' population of Cape Town. DNA from 17 cases was analysed by Southern blotting and hybridization with an alpha globin complementary DNA probe. Three types of alpha thalassaemia genetic determinants were detected: the 3.5 kb d...

journal_title：British journal of haematology

authors： Mathew CG,Rousseau J,Rees JS,Harley EH

更新日期：1983-09-01 00:00:00