Abstract:
:We describe eight patients (four children and four adults) with an acute lymphoblastic leukaemia (ALL) with cytoplasmic granules or inclusions. The incidence of this variant of acute leukaemia in our whole series of patients with ALL is 1.8%. The granules or inclusions were usually positive for aspecific esterases (ANAE) and/or acid phosphatase, and the immunophenotype was in all cases typical of a CALLA positive B-lineage ALL (CD10+, CD19+ and/or CD24+, DR+, TdT+, anti-T-, anti-My-, SIg-). In one paediatric case, CD33 was unusually coexpressed. Ultrastructural investigations were performed in one case and demonstrated large granules containing vesicles, usually membrane bound, in the majority of blast cells. In the two cases analysed, Ig heavy chain gene rearrangement was detected. In this series of patients prognosis was poor since three never achieved a complete remission, four relapsed and only one is still in first continuous remission.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Cantù-Rajnoldi A,Invernizzi R,Biondi A,Banfi P,Zoia A,De Fazio P,Polli Ndoi
10.1111/j.1365-2141.1989.tb07745.xsubject
Has Abstractpub_date
1989-11-01 00:00:00pages
309-14issue
3eissn
0007-1048issn
1365-2141journal_volume
73pub_type
杂志文章abstract::Heparin binding on polymorphonuclear leucocytes (PMNL) was characterized. Heparin binding was specific, rapid, saturable and reversible. One single class of heparin binding sites was found with a dissociation constant of 1.22 mumol/l and 7.7 x 10(6) sites per PMNL. The binding was independent of the anticoagulant acti...
journal_title:British journal of haematology
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journal_title:British journal of haematology
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journal_title:British journal of haematology
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