Abstract:
:A significant number of patients diagnosed with beta-thalassaemia develop clinical and histopathological manifestations similar to those of an inherited disorder called Pseudoxanthoma elasticum (PXE). The inherited PXE is caused by mutations in the ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (ABCC6) gene and is characterized by mineralized elastic fibres in dermal, vascular and ocular tissues. As no disease-causing variant was found in the ABCC6 gene of 10 beta-thalassaemia patients with a PXE-like phenotype, the present study suggests that the PXE-like symptoms in these beta-thalassaemic patients are not related to ABCC6 mutations.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Hamlin N,Beck K,Bacchelli B,Cianciulli P,Pasquali-Ronchetti I,Le Saux Odoi
10.1046/j.1365-2141.2003.04484.xsubject
Has Abstractpub_date
2003-09-01 00:00:00pages
852-4issue
5eissn
0007-1048issn
1365-2141pii
4484journal_volume
122pub_type
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