Normal aggregations of glycoprotein IV (CD36)-deficient platelets from seven healthy Japanese donors.

abstract：:The surface markers of immunoglobulin secreting cells (ISC) in bone marrow and peripheral blood were analysed. Circulating ISC bear surface Ig and Ia-like antigens. However, these markers were not detectable on ISC in bone marrow. Fc and complement receptors were not present on circulating ISC. The areas of plaques co...

journal_title：British journal of haematology

authors： Gyotoku Y,Mori M,Nonaka Y,Nagata Y,Saito Y

更新日期：1985-04-01 00:00:00

abstract：:Three identical alpha + thalassemia genes, one of which always carried the Hb J Tongariki mutation, have been observed in Vanuatuans. Despite the fact that at least two of them have arisen by different types of crossover event, the expression of all three haplotypes is identical. ...

journal_title：British journal of haematology

authors： Bowden DK,Pressley L,Higgs DR,Clegg JB,Weatherall DJ

更新日期：1982-06-01 00:00:00

abstract：:Idiopathic thrombotic thrombocytopenic purpura (TTP) is characterized by frequent recurrences. Effective screening for relapses will enable intervention prior to overt episodes of TTP. The present study used a modified assay to detect ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif, 13) ac...

journal_title：British journal of haematology

authors： Jin M,Casper TC,Cataland SR,Kennedy MS,Lin S,Li YJ,Wu HM

更新日期：2008-05-01 00:00:00

abstract：:We developed a novel method for the chemical modification of cytokines with synthetic polymers to increase the therapeutic efficacy of the former in vivo. A pH-reversible amino-protective reagent, dimethylmaleic anhydride (DMMAn), was used for modification of interleukin-6 (IL-6) with polyethylene glycol (PEG). The no...

journal_title：British journal of haematology

authors： Tsunoda S,Ishikawa T,Watanabe M,Kamada H,Yamamoto Y,Tsutsumi Y,Hirano T,Mayumi T

更新日期：2001-01-01 00:00:00

abstract：:Three TaqI restriction fragment length polymorphisms (RFLP) detected by the central portion of von Willebrand factor cDNA, which recognizes the true gene and in addition pseudogenic sequences, were characterized and mapped. Small cDNA fragments which hybridized with DNA from families with von Willebrand disease were u...

journal_title：British journal of haematology

authors： Bernardi F,Marchetti G,Casonato A,Gemmati D,Patracchini P,Legnani C,DeRosa V,Girolami A,Conconi F

更新日期：1990-03-01 00:00:00

abstract：:Hydroxyurea (HU), an inhibitor of DNA synthesis, can also induce haemoglobinization in certain erythroid cell lines. In this study, we report that intracellular peroxides levels were increased in HU-treated murine erythroleukaemia (MEL) cells and that l-acetyl-N-cysteine (LNAC), a potent reducing reagent, had a signif...

journal_title：British journal of haematology

authors： Nagai T,Tarumoto T,Miyoshi T,Ohmine K,Muroi K,Komatsu N,Sassa S,Ozawa K

更新日期：2003-05-01 00:00:00

abstract：:Results of bone marrow transplantation (BMT) in patients with Fanconi's anaemia (FA) in transformation are very poor and only a few cases with favourable outcome have been reported. We present the follow-up of two FA-myelodysplastic syndrome (MDS) patients with monosomy 7 and complex karyotype implicating chromosome 1...

journal_title：British journal of haematology

authors： Ortega M,Caballín MR,Ortega JJ,Olive T,Coll MD

更新日期：2000-10-01 00:00:00

abstract：:Bilateral adrenal masses were discovered incidentally in a patient with beta-thalassaemia intermedia. Endocrine investigations showed that the adrenal lesion was hormonally inactive. Extramedullary haemopoiesis involving the adrenal glands was suggested by the presence of reticuloendothelial tissue as demonstrated by ...

journal_title：British journal of haematology

authors： Wat NM,Tse KK,Chan FL,Lam KS

更新日期：1998-03-01 00:00:00

abstract：:Peripheral blood and bone marrow mononuclear cells from 10 patients with newly diagnosed Waldenström's macroglobulinaemia were analysed for the presence of leucocyte differentiation antigens using flow cytometry. Most patients had circulating intracytoplasmic-mu cells that were positive for the B-cell specific antigen...

journal_title：British journal of haematology

authors： Kucharska-Pulczynska M,Ellegaard J,Hokland P

更新日期：1987-04-01 00:00:00

abstract：:Limited therapies exist for patients with refractory and relapsed (RR) higher-risk myelodysplastic syndromes (HR-MDS) and acute myeloid leukaemia with trilineage dysplasia (AML-TD). High dose (HD) lenalidomide (50 mg) has activity as frontline therapy in elderly AML but there is limited data in the RR setting. This ph...

journal_title：British journal of haematology

authors： Zeidan AM,Smith BD,Carraway HE,Gojo I,DeZern A,Gore SD

更新日期：2017-01-01 00:00:00

abstract：:Myelofibrosis with myeloid metaplasia (MMM) is uniquely characterized by macroscopic bone marrow stromal changes that are believed to be both reactive and cytokine mediated. Furthermore, a prognostically detrimental increase in bone marrow angiogenesis has recently been demonstrated. These observations suggest a poten...

journal_title：British journal of haematology

authors： Elliott MA,Mesa RA,Li CY,Hook CC,Ansell SM,Levitt RM,Geyer SM,Tefferi A

更新日期：2002-05-01 00:00:00

abstract：:The contribution of red cell size (mean cell volume) to the clinical and haematological manifestations of homozygous sickle cell (SS) disease has been investigated by comparing the features of two groups of patients with low (less than or equal to 80 fl) and high (greater than 95 fl) MCV values after matching for age,...

journal_title：British journal of haematology

authors： Serjeant GR,Foster K,Serjeant BE

更新日期：1981-07-01 00:00:00

abstract：:It is widely recognized that thrombosis is the major event in the evolution of stable vascular disease to unstable ischaemic syndromes including myocardial infarction and stroke. The purpose of this case-control study was to establish clinical and laboratory data on the possible relationship between specific component...

journal_title：British journal of haematology

authors： Freeburn JC,Wallace JM,Strain JJ,Sinnamon DG,Craig BM,Johnson D,Gilmore WS

更新日期：1998-07-01 00:00:00

abstract：:FLT3-internal tandem duplication (ITD) mutations are heterogeneous with regards to length and proportion of DNA harbouring the mutation and the expression level of FLT3 also varies widely, however very little is known about the biological effects of these variables. We studied FLT3-associated biological parameters in ...

journal_title：British journal of haematology

authors： Seedhouse CH,Pallis M,Grundy M,Shang S,Russell NH

更新日期：2009-12-01 00:00:00

abstract：:The molecular basis accounting for the peculiar clinical and biological features of hairy cell leukaemia (HCL) is currently unknown. Deregulation of cell cycle genes plays a significant role in oncogenesis and there is considerable evidence suggesting that Cdk inhibitors (Ckis) function as tumour suppressors. We and o...

journal_title：British journal of haematology

authors： Chilosi M,Chiarle R,Lestani M,Menestrina F,Montagna L,Ambrosetti A,Prolla G,Pizzolo G,Doglioni C,Piva R,Pagano M,Inghirami G

更新日期：2000-10-01 00:00:00

abstract：:Hodgkin lymphoma (HL) is characterized by a minority of neoplastic Hodgkin-Reed Sternberg (HRS) cells surrounded by a non-neoplastic reactive infiltrate. As immunological mechanisms appear to be crucial in classical HL pathogenesis, altered serum chemokine levels might be related to disease activity. Serum levels of n...

journal_title：British journal of haematology

authors： Niens M,Visser L,Nolte IM,van der Steege G,Diepstra A,Cordano P,Jarrett RF,Te Meerman GJ,Poppema S,van den Berg A

更新日期：2008-03-01 00:00:00

abstract：:We report outcomes after myeloablative haematopoietic cell transplantation (HCT) from human leucocyte antigen (HLA)-matched sibling donors in 67 patients with sickle cell disease transplanted between 1989 and 2002. The most common indications for transplantation were stroke and recurrent vaso-occlusive crisis in 38% a...

journal_title：British journal of haematology

authors： Panepinto JA,Walters MC,Carreras J,Marsh J,Bredeson CN,Gale RP,Hale GA,Horan J,Hows JM,Klein JP,Pasquini R,Roberts I,Sullivan K,Eapen M,Ferster A,Non-Malignant Marrow Disorders Working Committee, Center for International Bl

更新日期：2007-06-01 00:00:00

abstract：:The specific sodium pump antagonist ouabain was used to study the effect of sodium pump inhibition on granulopoietic colony formation by normal human bone marrow cells cultured in soft agar for 7 d. Suppression of colony formation was dose-dependent and occurred at a low and reproducible concentration. The use of an e...

journal_title：British journal of haematology

authors： Steed AJ,Boardman KM,Delamore IW

更新日期：1982-07-01 00:00:00

abstract：:This study reports the characterization of a spontaneous lymphoblastoid cell line (LCL) raised from the peripheral blood of a patient with Kostmann's congenital neutropenia. The LCL was composed of EBV-infected polyclonal B cells and displayed surface markers and pattern of growth in vitro typical of normal LCLs. The ...

journal_title：British journal of haematology

authors： Corcione A,Roncella S,Cutrona G,Mori PG,Ferrarini M,Pistoia V

更新日期：1993-12-01 00:00:00

abstract：:We report the analysis of prognostic factors in a cohort of 660 patients entered in the first Medical Research Council trial in chronic lymphocytic leukaemia (CLL) between 1978 and 1984. The majority (94%) of patients were aged 50 or over and the number of men (M) was almost twice that of women (F) with an M:F ratio o...

journal_title：British journal of haematology

authors： Catovsky D,Fooks J,Richards S

更新日期：1989-06-01 00:00:00

abstract：:Colony-stimulating factor-1 (CSF-1) is a specific haematopoietic growth factor that stimulates the production of macrophages by both bone marrow macrophage precursors (GM-CFC) and certain more mature peripheral tissue macrophages. The relationship of CSF-1 utilization and cell production by macrophage precursors at va...

journal_title：British journal of haematology

authors： Chen BD,Chou TH,Clark CR

更新日期：1987-12-01 00:00:00

abstract：:The expression of the VAV proto-oncogene in 57 patients with chronic myeloproliferative disease (CMD), B-cell acute lymphoblastic leukaemia (B-ALL) and B-cell non-Hodgkin Lymphoma (B-NHL), and 61 with B-cell chronic lymphocytic leukaemia (B-CLL) was analysed. VAV overexpression was observed in 19.5% of cases and 81% o...

journal_title：British journal of haematology

authors： Prieto-Sánchez RM,Hernández JA,García JL,Gutiérrez NC,San Miguel J,Bustelo XR,Hernández JM

更新日期：2006-06-01 00:00:00

abstract：:We describe three cases of relapsed hairy cell leukaemia (HCL) treated with pentostatin plus rituximab. All three achieved bone marrow complete remission but had persistent splenomegaly and hypersplenism. Because of the clinical uncertainty of its significance, they were all splenectomized. The spleen histology showed...

journal_title：British journal of haematology

authors： Sarid N,Ahmad HN,Wotherspoon A,Dearden CE,Else M,Catovsky D

更新日期：2015-12-01 00:00:00

abstract：:An 18-month-old child, who had no evidence of liver disease, malabsorption, or chronic ingestion of coumarin compounds, was found to have plasma deficiencies of factors II, VII, IX and X. Assays for factor II and X by immunological techniques (antibody neutralization and immunoelectrophoresis) revealed normal or eleva...

journal_title：British journal of haematology

authors： Johnson CA,Chung KS,McGrath KM,Bean PE,Roberts HR

更新日期：1980-03-01 00:00:00

abstract：:Erythrocytes from elderly donors (> 70 years), but not young donors (18-35 years), are shown to undergo sequestration in an in vitro erythrophagocytosis assay. Comparable levels of sequestration are observed for high density erythrocytes from young individuals and both low density and high density erythrocytes from el...

journal_title：British journal of haematology

authors： Shapiro S,Kohn D,Gershon H

更新日期：1993-04-01 00:00:00

abstract：:Genomic DNA from 106 cases of adult de novo acute myeloid leukaemia (AML) was screened by polymerase chain reaction (PCR) and gel electrophoresis for FLT3 internal tandem duplication (ITD) mutations within the juxtamembrane (JM) domain. FLT3 mutations were detected in 14 cases (13.2%) and occurred in FAB types M1 (4 o...

journal_title：British journal of haematology

authors： Abu-Duhier FM,Goodeve AC,Wilson GA,Gari MA,Peake IR,Rees DC,Vandenberghe EA,Winship PR,Reilly JT

更新日期：2000-10-01 00:00:00

abstract：:Primary long-term bone marrow cultures grown in 40 mM HEPES-buffered McCoy's 5A medium produced granulocyte-macrophage colony-forming units (CFU-GM) for a median of 9 weeks compared with 7 weeks with CO2/bicarbonate-buffered cultures. Reducing the medium glucose concentration (from 12.5 to 2.75 mM) extended the cultur...

journal_title：British journal of haematology

authors： Tennant GB,Truran LN,Bailey-Wood R,Burnett AK

更新日期：2000-06-01 00:00:00

abstract：:Thrombocytopenia and neutropenia are common among neonates in intensive care units. Bone marrow aspirations are sometimes performed as part of their evaluation. However, marrow biopsies have not been reported from living neonates. Since architecture and cellularity cannot generally be accurately assessed from marrow a...

journal_title：British journal of haematology

authors： Sola MC,Rimsza LM,Christensen RD

更新日期：1999-11-01 00:00:00

abstract：:Notwithstanding the improvement in treatment results for paediatric T cell acute lymphoblastic leukaemia (T-ALL) it remains important to understand if genetic aberrations influence therapy response. PTEN tumour suppressor gene inactivation is a frequent event in T-ALL but its effect on patient therapy response is deba...

journal_title：British journal of haematology

authors： Paganin M,Grillo MF,Silvestri D,Scapinello G,Buldini B,Cazzaniga G,Biondi A,Valsecchi MG,Conter V,Te Kronnie G,Basso G

更新日期：2018-09-01 00:00:00

abstract：:Treatment-free remission (TFR) has recently emerged as a goal of treatment in chronic myeloid leukaemia (CML). Molecular remission is sustained in around 30% of imatinib-treated patients who stop treatment after ≥2 years with undetectable minimal residual disease (UMRD) by conventional real-time reverse transcription ...

journal_title：British journal of haematology

authors： Ross DM,Hughes TP

更新日期：2014-07-01 00:00:00