Characterization of polymorphic markers in the von Willebrand factor gene and pseudogene.

abstract：:Immune-mediated pathways have been recognized to be of importance in the pathogenesis of chronic lymphocytic leukaemia (CLL). We assessed a broad variety of immune-related and inflammatory conditions and subsequent CLL development among 4 million adult male veterans admitted to VA hospitals. We identified 3,680 CLL ca...

journal_title：British journal of haematology

authors： Landgren O,Gridley G,Check D,Caporaso NE,Morris Brown L

更新日期：2007-12-01 00:00:00

abstract：:Paroxysmal nocturnal haemoglobinuria (PNH) is a serious form of acquired haemolytic anaemia with several features that make it unique, including the fact that it is caused by clonal expansion, in the context of bone marrow failure, of a haematopoietic stem cell that has a somatic mutation in a gene crucial for the syn...

journal_title：British journal of haematology

authors： Luzzatto L,Gianfaldoni G,Notaro R

更新日期：2011-06-01 00:00:00

abstract：:To clarify the clinical and biological significance of serum thymidine kinase (TK) in adult T-cell leukaemia (ATL) associated with human lymphotropic virus type-I (HTLV-I) and in acute myeloid leukaemia (AML), TK was measured in 52 patients with ATL (acute ATL, 35 patients; lymphoma ATL, two patients; chronic ATL, 12 ...

journal_title：British journal of haematology

authors： Sadamori N,Ichiba M,Mine M,Hakariya S,Hayashibara T,Itoyama T,Nakamura H,Tomonaga M,Hayashi K

更新日期：1995-05-01 00:00:00

abstract：:Glanzmann thrombasthenia (GT) is a rare autosomal recessive bleeding disorder, caused by a quantitative or qualitative defect of the GPIIb-IIIa integrin (alpha IIb beta 3), which functions as the platelet fibrinogen receptor. We report a case of type I GT due to a homozygous mutation resulting in Ser 870 to stop codon...

journal_title：British journal of haematology

authors： Vinciguerra C,Khelif A,Alemany M,Morle F,Grenier C,Uzan G,Gulino D,Dechavanne M,Negrier C

更新日期：1996-11-01 00:00:00

abstract：:Megakaryopoiesis was examined in 10 patients (eight females and two males) with cyclic thrombocytopenia (CT) to investigate the underlying pathogenesis. Numbers of CFU-Meg and megakaryocytes and the mean cytoplasmic area (mean area) of megakaryocytes at the peak, nadir, ascent mid phase, and descent mid phase of the p...

journal_title：British journal of haematology

authors： Nagasawa T,Hasegawa Y,Kamoshita M,Ohtani K,Komeno T,Itoh T,Shinagawa A,Kojima H,Ninomiya H,Abe T

更新日期：1995-09-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) is a major cause of transplant-related mortality (TRM) after allogeneic haematopoietic stem cell transplantation (HSCT) and presents a challenge in haploidentical HSCT. GVHD may be prevented by ex vivo graft T-cell depletion or in vivo depletion of proliferating lymphocytes. However, b...

journal_title：British journal of haematology

authors： Roy DC,Lachance S,Cohen S,Delisle JS,Kiss T,Sauvageau G,Busque L,Ahmad I,Bernard L,Bambace N,Boumédine RS,Guertin MC,Rezvani K,Mielke S,Perreault C,Roy J

更新日期：2019-09-01 00:00:00

abstract：:Overt ischaemic stroke is one of the most devastating complications in children with sickle cell disease (SCD). The compensatory response to anaemia in SCD includes an increase in cerebral blood flow (CBF) by accessing cerebrovascular dilatory reserve. Exhaustion of dilatory reserve secondary to anaemic stress may lea...

journal_title：British journal of haematology

authors： Kosinski PD,Croal PL,Leung J,Williams S,Odame I,Hare GM,Shroff M,Kassner A

更新日期：2017-01-01 00:00:00

abstract：:Ibrutinib is associated with durable responses in patients with Waldenström macroglobulinaemia (WM). We hypothesized that response depth is predictive of progression-free survival (PFS) in WM patients treated with ibrutinib. Using landmark analyses, we evaluated response depth in two cohorts of WM patients treated wit...

journal_title：British journal of haematology

authors： Castillo JJ,Abeykoon JP,Gustine JN,Zanwar S,Mein K,Flynn CA,Demos MG,Guerrera ML,Kofides A,Liu X,Munshi M,Tsakmaklis N,King R,Yang G,Hunter ZR,Advani RH,Palomba ML,Ansell SM,Gertz MA,Kapoor P,Treon SP

更新日期：2020-11-18 00:00:00

abstract：:The expression and prognostic significance of hepatocyte growth factor (HGF) and its receptor c-MET (MET proto-oncogene) was analysed in 96 cases of diffuse large B-cell lymphoma (DLBCL). Tissue sections were immunohistochemically stained for HGF and c-Met. The prognosis of HGF-positive and c-Met-positive cases was si...

journal_title：British journal of haematology

authors： Kawano R,Ohshima K,Karube K,Yamaguchi T,Kohno S,Suzumiya J,Kikuchi M,Tamura K

更新日期：2004-11-01 00:00:00

abstract：:Minimal residual disease (MRD) assessments were performed retrospectively after allogeneic stem cell transplantation (SCT) in 32 patients (23 children and nine adults) with acute lymphoblastic leukaemia (ALL). Using immunoglobulin and T-cell receptor rearrangements as clonal markers, MRD was detected after SCT in nine...

journal_title：British journal of haematology

authors： Uzunel M,Jaksch M,Mattsson J,Ringdén O

更新日期：2003-09-01 00:00:00

abstract：:Factors affecting iron efflux from the isolated perfused rat liver were studied following the intravenous administration of transferrin-(59)Fe or transferrin-(55)Fe administered to the rat from 1.5 h to 3.5 d before perfusion of the liver. The liver was perfused with rat red cells suspended either in rat plasma or Eag...

journal_title：British journal of haematology

authors： Baker E,Morton AG,Tavill AS

更新日期：1980-08-01 00:00:00

abstract：:Beta2-glycoprotein I (beta2GPI) is an important target antigen for antiphospholipid antibodies (aPL) and thus beta2GPI polymorphisms may influence aPL production and the development of antiphospholipid syndrome. We have studied the relationship between the Val247Leu and Trp316Ser beta2GPI polymorphisms and the aPL sta...

journal_title：British journal of haematology

authors： Camilleri RS,Mackie IJ,Humphries SE,Machin SJ,Cohen H

更新日期：2003-03-01 00:00:00

abstract：:A female patient with delayed haemolytic transfusion reaction due to anti-M antibody is described. Diagnosis was based on laboratory evidence of haemolysis and on characteristic serological findings. Anti-M was detected in the recipient's serum 7 d after the last transfusion episode. This alloantibody had not been pre...

journal_title：British journal of haematology

authors： Sancho JM,Pujol M,Fernández F,Soler M,Manzano P,Feliu E

更新日期：1998-10-01 00:00:00

abstract：:Red cell membrane proteins have been examined in a family in which three children have severe transfusion-dependent homozygous hereditary elliptocytosis. The membranes in all three show a considerable excess of spectrin dimers over tetramers in spectrin extracts. The red cell membranes of their parents with heterozygo...

journal_title：British journal of haematology

authors： Evans JP,Baines AJ,Hann IM,Al-Hakim I,Knowles SM,Hoffbrand AV

更新日期：1983-06-01 00:00:00

abstract：:Immunochemotherapy with cyclophosphamide, adriamycin, vincristine, prednisone and rituximab (R-CHOP) is the standard treatment in non-immunosuppressed patients with diffuse large B-cell lymphoma (DLBCL), but its adequacy has not been definitively established in patients with human immunodeficiency virus (HIV)-related ...

journal_title：British journal of haematology

authors： Ribera JM,Oriol A,Morgades M,González-Barca E,Miralles P,López-Guillermo A,Gardella S,López A,Abella E,García M,PETHEMA, GELTAMO, GELCAB and GESIDA Groups.

更新日期：2008-02-01 00:00:00

abstract：:Cyclosporin A (CSA) exhibits greater multidrug resistance (MDR) modulating activity in vitro than other MDR modulators such as verapamil and quinidine. However, the immunosuppressive and nephrotoxic effects of CSA may limit its clinical use. PSC 833, a new cyclosporin D derivative, exerts a higher MDR reversal activit...

journal_title：British journal of haematology

authors： Jiang XR,Kelsey SM,Wu YL,Newland AC

更新日期：1995-06-01 00:00:00

abstract：:A pilot trial was initiated for chronic myeloid leukaemia patients, which employed imatinib for remission induction, followed by reduced-intensity conditioning and an in vivo T-cell depleted graft. Out of nine patients, six experienced a molecular relapse and one patient had a haematological relapse at a median interv...

journal_title：British journal of haematology

authors： Ringhoffer M,Harsdorf Sv,Schmitt M,Wiesneth M,Zenz T,Stilgenbauer S,Greiner J,Döhner K,Marx M,Döhner H,Bunjes D

更新日期：2007-01-01 00:00:00

abstract：:125I IgG anti-D binding to reticulocytes obtained by density fractionation is reduced relative to that bound to all other red cell (RBC) fractions. Maximum D antigen reactivity occurs following reticulocyte maturation with no detectable change in D reactivity of mature RBC throughout their life span. Reticulocytes hav...

journal_title：British journal of haematology

authors： Gray LS,Kleeman JE,Masouredis SP

更新日期：1983-10-01 00:00:00

abstract：:To examine the role of human DNA topoisomerase IIalpha (topo IIalpha) in drug resistance, we selectively inhibited topo IIalpha gene expression in U937 human monocytic leukaemia cells stably transfected with a plasmid that allowed for Zn-mediated conditional expression of a human alpha-topo IIalpha antisense sequence....

journal_title：British journal of haematology

authors： Towatari M,Adachi K,Marunouchi T,Saito H

更新日期：1998-06-01 00:00:00

abstract：:The peripheral blood lymphoid cells of five patients with Sézary syndrome (SS) were examined with respect to their surface membrane characteristics and their response to mitogens. These cells showed markedly defective mitogenic responses to a broad dose range of phytohaemagglutinin (PHA), pokeweed mitogen, concanavali...

journal_title：British journal of haematology

authors： Braylan R,Variakojis D,Yachnin S

更新日期：1975-12-01 00:00:00

abstract：:Marked changes in the concentration and proliferative state of circulating granulocytic progenitor cells (colony forming units in culture; CFUc) were observed in female patients following surgical trauma. Within one day of an abdominal hysterectomy there was an abrupt fall in the number of blood CFUc to between 10% an...

journal_title：British journal of haematology

authors： Philip MA,Standen G,Fletcher J

更新日期：1980-02-01 00:00:00

abstract：:The in vitro efficacies of three new drugs--clofarabine (CLOF), nelarabine (NEL) and flavopiridol (FP) - were assessed in a panel of acute lymphoblastic leukaemia (ALL) cell lines. The 50% inhibitory concentration (IC50) for CLOF across all lines was 188-fold lower than that of NEL. B-lineage, but not T-lineage lines,...

journal_title：British journal of haematology

authors： Beesley AH,Palmer ML,Ford J,Weller RE,Cummings AJ,Freitas JR,Firth MJ,Perera KU,de Klerk NH,Kees UR

更新日期：2007-04-01 00:00:00

abstract：:We attempted to identify the diagnostic markers and severity predictors of hepatic veno-occlusive disease (VOD) in 115 adult patients who were uniformly conditioned with busulphan and cyclophosphamide and who underwent allogeneic bone marrow transplantation (BMT). A diagnosis of VOD was made according to clinical crit...

journal_title：British journal of haematology

authors： Lee JH,Lee KH,Lee JH,Kim S,Seol M,Park CJ,Chi HS,Kang W,Kim ST,Kim WK,Lee JS

更新日期：2002-09-01 00:00:00

abstract：:In type 1 Gaucher disease a bleeding tendency occurs which is partly caused by thrombocytopenia due to massive splenomegaly. In addition, low levels of factors IX and XI have been described. The mechanism responsible for these clotting factor abnormalities is unknown. We performed a detailed study of parameters of coa...

journal_title：British journal of haematology

authors： Hollak CE,Levi M,Berends F,Aerts JM,van Oers MH

更新日期：1997-03-01 00:00:00

abstract：:The incidence of alpha-thalassaemia in an Italian population has been determined by a survey of random cord bloods for the presence of Hb Bart's. 144 out of 4730 (3%) had detectable amounts of Hb Bart's. Furthermore, alpha-globin gene analysis of 100 random cord bloods showed that five out of 100 had the common type o...

journal_title：British journal of haematology

authors： Velati C,Sampietro M,Biassoni M,Cappellini MD,Wainscoat JS,Higgs DR,Fiorelli G

更新日期：1986-07-01 00:00:00

abstract：:Hodgkin lymphoma (HL) is characterized by a minority of neoplastic Hodgkin-Reed Sternberg (HRS) cells surrounded by a non-neoplastic reactive infiltrate. As immunological mechanisms appear to be crucial in classical HL pathogenesis, altered serum chemokine levels might be related to disease activity. Serum levels of n...

journal_title：British journal of haematology

authors： Niens M,Visser L,Nolte IM,van der Steege G,Diepstra A,Cordano P,Jarrett RF,Te Meerman GJ,Poppema S,van den Berg A

更新日期：2008-03-01 00:00:00

abstract：:Novel agents have provided a new foundation for multiple myeloma therapies. When combined with other anti-myeloma agents, these compounds significantly enhance clinical efficacy. High-dose steroids are frequently used in anti-myeloma combination regimens; however, the doses employed are often poorly tolerated, especia...

journal_title：British journal of haematology

authors： Sher T,Ailawadhi S,Miller KC,Manfredi D,Wood M,Tan W,Wilding G,Czuczman MS,Hernandez-Ilizaliturri FJ,Hong F,Sood R,Soniwala S,Lawrence W,Jamshed S,Masood A,Iancu D,Lee K,Chanan-Khan A

更新日期：2011-07-01 00:00:00

abstract：:Increased osteoclastic bone resorption is the major causal factor of bone disease in multiple myeloma. Recently, non-invasive methods have been developed for the estimation of bone resorptive activity. To evaluate the biological sensitivity and clinical usefulness of five biochemical assays for measuring the C-termina...

journal_title：British journal of haematology

authors： Abildgaard N,Brixen K,Kristensen JE,Eriksen EF,Nielsen JL,Heickendorff L

更新日期：2003-01-01 00:00:00

abstract：:2-3-Dihydroxybenzoic acid was evaluated as a potentially useful, orally effective iron-chelating drug by performing iron balance studies in patients with beta-thalassaemia major. The administration of this substance at 25 mg/kg/d to five patients for 8 d caused an average increase in iron excretion of 4.5 mg/d. When t...

journal_title：British journal of haematology

authors： Peterson CM,Graziano JH,Grady RW,Jones RL,Vlassara HV,Canale VC,Miller DR,Cerami A

更新日期：1976-08-01 00:00:00

abstract：:Data on outcome, prognostic factors, and treatment for very elderly non-Hodgkin lymphomas (NHL) is sparse. We conducted a multicentre retrospective analysis of NHL patients ≥80 years (at diagnosis) treated between 1999 and 2009. Detailed characteristics were obtained including geriatric syndromes, activities of daily ...

journal_title：British journal of haematology

authors： Nabhan C,Smith SM,Helenowski I,Ramsdale E,Parsons B,Karmali R,Feliciano J,Hanson B,Smith S,McKoy J,Larsen A,Hantel A,Gregory S,Evens AM

更新日期：2012-01-01 00:00:00