Plasminogen activator inhibitor-1 is an independent diagnostic marker as well as severity predictor of hepatic veno-occlusive disease after allogeneic bone marrow transplantation in adults conditioned with busulphan and cyclophosphamide.

abstract：:Marginal zone B-cell lymphoma (MZBCL) represents a distinct subtype of B-cell non-Hodgkin's lymphoma (NHL) which has been recently recognized and defined as a disease entity. Cytogenetically, these lymphomas reveal a high prevalence of trisomy 3, and recent data obtained by comparative genomic hybridization indicate t...

journal_title：British journal of haematology

authors： Dierlamm J,Pittaluga S,Stul M,Wlodarska I,Michaux L,Thomas J,Verhoef G,Verhest A,Depardieu C,Cassiman JJ,Hagemeijer A,De Wolf-Peeters C,Van den Berghe H

更新日期：1997-09-01 00:00:00

abstract：:In two unrelated Spanish males with glucose-6-phosphate dehydrogenase (G6PD) deficiency and haemolytic anaemia, and two different novel point mutations in the G6PD gene, have been identified. A C to T transition at nucleotide 406 resulting in a (136) Arg to Cys substitution and a C to G transition at nucleotide 1155 r...

journal_title：British journal of haematology

authors： Zarza R,Pujades A,Rovira A,Saavedra R,Fernandez J,Aymerich M,Vives Corrons JL

更新日期：1997-09-01 00:00:00

abstract：:Allogeneic sibling bone marrow transplantation (BMT) is the recommended treatment for relapsed childhood acute lymphoblastic leukaemia (ALL), but appropriate donors are only available in 30% of cases. Unfortunately, BMT from unrelated donors (UD) has been associated with high rates of severe graft-versus-host disease ...

journal_title：British journal of haematology

authors： Oakhill A,Pamphilon DH,Potter MN,Steward CG,Goodman S,Green A,Goulden P,Goulden NJ,Hale G,Waldmann H,Cornish JM

更新日期：1996-09-01 00:00:00

abstract：:In this study we have investigated the molecular basis for a mild form of beta-thalassaemia in three patients of Italian descent. In two, belonging to different families and affected by a mild and late-presenting form of thalassaemia major, direct sequencing of amplified DNA detected a C----T substitution at position ...

journal_title：British journal of haematology

authors： Meloni A,Rosatelli MC,Faà V,Sardu R,Saba L,Murru S,Sciarratta GV,Baldi M,Tannoia N,Vitucci A

更新日期：1992-02-01 00:00:00

abstract：:In acute lymphoblastic leukaemia (ALL), investigation of minimal residual disease by conventional morphology and immunology fails to detect levels of residual disease of < 1 leukaemic in 10-100 normal cells. The use of polymerase chain reaction (PCR) to exploit the diversity of the complementarity determining region (...

journal_title：British journal of haematology

authors： Chim JC,Coyle LA,Yaxley JC,Cole-Sinclair MF,Cannell PK,Hoffbrand VA,Foroni L

更新日期：1996-01-01 00:00:00

abstract：:Lack of reliable laboratory parameters is the main challenge in the management of fetal and neonatal alloimmune thrombocytopenia (FNAIT). Despite the long-known association between the HLA-DRB3*01:01 allele and human platelet antigen 1a (HPA-1a) alloimmunisation, maternal human leucocyte antigen (HLA) typing has been ...

journal_title：British journal of haematology

authors： Sainio S,Javela K,Tuimala J,Haimila K

更新日期：2017-01-01 00:00:00

abstract：:Relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) in those unfit or ineligible for autologous stem cell transplantation is associated with a poor outcome and new treatment approaches are needed. Pixantrone is a novel aza-anthracenedione which is structurally similar to anthracyclines and is licenced i...

journal_title：British journal of haematology

authors： Eyre TA,Linton KM,Rohman P,Kothari J,Cwynarski K,Ardeshna K,Bailey C,Osborne WL,Rowntree C,Eden D,Shankara P,Eyre DW,Jasani P,Chaidos A,Collins GP,Hatton CS

更新日期：2016-06-01 00:00:00

abstract：:T cells modified with anti-CD19 chimeric antigen receptor (CAR) containing either CD28 or 4-1BB (also termed TNFRSF9, CD137) costimulatory signalling have shown great potential in the treatment of acute lymphoblastic leukaemia (ALL). However, the difference between CD28 and 4-1BB costimulatory signalling in CAR-T trea...

journal_title：British journal of haematology

authors： Li S,Zhang J,Wang M,Fu G,Li Y,Pei L,Xiong Z,Qin D,Zhang R,Tian X,Wei Z,Chen R,Chen X,Wan J,Chen J,Wei X,Xu Y,Zhang P,Wang P,Peng X,Yang S,Shen J,Yang Z,Chen J,Qian C

更新日期：2018-05-01 00:00:00

abstract：:Apoptotic cell death is induced by the cross-linking of Fas/APO-1 receptor (CD95) in acute myelogenous leukaemia (AML) cells. Since CD95 ligand (CD95L) is expressed on interleukin-2 (IL-2)-activated T cells, we investigated the involvement of CD95-CD95L pathway in T cell-mediated cytotoxicity against AML cells. Activa...

journal_title：British journal of haematology

authors： Komada Y,Zhou YW,Zhang XL,Chen TX,Tanaka S,Azuma E,Sakurai M

更新日期：1997-01-01 00:00:00

abstract：:Increasing use of direct oral anticoagulants (DOACs) has made management of non-valvular atrial fibrillation and venous thromboembolism easier in most patients. But the presence of co-existing renal impairment could render the use of DOACs problematic because all of these drugs have varying degrees of renal excretion....

journal_title：British journal of haematology

authors： Parker K,Thachil J

更新日期：2018-10-01 00:00:00

abstract：:Transient myeloproliferative disorder (TMD) of the newborn and acute megakaryoblastic leukaemia (AMKL) in children with Down syndrome (DS) represent paradigmatic models of leukaemogenesis. Chromosome 21 gene dosage effects and truncating mutations of the X-chromosomal transcription factor GATA1 synergize to trigger TM...

journal_title：British journal of haematology

authors： Haemmerling S,Behnisch W,Doerks T,Korbel JO,Bork P,Moog U,Hentze S,Grasshoff U,Bonin M,Rieß O,Janssen JW,Jauch A,Bartram CR,Reinhardt D,Koch KA,Bandapalli OR,Kulozik AE

更新日期：2012-04-01 00:00:00

abstract：:Besides circulating in normal plasma, von Willebrand factor (VWF) is also stored at relatively high concentration within the alpha-granules of platelets. This pool of platelet VWF exists distinct from plasma VWF, and is enriched in haemostatically-active high molecular weight multimers. Interestingly, the glycosylatio...

journal_title：British journal of haematology

authors： McGrath RT,McRae E,Smith OP,O'Donnell JS

更新日期：2010-03-01 00:00:00

abstract：:This study was performed to assess the methods which gave maximal recovery of purified CD34/45+ cells from a cord blood specimen and optimal growth of progenitors cultured from the purified cells. Cord blood samples were separated using Percoll gradients (either one (1.080) or two successive (1.080 and 1.068) gradient...

journal_title：British journal of haematology

authors： Charbord P,Newton I,Voillat L,Schaal JP,Herve P

更新日期：1996-09-01 00:00:00

abstract：:The regulatory human immunodeficiency virus-1 (HIV-1) Tat protein shows pleiotropic effects on the survival and growth of both HIV-1-infected and uninfected CD4+ T lymphocytes. In this study, we have demonstrated that low concentrations (10 ng/ml) of extracellular Tat protein induce the expression of both c-fos mRNA a...

journal_title：British journal of haematology

authors： Gibellini D,Re MC,Ponti C,Celeghini C,Melloni E,La Placa M,Zauli G

更新日期：2001-03-01 00:00:00

abstract：:The past decade has seen an explosion of interest in the epigenetics of cancer, with an increasing understanding that this form of genomic modification plays a critical role in pathogenesis. The malignant phenotype results from a step-wise increase of both genetic abnormalities and epigenetic modifications, leading to...

journal_title：British journal of haematology

authors： Boultwood J,Wainscoat JS

更新日期：2007-07-01 00:00:00

abstract：:This study assessed the incidence of immune thrombocytopenia (ITP) and characteristics associated with ITP in the paediatric population using the General Practice Research Database (GPRD). Two hundred and fifty-seven paediatric ITP patients were identified out of 1145 incident patients with ITP recorded between 1990 a...

journal_title：British journal of haematology

authors： Yong M,Schoonen WM,Li L,Kanas G,Coalson J,Mowat F,Fryzek J,Kaye JA

更新日期：2010-06-01 00:00:00

abstract：:Prior case-control studies reported that levels of the soluble form of the endothelial protein C receptor (sEPCR) were strongly controlled by the PROCR 6963A/G polymorphism and higher levels were a risk factor for venous thromboembolism (VTE). We sought to prospectively examine the association of sEPCR and the 6963A/G...

journal_title：British journal of haematology

authors： Yamagishi K,Cushman M,Heckbert SR,Tsai MY,Folsom AR

更新日期：2009-04-01 00:00:00

abstract：:Peripheral blood progenitor cell (PBPC) mobilization was evaluated in 53 patients receiving the high-dose sequential (HDS) regimen: 27 had non-Hodgkin's lymphoma or Hodgkin's disease, primary refractory or at first relapse, 26 had non-Hodgkin's lymphoma at diagnosis. Mobilization was assessed following either 7 g/m2 c...

journal_title：British journal of haematology

authors： Tarella C,Castellino C,Cherasco C,Bondesan P,Giaretta F,Corradini P,Caracciolo D,Gavarotti P,Pileri A

更新日期：1997-10-01 00:00:00

abstract：:Cyclosporin A (CSA) exhibits greater multidrug resistance (MDR) modulating activity in vitro than other MDR modulators such as verapamil and quinidine. However, the immunosuppressive and nephrotoxic effects of CSA may limit its clinical use. PSC 833, a new cyclosporin D derivative, exerts a higher MDR reversal activit...

journal_title：British journal of haematology

authors： Jiang XR,Kelsey SM,Wu YL,Newland AC

更新日期：1995-06-01 00:00:00

abstract：:Protein S is expressed in a number of tissue types, one of the most physiologically relevant being the liver. However, transcriptional control of protein S gene expression is poorly understood. We have characterised a 638 bp area in the 5' flanking region of the human protein S gene, spanning all 10 previously reporte...

journal_title：British journal of haematology

authors： Hall AJ,Peake IR,Winship PR

更新日期：2006-11-01 00:00:00

abstract：:T-cell large granular lymphocyte leukaemia (T-LGL) is a clonal disorder of T cells associated with neutropenia and anaemia. The clinical consequences are recurrent infections and transfusion dependence. The optimum treatment for severely affected patients remains to be defined. Current therapies require long-term admi...

journal_title：British journal of haematology

authors： Sternberg A,Eagleton H,Pillai N,Leyden K,Turner S,Pearson D,Littlewood T,Hatton C

更新日期：2003-02-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma, where survival has been remarkably improved by use of protocols including high dose cytarabine, rituximab and autologous stem cell transplantation, such as the Nordic MCL2/3 protocols. In 2008, a MCL international prognostic index (MIPI) was created to enabl...

journal_title：British journal of haematology

authors： Nordström L,Sernbo S,Eden P,Grønbaek K,Kolstad A,Räty R,Karjalainen ML,Geisler C,Ralfkiaer E,Sundström C,Laurell A,Delabie J,Ehinger M,Jerkeman M,Ek S

更新日期：2014-07-01 00:00:00

abstract：:The identification of acquired CALR mutations in patients with essential thrombocythaemia (ET) or myelofibrosis (MF) has meant that disease-initiating mutations can now be detected in about 90% of all patients with a myeloproliferative neoplasm (MPN). Here, we show that only those CALR mutations that cause a +1 frames...

journal_title：British journal of haematology

authors： Martin S,Wright CM,Scott LM

更新日期：2017-04-01 00:00:00

abstract：:This placebo-controlled study evaluated the efficacy of Flt-3 ligand (FL) combined with TPO in myelosuppressed rhesus monkeys. The monkeys were subjected to 5 Gy total body irradiation (TBI), resulting in 3 weeks of profound pancytopenia, and received either 5 microg/kg of rhesus TPO i.v. on d 1 (n = 4) and 100 microg...

journal_title：British journal of haematology

authors： Hartong SC,Neelis KJ,Wagemaker G

更新日期：2003-04-01 00:00:00

abstract：:Clinical and cytogenetic data were analysed in 54 patients with acute non-lymphocytic leukaemias (ANLL) or MDS (myelodysplastic syndromes) and deletion of the long arm of chromosome 7 (7q-), in order to determine if there is a commonly deleted region in 7q and to establish possible correlations between karyotypic feat...

journal_title：British journal of haematology

authors： Velloso ER,Michaux L,Ferrant A,Hernandez JM,Meeus P,Dierlamm J,Criel A,Louwagie A,Verhoef G,Boogaerts M,Michaux JL,Bosly A,Mecucci C,Van den Berghe H

更新日期：1996-03-01 00:00:00

abstract：:Lysosomal enzyme activities and isoenzyme profiles were measured in lymphoid and non-lymphoid leukaemic cells from childhood patients. High activities, especially of beta-hexosaminidase and alpha-mannosidase, were associated with leukaemic cells of myeloid or monocytic origin. Leukaemic cells from two children with ac...

journal_title：British journal of haematology

authors： Eden OB,Darbyshire P,Simpson RM,Besley GT,Moss S,Gentle T

更新日期：1985-01-01 00:00:00

abstract：:Very few studies have investigated the effects of exercise on the biological parameters involved in vaso-occlusive events in sickle cell anaemia (SCA). The aim of this study was to test how a mild-moderate endurance exercise modulates oxidative stress, nitric oxide bioavailability and endothelial activation in SCA pat...

journal_title：British journal of haematology

authors： Faes C,Balayssac-Siransy E,Connes P,Hivert L,Danho C,Bogui P,Martin C,Pialoux V

更新日期：2014-01-01 00:00:00

abstract：:Two chemoattractants, the peptide N-formyl-met-leu-phe (FMLP), and the ether phospholipid, platelet activating factor (PAF), each stimulate a variety of in vitro responses in polymorphonuclear leucocytes (PMN). Because often more than one inflammatory mediator is active during inflammation, we determined the effect on...

journal_title：British journal of haematology

authors： Ingraham LM,Lafuze JE,Boxer LA,Baehner RL

更新日期：1987-06-01 00:00:00

abstract：:To clarify the clinical and biological significance of serum thymidine kinase (TK) in adult T-cell leukaemia (ATL) associated with human lymphotropic virus type-I (HTLV-I) and in acute myeloid leukaemia (AML), TK was measured in 52 patients with ATL (acute ATL, 35 patients; lymphoma ATL, two patients; chronic ATL, 12 ...

journal_title：British journal of haematology

authors： Sadamori N,Ichiba M,Mine M,Hakariya S,Hayashibara T,Itoyama T,Nakamura H,Tomonaga M,Hayashi K

更新日期：1995-05-01 00:00:00

abstract：:The variable clinical outcomes of Multiple Myeloma (MM) patients are incompletely defined by current prognostication tools. We examined the clinical utility of high-resolution telomere length analysis as a prognostic marker in MM. Cohort stratification, using a previously determined length threshold for telomere dysfu...

journal_title：British journal of haematology

authors： Hyatt S,Jones RE,Heppel NH,Grimstead JW,Fegan C,Jackson GH,Hills R,Allan JM,Pratt G,Pepper C,Baird DM

更新日期：2017-07-01 00:00:00