Lysosomal isoenzyme profiles used to classify a case of acute undifferentiated leukaemia.

abstract：:We report the data of CD34+ cell immunoselection from peripheral blood after G-CSF-alone mobilization (10 micrograms/kg/d s.c.) in nine children with neuroblastoma (median age 4-5 years (2-8), median body weight 16 kg (10-20). Leukaphereses were carried out on a Cobe Spectra separator and two consecutive harvests (4 b...

journal_title：British journal of haematology

authors： Kanold J,Berger M,Rapatel C,de Lumley L,Lutz P,Plantaz D,Vannier JP,Bergeron C,Mechinaud F,Favrot M

更新日期：1995-10-01 00:00:00

abstract：:Resistance to the anticoagulant effects of activated protein C (APC) is now considered the most prevalent cause of inherited thrombophilia. The great majority of patients with activated protein C resistance (APCR) have a missense mutation in the factor V molecule (factor V Leiden, FVR506Q) resulting in defective inact...

journal_title：British journal of haematology

authors： Liebman HA,Sutherland D,Bacon R,McGehee W

更新日期：1996-12-01 00:00:00

abstract：:We report two patients with Felty's syndrome and chronic skin ulcers treated successfully with recombinant granulocyte colony stimulating factor (GCSF). In both cases granulocytes returned to the normal range within days of starting treatment, and their cutaneous ulcers improved. In one patient granulocytes were maint...

journal_title：British journal of haematology

authors： Choi MF,Mant MJ,Turner AR,Akabutu JJ,Aaron SL

更新日期：1994-03-01 00:00:00

abstract：:Erythroid colonies derived from the circulating early erythroid precursor (BFU-E) of a patient with congenital dyserythropoietic anaemia type I (CDA I) have been grown in plasma clot and studied by electron microscopy. The number of circulating BFU-E was in the normal range with a roughly normal appearance at the ligh...

journal_title：British journal of haematology

authors： Vainchenker W,Guichard J,Bouguet J,Breton-Gorius J

更新日期：1980-09-01 00:00:00

abstract：:Budd-Chiari syndrome and portal vein thrombosis (BCS/PVT) are frequently associated with polycythaemia vera (PV). In an attempt to elucidate the mechanisms of BCS/PVT secondary to PV (T-PV), CD11b neutrophil expression, neutrophil oxidative burst and platelet-neutrophil complexes (PNC) were assessed in 17 such patient...

journal_title：British journal of haematology

authors： Alvarez-Larrán A,García-Pagán JC,Abraldes JG,Arellano E,Reverter JC,Bosch J,Cervantes F

更新日期：2004-02-01 00:00:00

abstract：:Our study aimed to determine the expression pattern and clinical relevance of CD99 in paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). Our findings demonstrate that high expression levels of CD99 are mainly found in high-risk BCP-ALL, e.g. BCR-ABL1 and CRLF2Re/Hi, and that high CD99 mRNA levels are...

journal_title：British journal of haematology

authors： Chen D,Camponeschi A,Wu Q,Gerasimcik N,Li H,Shen X,Tan Y,Sjögren H,Nordlund J,Lönnerholm G,Abrahamsson J,Fogelstrand L,Mårtensson IL

更新日期：2019-02-01 00:00:00

abstract：:A new putative hepatitis virus has recently been discovered and termed GB virus C (GBV-C). We investigated the prevalence of this virus among 50 haemophiliacs treated with non-virus-inactivated clotting factor concentrates prior to 1985 and 21 haemophiliacs treated exclusively with virus-inactivated clotting factor co...

journal_title：British journal of haematology

authors： Uhle C,Zimmermann R,Goeser T,Seelig R

更新日期：1997-12-01 00:00:00

abstract：:The combination of tumour necrosis factor alpha (TNF alpha) and gamma-interferon induced transcription of class I HLA genes in chronic myelogenous leukaemia (CML) cell lines through the formation of a complex between nuclear proteins and the transcriptional enhancers associated with these genes. Although gamma-interfe...

journal_title：British journal of haematology

authors： Seong D,Sims S,Johnson E,Lyding J,Lopez A,Garovoy M,Talpaz M,Kantarjian H,Lopez-Berestein G,Reading C

更新日期：1991-07-01 00:00:00

abstract：:Lenalidomide (LEN) acts directly on multiple myeloma (MM) cells by inducing cereblon-mediated degradation of interferon regulatory factor 4, Ikaros (IKZF)1 and IKZF3, transcription factors that are essential for MM cell survival. The mucin 1 (MUC1) C-terminal transmembrane subunit (MUC1-C) oncoprotein is aberrantly ex...

journal_title：British journal of haematology

authors： Yin L,Tagde A,Gali R,Tai YT,Hideshima T,Anderson K,Avigan D,Kufe D

更新日期：2017-09-01 00:00:00

abstract：:Using comparative genomic hybridization (CGH), aberrations in DNA copy number were studied before and after transformation of follicular lymphoma to diffuse large B-cell lymphoma in six patients (15 lymph node biopsies in total). The most common and also the most discrete and intense amplification occurring in four ou...

journal_title：British journal of haematology

authors： Goff LK,Neat MJ,Crawley CR,Jones L,Jones E,Lister TA,Gupta RK

更新日期：2000-11-01 00:00:00

abstract：:This study describes the largest series reported to date, of individuals belonging to unrelated families carrying a beta-thalassaemia-like phenotype in whom the beta-globin gene was found to be structurally intact by sequence analysis. This genetic determinant appears haematologically heterogeneous, displaying either ...

journal_title：British journal of haematology

authors： Faà V,Meloni A,Moi L,Ibba G,Travi M,Vitucci A,Cao A,Rosatelli MC

更新日期：2006-03-01 00:00:00

abstract：:Haemophilia B Leyden is characterized by severe factor IX deficiency during childhood with partial resolution at puberty or following the administration of anabolic steroids. The disorder has recently been associated with point mutations in the putative factor IX promoter region, which contains an imperfect direct rep...

journal_title：British journal of haematology

authors： Royle G,Van de Water NS,Berry E,Ockelford PA,Browett PJ

更新日期：1991-02-01 00:00:00

abstract：:A 2-year-old girl is described with severe haemophilia A (factor VIII: C < 0.01 units/ml). Both of her parents were phenotypically normal. Cytogenetic analysis on the proband demonstrated an interstitial X chromosome deletion encompassing Xq26-q28. Molecular studies with several polymorphic markers close to and within...

journal_title：British journal of haematology

authors： Windsor S,Lyng A,Taylor SA,Ewenstein BM,Neufeld EJ,Lillicrap D

更新日期：1995-08-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma (MM), we tested the hypothesis that genetic variants in this region could play a role ...

journal_title：British journal of haematology

authors： Campa D,Martino A,Sainz J,Buda G,Jamroziak K,Weinhold N,Vieira Reis RM,García-Sanz R,Jurado M,Ríos R,Szemraj-Rogucka Z,Marques H,Lesueur F,Bugert P,Moreno V,Szemraj J,Orciuolo E,Gemignani F,Rossi AM,Dumontet C,Pet

更新日期：2012-05-01 00:00:00

abstract：:The bleeding time in healthy volunteers was determined according to both the Ivy and the Simplate II techniques. A significantly longer bleeding time in people with blood group O than in people with non-O blood groups was demonstrated with both techniques. This difference could not be attributed to a difference in sex...

journal_title：British journal of haematology

authors： Caekebeke-Peerlinck KM,Koster T,Briët E

更新日期：1989-10-01 00:00:00

abstract：:Massive genomic analyses have underscored the diversity of chronic lymphocytic leukaemia (CLL) between patients. Genetic heterogeneity of tumour clones within a patient may fuel tumour evolution. Several recurrently deregulated intra-cellular pathways are candidates for targeted therapies that are very promising and a...

journal_title：British journal of haematology

authors： Ghamlouch H,Nguyen-Khac F,Bernard OA

更新日期：2017-09-01 00:00:00

abstract：:Analysis of factor IX gene polymorphisms is considered the best approach for prenatal diagnosis and carrier detection of haemophilia B when the identification of the gene mutation is not possible. Studies involving factor IX gene polymorphisms in Black populations are scarce and essentially restricted to the North-Ame...

journal_title：British journal of haematology

authors： Figueiredo MS,Bowen DJ,Silva Júnior WA,Zago MA

更新日期：1994-08-01 00:00:00

abstract：:Previously described platelet-aggregating antibodies associated with thrombosis and thrombocytopenia required heparin for their in vivo and in vitro expression. We have observed a patient with thrombosis who became thrombocytopenic during heparin treatment, but who suffered further thrombotic events and continued thro...

journal_title：British journal of haematology

authors： Pfueller SL,David R,Firkin BG,Bilston RA,Cortizo WF,Raines G

更新日期：1990-03-01 00:00:00

abstract：:A 70-year-old man from an endemic area of human T-cell lymphotropic virus type I (HTLV-I) developed rapid generalized lymphadenopathy and abdominal tumours. The white blood cell count was 198.3 x 10(9)/l with 93% lymphocytes, 66.3% of which expressed large granular lymphocytes (LGLs). Bone marrow and lymph nodes were ...

journal_title：British journal of haematology

authors： Sakamoto Y,Kawachi Y,Uchida T,Abe T,Mori M,Setsu K,Indo N

更新日期：1994-02-01 00:00:00

abstract：:Leukaemic stem cells (LSC) have been experimentally defined as the leukaemia-propagating population and are thought to be the cellular reservoir of relapse in acute myeloid leukaemia (AML). Therefore, LSC measurements are warranted to facilitate accurate risk stratification. Previously, we published the composition of...

journal_title：British journal of haematology

authors： Hanekamp D,Snel AN,Kelder A,Scholten WJ,Khan N,Metzner M,Irno-Consalvo M,Sugita M,de Jong A,Oude Alink S,Eidhof H,Wilhelm M,Feuring-Buske M,Slomp J,van der Velden VHJ,Sonneveld E,Guzman M,Roboz GJ,Buccisano F,Vyas P

更新日期：2020-09-01 00:00:00

abstract：:Association between HLA haplotypes and long survival was investigated in 116 children with acute lymphoblastic leukaemia. It was found that patients with A2 B12 and/or A2 B40 haplotypes survived longer than patients wtihout these two haplotypes. Since all children were treated with transfer factor obtained from their ...

journal_title：British journal of haematology

authors： De Bruyère M,Cornu G,Heremans-Bracke T,Malchaire J,Sokal G

更新日期：1980-02-01 00:00:00

abstract：:The responsiveness of bone marrow erythroid progenitors (CFU-E and BFU-E) to recombinant human erythropoietin (rh-Ep) was investigated in vitro in 21 patients with multiple myeloma to assess the clinical usefulness of rh-Ep in this disease. CFU-E and BFU-E assays were performed by methylcellulose culture methods. The ...

journal_title：British journal of haematology

authors： Aoki I,Nishijima K,Homori M,Nakahara K,Higashi K,Ishikawa K

更新日期：1992-08-01 00:00:00

abstract：:In myeloid malignancies, T-cell and NK function has been shown to deteriorate with transformation from pre-leukaemia to advanced disease. Immune dysfunction in solid tumours has been attributed to abnormal signal transduction, possibly through altered expression of intracellular components of the TCR/CD3 complex (e.g....

journal_title：British journal of haematology

authors： Buggins AG,Hirst WJ,Pagliuca A,Mufti GJ

更新日期：1998-03-01 00:00:00

abstract：:Leucocyte interferon production in vitro and circulating interferon levels were studied in healthy subjects and in 80 patients with acute or chronic leukaemia. Circulating interferon was not found in either group. Interferon synthesis in response to a virus was normal in patients with acute leukaemia and appeared to b...

journal_title：British journal of haematology

authors： Chisholm M,Cartwright T

更新日期：1978-09-01 00:00:00

abstract：:Platelet antibodies either bound to the surface of platelets or free in the serum were sought in patients who had low platelet counts for a variety of reasons. They were detected by finding excess IgG on the surface of washed platelets either directly or after incubation of the serum with normal platelets. The techniq...

journal_title：British journal of haematology

authors： Hegde UM,Gordon-Smith EC,Worlledge S

更新日期：1977-01-01 00:00:00

abstract：:The inv(8)(p11q13) chromosomal abnormality, described in acute myeloid leukaemias (AML), fuses the histone acetyl-transferase (HAT) MYST3 (MOZ) gene with another HAT gene, NCOA2 (TIF2). We generated a transgenic zebrafish in which the MYST3/NCOA2 fusion gene was expressed under control of the spi1 promoter. An AML dev...

journal_title：British journal of haematology

authors： Zhuravleva J,Paggetti J,Martin L,Hammann A,Solary E,Bastie JN,Delva L

更新日期：2008-11-01 00:00:00

abstract：:Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare, recessively inherited genetic disorder with varying clinical presentation that is caused by ADAMTS13 mutations. Several studies have found limited associations between ADAMTS13 mutations and cTTP phenotype. The use of in silico tools that examine multipl...

journal_title：British journal of haematology

authors： Hing ZA,Schiller T,Wu A,Hamasaki-Katagiri N,Struble EB,Russek-Cohen E,Kimchi-Sarfaty C

更新日期：2013-03-01 00:00:00

abstract：:Immune reconstitution was studied prospectively in 66 children who underwent 77 haematopoietic cell transplantations (HCT): 46 autologous HCTs in 39 patients and 31 allogeneic HCTs in 27 patients. We studied the dynamic analysis of immune recovery with regard to potential factors affecting its speed, including age, ty...

journal_title：British journal of haematology

authors： Kalwak K,Gorczyńska E,Toporski J,Turkiewicz D,Slociak M,Ussowicz M,Latos-Grazyńska E,Król M,Boguslawska-Jaworska J,Chybicka A

更新日期：2002-07-01 00:00:00

abstract：:A previous dose-finding study has suggested that romiplostim is effective in patients with refractory aplastic anaemia (AA) and 10 µg/kg once weekly was recommended as a starting dose. In this Phase II/III, multicentre, open-label study, romiplostim was administered subcutaneously at a fixed dose of 10 µg/kg once week...

journal_title：British journal of haematology

authors： Jang JH,Tomiyama Y,Miyazaki K,Nagafuji K,Usuki K,Uoshima N,Fujisaki T,Kosugi H,Matsumura I,Sasaki K,Kizaki M,Sawa M,Hidaka M,Kobayashi N,Ichikawa S,Yonemura Y,Enokitani K,Matsuda A,Ozawa K,Mitani K,Lee JW,Nakao

更新日期：2021-01-01 00:00:00

abstract：:Osteonecrosis is a disabling complication in children and young adults with acute lymphoblastic leukaemia. It can affect any or multiple joints but the hip and knee are most frequently involved and a cause of long-term disability. The problem is almost exclusively that of older children and young adults of whom over 7...

journal_title：British journal of haematology

authors： Vora A

更新日期：2011-12-01 00:00:00