MUC1-C is a target in lenalidomide resistant multiple myeloma.

abstract：:The treatment of Hodgkin lymphoma (HL) is one of early success. However, disease-free survival (DFS) does not reflect latent organ injury and its impact on health status and well-being beyond 5 years. In fact, we are at a crossroads, in terms of needing individualized approaches to maintain DFS, while minimizing late ...

journal_title：British journal of haematology

authors： Castellino SM,Parsons SK,Kelly KM

更新日期：2019-12-01 00:00:00

abstract：:Treatment-free remission (TFR) has recently emerged as a goal of treatment in chronic myeloid leukaemia (CML). Molecular remission is sustained in around 30% of imatinib-treated patients who stop treatment after ≥2 years with undetectable minimal residual disease (UMRD) by conventional real-time reverse transcription ...

journal_title：British journal of haematology

authors： Ross DM,Hughes TP

更新日期：2014-07-01 00:00:00

abstract：:Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably indicate reduced iron stores, raised serum ferritin levels can be due to multiple different aetiologies, including iron overload, inflammation, liver or renal diseas...

journal_title：British journal of haematology

authors： Cullis JO,Fitzsimons EJ,Griffiths WJ,Tsochatzis E,Thomas DW,British Society for Haematology.

更新日期：2018-05-01 00:00:00

abstract：:The Kidd (JK) blood group system is of importance in transfusion medicine. The Jk(null) phenotype is associated with absence of the urea transporter in erythrocytes and moderately reduced ability to concentrate urine. We and others recently reported different molecular alterations in the silenced Jkb-like alleles of P...

journal_title：British journal of haematology

authors： Irshaid NM,Eicher NI,Hustinx H,Poole J,Olsson ML

更新日期：2002-02-01 00:00:00

abstract：:Fibrinogen Chapel Hill II is a hereditary, abnormal fibrinogen which is characterized by poor substrate reactivity toward thrombin, factor XIIIa and plasmin. The patient has a low plasma level of clottable protein with normal antigen concentration, high amounts of fibrinogen related material in serum, and prolonged th...

journal_title：British journal of haematology

authors： Carrell N,McDonagh J

更新日期：1982-09-01 00:00:00

abstract：:Antithrombin III (AT) levels from normal and AT deficiency persons were measured by electroimmunoassay (EIA) and the results compared with a chromogenic assay (S2238). Discrepant results were obtained when plasma and serum were compared using one antiserum, and therefore did not always relate to functional activity. A...

journal_title：British journal of haematology

authors： McKay EJ

更新日期：1980-10-01 00:00:00

abstract：:Juvenile haemochromatosis or haemochromatosis type 2 is a rare autosomal recessive disorder which causes iron overload at a young age, affects both sexes equally and is characterized by a prevalence of hypogonadism and cardiopathy. Patients with haemochromatosis type 2 have been reported in different ethnic groups. Li...

journal_title：British journal of haematology

authors： De Gobbi M,Roetto A,Piperno A,Mariani R,Alberti F,Papanikolaou G,Politou M,Lockitch G,Girelli D,Fargion S,Cox TM,Gasparini P,Cazzola M,Camaschella C

更新日期：2002-06-01 00:00:00

abstract：:This retrospective analysis was conducted in 64 patients diagnosed with type I cryoglobulinaemia (CG) followed at two French centres. Median follow-up was 6·75 years. CG was IgG in 60% and IgM in 40% of all cases and was asymptomatic in 16 patients (25%). Cold-triggered ischaemic skin manifestations were observed in 3...

journal_title：British journal of haematology

authors： Harel S,Mohr M,Jahn I,Aucouturier F,Galicier L,Asli B,Malphettes M,Szalat R,Brouet JC,Lipsker D,Fermand JP

更新日期：2015-03-01 00:00:00

abstract：:To clarify the mechanisms underlying thrombocytosis secondary to infections, we longitudinally studied serum levels of thrombopoietin (TPO) and interleukin (IL)-6 in 15 infants and young children with prominent thrombocytosis (platelets >700 x 10(9)/l) following acute infections and 116 age-matched controls using an e...

journal_title：British journal of haematology

authors： Ishiguro A,Suzuki Y,Mito M,Shimbo T,Matsubara K,Kato T,Miyazaki H

更新日期：2002-03-01 00:00:00

abstract：:Seven children (age range 1.8-11 years) with juvenile chronic myelomonocytic leukaemia (JCML) received an allogeneic bone marrow transplantation (BMT), four from an HLA-identical sibling and three from a matched unrelated donor. In the four children transplanted using an HLA-identical sibling, conditioning regimen inc...

journal_title：British journal of haematology

authors： Locatelli F,Pession A,Comoli P,Bonetti F,Giorgiani G,Zecca M,Taibi RM,Mongini ME,Ambroselli F,de Stefano P,Severi F,Paolucci G

更新日期：1996-01-01 00:00:00

abstract：:Human intravenous immunoglobulin (IVIg) and anti-D immunoglobulin preparations are used in the treatment of immune thrombocytopenic purpura (ITP). One mechanism proposed to explain their therapeutic effects in ITP patients is the induction of expression of anti-inflammatory cytokines, such as interleukin (IL)-10 or IL...

journal_title：British journal of haematology

authors： Aubin E,Lemieux R,Bazin R

更新日期：2007-03-01 00:00:00

abstract：:Myeloproliferative disorders (MPD) are reported in 25-65% of patients with splanchnic vein thrombosis (SVT). Diagnostic criteria for MPD have not been fully established in this context. Using clusters of abnormal megakaryocytes in bone marrow (BM) biopsy as a reference standard for Philadelphia negative MPD, we assess...

journal_title：British journal of haematology

authors： Chait Y,Condat B,Cazals-Hatem D,Rufat P,Atmani S,Chaoui D,Guilmin F,Kiladjian JJ,Plessier A,Denninger MH,Casadevall N,Valla D,Brière JB

更新日期：2005-05-01 00:00:00

abstract：:We analysed the incidence of graft failure, graft-versus-host disease (GVHD) and relapse of leukaemia in 208 patients undergoing allogeneic bone marrow transplantation (BMT) for chronic myeloid leukaemia in chronic phase in eight transplant centres in Europe and the United States. 106 patients received unmanipulated d...

journal_title：British journal of haematology

authors： Apperley JF,Mauro FR,Goldman JM,Gregory W,Arthur CK,Hows J,Arcese W,Papa G,Mandelli F,Wardle D

更新日期：1988-06-01 00:00:00

abstract：:Peripheral blood globin synthesis studies were done in 11 patients with delta beta-thalassaemia trait, Hb S-delta beta-thalassaemia or delta beta/betao-thalassaemia from two black and two Caucasian families. All patients had elevated Hb F and normal or decreased Hb A2 levels and 10 had family studies confirming the di...

journal_title：British journal of haematology

authors： Kinney TR,Friedman S,Cifuentes E,Kim HC,Schwartz E

更新日期：1978-01-01 00:00:00

abstract：:A total of 622 consecutive patients with acute promyelocytic leukaemia (APL) treated within the Gruppo Italiano per le Malattie Ematologiche dell'Adulto (GIMEMA) group during 1989-97 have been reviewed to assess the clinical effectiveness of all-trans retinoic acid (ATRA) on the incidence of early haemorrhagic deaths ...

journal_title：British journal of haematology

authors： Di Bona E,Avvisati G,Castaman G,Luce Vegna M,De Sanctis V,Rodeghiero F,Mandelli F

更新日期：2000-03-01 00:00:00

abstract：:Commercial preparations of ferritin inhibited reticulocyte-lysate cell-free protein synthesis and disaggregated polyribosomes to monoribosomes and ribosomal subunits. These effects were prevented by addition of reduced glutathione (GSH) to the incubation medium, but ferritin did not lower GSH concentration in the lysa...

journal_title：British journal of haematology

authors： Freedman ML,Cohen HS,Rosman J,Forte FJ

更新日期：1976-04-01 00:00:00

abstract：:Use of asparaginase (ASNase) in the treatment of relapsed childhood acute lymphoblastic leukaemia (ALL) is associated with a high rate of hypersensitive reactions. 'Silent' inactivation may additionally reduce treatment intensity. Therefore, PEG-ASNase (Oncaspar), a polyethylene glycol conjugate of the native Escheric...

journal_title：British journal of haematology

authors： Vieira Pinheiro JP,Müller HJ,Schwabe D,Gunkel M,Casimiro da Palma J,Henze G,von Schütz V,Winkelhorst M,Würthwein G,Boos J

更新日期：2001-04-01 00:00:00

abstract：:This study describes the effect of ferritin on lymphocyte function in vitro. Peripheral blood lymphocytes isolated from normal donors were incubated with purified human splenic ferritin, and the mitogenic effect of phytohaemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM) and mixed lymphocyte reaction ...

journal_title：British journal of haematology

authors： Matzner Y,Hershko C,Polliack A,Konijn AM,Izak G

更新日期：1979-07-01 00:00:00

abstract：:D-type cyclin genes are universally dysregulated in multiple myeloma (MM), but the functional consequences are unclear as D-type cyclin gene expression does not correlate with proliferation or disease progression. We examined the protein expression and regulation of D-type cyclins and other cell cycle regulators in hu...

journal_title：British journal of haematology

authors： Glassford J,Rabin N,Lam EW,Yong KL

更新日期：2007-10-01 00:00:00

abstract：:Of 125 patients aged 65 years or over, with atrial fibrillation taking warfarin for at least 12 months, with a standard deviation (SD) of prothrombin time, expressed as the International Normalized Ratio (INR) >0.5 over the previous 6 months, 40 were randomized to continue with usual clinic care and 85 to receive educ...

journal_title：British journal of haematology

authors： Khan TI,Kamali F,Kesteven P,Avery P,Wynne H

更新日期：2004-08-01 00:00:00

abstract：:Early T-cell precursor acute lymphoblastic leukaemia (ETP-ALL) is a recently identified subtype of T-ALL with distinctive gene expression and cell marker profiles, poor response to chemotherapy and a very high risk of relapse. We determined the reliability of restricted panel of cell markers to identify EPT-ALL using ...

journal_title：British journal of haematology

authors： Inukai T,Kiyokawa N,Campana D,Coustan-Smith E,Kikuchi A,Kobayashi M,Takahashi H,Koh K,Manabe A,Kumagai M,Ikuta K,Hayashi Y,Tsuchida M,Sugita K,Ohara A

更新日期：2012-02-01 00:00:00

abstract：:A human plasma cell leukaemia cell line (HSM-2) and a subclone (HSM-2.3) have been established from the bone marrow of a patient with bi-phenotypic leukaemia. Proliferation assays using a variety of cytokines demonstrated that HSM-2 proliferated in response to recombinant interleukin-6 (rIL-6), but did not respond to ...

journal_title：British journal of haematology

authors： Kobayashi M,Miyagishima T,Imamura M,Maeda S,Gotohda Y,Iwasaki H,Sakurada K,Miyazaki T

更新日期：1991-06-01 00:00:00

abstract：:We conducted a study to demonstrate vincristine-induced apoptosis in vivo in peripheral blood mononuclear cells of children with newly diagnosed acute lymphoblastic leukaemia (ALL). In five children, apoptosis was detected by terminal deoxynucleotide transferase-mediated dUTP-digoxigenin nick-end labelling (TUNEL) ass...

journal_title：British journal of haematology

authors： Groninger E,de Graaf SS,Meeuwsen-de Boer GJ,Sluiter WJ,Poppema S

更新日期：2000-12-01 00:00:00

abstract：:Graft rejection and graft-versus-host disease are major problems in mismatched marrow transplants along with toxicity from standard myeloablative host treatments. We have established a tolerization model, using 1 Gy irradiation, which reduces stem cell capacity to < 10% of control while causing minimal myelosuppressio...

journal_title：British journal of haematology

authors： Lambert JF,Colvin GA,Zhong S,Wang H,D'Hondt L,Abedi M,Frimberger AE,Stewart FM,Quesenberry PJ

更新日期：2002-10-01 00:00:00

abstract：:In a patient with immune thrombocytopenic purpura (ITP), we found a novel platelet-activating IgG (act-IgG) and an inhibitory IgG (inhi-IgG) that prevented activation induced by both CD9 monoclonal antibody (mAb) and the act-IgG. Purified IgG from the patient plasma caused a rise in [Ca2+]i and the aggregation of norm...

journal_title：British journal of haematology

authors： Yanabu M,Nomura S,Fukuroi T,Suzuki M,Kawakatsu T,Kido H,Yamaguchi K,Kokawa T,Yasunaga K

更新日期：1993-08-01 00:00:00

abstract：:We studied the trends of the Epstein-Barr virus (EBV) positivity rate in Hodgkin's disease (HD) between 1955 and 1999. The overall positivity rate gradually decreased over time [12 out of 23 (52%) in 1955-69; 18 out of 39 (46%) in 1970-84; 13 out of 44 (35%) in 1985-99; P = 0.135]. Interestingly, a marked decrease in ...

journal_title：British journal of haematology

authors： Takeuchi K,Morishita Y,Fukayama M,Mori S

更新日期：2001-05-01 00:00:00

abstract：:We previously demonstrated that multitransfused patients with severe aplastic anaemia (SAA) exhibit high numbers of alloreactive cytotoxic T lymphocyte precursors directed against their HLA identical siblings. In this study a group of patients who had received multiple blood transfusions for SAA, other haematological ...

journal_title：British journal of haematology

authors： Kaminski ER,Hows JM,Goldman JM,Batchelor JR

更新日期：1992-05-01 00:00:00

abstract：:Heparin binding on polymorphonuclear leucocytes (PMNL) was characterized. Heparin binding was specific, rapid, saturable and reversible. One single class of heparin binding sites was found with a dissociation constant of 1.22 mumol/l and 7.7 x 10(6) sites per PMNL. The binding was independent of the anticoagulant acti...

journal_title：British journal of haematology

authors： Leculier C,Benzerara O,Couprie N,Francina A,Lasne Y,Archimbaud E,Fiere D

更新日期：1992-05-01 00:00:00

abstract：:The in vitro growth characteristics of a large series of acute myeloid leukaemia (AML) patients and their relationship with other clinical and biological disease characteristics were analysed. Patients with AML were studied, 181 with de novo AML and 45 with secondary AML (24 myelodysplastic syndrome, sAML-MDS, 21 myel...

journal_title：British journal of haematology

authors： del Cañizo MC,Brufau A,Almeida J,Galende J,García Marcos MA,Mota A,García R,Fernández Calvo J,Ramos F,Fisac P,Orfao A,San Miguel JF

更新日期：1998-10-01 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) was previously demonstrated to be a mediator of oxidative stress-induced apoptosis in irradiated neoplastic B-cells and B-cell precursors. Defective BTK expression in leukaemic B-cell precursors from infants with t(4;11) acute lymphoblastic leukaemia has been associated with radiation re...

journal_title：British journal of haematology

authors： Uckun F,Ozer Z,Vassilev A

更新日期：2007-02-01 00:00:00