Suppressive effect of ferritin on in vitro lymphocyte function.


:This study describes the effect of ferritin on lymphocyte function in vitro. Peripheral blood lymphocytes isolated from normal donors were incubated with purified human splenic ferritin, and the mitogenic effect of phytohaemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM) and mixed lymphocyte reaction (MLR) were assessed by the uptake of 3H-thymidine (3H-TdR). Ferritin (0.25--5.0 micrograms/ml culture) caused a marked suppression of PHA nad Con A blastogenesis but had no suppressive effect on PWM-induced transformation. Maximal suppression was obtained at a ferritin concentration of 1 microgram/ml and this was not enhanced by increasing ferritin concentrations. Ferritin also reduced the Con A capping phenomenon in normal lymphocytes from 22% to 6%, suppressed the MLR reaction but had no effect on the ability of normal lymphocytes to form E, EA and EAC rosettes or on in vitro lymphocyte cytoxicity against the K-562 cell line. Visual proof of the suppressive effect of ferritin on mitogen induced blastogenesis was provided by scanning electron microscopy, and direct evidence for the ability of lymphocytes to bind ferritin was obtained from studies with radioiodine labelled ferritin. The above findings indicate that ferritin suppresses certain parameters of T-lymphocyte function in vitro. The relation of the present findings to recognized abnormalities of T-cell function encountered in certain neoplastic disorders associated with high serum ferritin levels is at present unknown.


Br J Haematol


Matzner Y,Hershko C,Polliack A,Konijn AM,Izak G




Has Abstract


1979-07-01 00:00:00












  • Assessment of complement binding by anti-D and anti-M antibodies employing labelled antiglobulin antibodies.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Freedman J,Massey A,Chaplin H,Monroe MC

    更新日期:1980-06-01 00:00:00

  • CD16 and CR3 receptors distinguish between the two mechanisms of tumour cytotoxicity in neutrophils.

    abstract::Previous studies have suggested that phorbol ester-activated neutrophils kill both antibody non-coated and antibody-coated K562 target cells. In this report the contribution of the receptors Fc gamma III (CD16) and CR3 (CD11b/CD18) in the lytic process was investigated. In neutrophils CD16 and CR3 are up-regulated by ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Gavioli R,Spisani S,Giuliani AL,Cosulich E,Risso A,Traniello S

    更新日期:1991-10-01 00:00:00

  • Effect of subcutaneously administered human recombinant erythropoietin on erythropoiesis in patients with myelodysplasia.

    abstract::In a phase II study, 12 patients with a myelodysplastic syndrome (MDS) and anaemia (nine transfusion-dependent) were treated with recombinant human erythropoietin (rHuEpo) to assess the therapeutic effect on erythropoiesis and on transfusion requirement. Patients with a low risk of developing acute leukaemia were incl...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: van Kamp H,Prinsze-Postema TC,Kluin PM,den Ottolander GJ,Beverstock GC,Willemze R,Fibbe WE

    更新日期:1991-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Cottin L,Riou J,Orvain C,Ianotto JC,Boyer F,Renard M,Truchan-Graczyk M,Murati A,Jouanneau-Courville R,Allangba O,Mansier O,Burroni B,Rousselet MC,Quintin-Roué I,Martin A,Sadot-Lebouvier S,Delneste Y,Chrétien JM,Hunaul

    更新日期:2020-03-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


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    更新日期:2014-02-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Burton C,Ell P,Linch D

    更新日期:2004-09-01 00:00:00

  • Gene expression profiles of erythroid precursors characterise several mechanisms of the action of hydroxycarbamide in sickle cell anaemia.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Costa FC,da Cunha AF,Fattori A,de Sousa Peres T,Costa GG,Machado TF,de Albuquerque DM,Gambero S,Lanaro C,Saad ST,Costa FF

    更新日期:2007-01-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: White JR,Josten KM,Chopra R,Tooze J,Saso R,Gordon-Smith EC,Rutherford TR

    更新日期:1995-12-01 00:00:00

  • Mobilization of Ph chromosome-negative peripheral blood stem cells in chronic myeloid leukaemia patients with imatinib mesylate-induced complete cytogenetic remission.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Drummond MW,Marin D,Clark RE,Byrne JL,Holyoake TL,Lennard A,United Kingdom Chronic Myeloid Leukaemia (UK CML) Working Party.

    更新日期:2003-11-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Sainio S,Javela K,Tuimala J,Haimila K

    更新日期:2017-01-01 00:00:00

  • Stomatin is mis-trafficked in the erythrocytes of overhydrated hereditary stomatocytosis, and is absent from normal primitive yolk sac-derived erythrocytes.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Fricke B,Parsons SF,Knöpfle G,von Düring M,Stewart GW

    更新日期:2005-10-01 00:00:00

  • Guideline: the laboratory diagnosis of malaria. General Haematology Task Force of the British Committee for Standards in Haematology.

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    journal_title:British journal of haematology

    pub_type: 信件,实务指引


    authors: Bailey JW,Williams J,Bain BJ,Parker-Williams J,Chiodini PL,General Haematology Task Force of the British Committee for Standards in Haematology.

    更新日期:2013-12-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Fuse I,Higuchi W,Uesugi Y,Aizawa Y

    更新日期:2001-03-01 00:00:00

  • Differentiation of functional dendritic cells and macrophages from human peripheral blood monocyte precursors is dependent on expression of p21 (WAF1/CIP1) and requires iron.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Kramer JL,Baltathakis I,Alcantara OS,Boldt DH

    更新日期:2002-06-01 00:00:00

  • Changes in the activities of some membrane-associated enzymes during in vivo ageing of the normal human erythrocyte.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Kadlubowski M,Agutter PS

    更新日期:1977-09-01 00:00:00

  • Protein C and protein S levels in two patients with acquired purpura fulminans.

    abstract::Purpura fulminans (PF) is a cutaneous manifestation of a dramatic and deadly syndrome of systemic disseminated intravascular coagulation (DIC). It is characterized by microvascular thrombosis in the dermis followed by perivascular haemorrhage. Since two other related syndromes involve the protein C (PC) system, we und...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Madden RM,Gill JC,Marlar RA

    更新日期:1990-05-01 00:00:00

  • Lessons in platelet production from inherited thrombocytopenias.

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    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Pecci A,Balduini CL

    更新日期:2014-04-01 00:00:00

  • Low-dose aspirin does not lower in vivo platelet activation in healthy smokers.

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    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pernerstorfer T,Stohlawetz P,Stummvoll G,Kapiotis S,Szekeres T,Eichler HG,Jilma B

    更新日期:1998-09-01 00:00:00

  • Constitutional trisomy 8p11.21-q11.21 mosaicism: a germline alteration predisposing to myeloid leukaemia.

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    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Ripperger T,Tauscher M,Praulich I,Pabst B,Teigler-Schlegel A,Yeoh A,Göhring G,Schlegelberger B,Flotho C,Niemeyer CM,Steinemann D

    更新日期:2011-10-01 00:00:00

  • Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Morris EC,Harrison G,Bailey CC,Hann IM,Hill FG,Gibson BE,Richards S,Webb DK,Medical Research Council Childhood Leukaemia Working Party.

    更新日期:2003-03-01 00:00:00

  • Platelet mass has prognostic value in patients with myelodysplastic syndromes.

    abstract::Platelet mass (mean platelet volume x platelet count) can be derived from data obtained from the routine full blood count and separates patients with myelodysplastic syndromes (MDS) at diagnosis into three distinct prognostic groups: low platelet mass group - median survival 5 months and 5-year survival 0%; intermedia...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Bowles KM,Warner BA,Baglin TP

    更新日期:2006-10-01 00:00:00

  • A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma.

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    pub_type: 杂志文章,多中心研究


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    更新日期:2013-05-01 00:00:00

  • CD59-deficient blood cells and PIG-A gene abnormalities in Japanese patients with aplastic anaemia.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Azenishi Y,Ueda E,Machii T,Nishimura J,Hirota T,Shibano M,Nakao S,Kinoshita T,Mizoguchi H,Kitani T

    更新日期:1999-03-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


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    更新日期:2019-04-01 00:00:00

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Schwab C,Willers J,Niederer E,Ludwig E,Kündig T,Grob P,Burg G,Dummer R

    更新日期:2002-09-01 00:00:00

  • The relevance of alpha-naphthyl acetate esterases to various monocyte functions.

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    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Oertel J,Hagner G,Kastner M,Huhn D

    更新日期:1985-12-01 00:00:00

  • Quality of life during and following sequential treatment of previously untreated patients with multiple myeloma: findings of the Medical Research Council Myeloma IX randomised study.

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    journal_title:British journal of haematology

    pub_type: 杂志文章,随机对照试验


    authors: Royle KL,Gregory WM,Cairns DA,Bell SE,Cook G,Owen RG,Drayson MT,Davies FE,Jackson GH,Morgan GJ,Child JA

    更新日期:2018-09-01 00:00:00

  • Splenic irradiation before bone marrow transplantation for chronic myeloid leukaemia. Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)

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    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gratwohl A,Hermans J,van Biezen A,Arcese W,Debusscher L,Ernst P,Ferrant A,Frassoni F,Gahrton G,Iriondo A,Kolb HJ,Link H,Niederwieser D,Ruutu T,Siegert W,Zwaan FE

    更新日期:1996-12-01 00:00:00

  • PCR-monitoring of minimal residual leukaemia after conventional chemotherapy and bone marrow transplantation in BCR-ABL-positive acute lymphoblastic leukaemia.

    abstract::We report the results of consecutive tests in nine BCR-ABL-positive ALL patients by one-step and two-step (nested primer) reverse transcriptase-polymerase chain reaction (RT-PCR). Six patients could be tested in complete haematological remission (CHR). One patient remained one-step positive; four patients became one-s...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Mitterbauer G,Födinger M,Scherrer R,Knöbl P,Jäger U,Laczika K,Schwarzinger I,Gaiger A,Geissler K,Greinix H

    更新日期:1995-04-01 00:00:00

  • Chronic lymphocytic leukaemia genomics and the precision medicine era.

    abstract::Massive genomic analyses have underscored the diversity of chronic lymphocytic leukaemia (CLL) between patients. Genetic heterogeneity of tumour clones within a patient may fuel tumour evolution. Several recurrently deregulated intra-cellular pathways are candidates for targeted therapies that are very promising and a...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Ghamlouch H,Nguyen-Khac F,Bernard OA

    更新日期:2017-09-01 00:00:00