Establishment and characterization of a plasma cell leukaemia cell line dependent for growth on IL-6 and a bi-phenotypic subclone dependent upon both IL-3 and IL-6.

abstract：:The Dutch beta zero-thalassaemia has few clinical symptoms in homozygotes, elevated fetal haemoglobin (4-11%) in heterozygotes, and has a DNA deletion previously estimated as 10 kb which removes the beta-globin gene (Gilman et al, 1984). A DNA fragment containing the breakpoints of the Dutch beta zero-thalassaemia del...

journal_title：British journal of haematology

authors： Gilman JG

更新日期：1987-11-01 00:00:00

abstract：:Fibroblast-like cells may be grown from human bone marrow. Adherent cultures show a logarithmic phase of growth lasting 6 d. Hydrocortisone (1 x 10(-8) M) decreases cell growth in 40-60% when measured as cell number and DNA synthesis. Fibroblasts bind the hormone by a high affinity, saturable process showing a Kd of 2...

journal_title：British journal of haematology

authors： Minguell JJ,Martínez J,Walter T

更新日期：1982-10-01 00:00:00

abstract：:Human IgG monoclonal antibodies (mabs) against the Rh D antigen have considerable potential for the prophylaxis of haemolytic disease of the newborn. We have carried out in vitro testing for cross-reactions with tissue components by screening two such mabs against animal tissues and a wide panel of human organs from n...

journal_title：British journal of haematology

authors： Thorpe SJ,Bailey SW

更新日期：1993-02-01 00:00:00

abstract：:Alternative donor bone marrow transplantation (BMT) to treat severe aplastic anaemia (SAA) in children and young adults has been complicated by high rates of graft rejection and severe graft-versus-host disease (GVHD). We hypothesized that increased immunosuppression combined with T-cell depletion of the marrow graft ...

journal_title：British journal of haematology

authors： Margolis D,Camitta B,Pietryga D,Keever-Taylor C,Baxter-Lowe LA,Pierce K,Kupst MJ,French J 3rd,Truitt R,Lawton C,Murray K,Garbrecht F,Flomenberg N,Casper J

更新日期：1996-07-01 00:00:00

abstract：:The blood-related cancer leukaemias were the first diseases where human cancer stem cells, or leukaemic stem cells (LSC), were isolated. The haematopoietic system is one of the best tissues for investigating cancer stem cells, because the developmental hierarchy of normal blood formation is well defined. Leukaemias ca...

journal_title：British journal of haematology

authors： Bonnet D

更新日期：2005-08-01 00:00:00

abstract：:Two non-anaemic subjects, a father and daughter, with a new form of congenital dyserythropoiesis are reported. The features of their disorder are: (1) an abnormal blood film with basophilic stippling of red cells and oval macrocytes, (2) various dysplastic changes in the erythroblasts, including internuclear chromatin...

journal_title：British journal of haematology

authors： Wickramasinghe SN,Spearing RL,Hill GR

更新日期：1998-12-01 00:00:00

abstract：:Epistaxis is a common problem amongst anti-coagulated patients. Application of first-aid principles can control the majority of bleeds. In our sample of 60 patients attending the anticoagulant clinic, 40% were unable to think of a single measure that would be helpful in controlling a nose bleed. 6 weeks after being gi...

journal_title：British journal of haematology

authors： Lavy J

更新日期：1996-10-01 00:00:00

abstract：:We have identified a tissue kallikrein in polymorphonuclear (PMN) leucocytes of normal human blood and bone marrow by immunocytochemistry, radioimmunoassay and enzymology. Immunoreactive tissue kallikrein was visualized in the mature neutrophil leucocytes and in immature forms such as metamyelocytes and myelocytes. No...

journal_title：British journal of haematology

authors： Figueroa CD,MacIver AG,Bhoola KD

更新日期：1989-07-01 00:00:00

abstract：:Myelodysplastic syndrome (MDS) is a common neoplasm of haematopoietic pluripotent stem cells. Although one third of MDS patients evolve to acute myeloid leukaemia (AML), little is understood about the mechanisms responsible for this progression. We have previously detected the frequent loss of heterozygosity (LOH) on ...

journal_title：British journal of haematology

authors： Mori N,Morosetti R,Mizoguchi H,Koeffler HP

更新日期：2003-07-01 00:00:00

abstract：:The 3q21q26 syndrome leukaemias are characterised by dystrophic megakaryocytes, elevated platelet counts, ectopic EVI1 protein production and poor prognosis. To investigate the molecular basis of this disease, we developed a model system to examine the biological activity of EVI1 in a megakaryocyte progenitor cell lin...

journal_title：British journal of haematology

authors： Kilbey A,Alzuherri H,McColl J,Calés C,Frampton J,Bartholomew C

更新日期：2005-09-01 00:00:00

abstract：:Recent studies have demonstrated that parenteral deferroxamine can prolong life in patients with iron overload. We have developed a non-human primate model of iron overload and have accurately determined negative iron balance in parenteral and oral studies of deferroxamine and a new chelator, desferrithiocin. Cebus mo...

journal_title：British journal of haematology

authors： Wolfe LC,Nicolosi RJ,Renaud MM,Finger J,Hegsted M,Peter H,Nathan DG

更新日期：1989-07-01 00:00:00

abstract：:Advances in multiple myeloma support the notion that the associated bone disease, characterized by increased osteoclastogenesis and suppressed osteoblastogenesis, is both a consequence and necessity of tumour progression. Osteoblastogenesis is suppressed by secreted inhibitors and dysregulation of cell-surface 'coupli...

journal_title：British journal of haematology

authors： Yaccoby S

更新日期：2010-05-01 00:00:00

abstract：:Patients with polycythaemia vera and secondary polycythaemia studied with 125I-labelled fibrinogen, had a significantly increased plasma fibrinogen turnover. The abnormalities were greater in polycythaemia vera and correlated with platelet count but not with packed cell volume. In six patients with polycythaemia vera,...

journal_title：British journal of haematology

authors： Boughton BJ,Dallinger KJ

更新日期：1983-01-01 00:00:00

abstract：:A prospective study of 7065 consecutive new pregnancies identified 230 with a positive screen, of which 27% (62/230) were 'enzyme-only' antibodies. 32 of these (52%) were potentially clinically important and were all of Rh specificity: 22 anti-E, seven anti-Cw, two anti-D and one anti-c. However, only three of these e...

journal_title：British journal of haematology

authors： Clark D,Greiss MA,Urbaniak SJ

更新日期：1999-09-01 00:00:00

abstract：:Early T-cell precursor acute lymphoblastic leukaemia (ETP-ALL) is a recently identified subtype of T-ALL with distinctive gene expression and cell marker profiles, poor response to chemotherapy and a very high risk of relapse. We determined the reliability of restricted panel of cell markers to identify EPT-ALL using ...

journal_title：British journal of haematology

authors： Inukai T,Kiyokawa N,Campana D,Coustan-Smith E,Kikuchi A,Kobayashi M,Takahashi H,Koh K,Manabe A,Kumagai M,Ikuta K,Hayashi Y,Tsuchida M,Sugita K,Ohara A

更新日期：2012-02-01 00:00:00

abstract：:Of 125 patients aged 65 years or over, with atrial fibrillation taking warfarin for at least 12 months, with a standard deviation (SD) of prothrombin time, expressed as the International Normalized Ratio (INR) >0.5 over the previous 6 months, 40 were randomized to continue with usual clinic care and 85 to receive educ...

journal_title：British journal of haematology

authors： Khan TI,Kamali F,Kesteven P,Avery P,Wynne H

更新日期：2004-08-01 00:00:00

abstract：:The integration of molecular and clinical information to tailor treatments remains an important research challenge in chronic lymphocytic leukaemia (CLL). This study aimed to identify genomic lesions associated with a poor outcome and a higher risk of histological transformation. A mono-institutional cohort of 147 cas...

journal_title：British journal of haematology

authors： Rinaldi A,Mian M,Kwee I,Rossi D,Deambrogi C,Mensah AA,Forconi F,Spina V,Cencini E,Drandi D,Ladetto M,Santachiara R,Marasca R,Gattei V,Cavalli F,Zucca E,Gaidano G,Bertoni F

更新日期：2011-09-01 00:00:00

abstract：:Interferon(rIFN)-alpha, a successful therapeutic agent in the control of thrombocytosis, has been shown to suppress human megakaryopoiesis. We investigated bone marrow biopsies from 12 patients with thrombocytosis due to chronic myeloproliferative disorders. Prior to treatment as well as during rIFN-alpha-2c therapy, ...

journal_title：British journal of haematology

authors： Chott A,Gisslinger H,Thiele J,Fritz E,Linkesch W,Radaszkiewicz T,Ludwig H

更新日期：1990-01-01 00:00:00

abstract：:Platelet activating factor (PAF) derived from antigen-stimulated, IgE-sensitized rabbit basophils acts on platelets to induce aggregation and secretion of their content of granule-bound vasoactive amines. Despite this, PAF did not activate platelet factor 3. In contrast, collagen induced aggregation, secretion and PF3...

journal_title：British journal of haematology

authors： Henson PM,Landes RR

更新日期：1976-10-01 00:00:00

abstract：:We evaluated the performance of eight d-assays for the exclusion of deep vein thrombosis (DVT); Biopool AutoDimer, Biopool MiniQuant, bioMèrieux MDA D-Dimer, VIDAS, Dade Behring D-Dimer Plus, Trinity Biotech AMAX, NycoCard D-dimer and IL Test D-Dimer. The assays were evaluated both as stand-alone tests, and in combina...

journal_title：British journal of haematology

authors： Gardiner C,Pennaneac'h C,Walford C,Machin SJ,Mackie IJ

更新日期：2005-03-01 00:00:00

abstract：:The EPB3 gene encodes band 3 (anion exchanger 1) of the red cell membrane. A subset of hereditary spherocytosis (HS) is associated with EPB3 gene mutations and band 3 deficiency. We report a large Italian family in which 10 of the 27 members investigated displayed an autosomal dominant HS. SDS-PAGE revealed a reductio...

journal_title：British journal of haematology

authors： Bianchi P,Zanella A,Alloisio N,Barosi G,Bredi E,Pelissero G,Zappa M,Vercellati C,Baronciani L,Delaunay J,Sirchia G

更新日期：1997-08-01 00:00:00

abstract：:Six hundred and nineteen patients with de novo acute myeloid leukaemia, entered into the Medical Research Council's eighth trial of therapy have been studied. All patients were treated with the same remission induction regimen. Pretreatment variables comprising age, clinical status, haematological status and a detaile...

journal_title：British journal of haematology

authors： Swirsky DM,de Bastos M,Parish SE,Rees JK,Hayhoe FG

更新日期：1986-11-01 00:00:00

abstract：:A 14-month-old child who had a haemolytic episode when he was 5 years old, and with psychomotor retardation, was found to have decreased red cell hexokinase activity. The mutant enzyme was characterized by an increased affinity for glucose associated with an increased inhibition constant for glucose-1,6-diphosphate. A...

journal_title：British journal of haematology

authors： Magnani M,Stocchi V,Canestrari F,Dachà M,Balestri P,Farnetani MA,Giorgi D,Fois A,Fornaini G

更新日期：1985-09-01 00:00:00

abstract：:We investigated the molecular basis for haemoglobin H disease in 50 Sardinian patients by restriction endonuclease analysis. We found that the majority (78% of the cases) are due to gene deletion (- -/- alpha). Among those with a combination of deletion and nondeletion defects (- -/alpha alpha th), the most prevalent ...

journal_title：British journal of haematology

authors： Paglietti E,Galanello R,Moi P,Pirastu M,Cao A

更新日期：1986-07-01 00:00:00

abstract：:Proinflammatory cytokines such as interleukin 6 (IL-6), tumour necrosis factor alpha (TNF-alpha) and IL-1beta are considered to be involved in the pathogenesis of multiple myeloma (MM). In the present study, we examined a G/C polymorphism at position -174 in the promoter region of IL-6, a biallelic polymorphism at pos...

journal_title：British journal of haematology

authors： Zheng C,Huang DR,Bergenbrant S,Sundblad A,Osterborg A,Björkholm M,Holm G,Yi Q

更新日期：2000-04-01 00:00:00

abstract：:An oscillatory pattern of platelet agglutination-disagglutination in response to Ristocetin (R) at narrow concentration ranges was observed in citrated platelet rich plasma (PRP) of 10 patients with Glanzmann's thrombasthenia. The cyclic pattern decreased in intensity over time, was reproducible, and was not pH depend...

journal_title：British journal of haematology

authors： Chediak J,Telfer MC,Vander Laan B,Maxey B,Cohen I

更新日期：1979-09-01 00:00:00

abstract：:Double-negative (DN) regulatory T cells (Tregs) are specialized T lymphocytes involved in the down-modulation of immune responses, resulting in allotolerance after allogeneic haematopoietic stem cell transplantation (HSCT). Most of the properties of DN Tregs were identified in murine models, including the unique abili...

journal_title：British journal of haematology

authors： McIver Z,Serio B,Dunbar A,O'Keefe CL,Powers J,Wlodarski M,Jin T,Sobecks R,Bolwell B,Maciejewski JP

更新日期：2008-04-01 00:00:00

abstract：:Comparative data on immunochemotherapy regimens for Waldenström macroglobulinaemia/lymphoplasmacytic lymphoma (WM/LPL) are lacking. We analysed overall survival (OS), risk of hospitalizations, transfusions and plasmapheresis in a population-based cohort of patients ≥65 years old initiating WM/LPL therapy in 1999-2013....

journal_title：British journal of haematology

authors： Olszewski AJ,Chen C,Gutman R,Treon SP,Castillo JJ

更新日期：2017-10-01 00:00:00

abstract：:A number of disorders cause iron overload: some are of genetic origin, such as hereditary haemochromatosis, while others are acquired, for instance due to repeated transfusions. This article reviews the treatment options for hereditary haemochromatosis, with special attention to the use of erythrocytapheresis. In gene...

journal_title：British journal of haematology

authors： Rombout-Sestrienkova E,van Kraaij MG,Koek GH

更新日期：2016-12-01 00:00:00

abstract：:In order to clarify the indications for splenectomy in patients with homozygous beta thalassaemia we studied, retrospectively, the basal pre-transfusion haemoglobin levels and blood transfusion requirements before and after splenectomy, in a series of patients with this disorder. Thirty-six patients, of whom 20 underw...

journal_title：British journal of haematology

authors： Engelhard D,Cividalli G,Rachmilewitz EA

更新日期：1975-11-01 00:00:00