CD99 expression is strongly associated with clinical outcome in children with B-cell precursor acute lymphoblastic leukaemia.


:Our study aimed to determine the expression pattern and clinical relevance of CD99 in paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). Our findings demonstrate that high expression levels of CD99 are mainly found in high-risk BCP-ALL, e.g. BCR-ABL1 and CRLF2Re/Hi, and that high CD99 mRNA levels are strongly associated with a high frequency of relapse, high proportion of positive for minimal residual disease at day 29 and poor overall survival in paediatric cohorts, which indicate that CD99 is a potential biomarker for BCP-ALL.


Br J Haematol


Chen D,Camponeschi A,Wu Q,Gerasimcik N,Li H,Shen X,Tan Y,Sjögren H,Nordlund J,Lönnerholm G,Abrahamsson J,Fogelstrand L,Mårtensson IL




Has Abstract


2019-02-01 00:00:00












  • The impact of SOCS1 mutations in diffuse large B-cell lymphoma.

    abstract::Mutations in SOCS1 are frequent in primary mediastinal B-cell lymphoma and classical Hodgkin lymphoma. In the latter, SOCS1 mutations affect the length of the encoded protein (major mutations) and are associated with shorter patient survival. Two independent studies examined the prognostic impact of SOCS1 mutations in...

    journal_title:British journal of haematology

    pub_type: 杂志文章,随机对照试验


    authors: Mellert K,Martin M,Lennerz JK,Lüdeke M,Staiger AM,Kreuz M,Löffler M,Schmitz N,Trümper L,Feller AC,Hartmann S,Hansmann ML,Klapper W,Stein H,Rosenwald A,Ott G,Ziepert M,Möller P

    更新日期:2019-12-01 00:00:00

  • Platelet-associated complement in chronic ITP.

    abstract::Chronic ITP is due to antibody-induced destruction of platelets by the reticuloendothelial (RE) system. The role of complement in this process is unclear. We measured platelet-associated complement (PAC) components C3, C3bi, C4 and C9 in 16 patients with chronic ITP, in two of these patients prior to and after splenec...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Kurata Y,Curd JG,Tamerius JD,McMillan R

    更新日期:1985-08-01 00:00:00

  • Pre-treatment metabolic tumour volume and total lesion glycolysis are superior to conventional positron-emission tomography/computed tomography variables for outcome prediction in patients with newly diagnosed multiple myeloma in clinical practice.

    abstract::Metabolic tumour volume (MTV) and total lesion glycolysis (TLG) are positron-emission tomography/computed tomography (PET/CT) variables for predicting multiple myeloma's (MM) outcome. We retrospectively investigated and compared the predictive value of MTV, TLG and high-risk PET/CT variables in clinical practice in 18...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Terao T,Machida Y,Tsushima T,Miura D,Narita K,Kitadate A,Takeuchi M,Matsue K

    更新日期:2020-10-01 00:00:00

  • Gemtuzumab ozogamicin for treatment of newly diagnosed acute myeloid leukaemia: a systematic review and meta-analysis.

    abstract::Evidence regarding the efficacy of gemtuzumab ozogamicin (GO) addition to standard induction chemotherapy in newly diagnosed acute myeloid leukaemia (AML) is conflicting. This systematic review aimed to identify and summarize all evidence regarding the benefits and harms of adding GO to conventional chemotherapy for i...

    journal_title:British journal of haematology

    pub_type: 杂志文章,meta分析,评审


    authors: Kharfan-Dabaja MA,Hamadani M,Reljic T,Pyngolil R,Komrokji RS,Lancet JE,Fernandez HF,Djulbegovic B,Kumar A

    更新日期:2013-11-01 00:00:00

  • Stem cell mobilization in normal donors for allogeneic transplantation: analysis of safety and factors affecting efficacy.

    abstract::The use of peripheral blood stem cells instead of bone marrow as the source of haemopoietic cells for allogeneic transplantation is being increasingly explored. We have analysed data from 17 normal donors who underwent stem cell mobilization for allogeneic transplantation with an identical protocol using G-CSF at a do...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Miflin G,Charley C,Stainer C,Anderson S,Hunter A,Russell N

    更新日期:1996-11-01 00:00:00

  • Corticosteroid resistance is increased in lymphoblasts from adults compared with children: preliminary results of in vitro drug sensitivity study in adults with acute lymphoblastic leukaemia.

    abstract::The prognosis of acute lymphoblastic leukaemia (ALL) in adults is poor compared with children in terms of complete remission (CR) and leukaemia-free survival. In children in vitro resistance of leukaemic cells to various cytotoxic agents is an independent poor prognostic marker, but the relevance of in vitro drug resi...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Maung ZT,Reid MM,Matheson E,Taylor PR,Proctor SJ,Hall AG

    更新日期:1995-09-01 00:00:00

  • Expression of functional interleukin-21 receptor on adult T-cell leukaemia cells.

    abstract::Adult T-cell leukaemia (ATL) is caused by human T-cell leukaemia virus type I (HTLV-I). It has been suggested that cytokines play a role in the development and in the neoplastic cell growth of ATL. However, the precise mechanism involved in this process still remains unclear. Interleukin-21 (IL-21) and its receptor (I...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Ueda M,Imada K,Imura A,Koga H,Hishizawa M,Uchiyama T

    更新日期:2005-01-01 00:00:00

  • A new Turkish type of beta-thalassaemia major with homozygosity for two non-consecutive 7.6 kb deletions of the psi beta and beta genes and an intact delta gene.

    abstract::In a 2.5-month-old infant with beta-thalassaemia major, DNA analysis of the gamma-beta region revealed homozygosity for two large deletions removing the entire psi beta and beta regions including their 5' promoter regions but leaving the delta gene intact. The downstream deletion was predicted to be 7.6 kb in length e...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Oner C,Oner R,Gürgey A,Altay C

    更新日期:1995-02-01 00:00:00

  • Autoantibodies directed against the epidermal growth factor-like domains of thrombomodulin inhibit protein C activation in vitro.

    abstract::No consensus has been obtained about the question whether autoantibodies, in particular antiphospholipid antibodies (aPL), may cause thrombosis by inhibiting thrombomodulin (TM) mediated protein C activation. In order to clarify the mechanism by which autoantibodies inhibit TM-mediated protein C activation, we have sc...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Oosting JD,Preissner KT,Derksen RH,de Groot PG

    更新日期:1993-12-01 00:00:00

  • Interaction of alpha and beta thalassaemia genes in two Sardinian families.

    abstract::Our paper describes two Sardinian families with alpha-beta thalassaemia interaction. In the first (family S), the propositus, whose haemoglobin pattern at birth consisted of about 25% Hb Bart's and 75% Hb F, successively developed a clinical and haematological picture typical of Cooleys anaemia. Haematological and glo...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Furbetta M,Galanello R,Ximenes A,Angius A,Melis MA,Serra P,Cao A

    更新日期:1979-02-01 00:00:00

  • Total body irradiation-high-dose cytosine arabinoside and melphalan followed by allogeneic bone marrow transplantation from HLA-identical siblings in the treatment of children with acute lymphoblastic leukaemia after relapse while receiving chemotherapy:

    abstract::We investigated the use of a new conditioning regimen followed by allogeneic bone marrow transplantation (BMT) for treating children with acute lymphoblastic leukaemia (ALL) after relapse within 6 months of the completion of therapy. One hundred and sixteen children with acute lymphoblastic leukaemia in second or subs...

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Bordigoni P,Esperou H,Souillet G,Pico J,Michel G,Lacour B,Reiffers J,Sadoun A,Rohrlich P,Jouet JP,Milpied N,Lutz P,Plouvier E,Cornu G,Vannier JP,Gandemer V,Rubie H,Gratecos N,Leverger G,Stephan JL,Boutard P,Vern

    更新日期:1998-08-01 00:00:00

  • Paediatric B-cell precursor acute lymphoblastic leukaemia with t(1;19)(q23;p13): clinical and cytogenetic characteristics of 47 cases from the Nordic countries treated according to NOPHO protocols.

    abstract::The translocation t(1;19)(q23;p13)/der(19)t(1;19) is a risk stratifying aberration in childhood B-cell precursor acute lymphoblastic leukaemia (BCP ALL) in the Nordic countries. We have identified 47 children/adolescents with t(1;19)/der(19)t(1;19)-positive BCP ALL treated on two successive Nordic Society of Paediatri...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Andersen MK,Autio K,Barbany G,Borgström G,Cavelier L,Golovleva I,Heim S,Heinonen K,Hovland R,Johannsson JH,Johansson B,Kjeldsen E,Nordgren A,Palmqvist L,Forestier E

    更新日期:2011-10-01 00:00:00

  • Cytogenetic and molecular study of 32 Down syndrome families: potential leukaemia predisposing role of the most proximal segment of chromosome 21q.

    abstract::Down syndrome (DS) children have a 10-20-fold increased risk of developing ALL or AML compared to non-DS children. An increased disomic homozygosity of the polymorphic DNA markers in the pericentromeric region of chromosome 21q (21q11) has repeatedly been found in DS patients with ANLL-M7 and DS-specific transient abn...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Cavani S,Perfumo C,Argusti A,Pierluigi M,Perroni L,Schmiegelow K,Petersen MB,Cotter FE,Strigini P,Dagna-Bricarelli F,Nizetić D

    更新日期:1998-10-01 00:00:00

  • The Sézary syndrome lymphoid cell: abnormal surface properties and mitogen responsiveness.

    abstract::The peripheral blood lymphoid cells of five patients with Sézary syndrome (SS) were examined with respect to their surface membrane characteristics and their response to mitogens. These cells showed markedly defective mitogenic responses to a broad dose range of phytohaemagglutinin (PHA), pokeweed mitogen, concanavali...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Braylan R,Variakojis D,Yachnin S

    更新日期:1975-12-01 00:00:00

  • Karyotype conversion in two patients with chronic myeloid leukaemia after busulphan-induced marrow hypoplasia.

    abstract:SUMMARY:We report two patients with chronic myeloid leukaemia (CML) developing hypoplasia and karyotype conversion after conventional busulphan therapy. Initially, the percentage of Ph-positive metaphases in marrow for both patients was 100%, which steadily diminished up to a complete disappearance in case 1 and decrea...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Xue Y,Zhou XJ,Yu F,Gu J,Guo Y,Xie X,Lin B

    更新日期:1996-03-01 00:00:00

  • Long-term safety and efficacy of deferasirox (Exjade) for up to 5 years in transfusional iron-overloaded patients with sickle cell disease.

    abstract::To date, there is a lack of long-term safety and efficacy data for iron chelation therapy in transfusion-dependent patients with sickle cell disease (SCD). To evaluate the long-term safety and efficacy of deferasirox (a once-daily oral iron chelator), patients with SCD completing a 1-year, Phase II, randomized, defero...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Vichinsky E,Bernaudin F,Forni GL,Gardner R,Hassell K,Heeney MM,Inusa B,Kutlar A,Lane P,Mathias L,Porter J,Tebbi C,Wilson F,Griffel L,Deng W,Giannone V,Coates T

    更新日期:2011-08-01 00:00:00

  • Haemolytic anaemia in analpha-lipoproteinaemia (Tangier disease): morphological, biochemical, and biophysical properties of the red blood cell.

    abstract::A patient with familial analpha-lipoproteinaemia (Tangier disease) was found to have stomatocytosis and haemolytic anaemia. The analysis of the red cell membrane constituents revealed a low cholesterol content (90 nmol/ml red cells, control 130 nmol/ml red cells), a decreased cholesterol/phospholipid ratio (0.54, cont...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Reinhart WH,Gössi U,Bütikofer P,Ott P,Sigrist H,Schatzmann HJ,Lutz HU,Straub PW

    更新日期:1989-06-01 00:00:00

  • Recombinant human erythropoietin for the treatment of the anaemia associated with autologous bone marrow transplantation.

    abstract::Patients with solid tumours undergoing high-dose chemotherapy with autologous bone marrow transplantation use an average of 10 units of packed red blood cells (PRBC) while awaiting haemopoietic reconstitution. They are also known to have inappropriately low endogenous erythropoietin levels for their degree of anaemia....

    journal_title:British journal of haematology

    pub_type: 临床试验,杂志文章


    authors: Ayash LJ,Elias A,Hunt M,Demetri G,Wheeler C,Tepler I,Schwartz G,Mazanet R,Reich E,McCauley M

    更新日期:1994-05-01 00:00:00

  • Changes in the activities of some membrane-associated enzymes during in vivo ageing of the normal human erythrocyte.

    abstract::Human erythrocytes from healthy male donors were fractionated with respect to in vivo age by simple centrifugation in order to characterize changes in the functional integrity of the membrane during the life-span of the cell. The three enzymes, Na/K-ATPase, glyceraldehyde-3-phosphate dehydrogenase and NADH-ferricyanid...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Kadlubowski M,Agutter PS

    更新日期:1977-09-01 00:00:00

  • Relapse of aplastic anaemia after immunosuppressive treatment: a report from the European Bone Marrow Transplantation Group SAA Working Party.

    abstract::This study was designed to determine the incidence of relapse and factors predictive for relapse in 719 patients with severe aplastic anaemia (SAA) after immunosuppressive treatment (IS). Patients developing myelodysplasia or acute leukaemia after IS, and patients receiving a transplant, were excluded from this analys...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Schrezenmeier H,Marin P,Raghavachar A,McCann S,Hows J,Gluckman E,Nissen C,van't Veer-Korthof ET,Ljungman P,Hinterberger W

    更新日期:1993-10-01 00:00:00

  • Liquid culture and cryopreservation of marrow cells of leukaemic patients prior to autologous bone marrow transplantation.

    abstract::The feasibility of marrow cryopreservation for autologous bone marrow transplantation after 7 d in liquid culture was assessed in 10 leukaemic patients. A median of 0.17 x 10(8) nucleated cells/kg and 0.4 x 10(4) CFU-GM/kg could be collected after the complete procedure, with overall a consistent cell loss. Long-term ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Stoppa AM,Maraninchi D,Lafage M,Mannoni P,Novakovitch G,Blaise D,Gaspard MH,Michel G,Carcassonne Y

    更新日期:1989-08-01 00:00:00

  • The promise of chimeric antigen receptor T cells (CARTs) in leukaemia.

    abstract::The success of genetically engineered T cells that express chimeric antigen receptors (CARTs) has been a momentous step forward in harnessing the potent cancer fighting abilities of the immune system. The efficacy seen in relapsed/refractory (r/r) acute lymphoblastic leukaemia (ALL), not only by inducing remission, bu...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Orlowski RJ,Porter DL,Frey NV

    更新日期:2017-04-01 00:00:00

  • Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children's Cancer Study Group Study L99-15.

    abstract::Early T-cell precursor acute lymphoblastic leukaemia (ETP-ALL) is a recently identified subtype of T-ALL with distinctive gene expression and cell marker profiles, poor response to chemotherapy and a very high risk of relapse. We determined the reliability of restricted panel of cell markers to identify EPT-ALL using ...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Inukai T,Kiyokawa N,Campana D,Coustan-Smith E,Kikuchi A,Kobayashi M,Takahashi H,Koh K,Manabe A,Kumagai M,Ikuta K,Hayashi Y,Tsuchida M,Sugita K,Ohara A

    更新日期:2012-02-01 00:00:00

  • Allodepleted T-cell immunotherapy after haploidentical haematopoietic stem cell transplantation without severe acute graft-versus-host disease (GVHD) in the absence of GVHD prophylaxis.

    abstract::Graft-versus-host disease (GVHD) is a major cause of transplant-related mortality (TRM) after allogeneic haematopoietic stem cell transplantation (HSCT) and presents a challenge in haploidentical HSCT. GVHD may be prevented by ex vivo graft T-cell depletion or in vivo depletion of proliferating lymphocytes. However, b...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Roy DC,Lachance S,Cohen S,Delisle JS,Kiss T,Sauvageau G,Busque L,Ahmad I,Bernard L,Bambace N,Boumédine RS,Guertin MC,Rezvani K,Mielke S,Perreault C,Roy J

    更新日期:2019-09-01 00:00:00

  • Determinants of haemoglobin level in sickle cell-haemoglobin C disease.

    abstract::The determinants of steady state haemoglobin levels in sickle cell-haemoglobin C (SC) disease were investigated by measuring routine haematological and biochemical indices, red cell survival, oxygen affinity, pitted erythrocytes, and red cell and plasma volumes in 31 adult patients (15 male; 16 female). Red cell survi...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Bannerman RM,Serjeant B,Seakins M,England JM,Serjeant GR

    更新日期:1979-09-01 00:00:00

  • Novel alleles at the JK blood group locus explain the absence of the erythrocyte urea transporter in European families.

    abstract::The Kidd (JK) blood group system is of importance in transfusion medicine. The Jk(null) phenotype is associated with absence of the urea transporter in erythrocytes and moderately reduced ability to concentrate urine. We and others recently reported different molecular alterations in the silenced Jkb-like alleles of P...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Irshaid NM,Eicher NI,Hustinx H,Poole J,Olsson ML

    更新日期:2002-02-01 00:00:00

  • Advances in understanding the pathogenesis of graft-versus-host disease.

    abstract::Acute graft-versus-host disease (GVHD) remains a major complication after allogeneic haematopoietic stem cell transplantation (allo-HSCT). The emergence of different immuno-prophylaxis strategies, such as post-transplant cyclophosphamide or anti-thymocyteglobulin has reduced the incidence of acute GVHD in recent years...

    journal_title:British journal of haematology

    pub_type: 杂志文章,评审


    authors: Zeiser R

    更新日期:2019-12-01 00:00:00

  • Specific polymorphisms of cytokine genes are associated with different risks to develop single-system or multi-system childhood Langerhans cell histiocytosis.

    abstract::Cytokines and chemokines determine mobilisation of Langerhans cells and their dysregulation is implicated in the pathogenesis of Langerhans cell histiocytosis (LCH). Twenty point mutations of 12 different cytokine genes were studied in 41 Italian children, 15 with single-system (SS) and 26 with multi-system disease. T...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: De Filippi P,Badulli C,Cuccia M,De Silvestri A,Dametto E,Pasi A,Garaventa A,del Prever AB,Todesco A,Trizzino A,Danesino C,Martinetti M,Aricò M

    更新日期:2006-03-01 00:00:00

  • Frontline treatment of elderly non transplant-eligible multiple myeloma patients using CyBorD with or without thalidomide-based consolidation: a retrospective multi-centre analysis of real-world data.

    abstract::Bortezomib in combination with cyclophosphamide and dexamethasone (CyBorD, is a well-established frontline chemotherapy regimen for patients with multiple myeloma, but prospective data on elderly non-transplant eligible patients is limited. A total of 155 patients aged 70 years or older with newly diagnosed multiple m...

    journal_title:British journal of haematology

    pub_type: 杂志文章,多中心研究


    authors: Chan H,Chai K,Shih S,Lewsey R,Chen K,McDiarmid B,Jackson S,Simpson D

    更新日期:2019-11-01 00:00:00

  • Chloramphenicol induced inhibition of platelet protein synthesis: in vitro and in vivo studies.

    abstract::Chloramphenicol (CAP), an antibiotic which causes various blood dyscrasias, was shown to inhibit in vitro protein synthesis of human blood platelets. The effect is dose- and time-dependent, it is reversible after incubation for 2 h, and is comparable with the suppression achieved by cycloheximide (CXM). Electron micro...

    journal_title:British journal of haematology

    pub_type: 杂志文章


    authors: Agam G,Gasner S,Bessler H,Fishman P,Djaldetti M

    更新日期:1976-05-01 00:00:00