Platelet antibodies in thrombocytopenic patients.

abstract：:Sixty patients with haematological malignancies received a myeloablative regimen of total body irradiation, cyclophosphamide and fludarabine followed by a T-cell-depleted peripheral blood stem cell transplant from a human leucocyte antigen identical sibling. To improve donor immune function, 1 x 10(7) CD3+ cells/kg we...

journal_title：British journal of haematology

authors： Montero A,Savani BN,Kurlander R,Read EJ,Leitman SF,Childs R,Solomon SR,Barrett AJ

更新日期：2005-09-01 00:00:00

abstract：:The EPB3 gene encodes band 3 (anion exchanger 1) of the red cell membrane. A subset of hereditary spherocytosis (HS) is associated with EPB3 gene mutations and band 3 deficiency. We report a large Italian family in which 10 of the 27 members investigated displayed an autosomal dominant HS. SDS-PAGE revealed a reductio...

journal_title：British journal of haematology

authors： Bianchi P,Zanella A,Alloisio N,Barosi G,Bredi E,Pelissero G,Zappa M,Vercellati C,Baronciani L,Delaunay J,Sirchia G

更新日期：1997-08-01 00:00:00

abstract：:During treatment of human red cells with phospholipase A2 from bee venom, a linear increase of the MCV and of the osmotic fragility occurs in parallel with the cleavage of the accessible phospholipids. However, even after maximal hydrolysis, i.e. degradation of up to 65% of the phosphatidylcholines and up to 6% of the...

journal_title：British journal of haematology

authors： Vaysse J,Pilardeau P,Gattegno L,Garnier M

更新日期：1987-03-01 00:00:00

abstract：:Continuation chemotherapy is a key component of the treatment of childhood acute lymphoblastic leukaemia. During this treatment phase, weekly dose adjustments are carried out based on current and historical full blood counts (FBCs). The dose decision pathway is complex and suboptimal therapy may result if information ...

journal_title：British journal of haematology

authors： Bury J,Hurt C,Roy A,Cheesman L,Bradburn M,Cross S,Fox J,Saha V

更新日期：2005-06-01 00:00:00

abstract：:Twenty adult patients with high-risk leukaemia underwent allogeneic haemopoietic stem cell transplantation after melphalan, busulphan and total body irradiation followed by short-term methotrexate and low-dose cyclosporine or tacrolimus. Three patients developed veno-occlusive disease and no patient developed renal dy...

journal_title：British journal of haematology

authors： Murata M,Nishida T,Haneda M,Kanie T,Taji H,Iida H,Suzuki R,Hamaguchi M,Minami S,Kodera Y

更新日期：1999-06-01 00:00:00

abstract：:The main objective of the present study was to determine the role of CD34+ cell subsets in the haemopoietic recovery of children undergoing peripheral blood stem cell transplantation. For this purpose, 38 leukaphereses from 33 children with malignancies mobilized with G-CSF were analysed. Using dual-colour flow cytome...

journal_title：British journal of haematology

authors： Gonzalez-Requejo A,Madero L,Díaz MA,Villa M,García-Escribano C,Balas A,Lillo R,García-Sanchez F,Benito A,Vicario JL

更新日期：1998-04-01 00:00:00

abstract：:The role of autologous stem cell transplantation (ASCT) and the optimal timing of such transplants in patients with follicular lymphoma (FL) remains contentious. We present a single-centre experience documenting the outcomes of 70 FL patients who underwent BEAM (carmustine, cytarabine, etopside, melphalan)-conditioned...

journal_title：British journal of haematology

authors： Kothari J,Peggs KS,Bird A,Thomson KJ,Morris E,Virchis AE,Lambert J,Goldstone AH,Linch DC,Ardeshna KM

更新日期：2014-05-01 00:00:00

abstract：:Cytokines and chemokines determine mobilisation of Langerhans cells and their dysregulation is implicated in the pathogenesis of Langerhans cell histiocytosis (LCH). Twenty point mutations of 12 different cytokine genes were studied in 41 Italian children, 15 with single-system (SS) and 26 with multi-system disease. T...

journal_title：British journal of haematology

authors： De Filippi P,Badulli C,Cuccia M,De Silvestri A,Dametto E,Pasi A,Garaventa A,del Prever AB,Todesco A,Trizzino A,Danesino C,Martinetti M,Aricò M

更新日期：2006-03-01 00:00:00

abstract：:A 43-year-old man with chronic myeloid leukaemia underwent a second transplant with CD34+ bone marrow cells selected from his two-loci HLA-mismatched sibling after rejection of the first graft from an HLA-matched unrelated donor. By immunomagnetic positive selection, CD34+ marrow cells at 0.95 x 10(6)/kg with 97% puri...

journal_title：British journal of haematology

authors： Fujimori Y,Kanamaru A,Hashimoto N,Okamoto T,Okada M,Kawaguchi K,Mori A,Saheki K,Takatsuka H,Wada H,Takemoto Y,Kohsaki M,Imai N,Kakishita E,Nagai K

更新日期：1996-07-01 00:00:00

abstract：:CD19 and CD21 (CR2) are co-receptors found on B-cells and various B-cell lymphomas, including non-Hodgkin lymphoma. To evaluate their suitability as targets for therapy of such lymphomas using internalization-dependent antibody-drug conjugates [such as antibody-4-(N-maleimidomethyl)cyclohexane-1-carboxylate, (N2'-deac...

journal_title：British journal of haematology

authors： Ingle GS,Chan P,Elliott JM,Chang WS,Koeppen H,Stephan JP,Scales SJ

更新日期：2008-01-01 00:00:00

abstract：:During definitive erythropoiesis, erythroid precursors undergo differentiation through multiple nucleated states to an enucleated reticulocyte, which loses its residual RNA/organelles to become a mature erythrocyte. Over the course of these transformations, continuous changes in membrane proteins occur, including shif...

journal_title：British journal of haematology

authors： Kodippili GC,Spector J,Kang GE,Liu H,Wickrema A,Ritchie K,Low PS

更新日期：2010-09-01 00:00:00

abstract：:Eradication of Helicobacter pylori infection has been associated with the correction of thrombocytopenia in patients with idiopathic thrombocytopenic purpura (ITP). We have analysed the response to eradication of H. pylori in a series of 56 adult patients with chronic ITP. Forty patients had H. pylori infection (71%) ...

journal_title：British journal of haematology

authors： Jarque I,Andreu R,Llopis I,De la Rubia J,Gomis F,Senent L,Jiménez C,Martín G,Martínez JA,Sanz GF,Ponce J,Sanz MA

更新日期：2001-12-01 00:00:00

abstract：:Peripheral blood stem cell autografts for the treatment of chronic myeloid leukaemia (CML) are currently under evaluation. A patient with CML received intensive chemotherapy followed by granulocyte colony-stimulating factor prior to the collection of peripheral blood derived stem cells. He developed unusually severe, ...

journal_title：British journal of haematology

authors： Clark RE,Lee ES

更新日期：1995-06-01 00:00:00

abstract：:Paediatric recommendations for unfractionated heparin (UFH) management are extrapolated from adult trials, a practice that may contribute to the inferior UFH-related outcomes in children compared to adults. This is the first study to determine UFH concentration in a population of children and correlated UFH concentrat...

journal_title：British journal of haematology

authors： Newall F,Ignjatovic V,Johnston L,Summerhayes R,Lane G,Cranswick N,Monagle P

更新日期：2010-09-01 00:00:00

abstract：:In this population-based survey covering two geographically distinct UK regions, we evaluated the number of myeloma patients aged < or =65 years who have not undergone transplantation. The combined data from both of these regions showed that 57% of age-eligible patients were not transplanted. While early death and com...

journal_title：British journal of haematology

authors： Morris TC,Velangi M,Jackson G,Marks DI,Ranaghan L,Northern Ireland Regional Haematology Group.,Northern Regional Haematologists Group.,Clinical Trials Committee of The British Scoiety for Blood and Marrow Transplantation.

更新日期：2005-02-01 00:00:00

abstract：:The tumour suppressor TP53 (previously termed p53) mediates a pathway that is considered to be one of the most important mechanisms in the maintenance of genomic stability. The function of TP53 can be abrogated by genomic deletion, mutation, or deregulation of upstream and downstream participants in the TP53 pathway. ...

journal_title：British journal of haematology

authors： Cheung KJ,Horsman DE,Gascoyne RD

更新日期：2009-08-01 00:00:00

abstract：:The presence of oestrogen receptors (ER) and type II oestrogen binding sites (type II EBS) have been investigated by a whole cell assay in seven cases of acute lymphoid leukaemia (ALL) and 16 cases of acute myeloid leukaemia (AML). ER were detected in 6/7 ALL patients with values ranging between 133 and 2268 sites/cel...

journal_title：British journal of haematology

authors： Larocca LM,Piantelli M,Leone G,Sica S,Teofili L,Panici PB,Scambia G,Mancuso S,Capelli A,Ranelletti FO

更新日期：1990-08-01 00:00:00

abstract：:The abilities of human recombinant IL-3, GM-CSF, G-CSF, M-CSF and Epo to induce maturation in human AML cells in vitro were investigated using cell specimens from 25 AML patients. The experiments were carried out under exactly defined serum-free culture conditions. In the absence of CSFs, monocytic and/or granulocytic...

journal_title：British journal of haematology

authors： Salem M,Delwel R,Mahmoud LA,Clark S,Elbasousy EM,Löwenberg B

更新日期：1989-03-01 00:00:00

abstract：:The close association between translocation of the proto-oncogene bcl-2 and follicular lymphomas has been well established in Caucasian patients and the de-regulation of bcl-2 has been implicated in follicular lymphomagenesis. Similar molecular structural alterations have also been detected in diffuse lymphomas with a...

journal_title：British journal of haematology

authors： Loke SL,Pittaluga S,Srivastava G,Raffeld M,Ho FC

更新日期：1990-09-01 00:00:00

abstract：:Besides circulating in normal plasma, von Willebrand factor (VWF) is also stored at relatively high concentration within the alpha-granules of platelets. This pool of platelet VWF exists distinct from plasma VWF, and is enriched in haemostatically-active high molecular weight multimers. Interestingly, the glycosylatio...

journal_title：British journal of haematology

authors： McGrath RT,McRae E,Smith OP,O'Donnell JS

更新日期：2010-03-01 00:00:00

abstract：:We describe genetic, haematological and biochemical properties of a new mouse pigment mutant, cocoa (coa). Cocoa is a recessive mutation located on the centromeric end of chromosome 3 near the Car-2 locus. The mutation causes increased bleeding time accompanied by symptoms of platelet storage pool deficiency (SPD), in...

journal_title：British journal of haematology

authors： Novak EK,Sweet HO,Prochazka M,Parentis M,Soble R,Reddington M,Cairo A,Swank RT

更新日期：1988-07-01 00:00:00

abstract：:A single immunoglobulin light chain lambda was identified in the blast cells of two out of 12 patients with common acute lymphoblastic leukaemia (C-ALL) using the alkaline phosphatase/anti-alkaline phosphatase (APAAP) technique. Inhibition at the cell surface proved that the reaction was a genuine anti-lambda reaction...

journal_title：British journal of haematology

authors： Markey GM,Alexander HD,Nolan RL,Morris TC,Robertson JH

更新日期：1989-01-01 00:00:00

abstract：:Mantle-cell lymphoma (MCL) is a B-cell tumour with a usually poor prognosis, characterized by the proliferation of small cleaved lymphocytes with a diffuse growth pattern. We report a polymerase chain reaction-based analysis of minimal residual disease in a patient who achieved complete remission after allogeneic bloo...

journal_title：British journal of haematology

authors： Corradini P,Ladetto M,Astolfi M,Voena C,Tarella C,Bacigalupo A,Pileri A

更新日期：1996-08-01 00:00:00

abstract：:Ph-negative chronic myeloproliferative disorders (CMPD) are characterized by constitutive Janus kinase-signal transducer and activator of transcription (JAK-STAT) activation. SOCS3, SOCS1 and PTPN6 (SHP1) are negative regulators of the JAK-STAT pathway. We investigated epigenetic and genetic inactivation of SOCS3, SOC...

journal_title：British journal of haematology

authors： Capello D,Deambrogi C,Rossi D,Lischetti T,Piranda D,Cerri M,Spina V,Rasi S,Gaidano G,Lunghi M

更新日期：2008-05-01 00:00:00

abstract：:Follicular lymphoma (FL) is a heterogeneous disease; therefore, reliable prognostic tools are needed to plan treatment strategies. The FL International Prognostic Index (FLIPI) was developed before the rituximab era, while the PRIMA-PI was built on rituximab chemotherapy. Our objective was to evaluate these two progno...

journal_title：British journal of haematology

authors： Kimby E,Lockmer S,Holte H,Hagberg H,Wahlin BE,Brown P,Østenstad B

更新日期：2020-05-14 00:00:00

abstract：:It was hypothesized that contact between chronic lymphocytic leukaemia (CLL) B-cells and marrow stromal cells impact both cell types. To test this hypothesis, we utilized a long-term primary culture system from bone biopsies that reliably generates a mesenchymal stem cell (MSC). Co-culture of MSC with CLL B-cells prot...

journal_title：British journal of haematology

authors： Ding W,Nowakowski GS,Knox TR,Boysen JC,Maas ML,Schwager SM,Wu W,Wellik LE,Dietz AB,Ghosh AK,Secreto CR,Medina KL,Shanafelt TD,Zent CS,Call TG,Kay NE

更新日期：2009-11-01 00:00:00

abstract：:An increase in bone marrow blood flow has been previously described in anaemic rabbits and dogs. We examined the effect of haemorrhage and haemolysis in female Sprague-Dawley rats, with the hypothesis that high blood flow was related to hyperplasia of bone marrow tissue and that the increase would affect bone as well....

journal_title：British journal of haematology

authors： Schoutens A,Verhas M,Dourov N,Verschaeren A,Mone M,Heilporn A

更新日期：1990-04-01 00:00:00

abstract：:MDX-1097 is an antibody specific for a unique B cell antigen called kappa myeloma antigen (KMA) that consists of cell membrane-associated free kappa light chain (κFLC). KMA was detected on kappa human multiple myeloma cell lines (κHMCLs), on plasma cells (PCs) from kappa multiple myeloma (κMM) patients and on κPC dysc...

journal_title：British journal of haematology

authors： Asvadi P,Cuddihy A,Dunn RD,Jiang V,Wong MX,Jones DR,Khong T,Spencer A

更新日期：2015-05-01 00:00:00

abstract：:2,3-Dihydroxybenzoic acid (2,3-DHB) inhibits the second wave of platelet aggregation release of serotonin, and malonaldehyde production. The effect is concentration dependent and reversible in vitro and in vivo. 50% inhibition of platelet aggregation induced in vitro with 70 micron adrenaline was obtained with 1.5 mM ...

journal_title：British journal of haematology

authors： Greenberg M,Grady RW,Peterson CM

更新日期：1977-12-01 00:00:00

abstract：:Bone involvement is the commonest clinical manifestation of sickle cell disease both in the acute setting such as painful vaso-occlusive crises, and as a source of chronic, progressive disability such as avascular necrosis. Management of these problems is often difficult because of the diagnostic imprecision of most l...

journal_title：British journal of haematology

authors： Almeida A,Roberts I

更新日期：2005-05-01 00:00:00