Osmotic properties of human erythrocytes treated by phospholipase A2 from bee venom.

abstract：:The combined incidence of classical Philadelphia-negative myeloproliferative neoplasm (MPN) is 6-9/100 000 with a peak frequency between 50 and 70 years. MPN is less frequent in women of reproductive age. However, for essential thrombocythaemia (ET) in particular there is a second peak in women of reproductive age and...

journal_title：British journal of haematology

authors： Robinson SE,Harrison CN

更新日期：2020-05-01 00:00:00

abstract：:Haemophagocytic lymphohistiocytosis (HLH) may cause meningoencephalitis and significant neurological sequelae. We examined the relationship between neurological symptoms and cerebrospinal fluid (CSF) at diagnosis, and long-term outcome, in all children enroled in the HLH-94-study prior to July 1, 2003, for whom inform...

journal_title：British journal of haematology

authors： Horne A,Trottestam H,Aricò M,Egeler RM,Filipovich AH,Gadner H,Imashuku S,Ladisch S,Webb D,Janka G,Henter JI,Histiocyte Society.

更新日期：2008-02-01 00:00:00

abstract：:Inhibitor formation in patients with haemophilia receiving factor VIII (FVIII) concentrate is a common problem requiring tolerance induction therapy. Immune tolerance is dependent on defective T cell/antigen-presenting cell (APC) interactions and inhibitor antibody formation is associated with effective T-cell/B-cell ...

journal_title：British journal of haematology

authors： Hodge G,Han P

更新日期：2000-04-01 00:00:00

abstract：:In a randomized study that compared human leucocyte antigen-identical allogeneic granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cell (PBSC) versus bone marrow (BM) transplantation, the expression of activation markers, CD23, CD25 and CD45RO by B cells, was compared in blood before and af...

journal_title：British journal of haematology

authors： Tayebi H,Lapierre V,Saas P,Lienard A,Sutton L,Milpied N,Attal M,Cahn JY,Kuentz M,Blaise D,Hervé P,Tiberghien P,Robinet E,Société Française de Greffe de Moelle et de Therapie Cellulaire.

更新日期：2001-09-01 00:00:00

abstract：:There is little information published comparing peripheral blood stem cells (PBSC) with bone marrow (BM) as the stem cell source in the long-term outcome in recipients of T-cell depleted (TCD) unrelated donor (UD) transplants. We present retrospective outcome data on 306 recipients of myeloablative, human leucocyte an...

journal_title：British journal of haematology

authors： Shaw BE,Apperley JF,Russell NH,Craddock C,Liakopoulou E,Potter MN,Wynn R,Gibson B,Pearce RM,Kirkland K,Lee J,Madrigal JA,Cook G,Byrne JL

更新日期：2011-04-01 00:00:00

abstract：:Combined lenalidomide and dexamethasone is a standard-of-care therapy for the treatment of older adults with multiple myeloma. Lenalidomide monotherapy has not been evaluated in newly diagnosed myeloma patients. We conducted a phase II study, evaluating a response-adapted therapy for older adults newly diagnosed with ...

journal_title：British journal of haematology

authors： Baz R,Naqvi SMH,Lee JH,Brayer J,Hillgruber N,Fridley BL,Shain KH,Sullivan DM,Alsina M

更新日期：2019-03-01 00:00:00

abstract：:The aim of this study was to analyse the expression of NK-associated antigens in both peripheral blood and bone marrow lymphocytes from a large series of newly diagnosed multiple myeloma patients. 112 patients with untreated multiple myeloma (MM) were included in the study. 36 sex- and age-matched healthy volunteers w...

journal_title：British journal of haematology

authors： García-Sanz R,González M,Orfão A,Moro MJ,Hernández JM,Borrego D,Carnero M,Casanova F,Bárez A,Jiménez R,Portero JA,San Miguel JF

更新日期：1996-04-01 00:00:00

abstract：:We describe and compare five assay systems for Protein C (PC) in human plasma; a functional assay for PC activity, Laurell electroimmunoassay with EDTA or calcium (EDTA-Laurell or Ca-Laurell), radioimmunoassay (RIA) and immunoradiometric assay (IRMA). The lower limit of sensitivity of PC in normal reference plasma was...

journal_title：British journal of haematology

authors： Mikami S,Tuddenham EG

更新日期：1986-01-01 00:00:00

abstract：:A t(5;12)(q33;p13) translocation has been detected in two patients with myeloid disorder and eosinophilia. Six other patients with haematological disease with eosinophilia with similar translocation have been published previously. The existence of a new entity, a myeloproliferative disorder with eosinophilia and t(5;1...

journal_title：British journal of haematology

authors： Baranger L,Szapiro N,Gardais J,Hillion J,Derre J,Francois S,Blanchet O,Boasson M,Berger R

更新日期：1994-10-01 00:00:00

abstract：:Karyotypic studies of bone marrow were conducted in 79 previously untreated patients with multiple myeloma who received a standard programme of chemotherapy. An abnormal karyotype was observed in 46% of patients, virtually all showing multiple abnormalities consistent with a long period of preclinical clonal evolution...

journal_title：British journal of haematology

authors： Seong C,Delasalle K,Hayes K,Weber D,Dimopoulos M,Swantkowski J,Huh Y,Glassman A,Champlin R,Alexanian R

更新日期：1998-04-01 00:00:00

abstract：:Three distinct categories of marginal zone lymphomas (MZLs) are currently recognized, principally based on their site of occurrence. They are thought to represent unique entities, but the relationship of one subtype with another is poorly understood. We investigated 17 non-splenic MZLs (seven nodal, 10 extranodal) by ...

journal_title：British journal of haematology

authors： Novak U,Basso K,Pasqualucci L,Dalla-Favera R,Bhagat G

更新日期：2011-11-01 00:00:00

abstract：:With the aim of producing unique targets for malignant cells we have identified peptide ligands for the clonal surface immunoglobulin isolated from the B cells of a chronic lymphocytic leukaemia (CLL) patient. The peptides were identified from random-peptide phage-display libraries. The obtained ligands bound specific...

journal_title：British journal of haematology

authors： Buhl L,Szecsi PB,Gisselø GG,Schafer-Nielsen C

更新日期：2002-03-01 00:00:00

abstract：:We present evidence that alterations in marrow adherent cell (M phi) function may play a role in the suppression of erythropoiesis in some patients with fungal infection. Bone marrow (BM) cells from 12 normals and 10 patients with histoplasmosis were cultured in plasma clots before and after removal of M phi. BM from ...

journal_title：British journal of haematology

authors： Zanjani ED,McGlave PB,Davies SF,Banisadre M,Kaplan ME,Sarosi GA

更新日期：1982-03-01 00:00:00

abstract：:We investigated the use of a new conditioning regimen followed by allogeneic bone marrow transplantation (BMT) for treating children with acute lymphoblastic leukaemia (ALL) after relapse within 6 months of the completion of therapy. One hundred and sixteen children with acute lymphoblastic leukaemia in second or subs...

journal_title：British journal of haematology

authors： Bordigoni P,Esperou H,Souillet G,Pico J,Michel G,Lacour B,Reiffers J,Sadoun A,Rohrlich P,Jouet JP,Milpied N,Lutz P,Plouvier E,Cornu G,Vannier JP,Gandemer V,Rubie H,Gratecos N,Leverger G,Stephan JL,Boutard P,Vern

更新日期：1998-08-01 00:00:00

abstract：:Antithrombin III (AT III) activity has been measured in 9669 healthy blood donors (5525 male and 4144 female). The distribution of AT III is approximately 'normal' with mean 105.6 IU/dl and standard deviation 11.2; however, definite age and sex related variations are evident. Pre-menopausal females have lower mean AT ...

journal_title：British journal of haematology

authors： Tait RC,Walker ID,Islam SI,McCall F,Conkie JA,Mitchell R,Davidson JF

更新日期：1993-07-01 00:00:00

abstract：:The retinoids: all-transretinoic acid (tretinoin), 13-cis retinoic acid (isotretinoin) and the aromatic retinoids etretinate and acitretin have a preventive and therapeutic effect on chemically-induced tumours. Clinically, retinoids have shown variable effectiveness in therapy and/or prevention of oncological diseases...

journal_title：British journal of haematology

authors： Bollag W

更新日期：1991-10-01 00:00:00

abstract：:Since the description in 1974 of the 5q--syndrome, only 29 cases have been reported. Over a 3 1/2 year period cytogenetic culture of bone marrow submitted from 344 patients being investigated for a blood disorder revealed nine patients with anomalies of chromosome 5. In five of these patients (samples arising from 37 ...

journal_title：British journal of haematology

authors： Tinegate H,Gaunt L,Hamilton PJ

更新日期：1983-05-01 00:00:00

abstract：:Thrombocytopenia and neutropenia are common among neonates in intensive care units. Bone marrow aspirations are sometimes performed as part of their evaluation. However, marrow biopsies have not been reported from living neonates. Since architecture and cellularity cannot generally be accurately assessed from marrow a...

journal_title：British journal of haematology

authors： Sola MC,Rimsza LM,Christensen RD

更新日期：1999-11-01 00:00:00

abstract：:The PFA-100(R) (PFA) diagnostic system for the detection of platelet dysfunction was evaluated to determine reference ranges in a normal population. The PFA determines the primary haemostasis capacity (PHC) of anticoagulated whole blood, expressed by the system's closure time (CT). In this study the CT reference range...

journal_title：British journal of haematology

authors： Böck M,De Haan J,Beck KH,Gutensohn K,Hertfelder HJ,Karger R,Heim MU,Beeser H,Weber D,Kretschmer V

更新日期：1999-09-01 00:00:00

abstract：:Pralatrexate inhibits folic acid metabolism, and preclinical studies have shown that it is cytotoxic to multiple myeloma cells. This phase 1 study investigated the safety and efficacy of pralatrexate in combination with bortezomib in adults with relapsed or refractory multiple myeloma. A standard 3 + 3 design was used...

journal_title：British journal of haematology

authors： Dunn TJ,Dinner S,Price E,Coutré SE,Gotlib J,Hao Y,Berube C,Medeiros BC,Liedtke M

更新日期：2016-04-01 00:00:00

abstract：:Current laboratory diagnostic methods for invasive fungal infection (IFI) in haemato-oncology patients are insensitive, resulting in late diagnosis and contributing to high mortality. In recent years, progress has been made in the development and evaluation of sensitive sero-diagnostic assays, including detection of g...

journal_title：British journal of haematology

authors： McLintock LA,Jones BL

更新日期：2004-08-01 00:00:00

abstract：:Between January 1987 and January 1997, 69 eligible patients with acute myeloid leukaemia (AML) in either second (CR2) or third (CR3) complete remission (CR2 = 60, CR3 = 9) underwent 4-hydroperoxycyclophosphamide-purged autologous bone marrow transplantation (BMT) at the Johns Hopkins Oncology Center. The patients' med...

journal_title：British journal of haematology

authors： Smith BD,Jones RJ,Lee SM,Piantadosi S,Vala MS,Fuller D,Gore SD,Noga SJ,O'Donnell PV,Braine H,Vogelsang GB,Fuchs EJ,Flinn IW,Brodsky RA,Ambinder RF,Miller CB

更新日期：2002-06-01 00:00:00

abstract：:The maintenance of physiological levels of haemoglobin is beneficial in the management of patients with thalassaemia major since it leads to better tissue oxygenation, reduction of blood volume, and reduced intestinal absorption of iron. We have studied 11 patients with thalassaemia major while treating them for 4-12 ...

journal_title：British journal of haematology

authors： Masera G,Terzoli S,Avanzini A,Fontanelli G,Mauri RA,Piacentini G,Ferrari M

更新日期：1982-09-01 00:00:00

abstract：:The polymerase chain reaction (PCR) assay was used to detect human parvovirus B19 DNA in 38 blood products and start plasma pools from five different manufacturers. The products examined were albumin, factor VIII, intravenous (i.v.) and intramuscular (i.m) immunoglobulin batches. The majority of pools from all the man...

journal_title：British journal of haematology

authors： Saldanha J,Minor P

更新日期：1996-06-01 00:00:00

abstract：:Epstein-Barr virus-associated haemophagocytic lymphohistiocytosis (EBV-HLH) is one of the most common subtypes of secondary HLH. However, more than 30% of patients do not respond to traditional treatment. Here, we investigated the efficacy and safety of the L-DEP regimen as a salvage therapy for paediatric refractory ...

journal_title：British journal of haematology

authors： Zhao Y,Li Z,Zhang L,Lian H,Ma H,Wang D,Zhao X,Zhang Q,Wang T,Zhang R

更新日期：2020-11-01 00:00:00

abstract：:Primary non-engraftment or early rejection after transplantation of haematopoietic stem cells represent life-threatening complications of allogeneic stem cell transplantation. Management of early graft failure has been problematic, as the risk of fatal infectious complications increases with the time of pancytopenia a...

journal_title：British journal of haematology

authors： Schlegel PG,Eyrich M,Bader P,Handgretinger R,Lang P,Niethammer D,Klingebiel T

更新日期：2000-11-01 00:00:00

abstract：:Isolated trisomy 8 (+8) is a frequent cytogenetic abnormality in the myelodysplastic syndromes (MDS), but its characteristics are poorly reported. We performed a retrospective study of 138 MDS patients with isolated +8, classified or reclassified as MDS (excluding MDS/myeloproliferative neoplasm). Myeloproliferative (...

journal_title：British journal of haematology

authors： Drevon L,Marceau A,Maarek O,Cuccuini W,Clappier E,Eclache V,Cluzeau T,Richez V,Berkaoui I,Dimicoli-Salazar S,Bidet A,Vial JP,Park S,Vieira Dos Santos C,Kaphan E,Berthon C,Stamatoullas A,Delhommeau F,Abermil N,Braun

更新日期：2018-09-01 00:00:00

abstract：:The effects of donor T cells, or their CD8+ subset, on engraftment and tolerance induction in fetal transplantation were evaluated using an F1-into-parent mouse-model that does not permit a graft-versus-host effect. Gestational day 13 C57BL/6 (H-2Kb) fetuses were transplanted with B6D2F1 (H-2Kb/d) light density bone m...

journal_title：British journal of haematology

authors： Chen JC,Chang ML,Lee H,Muench MO

更新日期：2004-08-01 00:00:00

abstract：:We examined major histocompatibility complex (MHC) class II expression in B cells, peripheral blood monocytes, activated T cells, epidermal Langerhans cells, monocyte-derived dendritic cells, dermal microvascular endothelial cells (DMEC) and fibroblasts of twin brothers with MHC class II deficiency. Although residual ...

journal_title：British journal of haematology

authors： Wolf HM,Thon V,Gulle H,Lechleitner S,Eibl MM,Petzelbauer P

更新日期：2001-11-01 00:00:00

abstract：:The regulatory human immunodeficiency virus-1 (HIV-1) Tat protein shows pleiotropic effects on the survival and growth of both HIV-1-infected and uninfected CD4+ T lymphocytes. In this study, we have demonstrated that low concentrations (10 ng/ml) of extracellular Tat protein induce the expression of both c-fos mRNA a...

journal_title：British journal of haematology

authors： Gibellini D,Re MC,Ponti C,Celeghini C,Melloni E,La Placa M,Zauli G

更新日期：2001-03-01 00:00:00