MDX-1097 induces antibody-dependent cellular cytotoxicity against kappa multiple myeloma cells and its activity is augmented by lenalidomide.

abstract：:Nd-HPFH are haematological conditions which are natural models to aid understanding of the haemoglobin (Hb) switch. In this paper we describe a new non-deletional hereditary persistence of fetal haemoglobin (nd-HPFH) associated with the highest Hb F level observed to date (up to 49% without haemopoietic stress). Seque...

journal_title：British journal of haematology

authors： Pissard S,M'rad A,Beuzard Y,Roméo PH

更新日期：1996-10-01 00:00:00

abstract：:Mobilization of haemopoietic precursor cells into the circulation by the combination of cytokines, stem cell factor (SCF) and G-CSF in previously untreated patients with carcinoma of the breast resulted in increased yield of collected peripheral blood precursor cells (PBPC). This mobilization of PBPC by SCF with G-CSF...

journal_title：British journal of haematology

authors： Roberts MM,Swart BW,Simmons PJ,Basser RL,Begley CG,To LB

更新日期：1999-03-01 00:00:00

abstract：:Plasma from patients with both acute and chronic liver disease has been examined for evidence of acquired dysfibrinogenaemia, using electrophoretic methods and coagulation tests. An examination of isolated fibrins upon SDS polyacryamide gel electrophoresis failed to demonstrate any molecular or structural defect assoc...

journal_title：British journal of haematology

authors： Lane DA,Scully MF,Thomas DP,Kakkar VV,Woolf IL,Williams R

更新日期：1977-02-01 00:00:00

abstract：:Very few studies have investigated the effects of exercise on the biological parameters involved in vaso-occlusive events in sickle cell anaemia (SCA). The aim of this study was to test how a mild-moderate endurance exercise modulates oxidative stress, nitric oxide bioavailability and endothelial activation in SCA pat...

journal_title：British journal of haematology

authors： Faes C,Balayssac-Siransy E,Connes P,Hivert L,Danho C,Bogui P,Martin C,Pialoux V

更新日期：2014-01-01 00:00:00

abstract：:Although 5-fluorouracil (FUra) has been the drug of choice for the treatment of patients with advanced colorectal carcinoma, the response rates are in the range of 15% and the median survival times do not exceed 9 months. Interferon alpha (IFN alpha) has limited antitumour activity in this disease. Recent clinical tri...

journal_title：British journal of haematology

authors： Rustum YM

更新日期：1991-10-01 00:00:00

abstract：:Treatment with 75 microg/kg/d intravenous (i.v.) anti-D was compared with 50 microg/kg/d in a prospective randomized study of 27 RhD-positive, human immunodeficiency virus-negative, adult, acute, non-splenectomized patients with immune thrombocytopenic purpura (ITP) and platelet counts < or = 30 x 109/l. The higher do...

journal_title：British journal of haematology

authors： Newman GC,Novoa MV,Fodero EM,Lesser ML,Woloski BM,Bussel JB

更新日期：2001-03-01 00:00:00

abstract：:Over 1000 monoclonal antibodies (MAB), previously characterized in terms of reactivity with various haemopoietic cells and including representatives from each of the currently known Clusters of Differentiation (CD), have now been evaluated by us for reactivity against human endothelial cells. In the current study, scr...

journal_title：British journal of haematology

authors： Favaloro EJ,Moraitis N,Bradstock K,Koutts J

更新日期：1990-04-01 00:00:00

abstract：:We treated 21 elderly patients with high-risk myelodysplasia (n = 14) or secondary acute myeloid leukaemia (n = 7) with 2 mg of melphalan orally once a day until a complete peripheral response was obtained or until there was evidence of treatment failure. We observed seven (30%) complete and two (10%) partial peripher...

journal_title：British journal of haematology

authors： Denzlinger C,Bowen D,Benz D,Gelly K,Brugger W,Kanz L

更新日期：2000-01-01 00:00:00

abstract：:The role of antiphospholipid antibodies in the pathogenesis of the thrombocytopenia observed during primary antiphospholipid antibody syndrome (APAS) and systemic lupus erythematosus (SLE) remains controversial. We have used the MAIPA test to examine the frequency and specificity of anti-platelet antibodies directed a...

journal_title：British journal of haematology

authors： Macchi L,Rispal P,Clofent-Sanchez G,Pellegrin JL,Nurden P,Leng B,Nurden AT

更新日期：1997-08-01 00:00:00

abstract：:Venesection of 10% of whole blood volume or plateletpheresis was performed in nine patients with chronic myeloproliferative disorders and in five normal control subjects. Before venesection, the patients showed impaired platelet aggregation in 33% of tests, most often in response to stimulation with 9 mumol adrenaline...

journal_title：British journal of haematology

authors： Boughton BJ

更新日期：1978-08-01 00:00:00

abstract：:Haemophilia B Leyden is characterized by severe factor IX deficiency during childhood with partial resolution at puberty or following the administration of anabolic steroids. The disorder has recently been associated with point mutations in the putative factor IX promoter region, which contains an imperfect direct rep...

journal_title：British journal of haematology

authors： Royle G,Van de Water NS,Berry E,Ockelford PA,Browett PJ

更新日期：1991-02-01 00:00:00

abstract：:Lymphoproliferative diseases of large granular lymphocytes (LDGL) may arise from either CD3+ T cells or CD3- natural killer (NK) cells. LDGL with clonal proliferation of large granular lymphocytes (LGL) is defined as LGL leukaemia. The number of patients with NK-LGL leukaemia reported is limited and the pathogenesis o...

journal_title：British journal of haematology

authors： Chou WC,Chiang IP,Tang JL,Su IJ,Huang SY,Chen YC,Liu MC,Lee FY,Wang CH,Shen MC,Chuang SM,Tien HF

更新日期：1998-12-01 00:00:00

abstract：:Myeloid neoplasms derive from the pathological clonal expansion of an abnormal stem cell and span a diverse spectrum of phenotypes including acute myeloid leukaemia (AML), myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS). Expansion of myeloid blasts with suppression of normal haematopoiesis is th...

journal_title：British journal of haematology

authors： Loh ML

更新日期：2011-03-01 00:00:00

abstract：:Neutrophils are amongst the first immune cells to arrive at sites of infection and play an important role as the host's first line of defence against invading pathogens. Defects of neutrophil number or function are usually recognized clinically by recurrent infections that often are life-threatening. Over the last few...

journal_title：British journal of haematology

authors： Bouma G,Ancliff PJ,Thrasher AJ,Burns SO

更新日期：2010-11-01 00:00:00

abstract：:Inhibitor formation in patients with haemophilia receiving factor VIII (FVIII) concentrate is a common problem requiring tolerance induction therapy. Immune tolerance is dependent on defective T cell/antigen-presenting cell (APC) interactions and inhibitor antibody formation is associated with effective T-cell/B-cell ...

journal_title：British journal of haematology

authors： Hodge G,Han P

更新日期：2000-04-01 00:00:00

abstract：:The determinants of steady state haemoglobin levels in sickle cell-haemoglobin C (SC) disease were investigated by measuring routine haematological and biochemical indices, red cell survival, oxygen affinity, pitted erythrocytes, and red cell and plasma volumes in 31 adult patients (15 male; 16 female). Red cell survi...

journal_title：British journal of haematology

authors： Bannerman RM,Serjeant B,Seakins M,England JM,Serjeant GR

更新日期：1979-09-01 00:00:00

abstract：:Accurate clinical staging is crucial for adequate risk-adapted treatment in Hodgkin lymphoma (HL) to prevent patients from under- or over-treatment. Within the latest German Hodgkin Study Group trial generation, diagnostic findings such as histopathology, computerized tomography imaging and clinical risk factors were ...

journal_title：British journal of haematology

authors： Bröckelmann PJ,Goergen H,Fuchs M,Kriz J,Semrau R,Baues C,Kobe C,Behringer K,Eichenauer DA,von Tresckow B,Klimm B,Halbsguth T,Wongso D,Plütschow A,Haverkamp H,Dietlein M,Eich HT,Stein H,Diehl V,Borchmann P,Engert A

更新日期：2015-11-01 00:00:00

abstract：:We studied MDS-associated inhibitory activity, which inhibited colony formation in vitro of granulocyte-macrophage progenitors (CFU-GM). Macrophages obtained from MDS bone marrow mononuclear cells (BM-MNC) when pretreated with granulocyte-macrophage colony stimulating factor (GM-CSF) suppressed the growth of normal CF...

journal_title：British journal of haematology

authors： Ohmori M,Ohmori S,Ueda Y,Tohyama K,Yoshida Y,Uchino H

更新日期：1990-02-01 00:00:00

abstract：:Long term outcomes and mutations in patients with mantle cell lymphoma (MCL) who discontinued ibrutinib have not been described. Using deep targeted next generation sequencing, we performed somatic mutation profiling from 15 MCL patients (including 5 patients with paired samples; before and after progression on ibruti...

journal_title：British journal of haematology

authors： Jain P,Kanagal-Shamanna R,Zhang S,Ahmed M,Ghorab A,Zhang L,Ok CY,Li S,Hagemeister F,Zeng D,Gong T,Chen W,Badillo M,Nomie K,Fayad L,Medeiros LJ,Neelapu S,Fowler N,Romaguera J,Champlin R,Wang L,Wang ML

更新日期：2018-11-01 00:00:00

abstract：:Megakaryocytic (Mk) cell maturation involves polyploidisation, and the number of platelets produced increases with Mk DNA content. Ploidy levels in cultured human MK cells are much lower than those observed in vivo. This study demonstrated that adding the water-soluble vitamin nicotinamide (NIC) to mobilised periphera...

journal_title：British journal of haematology

authors： Giammona LM,Fuhrken PG,Papoutsakis ET,Miller WM

更新日期：2006-11-01 00:00:00

abstract：:Using artificial receptors, it is possible to redirect the specificity of immune cells to tumour-associated antigens, which is expected to provide a useful strategy for cancer immunotherapy. Given that B-cell non-Hodgkin lymphoma (B-NHL) cells invariably express CD19 and CD38, these antigens may be suitable molecular ...

journal_title：British journal of haematology

authors： Mihara K,Yanagihara K,Takigahira M,Kitanaka A,Imai C,Bhattacharyya J,Kubo T,Takei Y,Yasunaga S,Takihara Y,Kimura A

更新日期：2010-10-01 00:00:00

abstract：:This phase 2 study (N = 116) evaluated single-agent vosaroxin, a first-in-class anticancer quinolone derivative, in patients ≥60 years of age with previously untreated unfavourable prognosis acute myeloid leukaemia. Dose regimen optimization was explored in sequential cohorts (A: 72 mg/m(2)  d 1, 8, 15; B: 72 mg/m(2) ...

journal_title：British journal of haematology

authors： Stuart RK,Cripe LD,Maris MB,Cooper MA,Stone RM,Dakhil SR,Turturro F,Stock W,Mason J,Shami PJ,Strickland SA,Costa LJ,Borthakur G,Michelson GC,Fox JA,Leavitt RD,Ravandi F

更新日期：2015-03-01 00:00:00

abstract：:Investigations of naturally occurring mutations, such as the deletional thalassaemias and hereditary persistence of fetal haemoglobins (HPFHs), have brought many insights into human globin switching, but limited data have been reported so far. We selected 15 individuals with elevated fetal haemoglobin (HbF) levels (>5...

journal_title：British journal of haematology

authors： Lee ST,Yoo EH,Kim JY,Kim JW,Ki CS

更新日期：2010-01-01 00:00:00

abstract：:Iron uptake and storage in peripheral blood leucocytes has been studies to test the hypothesis that the basic lesion in idiopathic haemochromatosis resides in a failure of mononuclear phagocytic cells to store iron. In seven fully treated cases of this disease there was no evidence of any abnormality in iron uptake, s...

journal_title：British journal of haematology

authors： Jacobs A,Summers MR

更新日期：1981-12-01 00:00:00

abstract：:The specific sodium pump antagonist ouabain was used to study the effect of sodium pump inhibition on granulopoietic colony formation by normal human bone marrow cells cultured in soft agar for 7 d. Suppression of colony formation was dose-dependent and occurred at a low and reproducible concentration. The use of an e...

journal_title：British journal of haematology

authors： Steed AJ,Boardman KM,Delamore IW

更新日期：1982-07-01 00:00:00

abstract：:A multiparameter flow-cytometrical method for the quantitation of CD34(+)-cells present in adult human peripheral blood cells (PBMC) has been developed. PBMC from 13 healthy adult subjects were analysed for CD34(+)-cells by flow-cytometry, with only the lymphoid population of cells negative for anti-CD3-moAb included ...

journal_title：British journal of haematology

authors： Serke S,Säuberlich S,Huhn D

更新日期：1991-04-01 00:00:00

abstract：:Commercial preparations of ferritin inhibited reticulocyte-lysate cell-free protein synthesis and disaggregated polyribosomes to monoribosomes and ribosomal subunits. These effects were prevented by addition of reduced glutathione (GSH) to the incubation medium, but ferritin did not lower GSH concentration in the lysa...

journal_title：British journal of haematology

authors： Freedman ML,Cohen HS,Rosman J,Forte FJ

更新日期：1976-04-01 00:00:00

abstract：:Five paediatric cases of haemophagocytic lymphohistiocytosis (HLH) which showed proliferation of granular atypical lymphocytoid cells in bone marrow are reported. All cases were girls aged 8 months to 4 years who had marked hepatosplenomegaly. Marker analysis on peripheral blood mononuclear cells revealed an increase ...

journal_title：British journal of haematology

authors： Imashuku S,Hibi S,Morinaga S,Takagi K,Chen J,Mugishima H,Ishii T,Sako M,Arakawa H,Kato M

更新日期：1997-03-01 00:00:00

abstract：:Mutations of the p53 tumour suppressor gene occur in 20% of chronic myeloid leukaemia (CML) patients in blastic crisis, but it is still uncertain whether this inactivation plays a role in the pathogenesis of blastic transformation or in maintaining the leukaemic proliferation in CML, as it does in several solid tumour...

journal_title：British journal of haematology

authors： Lanza F,Bi S,Moretti S,Castoldi G,Goldman JM

更新日期：1995-05-01 00:00:00

abstract：:SAn ageing population and the continuing expansion of clinical indications for coumadin therapy have increased pressure on hospital anticoagulant clinics. One solution is patient self-testing (PST) of the international normalized ratio (INR) using capillary blood samples on point-of-care coagulation monitors at home. ...

journal_title：British journal of haematology

authors： Gardiner C,Williams K,Mackie IJ,Machin SJ,Cohen H

更新日期：2005-01-01 00:00:00