Abstract:
:Over 1000 monoclonal antibodies (MAB), previously characterized in terms of reactivity with various haemopoietic cells and including representatives from each of the currently known Clusters of Differentiation (CD), have now been evaluated by us for reactivity against human endothelial cells. In the current study, screening was performed on both fixed, and on non-fixed, endothelial cells derived and cultured from umbilical cord veins. Results indicate that endothelial cells co-express a wide variety of antigens that are otherwise characterized by expression on haemopoietic cells. The most intense and consistent degree of reactivity was seen using MAB to CD-9, CD-13, CD-29, CD-31, CD-44, CD-46, CD-51, CD-54 and CD-55, although reactivity was also observed using MAB belonging to CD-41, CD-47, CD-49, CD-61 and CD-71, in addition to a number of non-clustered MAB.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Favaloro EJ,Moraitis N,Bradstock K,Koutts Jdoi
10.1111/j.1365-2141.1990.tb06324.xsubject
Has Abstractpub_date
1990-04-01 00:00:00pages
385-94issue
4eissn
0007-1048issn
1365-2141journal_volume
74pub_type
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journal_title:British journal of haematology
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